Robert Sorge

Robert Sorge
Associate Professor

Scientist (C), UWIRC Microbiome Center , School of Medicine
Scientist (C), Comprehensive Diabetes Center , School of Medicine
Associate Scientist (C), Comprehensive Neuroscience Center , General Clinical Research Center
Scientist (C), Nutrition Obesity Res Center (NORC) , Nutrition Sciences Research
Scientist (C), Civitan International Research Center , Academic Joint Departments
Associate Professor (P), Psychology , College of Arts and Sciences

Overview

Born in a little hamlet in rural Canada, I have spent the majority of my life in the north. I completed a Bachelor’s degree in Hamilton, Ontario, Canada in 2000 under the supervision of Dr. Geoff Galef (environmental enrichment), a Master’s degree from Wilfrid Laurier University in Waterloo, Ontario, Canada under Dr. Linda Parker (THC and nausea, 2001) and a PhD from Concordia University in Montreal, Quebec, Canada in 2006 under Dr. Jane Stewart (heroin and cocaine addiction).

Continuing my love for Montreal, I completed a postdoctoral fellowship at McGill University under Dr. Paul Clarke (nicotine addiction, 2009) and under Dr. Jeff Mogil (genetics and pain, 2012). I started at UAB in the Department of Psychology in the summer of 2012 and have been here ever since.

I am currently enjoying Alabama with my family and return to Canada in the warmer months of the year to avoid the snow. As animal lovers, we currently have 2 dogs, a cat, a rat, a snake, and eight fish, and we watch friends’ animals when they are out of town.

Selected Publications

Academic Article

Year	Title	Altmetric
2022	Corrigendum to "An improved model of type 2 diabetes with effects on glucose tolerance, neuropathy and retinopathy with and without obesity"✰.. Physiology and Behavior. 251:113823. 2022
2022	An improved model of type 2 diabetes with effects on glucose tolerance, neuropathy and retinopathy with and without obesity. Physiology and Behavior. 248. 2022
2022	Dietary Inflammatory Index (DII) is Associated with Movement-Evoked Pain Severity in Adults with Chronic Low Back Pain: Sociodemographic Differences.. Journal of Pain. 2022
2022	Racial Differences in Pain, Nutrition, and Oxidative Stress 2022
2022	Relationship between diet and relative risk of pain in a cross-sectional analysis of the REGARDS longitudinal study. Pain Management. 12:168-179. 2022
2021	Sleep and neighborhood socioeconomic status: a micro longitudinal study of chronic low-back pain and pain-free individuals. Journal of Behavioral Medicine. 44:811-821. 2021
2021	Temporal summation of mechanical pain prospectively predicts movement-evoked pain severity in adults with chronic low back pain. BMC Musculoskeletal Disorders. 22. 2021
2021	The effect of the Standard American Diet on Iba-1 immunoreactivity in the spinal cord before and after peripheral inflammatory injury in rats 2021
2020	Obesity diminishes response to PD-1-based immunotherapies in renal cancer. Journal for ImmunoTherapy of Cancer. 8. 2020
2020	Dietary Interventions for Treatment of Chronic Pain: Oxidative Stress and Inflammation 2020
2020	Obesity-Associated Myeloid-Derived Suppressor Cells Promote Apoptosis of Tumor-Infiltrating CD8 T Cells and Immunotherapy Resistance in Breast Cancer. Frontiers in Immunology. 11. 2020
2020	The sad weekend: A perilous North American tradition 2020
2020	Spinal Mobilization Prevents NGF-Induced Trunk Mechanical Hyperalgesia and Attenuates Expression of CGRP. Frontiers in Neuroscience. 14. 2020
2020	Sex and gender are not the same: Why identity is important for people living with HIV and chronic pain. Journal of Pain Research. 13:829-835. 2020
2020	The effect of low-carbohydrate and low-fat diets on pain in individuals with knee osteoarthritis. Pain Medicine. 21:150-160. 2020
2018	Sex differences in pain responses. Current Opinion in Physiology. 6:75-81. 2018
2018	Effects of diet on immune cells within the central nervous system. Physiology and Behavior. 196:158-164. 2018
2018	Effects of a Standard American Diet and an anti-inflammatory diet in male and female mice. European Journal of Pain. 22:1203-1213. 2018
2018	Neuropsychiatric Phenotypes Produced by GABA Reduction in Mouse Cortex and Hippocampus. Neuropsychopharmacology. 43:1445-1456. 2018
2017	The impact of the Standard American Diet in rats: Effects on behavior, physiology and recovery from inflammatory injury. Scandinavian Journal of Pain. 17:316-324. 2017
2017	Epiregulin and EGFR interactions are involved in pain processing. Journal of Clinical Investigation. 127:3353-3366. 2017
2017	Brief Report: IL-1β Levels Are Associated with Chronic Multisite Pain in People Living with HIV 2017
2017	Immune system involvement in specific pain conditions. Molecular Pain. 13. 2017
2017	Sex Differences in Pain. Journal of Neuroscience Research. 95:1271-1281. 2017
2017	A novel zebrafish-based model of nociception. Physiology and Behavior. 174:83-88. 2017
2016	eIF2α phosphorylation controls thermal nociception 2016
2016	Efficacy of Common Analgesics for Postsurgical Pain in Rats. Response to Dr Shientag's Letter to the Editor 2016
2016	Efficacy of common analgesics for postsurgical pain in rats 2016
2016	Total Western Diet Alters Mechanical and Thermal Sensitivity and Prolongs Hypersensitivity Following Complete Freund's Adjuvant in Mice. Journal of Pain. 17:119-125. 2016
2015	Translational control of nociception via 4E-binding protein 1. eLife. 4. 2015
2015	Different immune cells mediate mechanical pain hypersensitivity in male and female mice. Nature Neuroscience. 18:1081-1083. 2015
2015	Efficacy of common analgesics for postsurgical pain in rats 2015
2015	The nicotinic α6 subunit gene determines variability in chronic pain sensitivity via cross-inhibition of P2X2/3 receptors. Science Translational Medicine. 7. 2015
2015	Protease-activated receptor 2 activation is sufficient to induce the transition to a chronic pain state. PAIN. 156:859-867. 2015
2015	Spinal dopaminergic projections control the transition to pathological pain plasticity via a D1/D5-mediated mechanism 2015
2015	Dietary influence on pain via the immune system. Progress in Molecular Biology and Translational Science. 131:435-469. 2015
2014	Smads as muscle biomarkers in amyotrophic lateral sclerosis. Annals of Clinical and Translational Neurology. 1:778-787. 2014
2014	Quantifying blood-spinal cord barrier permeability after peripheral nerve injury in the living mouse. Molecular Pain. 10. 2014
2014	Olfactory exposure to males, including men, causes stress and related analgesia in rodents. Nature methods. 11:629-632. 2014
2013	The Yin and Yang of pain: Variability in formalin test nociception and morphine analgesia produced by the Yin Yang 1 transcription factor gene. Genes, Brain and Behavior. 12:405-413. 2013
2013	Control of synaptic plasticity and memory via suppression of poly(A)-Binding protein. Neuron. 78:298-311. 2013
2013	MTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK. PAIN. 154:1080-1091. 2013
2012	A role for PACE4 in osteoarthritis pain: Evidence from human genetic association and null mutant phenotype. Annals of the Rheumatic Diseases. 71:1042-1048. 2012
2012	Serotonin-Induced Hypersensitivity via Inhibition of Catechol O-Methyltransferase Activity. Molecular Pain. 8. 2012
2012	Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. Nature Medicine. 18:595-599. 2012
2012	Using the mouse grimace scale to reevaluate the efficacy of postoperative analgesics in laboratory mice 2012
2011	Pain sensitivity and vasopressin analgesia are mediated by a gene-sex-environment interaction. Nature Neuroscience. 14:1569-1573. 2011
2011	Spinal cord Toll-like receptor 4 mediates inflammatory and neuropathic hypersensitivity in male but not female mice. 2011
2011	Spinal cord toll-like receptor 4 mediates inflammatory and neuropathic hypersensitivity in male but not female mice 2011
2011	The Rat Grimace Scale: A partially automated method for quantifying pain in the laboratory rat via facial expressions. Molecular Pain. 7. 2011
2010	Oxytocin-induced analgesia and scratching are mediated by the vasopressin-1A receptor in the mouse 2010
2010	Coding of facial expressions of pain in the laboratory mouse. Nature methods. 7:447-449. 2010
2009	Facilitation of intravenous nicotine self-administration in rats by a motivationally neutral sensory stimulus. Psychopharmacology. 207:191-200. 2009
2009	Rats self-administer intravenous nicotine delivered in a novel smoking-relevant procedure: Effects of dopamine antagonists. Journal of Pharmacology and Experimental Therapeutics. 330:633-640. 2009
2007	High-dose methadone maintenance in rats: Effects on cocaine self-administration and behavioral side effects. Neuropsychopharmacology. 32:2290-2300. 2007
2007	Chronic buprenorphine reduces the response to sucrose-associated cues in non food-deprived rats 2007
2006	Dopamine has bidirectional effects on synaptic responses to cortical inputs in layer II of the lateral entorhinal cortex. Journal of Neurophysiology. 96:3006-3015. 2006
2006	The effects of chronic buprenorphine on intake of heroin and cocaine in rats and its effects on nucleus accumbens dopamine levels during self-administration. Psychopharmacology. 188:28-41. 2006
2006	The effects of long-term chronic buprenorphine treatment on the locomotor and nucleus accumbens dopamine response to acute heroin and cocaine in rats 2006
2005	The contribution of drug history and time since termination of drug taking to footshock stress-induced cocaine seeking in rats. Psychopharmacology. 183:210-217. 2005
2005	Rats maintained chronically on buprenorphine show reduced heroin and cocaine seeking in tests of extinction and drug-induced reinstatement. Neuropsychopharmacology. 30:1681-1692. 2005
2004	Effect of low doses of Δ⁹-tetrahydrocannabinol and cannabidiol on the extinction of cocaine-induced and amphetamine-induced conditioned place preference learning in rats. Psychopharmacology. 175:360-366. 2004
2004	Methadone maintenance reduces heroin- and cocaine-induced relapse without affecting stress-induced relapse in a rodent model of poly-drug use. Neuropsychopharmacology. 29:1312-1320. 2004
2003	A role for the prefrontal cortex in stress- and cocaine-induced reinstatement of cocaine seeking in rats. Psychopharmacology. 168:66-74. 2003
2002	Effect of sodium deprivation on morphine- and lithium-induced conditioned salt avoidance and taste reactivity. Psychopharmacology. 160:84-91. 2002

Book

Year	Title	Altmetric
2011	Nicotine self-administration. Ed. 53. 2011

Research Overview

The research in my lab follows a number of different paths that generally fall under the umbrella of innate immune system involvement in pain and addiction.

First, we have shown that alteration of the innate immune system can change pain expression in animals and that the different sexes use separate cellular mechanisms to mediate pain. One are of research in my lab is examining the impact of diet on the functioning of the immune system and the resulting effect on acute pain sensitivity and persistence of chronic pain. We are looking at rodent models of diet and pain as well as developing models of nutrition and pain in zebrafish in collaboration with the Department of Biology. Recently we have started to look at the impact of diet interventions on pain in human patients with knee pain and plan to continue our parallel work in animals and human patients.

Second, we have a number of lines of knockout mice that allow us to examine the role of various innate immune system pathways in the expression of acute and chronic pain. We are interested in the toll-like receptors and their downstream targets, the inflammasomes. Currently we have characterized the role of a number of these pathways and are actively investigating the possibility of developing pharmacological treatments to reduce pain behavior.

Third, we are investigating the involvement of the innate immune system in the rewarding properties of drugs of abuse. Almost every drug of abuse has painkilling properties and there is evidence that these drugs also activate the immune system. Our work is focused on discovering whether we can modulate the rewarding value of opioid and stimulant drugs via immune system treatments using the conditioned place preference procedure.

Finally, we are using the operant self-administration procedure to allow rats to self-medicate with pain-killing drugs while in a mild chronic pain state. This will allow us to measure the pain-killing and rewarding value of novel pain treatments within a single experimental procedure as a model for patient-controlled analgesia. The goal of this research is to test new drugs for their addictive potential prior to testing in humans.

Innate immune system involvement in pain and addiction