Positions

Selected Publications

Academic Article

Year Title Altmetric
2020 Scaffoldless tissue-engineered cartilage for studying transforming growth factor beta-mediated cartilage formation.  Biotechnology Progress.  36. 2020
2019 Antagonism of BMP signaling is insufficient to induce fibrous differentiation in primary sclerotome.  Experimental Cell Research.  378:11-20. 2019
2019 Development of the axial skeleton and intervertebral disc.  Current Topics in Developmental Biology.  133:49-90. 2019
2018 IVD Development: Nucleus pulposus development and sclerotome specification. 2018
2017 Tgfbr2 is required in osterix expressing cells for postnatal skeletal development.  BONE.  97:54-64. 2017
2015 Function and regulation of primary cilia and intraflagellar transport proteins in the skeleton.  Annals of the New York Academy of Sciences.  1335:78-99. 2015
2014 Erg cooperates with TGF-β to control mesenchymal differentiation.  Experimental Cell Research.  328:410-418. 2014
2014 Normal mammary development and function in mice with Ift88 deleted in MMTV- and K14-Cre expressing cells.  Cilia.  3. 2014
2013 Inactivation of Tgfbr2 in Osterix-Cre expressing dental mesenchyme disrupts molar root formation.  Developmental Biology.  382:27-37. 2013
2012 PDGF mediates TGFβ-induced migration during development of the spinous process.  Developmental Biology.  365:110-117. 2012
2012 Altered responsiveness to TGF-β results in reduced Papss2 expression and alterations in the biomechanical properties of mouse articular cartilage 2012
2011 Misexpression of wingless-related MMTV integration site 5A in mouse mammary gland inhibits the milk ejection response and regulates connexin43 phosphorylation.  Biology of Reproduction.  85:907-915. 2011
2011 Chondrocyte-specific regulatory activity of Runx2 is essential for survival and skeletal development 2011
2010 Inhibiting breast cancer progression by exploiting TGFβ signaling.  Current Drug Targets.  11:1089-1102. 2010
2010 Molecular profiling of the developing mouse axial skeleton: A role for Tgfbr2 in the development of the intervertebral disc.  BMC Developmental Biology.  10. 2010
2009 Tgfbr2 is required for development of the skull vault.  Developmental Biology.  334:481-490. 2009
2009 Loss of TGF-β or Wnt5a results in an increase in Wnt/β-catenin activity and redirects mammary tumour phenotype.  Breast Cancer Research.  11. 2009
2008 Chapter 11 Cilia Involvement in Patterning and Maintenance of the Skeleton.  Current Topics in Developmental Biology.  85:303-332. 2008
2008 Role of intraflagellar transport and primary cilia in skeletal development.  Anatomical Record.  291:1049-1061. 2008
2008 Role for primary cilia in the regulation of mouse ovarian function.  Developmental Dynamics.  237:2053-2060. 2008
2008 Transforming growth factor-β signaling mediates hypoxia-induced pulmonary arterial remodeling and inhibition of alveolar development in newborn mouse lung 2008
2007 Wnt5a is required for proper mammary gland development and TGF-β-mediated inhibition of ductal growth 2007
2007 Deletion of Tgfbr2 in Prx1-cre expressing mesenchyme results in defects in development of the long bones and joints.  Developmental Biology.  310:304-316. 2007
2007 Conditional Kif3a ablation causes abnormal hedgehog signaling topography, growth plate dysfunction, and excessive bone and cartilage formation during mouse skeletogenesis 2007
2007 Development of the post-natal growth plate requires intraflagellar transport proteins.  Developmental Biology.  305:202-216. 2007
2007 C-type natriuretic peptide regulates endochondral bone growth through p38 MAP kinase-dependent and - Independent pathways.  BMC Developmental Biology.  7. 2007
2007 Intraflagellar transport is essential for endochondral bone formation 2007
2006 Tgfbr2 regulates the maintenance of boundaries in the axial skeleton.  Developmental Biology.  296:363-374. 2006
2006 Transforming growth factor-β signaling helps specify tumor type in DMBA and hormone-induced mammary cancers.  Differentiation.  74:40-52. 2006
2005 Mouse models of transforming growth factor β impact in breast development and cancer.  Endocrine-Related Cancer.  12:749-760. 2005
2005 TGF-β, c-Cbl, and PDGFR-α the in mammary stroma.  Developmental Biology.  279:58-72. 2005
2004 Conditional deletion of the TGF-β type II receptor in Col2a expressing cells results in defects in the axial skeleton without alterations in chondrocyte differentiation or embryonic development of long bones.  Developmental Biology.  276:124-142. 2004
2004 Unique and redundant roles of Smad3 in TGF-β-mediated regulation of long bone development in organ culture.  Developmental Dynamics.  230:685-699. 2004
2003 TGF-β Signaling in Human Skeletal and Patterning Disorders 2003
2003 TGF-β mammary gland development and breast cancer.  Breast Disease.  18:61-73. 2003
2002 TGFβ2 mediates the effects of Hedgehog on hypertrophic differentiation and PTHrP expression 2002
2001 The perichondrium plays an important role in mediating the effects of TGF-β1 on endochondral bone formation.  Developmental Dynamics.  221:311-321. 2001
2001 Antagonistic effects of TGF/β1 and BMP-6 on skin keratinocyte differentiation.  Experimental Cell Research.  263:265-273. 2001
1999 Transforming growth factor-beta in development and disease.  Biotecnología Aplicada.  16:205-218. 1999
1996 Regulation of differentiation by TGF-β.  Current Opinion in Genetics and Development.  6:581-586. 1996
1995 pRb is necessary for inhibition of N-myc expression by TGF-β1 in embryonic lung organ cultures 1995
1994 TGFβ1 inhibits branching morphogenesis and N-myc expression in lung bud organ cultures 1994

Chapter

Year Title Altmetric
2014 Development of the intervertebral disc.  33-51. 2014

Research Overview

  • The overall goal of the laboratory is to understand the role and mechanism of TGF-ß signaling in embryonic and post-natal skeletal development and to apply this knowledge to skeletal repair and regeneration.

    • Principal Investigator On

  • Chondrocytic Cilia and Mechano-Sensation  awarded by United States - Israel Binational Science Foundation
  • Mechanism of Tgfbr2 in Chondroprotection  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Mechanism of Tgfbr2 in Chondroprotection  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Mechanisms Of Growth Plate Organization In Response To Mechanical Load  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Mechanisms Regulating Afferent Innervation in the Dental Pulp  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS
  • Mechanisms of TGFb in Prostaglandin Metabolism and Fertilization  awarded by National Institute of Child Health and Human Development/NIH/DHHS
  • Orchestration of Breast Cancer Osteolytic Bone Metastasis by MIF  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Primary Cilia in Breast Cancer Progression  awarded by DOD - ARMY MEDICAL RESEARCH ACQUISITION ACTIVITY
  • Sox9 in TGF-Mediated Maintenance of beta Chondrocyte Phenotype  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • TGF-Beta in the Pathology and Development of the Spine  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • TGF-beta in the Pathology and Development of the Spine  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • TGF-beta in the Pathology and Development of the Spine  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • The Mechanism of Tgfbr2 Action in Joint Degeneration  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS
  • Wnt5a and TGF-beta in Mammary Development and Cancer  awarded by National Cancer Institute/NIH/DHHS

    • Investigator On

    Education And Training

  • Doctor of Philosophy in Cell / Cellular and Molecular Biology, Pennsylvania State System of Higher Education 1992

    • Awards And Honors

    Full Name

  • Rosa Serra