Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Antagonism of BMP signaling is insufficient to induce fibrous differentiation in primary sclerotome 2019
2019 Development of the axial skeleton and intervertebral disc 2019
2019 Prg4 prevents osteoarthritis induced by dominant-negative interference of TGF-ß signaling in mice 2019
2017 Mechanical loading regulates organization of the actin cytoskeleton and column formation in postnatal growth plate 2017
2017 Tgfbr2 is required in osterix expressing cells for postnatal skeletal development 2017
2017 SOX9 protein is stabilized by TGF-β and regulates PAPSS2 mRNA expression in chondrocytes 2017
2016 TGF-β regulates phosphorylation and stabilization of Sox9 protein in chondrocytes through p38 and Smad dependent mechanisms 2016
2016 Wnt5a Signals through DVL1 to Repress Ribosomal DNA Transcription by RNA Polymerase I 2016
2016 An investigation on wind turbine resonant vibrations 2016
2016 Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation 2016
2016 Erratum: The Tunguska event and Cheko lake origin: Dendrochronological analysis (International Journal of Astrobiology (2014) DOI: 10.1017/S1473550414000445) 2016
2015 Function and regulation of primary cilia and intraflagellar transport proteins in the skeleton 2015
2014 Wnt5a suppresses tumor formation and redirects tumor phenotype in MMTV-Wnt1 tumors 2014
2014 Erg cooperates with TGF-β to control mesenchymal differentiation 2014
2014 Chondrocyte-specific knockout of Cbfβ reveals the indispensable function of Cbfβ in chondrocyte maturation, growth plate development and trabecular bone formation in mice 2014
2014 Normal mammary development and function in mice with Ift88 deleted in MMTV- and K14-Cre expressing cells 2014
2014 Depletion of chondrocyte primary cilia reduces the compressive modulus of articular cartilage 2014
2014 Runx2 regulates endochondral ossification through control of chondrocyte proliferation and differentiation 2014
2013 Inactivation of Tgfbr2 in Osterix-Cre expressing dental mesenchyme disrupts molar root formation 2013
2013 WNT5A Inhibits Metastasis and Alters Splicing of Cd44 in Breast Cancer Cells 2013
2013 Ift88 regulates Hedgehog signaling, Sfrp5 expression, and β-catenin activity in post-natal growth plate 2013
2012 PDGF mediates TGFβ-induced migration during development of the spinous process 2012
2012 Altered responsiveness to TGF-β results in reduced Papss2 expression and alterations in the biomechanical properties of mouse articular cartilage 2012
2012 Depletion of primary cilia in articular chondrocytes results in reduced Gli3 repressor to activator ratio, increased Hedgehog signaling, and symptoms of early osteoarthritis 2012
2011 Misexpression of wingless-related MMTV integration site 5A in mouse mammary gland inhibits the milk ejection response and regulates connexin43 phosphorylation 2011
2011 Chondrocyte-specific regulatory activity of Runx2 is essential for survival and skeletal development 2011
2011 TMJ development and growth require primary cilia function 2011
2011 Wnt5a as an effector of TGFβ in mammary development and cancer 2011
2011 Disruption of PCP signaling causes limb morphogenesis and skeletal defects and may underlie Robinow syndrome and brachydactyly type B 2011
2011 TGF-β2 suppresses macrophage cytokine production and mucosal inflammatory responses in the developing intestine 2011
2010 Inhibiting breast cancer progression by exploiting TGFβ signaling 2010
2010 Molecular profiling of the developing mouse axial skeleton: A role for Tgfbr2 in the development of the intervertebral disc 2010
2010 PIKE-A is required for prolactin-mediated STAT5a activation in mammary gland development 2010
2010 Primary cilia are decreased in breast cancer: Analysis of a collection of human breast cancer cell lines and tissues 2010
2009 Tgfbr2 is required for development of the skull vault 2009
2009 TGF-β promotes Th17 cell development through inhibition of SOCS3 2009
2009 Roles of the primary cilium component polaris in synchondrosis development 2009
2009 Loss of TGF-β or Wnt5a results in an increase in Wnt/β-catenin activity and redirects mammary tumour phenotype 2009
2008 Chapter 11 Cilia Involvement in Patterning and Maintenance of the Skeleton 2008
2008 Role of intraflagellar transport and primary cilia in skeletal development 2008
2008 Role for primary cilia in the regulation of mouse ovarian function 2008
2008 Transforming growth factor-β signaling mediates hypoxia-induced pulmonary arterial remodeling and inhibition of alveolar development in newborn mouse lung 2008
2007 Wnt5a is required for proper mammary gland development and TGF-β-mediated inhibition of ductal growth 2007
2007 Deletion of Tgfbr2 in Prx1-cre expressing mesenchyme results in defects in development of the long bones and joints 2007
2007 Conditional Kif3a ablation causes abnormal hedgehog signaling topography, growth plate dysfunction, and excessive bone and cartilage formation during mouse skeletogenesis 2007
2007 Development of the post-natal growth plate requires intraflagellar transport proteins 2007
2007 C-type natriuretic peptide regulates endochondral bone growth through p38 MAP kinase-dependent and - Independent pathways 2007
2007 Intraflagellar transport in skeletal development. 2007
2007 Intraflagellar transport is essential for endochondral bone formation 2007
2006 Tgfbr2 regulates the maintenance of boundaries in the axial skeleton 2006
2006 Dominant negative mutation of the TGF-β eceptor blocks hypoxia-induced pulmonary vascular remodeling 2006
2006 Transforming growth factor-β signaling helps specify tumor type in DMBA and hormone-induced mammary cancers 2006
2005 Mouse models of transforming growth factor β impact in breast development and cancer 2005
2005 TGF-β, c-Cbl, and PDGFR-α the in mammary stroma 2005
2005 Co-ordination of TGF-β and FGF signaling pathways in bone organ cultures 2005
2005 Expression patterns of matrix metalloproteinases and vascular endothelial growth factor during epiphyseal ossification 2005
2004 Conditional deletion of the TGF-β type II receptor in Col2a expressing cells results in defects in the axial skeleton without alterations in chondrocyte differentiation or embryonic development of long bones 2004
2004 Unique and redundant roles of Smad3 in TGF-β-mediated regulation of long bone development in organ culture 2004
2004 Prolactin and transforming growth factor-β signaling exert opposing effects on mammary gland morphogenesis, involution, and the Akt-forkhead pathway 2004
2003 TGF-β Signaling in Human Skeletal and Patterning Disorders 2003
2003 TGF-β mammary gland development and breast cancer 2003
2002 Developmental and TGF-β-mediated regulation of Ank mRNA expression in cartilage and bone 2002
2002 TGFβ2 mediates the effects of Hedgehog on hypertrophic differentiation and PTHrP expression 2002
2001 Signaling to the epithelium is not sufficient to mediate all of the effects of transforming growth factor β and bone morphogenetic protein 4 on murine embryonic lung development 2001
2001 The perichondrium plays an important role in mediating the effects of TGF-β1 on endochondral bone formation 2001
2001 Antagonistic effects of TGF/β1 and BMP-6 on skin keratinocyte differentiation 2001
1999 Transforming growth factor-beta in development and disease 1999
1999 Parathyroid hormone-related peptide (PTHrP)-dependent and -independent effects of transforming growth factor β (TGF-β)on endochondral bone formation 1999
1999 Overexpression of a kinase-deficient transforming growth factor-β type II receptor in mouse mammary stroma results in increased epithelial branching 1999
1998 Dominant-negative interference of the transforming growth factor β type II receptor in mammary gland epithelium results in alveolar hyperplasia and differentiation in virgin mice 1998
1997 Expression of a truncated, kinase-defective TGF-β type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis 1997
1996 Regulation of differentiation by TGF-β 1996
1996 Tumor suppressor genes in the TGF-β signaling pathway? Loss of response to TGF-βs may be an important step in the development and progression of cancer. Recent studies show that receptors and proteins involved in TGF-β signaling may act as tumor suppressors 1996
1995 pRb is necessary for inhibition of N-myc expression by TGF-β1 in embryonic lung organ cultures 1995
1994 TGFβ1 inhibits branching morphogenesis and N-myc expression in lung bud organ cultures 1994
1994 TGF beta regulation of cell proliferation. 1994
1994 Transforming growth factor β1 suppresses transformation in hepatocytes by regulating α1β1 integrin expression 1994
1993 Stimulation of DNA synthesis and protooncogene expression in primary rat hepatocytes in long‐term DMSO culture 1993
1992 Functional analyses of albumin expression in a series of hepatocyte cell lines and in primary hepatocytes. 1992
1992 Transforming growth factor beta 1 partially suppresses the transformed phenotype of ras-transformed hepatocytes. 1992

Chapter

Year Title Altmetric
2014 Development of the intervertebral disc.  33-51. 2014

Principal Investigator On

  • Mechanisms of TGFb in Prostagladin Metabolism and Fertilization  awarded by National Institute of Child Health and Human Development/NIH/DHHS 2019 - 2022
  • Mechanisms Of Growth Plate Organization In Response To Mechanical Load  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2018 - 2020
  • Mechanisms Regulating Afferent Innervation in the Dental Pulp  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2018 - 2020
  • Mechanism of Tgfbr2 in Chondroprotection  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2013 - 2019
  • TGF-beta in the Pathology and Development of the Spine  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2013 - 2019
  • Chondrocytic Cilia and Mechano-Sensation  awarded by United States - Israel Binational Science Foundation 2012 - 2016
  • Wnt5a and TGF-beta in Mammary Development and Cancer  awarded by National Cancer Institute/NIH/DHHS 2009 - 2014
  • Sox9 in TGF-Mediated Maintenance of beta Chondrocyte Phenotype  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2011 - 2014
  • Orchestration of Breast Cancer Osteolytic Bone Metastasis by MIF  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2013 - 2014
  • TGF-Beta in the Pathology and Development of the Spine  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2007 - 2013
  • Primary Cilia in Breast Cancer Progression  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY 2009 - 2011
  • The Mechanism of Tgfbr2 Action in Joint Degeneration  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2011
  • Education And Training

  • Doctor of Philosophy in Cell / Cellular and Molecular Biology, Pennsylvania State System of Higher Education 1992
  • Full Name

  • Rosa Serra