Positions

Overview

  • Dr. Sabbaj’s research interests are mainly focused on the study of HIV-specific T cells from peripheral blood and different mucosal compartments and their role in the pathogenesis of HIV-infection. She has studied T cells isolated from peripheral blood, breast milk and more recently menstrual blood in order to understand how these cells control infection. She has extensive experience and expertise in isolating and characterizing T cells from multiple cell sources from both HIV infected and HIV vaccinated healthy individuals. She was the first to demonstrate that HIV-specific T cells were present in the breast milk of infected women and was the first to isolate and characterize T cells from menstrual blood.

    She has various publications demonstrating her ability to measure both CD4 and CD8 antigen-specific responses in humans using a plethora of assays including the IFN-g ELISPOT, intracellular cytokine staining and CFSE staining using multicolor flow cytometry. Additional interests include studying T cell responses generated to an experimental vaccine against CMV and understanding NK cells and their functions via HLA-E bound to HIV peptides.
  • Investigator On

  • UAB-MISS MACS/WIHS Combined Cohort Study (MACS/WIHS-CCS)  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2019 - 2026
  • Host Immune Responses to Chlamydia trachomatis Candidate Vaccine Antigens and their Association with Clinical Correlates of Protective Immunity in Women  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2020 - 2025
  • Mechanisms and Correlates of Immune Protection against Genital Chlamydia in Humans  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2020 - 2024
  • UAB Center for AIDS Research (CFAR)  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2019 - 2024
  • Identification of Drugs that Induce Terminal Transcriptional Silencing of Latent HIV-1 Infection  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2017 - 2021
  • Overcoming HIV-1 Transcriptional Latency in Unresponsive CD4 T Cells  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2016 - 2021
  • CTL and HIV Polymorphisms in Heterosexual Transmission  awarded by Emory University 2015 - 2021
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2019 - 2021
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2019 - 2021
  • Comprehensive Cancer Center Core Support Grant - Administrative Supplement to Stimulate Research in HIV/AIDS Cancer Research  awarded by National Cancer Institute/NIH/DHHS 2019 - 2021
  • Comprehensive Cancer Center Core Support Grant - Administrative Supplement to Stimulate Research in HIV/AIDS Cancer Research  awarded by National Cancer Institute/NIH/DHHS 2019 - 2021
  • Kinomic Analysis of Host Cell Factors Controlling Latent HIV-1 Infection  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2016 - 2020
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2017 - 2019
  • Comprehensive Cancer Center Core Support Grant - Administrative Supplement to Stimulate Research in HIV/AIDS Cancer Research  awarded by National Cancer Institute/NIH/DHHS 2017 - 2019
  • MTN 026 Protocol Funds  awarded by Magee-Womens Research Institute (MWRI) 2015 - 2018
  • Private Grant  awarded by GENOCEA BIOSCIENCES, INC. 2016 - 2017
  • Mechanisms and Correlates of Immune Protection Against Genital Chlamydia in Humans  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2011 - 2017
  • Kinomic Analysis of Host Cell Factors Controlling Latent HIV-1 Infection  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2014 - 2016
  • Effector and Regulatory Activities of HLA-E-Restricted HIV-Specific aBCD8 T Cells  awarded by UNIVERSITY OF TEXAS (EL PASO) 2012 - 2016
  • HIV-1 Cryptic Epitopes: Implications for Vaccine Design  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2009 - 2015
  • CTL and HIV Polymorphisms in Heterosexual Transmission  awarded by Emory University 2010 - 2015
  • Analysis of Variant Epitope Specific CD8 T-Cells to Optimize HIV Vaccine Design  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2012 - 2014
  • Education And Training

  • Doctor of Philosophy in Immunology, Ohio State University System : Columbus 1994
  • Full Name

  • Steffanie Sabbaj