Selected Publications

Academic Article

Year Title Altmetric
2023 Differential impact of PI3K/AKT/mTOR signaling on tumor initiation and progression in animal models of prostate cancer 2023
2022 Dual CRISPR interference and activation for targeted reactivation of X-linked endogenous FOXP3 in human breast cancer cellsMolecular Cancer.  21. 2022
2022 TUBB4A interacts with MYH9 to protect the nucleus during cell migration and promotes prostate cancer via GSK3β/β-catenin signallingNature Communications.  13. 2022
2022 The microRNA-3622 family at the 8p21 locus exerts oncogenic effects by regulating the p53-downstream gene network in prostate cancer progressionOncogene.  41:3186-3196. 2022
2022 Epigenetic regulation of EIF4A1 through DNA methylation and an oncogenic role of eIF4A1 through BRD2 signaling in prostate cancerOncogene.  41:2778-2785. 2022
2022 CRISPR interference and activation of the microRNA-3662-HBP1 axis control progression of triple-negative breast cancerOncogene.  41:268-279. 2022
2021 Anti-cd47 monoclonal antibody–drug conjugate: A targeted therapy to treat triple-negative breast cancersVaccines.  9. 2021
2020 Selective Response to Bacterial Infection by Regulating Siglec-E ExpressioniScience.  23. 2020
2020 Fibrinogen alpha chain knockout promotes tumor growth and metastasis through integrin-akt signaling pathway in lung cancerMolecular Cancer Research.  18:943-954. 2020
2020 A CD24-p53 axis contributes to African American prostate cancer disparities 2020
2019 MicroRNA-1205, encoded on chromosome 8q24, targets EGLN3 to induce cell growth and contributes to risk of castration-resistant prostate cancerOncogene.  38:4820-4834. 2019
2019 Loss of FOXP3 and TSC1 accelerates prostate cancer progression through synergistic transcriptional and posttranslational regulation of c-MycCancer Research.  79:1413-1425. 2019
2018 Bioprocess development of antibody-drug conjugate production for cancer treatmentPLoS One.  13. 2018
2018 FOXP3 activates SUMO-conjugating UBC9 gene in MCF7 breast cancer cellsInternational Journal of Molecular Sciences.  19. 2018
2018 Integrated oncogenomic profiling of copy numbers and gene expression in lung adenocarcinomas without EGFR mutations or ALK fusionJournal of Cancer.  9:1096-1105. 2018
2017 MicroRNA-200c and microRNA- 141 are regulated by a FOXP3-KAT2B axis and associated with tumor metastasis in breast cancerBreast Cancer Research.  19. 2017
2017 CD24 is a genetic modifier for risk and progression of prostate cancerMolecular Carcinogenesis.  56:641-650. 2017
2017 Jun dimerization protein 2 activates Mc2r transcriptional activity: Role of phosphorylation and SUMOylationInternational Journal of Molecular Sciences.  18. 2017
2017 MicroRNA-155, induced by FOXP3 through transcriptional repression of BRCA1, is associated with tumor initiation in human breast cancerOncotarget.  8:41451-41464. 2017
2016 Rhamnose links moonlighting proteins to membrane phospholipid in mycoplasmasPLoS One.  11. 2016
2016 Cinobufagin inhibits tumor growth by inducing intrinsic apoptosis through AKT signaling pathway in human nonsmall cell lung cancer cellsOncotarget.  7:28935-28946. 2016
2016 Silencing of CD24 enhances the PRIMA-1-induced restoration of mutant p53 in prostate cancer cellsClinical Cancer Research.  22:2545-2554. 2016
2016 The Key Regulator for Language and Speech Development, FOXP2, is a Novel Substrate for SUMOylationJournal of Cellular Biochemistry.  117:426-438. 2016
2015 FOXP3 controls an MIR-146/NF-κB negative feedback loop that inhibits apoptosis in breast cancer cellsCancer Research.  75:1703-1713. 2015
2015 FOXP3-MIR-146-NF-κB axis and therapy for precancerous lesions in prostateCancer Research.  75:1714-1724. 2015
2015 An mTORC1-Mdm2-Drosha axis for miRNA biogenesis in response to glucose- and amino acid-deprivationMolecular Cell.  57:708-720. 2015
2015 Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivationNature Communications.  6. 2015
2015 A new mitochondrial pool of cyclin E, regulated by Drp1, is linked to cell-density-dependent cell proliferationJournal of Cell Science.  128:4171-4182. 2015
2015 FOXP3-microRNA-146-NF-κB as oncotargetOncoscience.  2:839-840. 2015
2014 SUMOylation of FOXM1B alters its transcriptional activity on regulation of MiR-200 family and JNK1 in MCF7 human breast cancer cellsInternational Journal of Molecular Sciences.  15:10233-10251. 2014
2013 Acidic residue Glu199 increases SUMOylation level of nuclear hormone receptor NR5A1International Journal of Molecular Sciences.  14:22331-22345. 2013
2012 Inactivation of X-linked tumor suppressor genes in human cancerFuture Oncology.  8:463-481. 2012
2012 A hypermorphic SP1-binding CD24 variant associates with risk and progression of multiple sclerosisAmerican Journal of Translational Research.  4:347-356. 2012
2011 FOXP3 orchestrates H4K16 acetylation and H3K4 trimethylation for activation of multiple genes by recruiting MOF and causing displacement of PLU-1Molecular Cell.  44:770-784. 2011
2011 Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancersCancer Research.  71:2162-2171. 2011
2010 Quantification and application of the placental epigenetic signature of the RASSF1A gene in maternal plasmaPrenatal Diagnosis.  30:778-782. 2010
2010 Prevalence and type distribution of human papillomavirus infection in women from Datong, ChinaInfectious Diseases.  42:72-75. 2010
2010 Quantitative detection of the hypermethylated RASSF1A gene in maternal plasma of pre-eclampsiaZhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics.  27:73-76. 2010
2010 FOXP3 as an X-linked tumor suppressor.Discovery medicine.  10:322-328. 2010
2009 Somatic Single Hits Inactivate the X-Linked Tumor Suppressor FOXP3 in the ProstateCancer Cell.  16:336-346. 2009
2009 Pd-CNT-catalyzed ligandless and additive-free heterogeneous Suzuki-Miyaura cross-coupling of arylbromides 2009
2009 Asymmetric synthesis of 3-hydroxyl-2-alkanones via tandem organocatalytic aminoxylation of aldehydes and chemoselective diazomethane homologation 2009
2009 Stereospecific, flexible and redox-economic asymmetric synthesis of cis- And trans-3-hydroxypipecolic acids and analogsEuropean Journal of Organic Chemistry.  2845-2851. 2009
2009 F0XP3 Up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/histone deacetylase 4 association to the locusCancer Research.  69:2252-2259. 2009
2008 Laforin negatively regulates cell cycle progression through glycogen synthase kinase 3β-dependent mechanismsMolecular and Cellular Biology.  28:7236-7244. 2008
2008 Studies on fluorescence property of Eu3+ dinuclear complexes with 2-thiopheneacetic acid and o-phenanthroline 2008
2008 TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen speciesJournal of Experimental Medicine.  205:2397-2408. 2008
2008 Expression of MCM4 and CDC6 in uterine cervical carcinoma and its relation with HPV16/18 infection 2008
2008 Study on relationship between microsatellite alterations of FHIT gene and HPV infection and cervical carcinomaChinese Journal of Cancer Prevention and Treatment.  15:404-407. 2008
2008 Study on the relationship between microsatellite alterations of RASSF1A gene and the development of cervical carcinomaZhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology.  22:345-347. 2008
2007 Correlation between the expression of Bcl-2, Survivin and CD44v6 and infection with HPV16/18 in the carcinogenesis of cervical cancerChinese Journal of Clinical Oncology.  34:426-429. 2007
2007 FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2Journal of Clinical Investigation.  117:3765-3773. 2007
2007 Oral pioglitazone administration increases food intake through ghrelin-independent pathway in Zucker fatty ratDiabetes Research and Clinical Practice.  77:351-356. 2007
2007 Effect of blockage of costimulatory signal on murine abortion-prone model 2007
2007 A dinucleotide deletion in CD24 confers protection against autoimmune diseasesPLoS Genetics.  3:0508-0517. 2007
2004 The expression and functional role of nicotinic acetylcholine receptors in rat adipocytesJournal of Pharmacology and Experimental Therapeutics.  310:52-58. 2004
2003 Long-term oral nicotine administration reduces insulin resistance in obese ratsEuropean Journal of Pharmacology.  458:227-234. 2003
2002 Early events involved in the development of insulin resistance in Zucker fatty ratInternational Journal of Obesity.  26:318-326. 2002
2001 Oral nicotine administration decreases tumor necrosis factor-alpha expression in fat tissues in obese rats 2001

Education And Training

  • Doctor of Philosophy Level Degree in Medical Genetics, University of Miyazaki 2002
  • Full Name

  • Runhua Liu