Positions

Overview

  • Introduction & Research:

    The overall goal of Dr. Lu’s laboratory is to better understand the epigenetic mechanisms that underlie cancer cell development, and to develop mechanism-based and targeted therapeutic approaches. Dr. Lu’s lab currently is focusing on understanding epigenetic regulations in blood cancer. Recent projects in Dr. Lu’s lab include the following directions: (1) understanding the molecular basis of driver mutations in cancer; (2) discovery of novel targets for cancer epigenetic therapies; (3) development of new epigenome editing tools to study gene regulation in normal and cancer cells.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2022 TBX20 Improves Contractility and Mitochondrial Function During Direct Human Cardiac Reprogramming.Circulation.  101161CIRCULATIONAHA12205. 2022
    2021 Acute depletion of CTCF rewires genome-wide chromatin accessibilityGenome Biology.  22. 2021
    2021 Metabolic alterations mediated by STAT3 promotes drug persistence in CMLLeukemia.  35:3371-3382. 2021
    2021 Transcription factor MEF2D is required for the maintenance of MLL-rearranged acute myeloid leukemiaBlood Advances.  5:4727-4740. 2021
    2021 Inhibition of EZH2 primes the cardiac gene activation via removal of epigenetic repression during human direct cardiac reprogrammingStem Cell Research.  53. 2021
    2021 Molecular regulators of HOXA9 in acute myeloid leukemiaThe Federation of European Biochemical Societies (FEBS) Journal2021
    2020 Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screeneLife.  9:1-30. 2020
    2020 Probing the therapeutic potential of TRPC6 for Alzheimer's disease in live neurons from patient-specific iPSCsJournal of Molecular Cell Biology.  12:807-816. 2020
    2020 E2A-PBX1 functions as a coactivator for RUNX1 in acute lymphoblastic leukemiaBlood.  136:11-23. 2020
    2019 A model system for studying the DNMT3A HOTSPO mutation (DNMT3AR882) demonstrates a causal relationship between its dominant-negative effect and leukemogenesisCancer Research.  79:3583-3594. 2019
    2018 ZFX Mediates Non-canonical Oncogenic Functions of the Androgen Receptor Splice Variant 7 in Castrate-Resistant Prostate CancerMolecular Cell.  72:341-354.e6. 2018
    2018 Effect of intrahippocampal injection of anti-cellular prion protein monoclonal antibody on cognitive deficits in APPswe/PSEN1dE9 transgenic miceNan fang yi ke da xue xue bao = Journal of Southern Medical University.  38:443-449. 2018
    2018 The Chromatin Remodeler BPTF Activates a Stemness Gene-Expression Program Essential for the Maintenance of Adult Hematopoietic Stem CellsStem Cell Reports.  10:675-683. 2018
    2018 Reduced TRPC6 mRNA levels in the blood cells of patients with Alzheimer's disease and mild cognitive impairmentMolecular Psychiatry.  23:767-776. 2018
    2018 Structural basis for DNMT3A-mediated de novo DNA methylationNature.  554:387-391. 2018
    2017 Pharmacologic targeting of chromatin modulators as therapeutics of acute myeloid leukemiaFrontiers in Oncology.  7. 2017
    2016 Epigenetic Perturbations by Arg882-Mutated DNMT3A Potentiate Aberrant Stem Cell Gene-Expression Program and Acute Leukemia DevelopmentCancer Cell.  30:92-107. 2016
    2016 Bmi1 Is a Key Epigenetic Barrier to Direct Cardiac ReprogrammingCell Stem Cell.  18:382-395. 2016
    2016 Advances in genome-wide association studies of sporadic Alzheimer’s diseaseGuoji Yaoxue Yanjiu Zazhi.  43:8-14. 2016
    2016 Gene enhancer deregulation and epigenetic vulnerabilityOncoscience.  3:299-301. 2016
    2015 TRPC6 specifically interacts with APP to inhibit its cleavage by I 3-secretase and reduce Aβ productionNature Communications.  6. 2015
    2015 Stk40 represses adipogenesis through translational control of CCAAT/enhancer-binding proteinsJournal of Cell Science.  128:2881-2890. 2015
    2013 Tudor: A versatile family of histone methylation 'readers'Trends in Biochemical Sciences.  38:546-555. 2013
    2013 An H3K36 Methylation-Engaging Tudor Motif of Polycomb-like Proteins Mediates PRC2 Complex TargetingMolecular Cell.  49:571-582. 2013
    2011 Nucleolin maintains embryonic stem cell self-renewal by suppression of p53 protein-dependent pathwayJournal of Biological Chemistry.  286:43370-43382. 2011
    2011 Dual functions of T-box 3 (Tbx3) in the control of self-renewal and extraembryonic endoderm differentiation in mouse embryonic stem cellsJournal of Biological Chemistry.  286:8425-8436. 2011
    2010 Regulation of β cleavage of amyloid precursor proteinNeuroscience Bulletin.  26:417-427. 2010
    2010 Stk40 links the pluripotency factor Oct4 to the Erk/MAPK pathway and controls extraembryonic endoderm differentiationProceedings of the National Academy of Sciences of USA.  107:1402-1407. 2010
    2009 Ly-1 antibody reactive clone is an important nucleolar protein for control of self-renewal and differentiation in embryonic stem cellsStem Cells.  27:1244-1254. 2009
    2006 Inducible and reversible suppression of Npm1 gene expression using stably integrated small interfering RNA vector in mouse embryonic stem cellsBiochemical and Biophysical Research Communications.  347:1129-1137. 2006

    Chapter

    Year Title Altmetric
    2017 TRPC channels and Alzheimer’s disease.  73-83. 2017

    Education And Training

  • University of North Carolina at Chapel Hill, Postdoctoral Fellowship
  • Doctor of Philosophy in Developmental Biology and Embryology, University of the Chinese Academy of Sciences 2011
  • Bachelor of Science or Mathematics in Biology, Nanjing Normal University 2005
  • Full Name

  • Rui Lu