Obtained his B.S degree in Chemistry at Birzeit University in Palestine (1996), M.S degree in Bioinorganic Chemistry at Bergen University in Norway (1998; advisor: Dr. Einar Sletten), and a Ph.D degree in Bioinorganic Chemistry at Emory University in Atlanta (2002; advisor: Dr. Luigi Marzilli). His M.S. and Ph.D studies focused on studying the interactions of cisplatin, a leading anticancer drug, with DNA by using Nuclear Magnetic Resonance (NMR) and other biophysical methods. Dr. Saad's postdoctoral work in Dr. Michael Summers' lab (HHMI, UMBC) focused on the mechanism by which retroviruses are directed to specific cellular membranes for assembly. Dr. Saad joined the UAB faculty in 2007.
HIV-Host Interactions and Fas-Mediated Apoptosis - My lab is interested in understanding biological mechanisms in virology and cancer at the atomic level. Our biggest state-of-the-art toy in the lab is called Nuclear Magnetic Resonance (NMR). We apply this technology to assess how proteins interact with membranes, other proteins, small molecules, and sugars. In collaboration with UAB colleagues, we are starting to apply NMR Spectroscopy methods to detect and quantify metabolites in animal cells and tissues. Our main focus in the virology field is aimed at elucidating molecular mechanisms of HIV assembly. Our cancer projects include those aimed at characterization of protein-protein interactions pertaining to Fas-mediated apoptosis in cholangiocarcinoma. Most recently, we have been investigating at the structural level how the Akt protein interacts with lipids and proteins to facilitate translocation to the plasma membrane for activation in many cancer cells.