Positions

Overview

  • Richard Whitley, M.D., is a Distinguished Professor of Pediatrics, Professor of Microbiology, Medicine and Neurosurgery; Loeb Eminent Scholar Chair in Pediatrics; Co-Director, Division of Pediatric Infectious Diseases; Vice-Chair, Department of Pediatrics; Senior Scientist, Department of Gene Therapy; Scientist, Cancer Research and Training Center; Faculty, Gene Therapy Center; Associate Director for Drug Discovery and Development and Senior Leader, Pediatric Oncology Program, O’Neal Comprehensive Cancer Center at UAB; and Co-Founder and Co-Director, Alabama Drug Discovery Alliance.

    Whitley is responsible for the National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group whose role is to perform clinical trials of antiviral therapies directed against medically important viral diseases of children and adults including viruses considered as threats to human health. Whitley’s other research interest is in the translation of molecular biology to clinical application, particularly in the development of human monoclonal antibodies for therapy of herpesvirus infections and engineering of herpes simplex virus for gene therapy. In these latter studies, he and his colleagues have engineered herpes simplex virus to serve as a vector for foreign gene expression.

    He received his B.A. in chemistry from Duke University and his M.D. from the George Washington University. He subsequently completed an internship in pediatrics and a fellowship in infectious diseases/virology at UAB. He has published more than 347 articles. He participates in numerous Data Safety and Monitoring Boards for ongoing clinical studies. He is a past President of the Infectious Diseases Society of America (IDSA) and received the UAB President’s Medal in 2007. In 2013, he was named as the inaugural recipient of the Distinguished Clinical Research Scholar and Educator in Residence at the NIH Clinical Center.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Congenital Cytomegalovirus and Neonatal Herpes Simplex Virus Infections: To Treat or Not to Treat? 2019
    2019 Valaciclovir therapy for herpes encephalitis: caution advised 2019
    2019 Blood Viral Load in Symptomatic Congenital Cytomegalovirus Infection 2019
    2019 Genotypic and phenotypic diversity of herpes simplex virus 2 within the infected neonatal population 2019
    2019 Safety and efficacy of oncolytic HSV-1 G207 inoculated into the cerebellum of mice 2019
    2018 Comparison of antiviral resistance across acute and chronic viral infections 2018
    2018 Efficacy and Safety of Oseltamivir in Children: Systematic Review and Individual Patient Data Meta-analysis of Randomized Controlled Trials 2018
    2018 Five years of monitoring for the emergence of oseltamivir resistance in patients with influenza A infections in the Influenza Resistance Information Study 2018
    2018 Clinical management of herpes simplex virus infections: past, present, and future 2018
    2017 Herpes Simplex Encephalitis: an Update 2017
    2017 Accelerating Drug Development: Antiviral Therapies for Emerging Viruses as a Model 2017
    2017 Pathogenesis of Non-Zika Congenital Viral Infections 2017
    2016 The authors reply 2016
    2016 Viral infection in the development and progression of pediatric acute respiratory distress syndrome 2016
    2016 Genital herpes 2016
    2016 Consortia's critical role in developing medical countermeasures for re-emerging viral infections: A USA perspective 2016
    2016 Oseltamivir for influenza - Authors' reply 2016
    2015 Herpes Simplex Virus Infections of the Central Nervous System 2015
    2015 A randomized, double-blind, placebo-controlled trial of pleconaril for the treatment of neonates with enterovirus sepsis 2015
    2015 Addendum: Kong, M.Y.; Whitley, R.J.; Peng, N.; Oster, R.; Schoeb, T.R.; Sullender, W.; Ambalavanan, N.; Clancy, J.P.; Gaggar, A.; Blalock J.E. Matrix Metalloproteinase-9 Mediates RSV Infection in Vitro and in Vivo. Viruses 2015, 30, 7, 4230–4253. 2015
    2015 Matrix metalloproteinase-9 mediates RSV infection in vitro and in vivo 2015
    2015 Oseltamivir treatment for influenza in adults: A meta-analysis of randomised controlled trials 2015
    2015 Challenges and opportunities in developing respiratory syncytial virus therapeutics 2015
    2015 Valganciclovir for symptomatic congenital cytomegalovirus disease 2015
    2015 Authors reply 2015
    2015 Herpes simplex encephalitis: Lack of clinical benefit of long-term valacyclovir therapy 2015
    2015 Single dose peramivir for the treatment of acute seasonal influenza: Integrated analysis of efficacy and safety from two placebo-controlled trials 2015
    2015 Use of clinical and neuroimaging characteristics to distinguish temporal lobe herpes simplex encephalitis from its mimics 2015
    2015 Valganciclovir for Symptomatic Congenital Cytomegalovirus Disease 2015
    2015 Waning efficacy of the herpes zoster vaccine 2015
    2014 West Nile virus neuroinvasive disease: Neurological manifestations and prospective longitudinal outcomes 2014
    2014 Erratum: Global assessment of resistance to neuraminidase inhibitors, 2008-2011: The Influenza Resistance Information Study (IRIS) (Clinical Infectious Diseases (2013) 56 (1197-205)) 2014
    2014 Evaluation of the safety and biodistribution of M032, an attenuated herpes simplex virus type 1 expressing hIL-12, after intracerebral administration to Aotus Nonhuman Primates 2014
    2014 A novel potential therapy for HSV 2014
    2014 A phase 1 trial of oncolytic HSV-1, g207, given in combination with radiation for recurrent GBM demonstrates safety and radiographic responses 2014
    2014 Assessment of oncolytic HSV efficacy following increased entry-receptor expression in malignant peripheral nerve sheath tumor cell lines 2014
    2014 Herpes simplex virus 2014
    2014 Oral GS-5806 activity in a respiratory syncytial virus challenge study 2014
    2014 The development of new therapies for human herpesvirus 6 2014
    2014 The posology of oseltamivir in infants with influenza infection using a population pharmacokinetic approach 2014
    2013 Production of bioactive soluble interleukin-15 in complex with interleukin-15 receptor alpha from a conditionally-replicating oncolytic HSV-1 2013
    2013 Case definitions, diagnostic algorithms, and priorities in encephalitis: Consensus statement of the international encephalitis consortium 2013
    2013 An inquiry into the molecular basis of HSV latency and reactivation 2013
    2013 Viral therapy of glioblastoma multiforme 2013
    2013 Global assessment of resistance to neuraminidase inhibitors, 2008-2011: The influenza resistance information study (IRIS) 2013
    2013 Erratum: Changing epidemiology of herpes simplex virus infections (Clinical Infectious Diseases (2013) 56 (352-353)) 2013
    2013 Oseltamivir pharmacokinetics, dosing, and resistance among children aged <2 years with influenza 2013
    2013 Editorial commentary: Changing Epidemiology of Herpes Simplex Virus Infections 2013
    2012 Predictors of undiagnosed herpes simplex virus type 2 seropositivity among persons attending an HIV care clinic 2012
    2012 Correlation and clinical utility of pp65 antigenemia and quantitative polymerase chain reaction assays for detection of cytomegalovirus in pediatric renal transplant patients 2012
    2012 Preclinical evaluation of a genetically engineered herpes simplex virus expressing interleukin-12 2012
    2012 The Use of Antiviral Drugs During the Neonatal Period 2012
    2012 The authors reply 2012
    2012 Current management and recommendations for access to antiviral therapy of herpes labialis 2012
    2011 Neonatal herpes simplex virus infections: Where are we now? 2011
    2011 Oral acyclovir suppression and neurodevelopment after neonatal herpes 2011
    2011 A Genome-Wide comparative evolutionary analysis of herpes simplex virus type 1 and varicella zoster virus 2011
    2011 The Alabama drug discovery alliance: A collaborative partnership to facilitate academic drug discovery 2011
    2011 Engineered herpes simplex virus vectors for antitumor therapy and vaccine delivery 2011
    2011 Antiviral drugs and antiviral drug resistance 2011
    2011 Safety and pharmacokinetics of ribavirin for the treatment of la crosse encephalitis 2011
    2010 Moving toward elimination of healthcare-associated infections: A call to action 2010
    2010 Moving toward elimination of healthcare-associated infections: A call to action 2010
    2010 Reply to Johnson and Stricker 2010
    2010 Treatment of herpes simplex virus infections in pediatric patients: Current status and future needs 2010
    2010 Oseltamivir dosing for influenza infection in premature neonates 2010
    2010 Management of herpes zoster and post-herpetic neuralgia now and in the future 2010
    2010 Herpes simplex virus in African American heterosexual males: The roles of age and male circumcision 2010
    2010 Of ferrets and humans: Influenza pathogenesis 2010
    2010 Incomplete financial disclosures in an editorial, clinical crossroads, and reply letter related to herpes zoster 2010
    2010 Safety of oseltamivir compared with the adamantanes in children less than 12 months of age 2010
    2009 In reply 2009
    2009 Inhibition of herpesvirus replication by 5-substituted 4′- thiopyrimidine nucleosides 2009
    2009 Neurodevelopmental outcomes following ganciclovir therapy in symptomatic congenital cytomegalovirus infections involving the central nervous system 2009
    2009 Antiviral therapy for herpesvirus central nervous system infections: Neonatal herpes simplex virus infection, herpes simplex encephalitis, and congenital cytomegalovirus infection 2009
    2009 A 70-year-old woman with shingles: Review of herpes zoster 2009
    2009 Treatment of recurrent malignant glioma with G207, a genetically engineered herpes simplex virus-1, followed by irradiation: Phase I study results. 2009
    2009 Treatment of congenital cytomegalovirus infection: Implications for future therapeutic strategies 2009
    2009 Herpes zoster in the age of focused immunosuppressive therapy 2009
    2009 Phase Ib trial of mutant herpes simplex virus G207 inoculated pre-and post-tumor resection for recurrent GBM 2009
    2008 Detection and diagnosis of herpes simplex virus infection in adults with acute liver failure 2008
    2008 Therapy of herpes virus infections in children 2008
    2008 The management of encephalitis: Clinical practice guidelines by the Infectious Diseases Society of America 2008
    2008 Seasonal and pandemic influenza: A 2007 update on challenges and solutions 2008
    2008 Pharmacokinetic and pharmacodynamic assessment of oral valganciclovir in the treatment of symptomatic congenital cytomegalovirus disease 2008
    2008 The new age of molecular diagnostics for microbial agents 2008
    2008 Diagnosis and Assessment of Pain Associated With Herpes Zoster and Postherpetic Neuralgia 2008
    2008 Neonatal herpes - The forgotten perinatal infection 2008
    2007 (Herpes (2007) 14, SUPPL. 2, (25A-29A)) 2007
    2007 The incidence and severity of herpes simplex encephalitis in Sweden, 1990-2001 2007
    2007 The role of oseltamivir in the treatment and prevention of influenza in children. 2007
    2007 HIV-189.6 Gag expressed from a replication competent HSV-1 vector elicits persistent cellular immune responses in mice 2007
    2007 Incidence of neonatal herpes simplex virus infections in a managed-care population 2007
    2007 An update on short-course intermittent and prevention therapies for herpes labialis 2007
    2007 Ganciclovir population pharmacokinetics in neonates following intravenous administration of ganciclovir and oral administration of a liquid valganciclovir formulation 2007
    2007 Review of recent HSV recurrent-infection treatment studies 2007
    2007 Current non-AIDS antiviral chemotherapy 2007
    2007 Varicella-zoster vaccine for the prevention of herpes zoster 2007
    2007 Engineered herpes simplex virus expressing bacterial cytosine deaminase for experimental therapy of brain tumors 2007
    2007 Randomized controlled multicenter trial of aerosolized ribavirin for respiratory syncytial virus upper respiratory tract infection in hematopoietic cell transplant recipients 2007
    2007 Recommendations for the management of herpes zoster 2007
    2007 Short-course therapy for recurrent genital herpes and herpes labialis 2007
    2007 The role of oseltamivir in the treatment and prevention of influenza in children 2007
    2006 Lessons learned from reconstructing the 1918 influenza pandemic 2006
    2006 Oncolytic HSV-1 for the treatment of brain tumours 2006
    2006 Prevention and treatment of influenza in high-risk groups: Children, pregnant women, immunocompromised hosts, and nursing home residents 2006
    2006 Recurrent benign lymphocytic meningitis 2006
    2006 Seasonal and pandemic influenza preparedness: A global threat 2006
    2006 Seasonal and pandemic influenza: Recommendations for preparedness in the United States 2006
    2006 Herpes simplex encephalitis: Adolescents and adults 2006
    2006 New approaches to the therapy of HSV infections 2006
    2006 Serial passage through human glioma xenografts selects for a Δγ134.5 herpes simplex virus type 1 mutant that exhibits decreased neurotoxicity and prolongs survival of mice with experimental brain tumors 2006
    2006 Enteroviral meningitis: Natural history and outcome of pleconaril therapy 2006
    2006 Single-day famciclovir therapy for recurrent genital herpes 2006
    2006 Regulatory challenges: Lessons from recent West Nile virus trials in the United States 2006
    2006 The spectrum of genital herpes simplex virus infection in men attending a sexually transmitted disease clinic 2006
    2006 Genetically engineered herpes simplex viruses that express IL-12 or GM-CSF as vaccine candidates 2006
    2006 Valacyclovir therapy to reduce recurrent genital herpes in pregnant women 2006
    2005 Neonatal herpes should be a reportable disease 2005
    2005 A randomized, open-label study to evaluate the safety and pharmacokinetics of human hepatitis C immune globulin (Civacir) in liver transplant recipients 2005
    2005 Historical correlates of genital herpes simplex virus type 2 infection in men attending an STD clinic 2005
    2005 Increased efficacy of an interleukin-12-secreting herpes simplex virus in a syngeneic intracranial murine glioma model 2005
    2005 Changing dynamics of varicella-zoster virus infections in the 21st century: The impact of vaccination 2005
    2005 Enhanced inhibition of syngeneic murine tumors by combinatorial therapy with genetically engineered HSV-1 expressing CCL2 and IL-12 2005
    2005 The use of dexamethasone in bacterial meningitis [2] (multiple letters) 2005
    2005 Human herpesvirus 6 infection of the central nervous system: Is it just a case of mistaken association? 2005
    2005 Detection of cytomegalovirus (CMV) DNA by polymerase chain reaction is associated with hearing loss in newborns with symptomatic congenital CMV infection involving the central nervous system 2005
    2005 Herpes simplex: Encephalitis children and adolescents 2005
    2005 Neonatal herpes: What have we learned 2005
    2005 Seminars in Pediatric Infectious Diseases: Introduction 2005
    2004 Placebo-controlled, double-blind trial of intravenous ribavirin for the treatment of hantavirus cardiopulmonary syndrome in North America 2004
    2004 Practice guidelines for the management of bacterial meningitis 2004
    2004 Commentary: Ch'ien LT, Cannon NJ, Charamella LJ, et al. Effect of adenine arabinoside on severe herpesvirus hominis infections in man: Preliminary report. J Infect Dis 1973; 128:658-63 2004
    2004 Congenital cytomegalovirus infection: Epidemiology and treatment 2004
    2004 HSV shedding 2004
    2004 HSV-2 transmission 2004
    2004 Lessons from HIV and hepatitis viruses 2004
    2004 Cytomegalovirus and HIV: Inextricably entwined pathogens 2004
    2004 Herpesvirus infections of the central nervous system 2004
    2004 Neonatal herpes simplex virus infection 2004
    2004 Effect of adenine arabinoside on severe Herpesvirus hominis infections in man. 1973. 2004
    2004 Introduction: Is viral shedding a surrogate marker for transmission of genital herpes? 2004
    2004 Issues in regulatory guidelines for data monitoring committees 2004
    2003 Effect of ganciclovir therapy on hearing in symptomatic congenital cytomegalovirus disease involving the central nervous system: A randomized, controlled trial 2003
    2003 Herpes zoster [8] (multiple letters) 2003
    2003 Double blind placebo-controlled trial of pleconaril in infants with enterovirus meningitis 2003
    2003 Double blind placebo-controlled trial of pleconaril in infants with enterovirus meningitis. 2003
    2003 Smallpox: A potential agent of bioterrorism 2003
    2002 Herpes zoster 2002
    2002 The case of the vanishing herpes simplex virus 2002
    2002 Herpes simplex viruses: is a vaccine tenable? 2002
    2002 Clinical applications for change-point analysis of herpes zoster pain 2002
    2002 Herpes Simplex Virus in Children. 2002
    2002 The use of a genetically engineered herpes simplex virus (R7020) with ionizing radiation for experimental hepatoma 2002
    2002 Viral encephalitis: Familiar infections and emerging pathogens 2002
    2002 Friendly fire: Redirecting herpes simplex virus-1 for therapeutic applications 2002
    2002 Herpes simplex virus infection 2002
    2002 Herpes simplex viruses: Is a vaccine tenable? 2002
    2002 The use of a genetically engineered herpes simplex virus (R7020) with ionizing radiation for experimental hepatoma 2002
    2001 Prevention of hepatitis B in adolescents [12] 2001
    2001 Phase specific analysis of herpes zoster associated pain data: A new statistical approach 2001
    2001 Natural history of neonatal herpes simplex virus infections in the acyclovir era 2001
    2001 Safety and efficacy of high-dose intravenous acyclovir in the management of neonatal herpes simplex virus infections 2001
    2001 Natural history of neonatal herpes simplex virus infections in the acyclovir era. 2001
    2001 Safety and efficacy of high-dose intravenous acyclovir in the management of neonatal herpes simplex virus infections. 2001
    2001 Herpes simplex virus infections 2001
    2001 Genetically engineered human herpes simplex virus in the treatment of brain tumours 2001
    2001 The nine ages of herpes simplex virus 2001
    2001 Oral oseltamivir treatment of influenza in children 2001
    2001 Recommended childhood immunization schedule - United States, January-December 2001 2001
    2001 Erratum: Oral oseltamivir treatment of influenza in children (Pediatric Infectious Disease Journal (february 20001) 20:2 (127-133)) 2001
    2001 Immunologic approach to herpes simplex virus 2001
    2001 Oral oseltamivir treatment of influenza in children 2001
    2000 Our evolving knowledge of herpesviruses 2000
    2000 Technical Report: Transmissible spongiform encephalopathies: A review for pediatricians 2000
    2000 American Academy of Pediatrics. Technical report: transmissible spongiform encephalopathies: A review for pediatricians. Committee on Infectious Diseases. 2000
    2000 Editorial: Our Evolving Knowledge of Herpesviruses. 2000
    2000 Genetically engineered HSV in the treatment of glioma: A review 2000
    2000 Engineered herpes simplex virus expressing IL-12 in the treatment of experimental murine brain tumors 2000
    2000 Chemical-biological terrorism and its impact on children: A subject review 2000
    2000 HSV resistance - Is there an issue? 2000
    2000 Infection control in physicians' offices 2000
    2000 Introduction 2000
    2000 Meningococcal disease prevention and control strategies for practice-based physicians (Addendum: Recommendations for college students) 2000
    2000 Optimizing the management of genital herpes - STD physician's perspective 2000
    2000 Policy statement: Recommendations for the prevention of pneumococcal infections, including the use of pneumococcal conjugate vaccine (Prevnar), pneumococcal polysaccharide vaccine, and antibiotic prophylaxis 2000
    2000 Prevention of lyme disease 2000
    2000 Recommended Childhood Immunization Schedule - United States, January- December 2000 2000
    2000 Varicella vaccine update 2000
    1999 Herpes zoster: Focus on treatment in older adults 1999
    1999 Prevention of poliomyelitis: Recommendations for use of only inactivated poliovirus vaccine for routine immunization 1999
    1999 Therapeutic approaches to the management of herpes zoster 1999
    1999 Effect of recombinant human interferon α B/D (rHu-IFN-α B/D) in combination with acyclovir in experimental HSV-1 encephalitis 1999
    1999 Clinical significance of enteroviruses in serious summer febrile illnesses of children 1999
    1999 Possible association of intussusception with rotavirus vaccination 1999
    1999 Immunizations for native American children 1999
    1999 Possible association of intussusception with rotavirus vaccination. American Academy of Pediatrics. Committee on Infectious Diseases. 1999
    1999 A mixed model for factors predictive of pain in AIDS patients with herpes zoster 1999
    1999 Ionizing radiation improves survival in mice bearing intracranial high- grade gliomas injected with genetically modified herpes simplex virus 1999
    1999 New Thoughts on Pathogenesis and Diagnosis of Encephalitis. 1999
    1999 Measles immunization in HIV-infected children 1999
    1999 Replication-competent, nonneuroinvasive genetically engineered herpes virus is highly effective in the treatment of therapy-resistant experimental human tumors 1999
    1999 Cytomegalovirus retinitis - Evolving therapies in a new era 1999
    1999 Herpes zoster: Risk categories for persistent pain 1999
    1999 A new role for herpes simplex virus? 1999
    1999 Approaches to the treatment of varicella-zoster virus infections. 1999
    1999 Poliomyelitis prevention: Revised recommendations for use of inactivated and live oral poliovirus vaccines 1999
    1999 Recommended childhood immunization schedule - United States, January- December 1999 1999
    1999 Thimerosal in vaccines - An interim report to clinicians 1999
    1999 Use of the ganciclovir implant for the treatment of cytomegalovirus retinitis in the era of potent antiretroviral therapy: Recommendations of the international AIDS society-USA panel 1999
    1999 Viral encephalitis. 1999
    1998 Comparison of antiviral compounds against human herpesvirus 6 and 7 1998
    1998 Application of competitive PCR to cerebrospinal fluid samples from patients with herpes simplex encephalitis 1998
    1998 Guidelines for the treatment of cytomegalovirus diseases in patients with AIDS in the era of potent antiretroviral therapy: Recommendations of an international panel 1998
    1998 Sorivudine versus acyclovir for treatment of dermatomal herpes zoster in human immunodeficiency virus-infected patients: Results from a randomized, controlled clinical trial 1998
    1998 Sorivudine versus acyclovir for treatment of dermatomal herpes zoster in human immunodeficiency virus-infected patients: results from a randomized, controlled clinical trial. Collaborative Antiviral Study Group/AIDS Clinical Trials Group, Herpes Zoster Study Group. 1998
    1998 Summary of the III international consensus symposium on combined antiviral therapy 1998
    1998 Herpes simplex viruses 1998
    1998 Hepatitis C virus infection 1998
    1998 Age for routine administration of the second dose of measles-mumps- rubella vaccine 1998
    1998 Erratum: Retraction: A rabbit model for human cytomegalovirus-induced chorioretinal disease (The Journal of Infectious Diseases (1998) 177 (1778)) 1998
    1998 Human herpesvirus-6: Neurologic implications of a newly-described viral pathogen 1998
    1998 Pharmacokinetics of oral valacyclovir and acyclovir in late pregnancy 1998
    1998 Prevention of respiratory syncytial virus infections: Indications for the use of palivizumab and update on the use of RSV-IGIV 1998
    1998 Prevention of rotavirus disease: Guidelines for use of rotavirus vaccine 1998
    1998 Recommended childhood immunization schedule - United states, January- December 1998 1998
    1998 Retraction: A rabbit model for human cytomeglovirus--induced chorioretinal disease (J Infect Dis 1993;168:336-44). 1998
    1998 Severe invasive group a streptococcal infections: A subject review 1998
    1998 Sexually transmitted diseases. 1998
    1998 The identification of risk factors associated with persistent pain following herpes zoster 1998
    1998 Treatment of intracranial gliomas in immunocompetent mice using herpes simplex viruses that express murine interleukins 1998
    1997 Antiviral Therapy for Neonatal Herpes Simplex Virus: A Cost-Effectiveness Analysis 1997
    1997 Treatment of viral infections during pregnancy and the neonatal period 1997
    1997 Evaluation of genetically engineered herpes simplex viruses as oncolytic agents for human malignant brain tumors 1997
    1997 Ganciclovir treatment of symptomatic congenital cytomegalovirus infection: results of a phase II study. National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group. 1997
    1997 Recommended childhood immunization schedule - United States, January- December 1997 1997
    1997 Diagnosis of enterovirus infection by polymerase chain reaction of multiple specimen types 1997
    1997 Respiratory syncytial virus immune globulin intravenous: Indications for use 1997
    1997 New therapeutic approaches to the alphaherpesvirus infections 1997
    1997 Immunization of adolescents: Recommendations of the Advisory Committee on Immunization Practices, the American Academy of Pediatrics, the American Academy of Family Physicians, and the American Medical Association 1997
    1997 Revised guidelines for prevention of early-onset group B streptococcal (GBS) infection 1997
    1997 Acellular pertussis vaccine: Recommendations for use as the initial series in infants and children 1997
    1997 Poliomyelitis prevention: Recommendations for use of inactivated poliovirus vaccine and live oral poliovirus vaccine 1997
    1997 Therapy for children with invasive pneumococcal infections 1997
    1997 A foot in the door 1997
    1997 Acyclovir plus steroids for herpes zoster [5] (multiple letters) 1997
    1997 Assessment of pain in herpes zoster: Lessons learned from antiviral trials 1997
    1997 Ganciclovir treatment of symptomatic congenital cytomegalovirus infection: Results of a phase II study 1997
    1997 Prophylaxis and treatment of herpesvirus infections in children 1997
    1997 The management of herpesvirus infections in individuals with human immunodeficiency virus or AIDS 1997
    1996 Advances in the treatment of cytamegalovirus retinitis in patients with AIDS 1996
    1996 Antiviral therapy: Present approaches, clinical needs, and drug development strategies 1996
    1996 Prevention of hepatitis A infections: Guidelines for use of hepatitis A vaccine and immune globulin 1996
    1996 Summary of the International Consensus Symposium on advances in the diagnosis, treatment and prophylaxis of cytomegalovirus infection 1996
    1996 The application of genetically engineered herpes simplex viruses to the treatment of experimental brain tumors 1996
    1996 The pathogenesis of AIDS: Lessons learned from other medical conditions 1996
    1996 Drug discovery for human immunodeficiency virus infection: Conquests and hurdles 1996
    1996 Acyclovir with and without prednisone for the treatment of herpes zoster. A randomized, placebo-controlled trial. The National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group. 1996
    1996 Population pharmacokinetics of ganciclovir in newborns with congenital cytomegalovirus infections 1996
    1996 Population pharmacokinetics of ganciclovir in newborns with congenital cytomegalovirus infections. NIAID Collaborative Antiviral Study Group. 1996
    1996 Recommended childhood immunization schedule 1996
    1996 Sorivudine: A potent inhibitor of varicella zoster virus replication 1996
    1996 Antiviral resistance: Mechanisms, clinical significance, and future implications 1996
    1996 A method for detection of HHV-6 antigens and its use for evaluating antiviral drugs 1996
    1996 Administration of oral acyclovir suppressive therapy after neonatal herpes simplex virus disease limited to the skin, eyes and mouth: Results of a phase I/II trial 1996
    1996 Update on tuberculosis skin testing of children 1996
    1996 The relationship between pertussis vaccine and central nervous system sequelae: Continuing assessment 1996
    1996 Recommended childhood immunization schedule 1996
    1996 Acyclovir with and without Prednisone for the Treatment of Herpes Zoster: A Randomized, Placebo-Controlled Trial 1996
    1996 Advances in the management of herpesvirus infections. Introduction. 1996
    1996 Application of the polymerase chain reaction to the diagnosis and management of neonatal herpes simplex virus disease 1996
    1996 Differential effect of recombinant human and mouse interferons on replication of herpes simplex virus type 1 in mouse cells 1996
    1996 Oral acyclovir therapy accelerates pain resolution in patients with herpes zoster: A meta-analysis of placebo-controlled trials 1996
    1996 Reassessment of the indications for ribavirin therapy in respiratory syncytial virus infections 1996
    1996 The past as prelude to the future: History, status, and future of antiviral drugs 1996
    1996 Unique clinical trial design: Combination acyclovir plus prednisone therapy of localized zoster in the normal host 1996
    1995 Evolution of therapy for herpes zoster: What's next? 1995
    1995 Sorivudine: a promising drug for the treatment of varicella-zoster virus infection. 1995
    1995 Herpes zoster in patients with human immunodeficiency virus infection--an ever-expanding spectrum of disease. 1995
    1995 Diagnosis of herpes simplex encephalitis: application of polymerase chain reaction to cerebrospinal fluid from brain-biopsied patients and correlation with disease. National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study Group. 1995
    1995 Comparison of genetically engineered herpes simplex viruses for the treatment of brain tumors in a scid mouse model of human malignant glioma 1995
    1995 Antiviral resistance - an emerging problem 1995
    1995 Antiviral resistance in clinical practice 1995
    1995 Assays for antiviral drug resistance 1995
    1995 Diagnosis of herpes simplex encephalitis: Application of polymerase chain reaction to cerebrospinal fluid from brain-biopsied patients and correlation with disease 1995
    1995 Editorial response: Herpes zoster in patients with human immunodeficiency virus infection–an ever-expanding spectrum of disease 1995
    1995 Guidelines for the prevention and treatment of B-virus infections in exposed persons 1995
    1995 Herpes simplex virus infections of the central nervous system: Therapeutic and diagnostic considerations 1995
    1995 Herpesvirus infections in persons infected with human immunodeficiency virus 1995
    1995 Human herpesvirus 6 is associated with focal encephalitis 1995
    1995 Models of antiviral resistance 1995
    1995 Molecular mechanisms of antiviral resistance 1995
    1995 Research initiatives in studies of antiviral resistance and consensus points and recommendations 1995
    1995 Sorivudine: A promising drug for the treatment of varicella-zoster virus infection 1995
    1995 The Data and Safety Monitoring Board and Acquired immune deficiency syndrome (AIDS) clinical trials 1995
    1995 USPHS/IDSA guidelines for the prevention of opportunistic infections in persons infected with human immunodeficiency virus: Disease-specific recommendations 1995
    1994 Antiviral resistance: Do we know what it means? 1994
    1994 Penciclovir/famciclovir: Parent and child in the treatment of herpes virus infections 1994
    1994 Herpes simplex virus infections of women and their offspring: Implications for a developed society 1994
    1994 A rapid protein A binding radioimmunoassay for the evaluation of antiviral agents 1994
    1994 Neonatal herpes simplex virus infections: Is there a role for immunoglobulin in disease prevention and therapy ? 1994
    1994 Viral Encephalitis: Diagnosis and Treatment 1994
    1993 A Short-Term Clinical Evaluation of L-697,661, a Non-Nucleoside Inhibitor of HIV-1 Reverse Transcriptase 1993
    1993 Evaluation of new anti-infective drugs for the treatment of infection with human immunodeficiency virus 1993
    1993 Evaluation of new anti-infective drugs for the treatment of infection with human immunodeficiency virus. The European Working Party of the European Society of Clinical Microbiology and Infectious Diseases. 1993
    1993 A Rabbit Model for Human Cytomegalovirus-Induced Chorioretinal Disease 1993
    1993 Antiviral effect of the extract of culture medium of Lentinus edodes mycelia on the replication of herpes simplex virus type 1 1993
    1993 Antiviral therapy: The time has come 1993
    1993 Diabetes insipidus associated with symptomatic congenital cytomegalovirus infection 1993
    1993 Famciclovir/penciclovir workshop: Introduction 1993
    1993 Linear single‐dose pharmacokinetics of ganciclovir in newborns with congenital cytomegalovirus infections 1993
    1993 Neonatal herpes simplex virus infections 1993
    1993 Prospects for vaccination against herpes simplex virus. 1993
    1993 Replication, establishment of latency, and induced reactivation of herpes simplex virus γ1 34.5 deletion mutants in rodent models 1993
    1993 Therapy for varicelia-zoster virus infections: Where do we stand? 1993
    1993 Viral infections in the immunocompromised host 1993
    1992 Evaluation of new anti-infective drugs for the treatment of acute bacterial meningitis. Infectious Diseases Society of America and the Food and Drug Administration. 1992
    1992 Evaluation of new anti-infective drugs for the treatment of cryptococcal meningitis. Infectious Diseases Society of America and the Food and Drug Administration. 1992
    1992 Evaluation of new anti-infective drugs for the treatment of toxoplasma encephalitis. Infectious Diseases Society of America and the Food and Drug Administration. 1992
    1992 Evaluation of new anti-infective drugs for the treatment of viral encephalitis. Infectious Diseases Society of America and the Food and Drug Administration. 1992
    1992 Transmission of herpes simplex virus type 1 infection in an intensive care unit 1992
    1992 Acyclovir: A Decade Later 1992
    1992 Rigor in clinical trials. 1992
    1992 Acyclovir in chickenpox 1992
    1992 Acyclovir treatment of varicella in otherwise healthy adolescents. The Collaborative Acyclovir Varicella Study Group. 1992
    1992 Disseminated herpes zoster in the immunocompromised host: a comparative trial of acyclovir and vidarabine. The NIAID Collaborative Antiviral Study Group. 1992
    1992 Prevalence of herpes simplex virus antibodies in dental students. 1992
    1992 Acyclovir treatment of varicella in otherwise healthy adolescents 1992
    1992 Disseminated Herpes Zoster in the Immunocompromised Host: A Comparative Trial of Acyclovir and Vidarabine 1992
    1992 Effect of (S)-1-[(3-hydroxy-2-phosphonyl methoxy) propyl] cytosine on the replication and morphogenesis of herpes simplex virus type 1 1992
    1992 Evaluation of new anti-infective drugs for the treatment of acute bacterial meningitis 1992
    1992 Evaluation of new anti-infective drugs for the treatment of cryptococcal meningitis 1992
    1992 Evaluation of new anti-infective drugs for the treatment of toxoplasma encephalitis 1992
    1992 Evaluation of new anti-infective drugs for the treatment of viral encephalitis 1992
    1992 Herpes simplex vaccines. 1992
    1992 Management of rfcurrency of herpes simplex virus infection in young infants 1992
    1992 Neonatal herpes simplex virus infections: Pathogenesis and therapy 1992
    1992 Reply 1992
    1992 Risk of acyclovir therapy in pregnant adolescent [7] 1992
    1992 The management of pregnancies complicated by genital infections with herpes simplex virus 1992
    1992 Therapeutic Approaches to Varicella-Zoster Virus Infections 1992
    1991 A Controlled Trial of Acyclovir for Chickenpox in Normal Children 1991
    1991 Humanized antibodies for antiviral therapy 1991
    1991 A Controlled Trial Comparing Vidarabine with Acyclovir in Neonatal Herpes Simplex Virus Infection 1991
    1991 Predictors of morbidity and mortality in neonates with herpes simplex virus infections 1991
    1991 Apical expression of herpes simplex virus type 2 glycoproteins in human neuroblastoma cells 1991
    1991 Evaluation of a test based on baculovirus-expressed glycoprotein G for detection of herpes simplex virus type-specific antibodies 1991
    1991 Herpes Simplex Virus Infections of the Central Nervous System: Encephalitis and Neonatal Herpes 1991
    1991 Herpes simplex encephalitis: The case against brain biopsy [1] 1991
    1991 High-level viremia in adults and children infected with human immunodeficiency virus: Relation to disease stage and cd4+lymphocyte levels 1991
    1991 Natural history and treatment of varicella-zoster in high-risk populations 1991
    1991 Perinatal herpes simplex virus infections 1991
    1991 Predictors of morbidity and mortality in neonates with herpes simplex virus infections 1991
    1991 Use of brain biopsy for diagnostic evaluation of patients with suspected herpes simplex encephalitis: A statistical model and its clinical implications 1991
    1991 Use of brain biopsy for diagnostic evaluation of patients with suspected herpes simplex encephalitis: a statistical model and its clinical implications. NIAID Collaborative Antiviral Study Group. 1991
    1990 Acyclovir: The past ten years 1990
    1990 Preface 1990
    1990 Mapping of herpes simplex virus-1 neurovirulence toγ134.5, a gene nonessential for growth in culture 1990
    1990 Viral Encephalitis 1990
    1990 Expression of HSV-1 glycoproteins in tunicamycin-treated monkey kidney cells 1990
    1990 Rapid detection of herpes-simplex-virus DNA in cerebrospinal fluid of patients with herpes simplex encephalitis 1990
    1990 Chickenpox: Where do we stand with treatment? 1990
    1990 In vivo behavior of genetically engineered herpes simplex viruses R7017 and R7020. II. Studies in immunocompetent and immunosuppressed owl monkeys Aotus trivirgatus 1990
    1990 Individual NK cell clones lyse both tumor cell targets and herpes simplex virus-infected fibroblasts in the absence of interferon 1990
    1990 Long-Term Cognitive Sequelae of Acyclovir-Treated Herpes Simplex Encephalitis 1990
    1990 Novel Pharmacological Strategies in the Treatment of Life‐Threatening Cytomegalovirus Infections: Clinical Experience with Continuous Infusion 9‐(1,3‐Dihydroxy‐2‐Propoxymethyl) Guanine 1990
    1990 Reference Values in Pediatric Medicine 1990
    1990 Treatment of condyloma acuminatum with three different interferon-α preparations administered parenterally: A double-blind, placebocontrolled trial 1990
    1990 Viral encephalitis 1990
    1989 Diseases That Mimic Herpes Simplex Encephalitis: Diagnosis, Presentation, and Outcome 1989
    1989 A role for herpes simplex virus type 1 glycoprotein E in induction of cell fusion 1989
    1989 Editorial 1989
    1989 Effect of recombinant hybrid human interferon on replication and morphogenesis of HSV-1 in monkey cells 1989
    1989 Immunological alterations associated with recurrent herpes simplex genitalis 1989
    1989 Intrauterine herpes simplex virus infection 1989
    1989 Teratogen update: Intrauterine herpes simplex virus infection 1989
    1989 Varicella–zoster virus infections: Chronic disease in the immunocompromised host: Evidence for persistent excretion of virus 1989
    1988 Neonatal herpes simplex virus infections 1988
    1988 Intravenous acyclovir therapy of first episodes of genital herpes: a multicenter double-blind, placebo-controlled trial. 1988
    1988 Herpes simplex virus infections of the central nervous system. A review. 1988
    1988 The Frustrations of Treating Herpes Simplex Virus Infections of the Central Nervous System 1988
    1988 Neurovirulence in an experimental focal herpes encephalitis: relationship to observed seizures 1988
    1988 DIFFERENCE BETWEEN HERPES SIMPLEX VIRUS TYPE I AND TYPE 2 NEONATAL ENCEPHALITIS IN NEUROLOGICAL OUTCOME 1988
    1988 An isoelectric focusing study in herpes simplex virus encephalitis 1988
    1988 Antibody response of the newborn after herpes simplex virus infection 1988
    1988 Antiviral treatment of a serious herpes simplex infection: Encephalitis 1988
    1988 Antiviral treatment of a serious herpes simplex infection: encephalitis. 1988
    1988 Changing patterns of herpes simplex virus infection in neonates 1988
    1988 Condylomata acuminata in IDDM. 1988
    1988 Difference between herpes simplex virus type 1 and type 2 neonatal encephalitis in neurological outcome 1988
    1988 Ganciclovir - Have we established clinical value in the treatment of cytomegalovirus infections? 1988
    1988 Herpes simplex virus infections of the central nervous system. A review 1988
    1988 Intravenous acyclovir therapy of first episodes of genital herpes: A multicenter double-blind, placebo-controlled trial 1988
    1988 Isolated Cryptococcus neoformans osteomyelitis in an immunocompetent child 1988
    1988 Natural History and Pathogenesis of Neonatal Herpes Simplex Virus Infections 1988
    1988 Protection against herpetic ocular disease by immunotherapy with monoclonal antibodies to herpes simplex virus glycoproteins. 1988
    1988 Questions and answers 1988
    1988 Questions and answers 1988
    1988 Treatment of condyloma acuminatum with three different interferons administered intralesionallv: a double blind placebo controlled trial 1988
    1988 Treatment of condyloma acuminatum with three different interferons administered intralesionally: A double-blind, placebo-controlled trial 1988
    1987 Condyloma acuminatum: Epidemiological, clinical and therapeutic aspects 1987
    1987 Patients with condyloma acuminatum exhibit decreased interleukin-2 and interferon gamma production and depressed natural killer activity 1987
    1987 Infant pneumonitis associated with cytomegalovirus, Chlamydia, Pneumocystis, and Ureaplasma: Follow-up 1987
    1987 Analysis of immune function in herpes zoster patients: Demonstration and characterization of suppressor cells 1987
    1987 Antiviral therapy and pulmonary disease 1987
    1987 Approaches to therapy of viral infections. 1987
    1987 Congenital cytomegalovirus: Immunological alterations 1987
    1987 Detection of Antibodies to Herpes Simplex Virus in the Cerebrospinal Fluid of Patients with Herpes Simplex Encephalitis 1987
    1987 Detection of antigen to herpes simplex virus in cerebrospinal fluid from patients with herpes simplex encephalitis 1987
    1987 Factors indicative of outcome in a comparative trial of acyclovir and vidarabine for biopsy-proven herpes simplex encephalitis 1987
    1987 Identification of a herpes simplex virus 1 glycoprotein gene within a gene cluster dispensable for growth in cell culture 1987
    1987 Intrauterine herpes simplex virus infections 1987
    1987 Passive immunization with monoclonal antibodies against herpes simplex virus glycoproteins protects mice against herpetic ocular disease 1987
    1987 Pharmacokinetics and tolerance of desciclovir, a prodrug of acyclovir, in healthy human volunteers 1987
    1987 Protective immunity against herpetic ocular disease in an outbred mouse model 1987
    1987 T-cell imbalances and NK activity in varicella-zoster virus infections 1987
    1987 The reply 1987
    1987 Therapy of viral infections in children. 1987
    1987 Transfusion-associated viral infections 1987
    1987 Yes, Brain Biopsy Should Be a Prerequisite for Herpes Simplex Encephalitis Treatment 1987
    1986 Brain biopsy for encephalitis. 1986
    1986 CNS diseases associated with varicella zoster virus and herpes simplex virus infection. Pathogenesis and current therapy 1986
    1986 Delta hepatitis. An overview. 1986
    1986 Demonstration of NK cell-mediated lysis of varicella-zoster virus (VZV)-infected cells: Characterization of the effector cells 1986
    1986 Herpesvirus Infections of Pregnancy 1986
    1986 Neonatal herpes simplex virus infections. Presentation and management. 1986
    1986 Vidarabine versus Acyclovir Therapy in Herpes Simplex Encephalitis 1986
    1986 A rabbit model of focal herpes simplex encephalitis 1986
    1986 Analysis of dna from recurrent genital herpes simplex virus isolates by restriction endonuclease digestion 1986
    1986 Herpesvirus infections in the immunocompromised host: diagnosis and management. 1986
    1986 Human antibody response to herpes simplex virus-specific polypeptides after primary and recurrent infection 1986
    1986 Neonatal herpes simplex virus infections. Presentation and management 1986
    1986 Progressive multifocal leukoencephalopathy: Three patients diagnosed by brain biopsy, with prolonged survival in two 1986
    1986 Replication of varicella zoster virus in Raji cells 1986
    1986 Studies on herpes simplex virus type 1 glycoproteins using monoclonal antibodies 1986
    1985 Effect of cloned human interferons on protein synthesis and morphogenesis of herpes simplex virus 1985
    1985 Herpesvirus Infections of Pregnancy: Herpes Simplex Virus and Varicella–Zoster Virus Infections 1985
    1985 Herpesvirus Infections of Pregnancy: Cytomegalovirus and Epstein–Barr Virus Infections 1985
    1985 Parvovirus Infection: Chance and Investigation 1985
    1985 Therapy for human herpesvirus infections. A perspective. 1985
    1985 DESIGN OF THERAPEUTIC STUDIES IN HERPES SIMPLEX ENCEPHALITIS 1985
    1985 Design of therapeutic studies in herpes simplex encephalitis 1985
    1985 High-pressure liquid chromatographic methods for determining arabinosyladenine-5'-monophosphate, arabinosyladenine, and arabinosylhypoxanthine in plasma and urine 1985
    1985 Psychosis and herpes simplex encephalitis 1985
    1985 Reply 1985
    1985 Therapeutic challenges of neonatal herpes simplex virus infection 1985
    1984 Diagnosis of viral encephalitis by brain biopsy 1984
    1984 Therapeutic approaches to the control of cytomegalovirus infections 1984
    1984 Treatment of human herpesvirus infections with special reference to encephalitis 1984
    1984 Medical pathology conference. Headache, fever, abnormal behavior, and dysphasia in an elderly man. 1984
    1984 Therapy of human herpesvirus infections 1984
    1984 Treatment of Herpesvirus Infections 1984
    1984 Dermatitis Due to Larvae of a Soil Nematode, Pelodera strongyloides 1984
    1984 Effect of cloned human interferons on the replication of and cell fusion induced by herpes simplex virus 1984
    1984 Infections caused by herpes simplex virus in the immunocompromised host: Natural history and topical acyclovir therapy 1984
    1984 Prophylactic or anticipatory antiviral therapy for newborns exposed to herpes simplex infection 1984
    1984 Vidarabine therapy for mucocutaneous herpes simplex virus infections in the immunocompromised host 1984
    1983 Interim summary of mortality in herpes simplex encephalitis and neonatal herpes simplex virus infections: Vidarabine versus acyclovir 1983
    1983 Neonatal herpes simplex virus infection: Follow-up evaluation of vidarabine therapy 1983
    1983 Vidarabine for Herpes Zoster 1983
    1983 Acyclovir: Mechanism of Action, Pharmacokinetics, Safety and Clinical Applications 1983
    1983 Elisa for the detection of herpes simplex virus antigens in the cerebrospinal fluid of patients with encephalitis 1983
    1983 Experience with brain biopsy for suspected herpes encephalitis: A review of forty consecutive cases 1983
    1983 Management of infections. 1983
    1983 Rapid diagnosis of pneumonia due to cytomegalovirus with specific monoclonal antibodies. 1983
    1983 Thymic Hyperplasia in a case of Hodgkin’s Disease 1983
    1983 Towards therapy and prevention of herpetic infections 1983
    1982 DNA Restriction-Enzyme Analysis of Herpes Simplex Virus Isolates Obtained from Patients with Encephalitis 1982
    1982 Early Vidarabine Therapy to Control the Complications of Herpes Zoster in Immunosuppressed Patients 1982
    1982 REPEATED SUPPRESSION OF CREUTZFELDT-JAKOB DISEASE WITH VIDARABINE 1982
    1982 In Reply 1982
    1982 Mucocutaneous herpes simplex virus infections in immunocompromised patients. A model for evaluation of topical antiviral agents 1982
    1982 Pharmacokinetics of acyclovir in humans following intravenous administration. A model for the development of parenteral antivirals 1982
    1982 Pharmacokinetics of acyclovir in humans following intravenous administration. A model for the development of parenteral antivirals. 1982
    1982 HERPES SIMPLEX ENCEPHALITIS AND CLINICAL TRIAL DESIGN 1982
    1982 Herpes simplex encephalitis. Clinical assessment 1982
    1982 Herpes Simplex Encephalitis: Clinical Assessment 1982
    1982 Herpes simplex virus encephalitis: Laboratory evaluations and their diagnostic significance 1982
    1982 Herpesvirus infections in childhood: Diagnostic dilemmas and therapy 1982
    1982 Vidrabine therapy of varicella in immunosuppressed patients 1982
    1981 Antiviral agents: clinical status report 1981
    1981 Preventive and therapeutic approaches to the newborn infant with perinatal viral and toxoplasma infections 1981
    1981 Infant pneumonitis associated with cytomegalovirus, Chlamydia, Pneumocystis, and Ureaplasma: A prospective study 1981
    1981 Specific lymphocyte blastogenic responses in children with cytomegalovirus and herpes simplex virus infections acquired early in infancy 1981
    1981 Herpes Simplex Encephalitis 1981
    1981 Herpes Simplex Encephalitis: Vidarabine Therapy and Diagnostic Problems 1981
    1981 Diagnosis and treatment of herpes simplex encephalitis. 1981
    1981 The natural history of herpes simplex virus infection of mother and newborn 1981
    1981 Virology findings in progressive multifocal leukoencephalopathy. 1981
    1980 The natural history of herpes simplex virus infection of mother and newborn 1980
    1980 Vidarabine therapy of neonatal herpes simplex virus infection 1980
    1980 Herpes Simplex Encephalitis: Need for Accurate Diagnosis 1980
    1980 Adenine arabinoside therapy of neonatal herpes simplex viral infection 1980
    1980 Cytomegalovirus infection in patients with renal transplants: Potentiation by antithymocyte globulin and an incompatible graft 1980
    1980 Herpes Zoster in Early Infancy 1980
    1980 Pharmacology, tolerance, and antiviral activity of vidarabine monophosphate in humans 1980
    1980 Plasma levels and urinary excretion of vidarabine after repeated dosing 1980
    1980 Vidarabine: A Preliminary Review of its Pharmacological Properties and Therapeutic Use 1980
    1979 Developmental aspects of adenine arabinoside for parenteral therapy of human herpesvirus infections. 1979
    1979 Effect of primary and recurrent cytomegalovirus infections upon graft and patient survival after renal transplantation. 1979
    1979 Outcome of renal transplantation in patients with primary cytomegalovirus infection 1979
    1979 Distribution of Adenine Arabinoside and Interferon 1979
    1979 Acyclovir kinetics after intravenous infusion 1979
    1979 Distribution of adenine arabinoside and interferon 1979
    1979 Effect of primary and recurrent cytomegalovirus infections upon graft and patient survival after renal transplantation 1979
    1979 Identification of patients with increased risk of infection with herpes simplex virus after renal transplantation 1979
    1979 Serum Antibody Levels as Risk Factors in the Dissemination of Herpes Zoster 1979
    1978 Herpes simplex virus encephalitis: an atypical presentation. 1978
    1978 NIH conference. Herpes zoster-varicella infections in immunosuppressed patients. 1978
    1978 Current status of antiviral chemotherapy 1978
    1978 Developmental aspects of selected antiviral chemotherapeutic agents. 1978
    1978 Herpes zoster-varicella infections in immunosuppressed patients 1978
    1978 Productive infection with cytomegalovirus and herpes simplex virus in renal transplant recipients: Role of source of kidney 1978
    1978 Purification and characterization of proteins excreted by cells infected with herpes simplex virus and their use in diagnosis 1978
    1977 Ara-A for Herpes Encephalitis 1977
    1977 Adenine arabinoside therapy of biopsy-proved herpes simplex encephalitis. 1977
    1977 Adenine Arabinoside Therapy of Biopsy-Proved Herpes Simplex Encephalitis: National Institute of Allergy and Infectious Diseases Collaborative Antiviral Study 1977
    1977 Adenine arabinoside therapy of herpes simplex encephalitis: NIAID collaborative antiviral study group 1977
    1977 Adenine arabinoside therapy of varicella zoster in immunocompromised patients 1977
    1976 Cerebellar hypoplasia in an infant with congenital cytomegalovirus infection 1976
    1976 Therapy of herpetic infections in man: a status report. 1976
    1976 Treatment of infections due to Herpesvirus in humans: a critical review of the state of the art. 1976
    1976 Adenine Arabinoside Therapy of Herpes Zoster in the Immunosuppressed: NIAID Collaborative Antiviral Study 1976
    1976 Adenine Arabinoside for Therapy of Herpes Zoster in Immunosuppressed Patients: Preliminary Results of a Collaborative Study 1976
    1976 Protracted pneumonitis in young infants associated with perinatally acquired cytomegaloviral infection 1976
    1976 Protracted pneumonitis in young infants associated with perinatally acquired cytomegaloviral infection 1976
    1975 Antiviral chemotherapy and neonatal herpes simplex virus infection: a pilot study. Experience with adenine arabinoside (ARA-A) 1975
    1975 Neonatal herpes simplex virus infection 1975
    1974 Adenine arabinoside (ARA-A) and neonatal herpes simplex virus infection 1974
    1974 Effect of adenine arabinoside on cytomegalovirus infections 1974
    1973 Effect of adenine arabinoside on severe herpesvirus hominis infections in man 1973

    Book

    Year Title Altmetric
    2014 Infections of the Central Nervous System: Fourth Edition 2014
    2014 Introduction: Approach to the patient with central nervous system infection 2014
    2014 Preface 2014
    2014 Preface to the first edition 2014
    2007 Human herpesviruses: Biology, therapy, and immunoprophylaxis 2007
    1985 Foreword.  Ed. 1.  1985

    Chapter

    Year Title Altmetric
    2017 Neonatal herpes simplex virus infection.  395-410. 2017
    2015 Herpes simplex viruses 1 and 2.  1193-1198. 2015
    2014 Chickenpox and Herpes Zoster (Varicella-Zoster Virus).  1731-1737.e2. 2014
    2014 Arthropod-borne viral encephalitidesm 2014
    2014 B virus 2014
    2014 Herpes simplex virus 2014
    2014 Neurologic manifestations of varicella and herpes zoster 2014
    2014 Pathogenesis and pathophysiology of viral infections of the central nervous system 2014
    2014 Herpes simplex virus infections of the central nervous system.  263-290. 2014
    2014 Herpesviruses, Human.  557-558. 2014
    2011 Herpes Simplex Virus Infections.  813-833. 2011
    2011 Herpes Simplex Virus Infections.  2125-2128. 2011
    2010 Herpes simplex viruses 1 and 2.  1275-1280. 2010
    2007 Antiviral therapy of HSV-1 and-2.  1153-1174. 2007
    2007 HSV-1 and 2: Pathogenesis and disease.  589-601. 2007
    2006 Clinical trials of herpes simplex encephalitis: The role of the data monitoring committee.  285-291. 2006
    2006 Herpes Simplex Virus Infections.  845-865. 2006
    2005 Neonatal herpes simplex virus infection.  395-410. 2005
    2002 Herpes simplex virus.  69-118. 2002

    Principal Investigator On

  • In Vitro Assessments of Antimicrobial Activity  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2019 - 2026
  • Antiviral Drug Discovery and Development Center (AD3C)  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2019 - 2024
  • Targeted Clinical Research to Address Select Viral Infections-A Phase II Randomized Six Weeks of Oral Valganciclovir Therapy in CMV Infants with Hearing Loss  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2011 - 2020
  • Targeted Clinical Research to Address Select Viral Infections-An Adaptive, Sequential Study Evaluation Prevention of Neonatal Herpes Simplex Virus Disease: Detection of Maternal Herpes Simplex Virus Shedding at Delivery  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2011 - 2020
  • Targeted Clinical Research to Address Select Viral Infections-Pharmacokinetic, Pharmacodynamic and Resistance Evaluation of Intravenous Ganciclovir in Premature Infants  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2011 - 2020
  • Targeted Clinical Research to Address Select Viral Infections-Safety, Tolerability and Pharmacokinetic Properties of CMX001 in Renal Transplant Recipients with BK Viremia.  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2011 - 2020
  • Antiviral Drug Discovery and Development Center - Centers of Excellence for Translational Research  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2014 - 2020
  • Targeted Clinical Research to Address Select Viral Infections-An Adaptive Pharmacokinetic, Pharmacodynamic, Concentration Response Investigation of CMX-001 in the Infants with Neonatal Herpes (HSV) Followed by Randomized Assessment  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2011 - 2019
  • Engineered HSV for the Treatment of Malignant Glioma  awarded by National Cancer Institute/NIH/DHHS 2009 - 2015
  • Engineered HSV for the Treatment of Malignant Glioma - Core A. Administrative Core  awarded by National Cancer Institute/NIH/DHHS 2009 - 2015
  • Engineered HSV for the Treatment of Malignant Glioma - Project 1  awarded by National Cancer Institute/NIH/DHHS 2009 - 2015
  • Engineered HSV for the Treatment of Malignant Glioma - Project 2 - Radiation Enhancement of HSV Anti-Tumor Effects  awarded by National Cancer Institute/NIH/DHHS 2009 - 2015
  • Engineered HSV for the Treatment of Malignant Glioma - Project 3 - Preclinical Evaluation of Oncolytic HSV for Anaplastic Glioma Therapy  awarded by National Cancer Institute/NIH/DHHS 2009 - 2015
  • Regional Centers of Excellence for Biodefense and Emerging Infectious Disease Research  awarded by University of North Carolina at Chapel Hill 2009 - 2014
  • Regional Centers of Excellence for Biodefense and Emerging Infectious Disease Research: Administrative Core  awarded by University of North Carolina at Chapel Hill 2009 - 2014
  • Regional Centers of Excellence for Biodefense and Emerging Infectious Disease Research: Program 10 - Scientific Coordination  awarded by University of North Carolina at Chapel Hill 2009 - 2014
  • Investigator On

  • In Vitro Assessments of Antimicrobial Activity  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2019 - 2026
  • Center for Clinical and Translational Science (3 Linked Awards UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2019 - 2024
  • A Phase II, Single-Stage, Single Arm Investigation of Oral Valganciclovir Therapy in Infants with Asymptomatic Congenital Cytomegalovirus Infection  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2016 - 2021
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2019 - 2021
  • Comprehensive Cancer Center Core Support Grant - Administrative Core  awarded by National Cancer Institute/NIH/DHHS 2019 - 2021
  • Ph1 of HSV G207 and Radiation to Treat Pediatric Brain Tumors IND16294 (12/10/14)  awarded by Food & Drug Administration 2016 - 2020
  • Safety and Effectiveness of Live Zoster Vaccine in Anti-TNF Users (VERVE Trial)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2014 - 2019
  • UAB Center for Clinical and Translational Science (CCTS) (3 Linked Awards UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2015 - 2019
  • Matrix Metalloproteinase Driven Lung Inflammation in RSV Disease  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2014 - 2019
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2017 - 2019
  • Comprehensive Cancer Center Core Support Grant - Adiministrative Core  awarded by National Cancer Institute/NIH/DHHS 2017 - 2019
  • Inhibition of Herpes Simplex Viruses Type 2 by Tenofovir  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2012 - 2017
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2016 - 2017
  • Comprehensive Cancer Center Core Support Grant - Administrative Core  awarded by National Cancer Institute/NIH/DHHS 2016 - 2017
  • A Pilot Study of the Safety and Effectiveness of the Live Zoster Vaccine in Anti-TNF Users  awarded by RHEUMATOLOGY RESEARCH FOUNDATION 2013 - 2016
  • UAB Center for Clinical and Translational Science (CCTS) (3 linked awards: UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2014 - 2015
  • UAB Center for Clinical and Translational Science (CCTS) UL1  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2011 - 2014
  • Pediatric Physician Training in Translational Research  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2008 - 2013
  • Teaching Activities

  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2019) 2019
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Spring Term 2019) 2019
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Spring Term 2019) 2019
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Spring Term 2019) 2019
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Spring Term 2019) 2019
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2018) 2018 - 2019
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2018) 2018
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2018) 2018
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2018) 2018
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2018) 2018
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2018) 2018
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2018) 2018
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Spring Term 2018) 2018
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Spring Term 2018) 2018
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Spring Term 2018) 2018
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2017) 2017
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2017) 2017
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2017) 2017
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2017) 2017
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2017) 2017
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2017) 2017
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Spring Term 2017) 2017
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Spring Term 2017) 2017
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Spring Term 2017) 2017
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Spring Term 2017) 2017
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Spring Term 2017) 2017
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2016) 2016
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2016) 2016
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2016) 2016
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2016) 2016
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Spring Term 2015) 2015
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Spring Term 2015) 2015
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2014) 2014
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2014) 2014
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2013) 2013
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Spring Term 2013) 2013
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Spring Term 2013) 2013
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2012) 2012
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2012) 2012
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2012) 2012
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2012) 2012
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2012) 2012
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Spring Term 2012) 2012
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Spring Term 2012) 2012
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Spring Term 2012) 2012
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2011) 2011
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2011) 2011
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2011) 2011
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2011) 2011
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2011) 2011
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Spring Term 2011) 2011
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Spring Term 2011) 2011
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2010) 2010
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Spring Term 2010) 2010
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Spring Term 2010) 2010
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2009) 2009
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2009) 2009
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2009) 2009
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Spring Term 2008) 2008
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2007) 2007
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2007) 2007
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2007) 2007
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Fall Term 2007) 2007
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Spring Term 2007) 2007
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Spring Term 2007) 2007
  • 52-420 - PEDIATRIC INFECTIOUS DISEASE (Spring Term 2007) 2007
  • Education And Training

  • Doctor of Medicine, George Washington University 1971
  • Bachelor's Degree, Duke University 1967
  • UAB Hospital, Internship 1972
  • The University of Alabama at Birmingham Pediatrics, Internship 1972
  • UAB Hospital, Residency 1973
  • UAB Hospital, Postdoctoral Fellowship 1976
  • Full Name

  • Richard Whitley