Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Inhibition of Hedgehog signaling reprograms the dysfunctional immune microenvironment in breast cancerOncoImmunology.  8. 2019
2019 O-GlcNAcylation of GLI transcription factors in hyperglycemic conditions augments Hedgehog activityLaboratory Investigation.  99:260-270. 2019
2019 The nucleolus: a central response hub for the stressors that drive cancer progressionCellular and Molecular Life Sciences2019
2018 Correction: Niclosamide and its analogs are potent inhibitors of Wnt/β-catenin, mTOR and STAT3 signaling in ovarian cancer [Oncotarget., 7, (2016) (86803-86815)] 10.18632/oncotarget.13466Oncotarget.  9:19459-19459. 2018
2018 Conditional knockout of N-Myc and STAT interactor disrupts normal mammary development and enhances metastatic ability of mammary tumorsOncogene.  37:1610-1623. 2018
2018 Evaluating the use of external beam radiation alone in the management of cervix cancerJournal of Radiotherapy in Practice.  17:37-43. 2018
2018 Deficiency of tumor suppressor Merlin facilitates metabolic adaptation by co-operative engagement of SMAD-Hippo signaling in breast cancerCarcinogenesis.  39:1165-1175. 2018
2018 Phage ligands for identification of mesenchymal-like breast cancer cells and cancer-associated fibroblastsFrontiers in Oncology.  8. 2018
2017 Methods to Evaluate Cell Growth, Viability, and Response to Treatment in a Tissue Engineered Breast Cancer ModelScientific Reports.  7. 2017
2017 Neuroligin 4X overexpression in human breast cancer is associated with poor relapse-free survivalPLoS ONE.  12. 2017
2017 Perspective on the interpretation of research and translation to clinical care with therapy-associated metastatic breast cancer progression as an exampleClinical and Experimental Metastasis.  34:443-447. 2017
2017 Developing Cures: Targeting Ontogenesis in CancerTrends in Cancer.  3:126-136. 2017
2017 Loss of Merlin induces metabolomic adaptation that engages dependence on Hedgehog signalingScientific Reports.  7. 2017
2016 Emerging roles and underlying molecular mechanisms of DNAJB6 in cancerOncotarget.  7:53984-53996. 2016
2016 Roles of N-Myc and STAT interactor in cancer: From initiation to disseminationInternational Journal of Cancer.  139:491-500. 2016
2016 Loss of tumor suppressor Merlin results in aberrant activation of Wnt/β-catenin signaling in cancerOncotarget.  7:17991-18005. 2016
2016 Niclosamide and its analogs are potent inhibitors of Wnt/ß- catenin, mTOR and STAT3 signaling in ovarian cancerOncotarget.  7:86803-86815. 2016
2015 Nuclear Localization of DNAJB6 Is Associated with Survival of Patients with Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer CellsGastroenterology.  149:1825-1836.e5. 2015
2015 The impact of hedgehog signaling pathway on DNA repair mechanisms in human cancerCancers.  7:1333-1348. 2015
2015 N-Myc and STAT Interactor regulates autophagy and chemosensitivity in breast cancer cellsScientific Reports.  5. 2015
2014 MicroRNA-29 negatively regulates EMT regulator N-myc interactor in breast cancerMolecular Cancer.  13. 2014
2014 Multi-targeted therapy of cancer by niclosamide: A new application for an old drugCancer Letters.  349:8-14. 2014
2014 Nonclassical HEDGEHOG-GLI signaling and its clinical implicationsInternational Journal of Cancer.  135:1-6. 2014
2014 Role of osteopontin in the pathophysiology of cancerCollagen and related research.  37:131-141. 2014
2014 Loss of N-Myc interactor promotes epithelial-mesenchymal transition by activation of TGF-β/SMAD signalingOncogene.  33:2620-2628. 2014
2014 Effect of niclosamide on basal-like breast cancersMolecular Cancer Therapeutics.  13:800-811. 2014
2014 Inhibition of Wnt/β-catenin pathway by niclosamide: A therapeutic target for ovarian cancerGynecologic Oncology.  134:112-120. 2014
2014 NMI and EMTOncoscience.  1:476-477. 2014
2013 Nonclassical activation of Hedgehog signaling enhances multidrug resistance and makes cancer cells refractory to smoothened-targeting Hedgehog inhibitionJournal of Biological Chemistry.  288:11824-11833. 2013
2012 Sulindac inhibits tumor cell invasion by suppressing NF-κB-mediated transcription of microRNAsOncogene.  31:4979-4986. 2012
2012 DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3β to downregulate β-catenin transcription target, osteopontinOncogene.  31:4472-4483. 2012
2012 Cytoplasmic translocation of p21 mediates NUPR1-induced chemoresistance: NUPR1 and p21 in chemoresistanceFEBS Letters.  586:3429-3434. 2012
2012 Micro-RNA-632 downregulates DNAJB6 in breast cancerLaboratory Investigation.  92:1310-1317. 2012
2012 Increased vascularity and spontaneous metastasis of breast cancer by hedgehog signaling mediated upregulation of cyr61Oncogene.  31:3370-3380. 2012
2012 DNAJB6 governs a novel regulatory loop determining Wnt/β-catenin signalling activityBiochemical Journal.  444:573-580. 2012
2012 Cellular stress stimulates nuclear localization signal (NLS) independent nuclear transport of MRJExperimental Cell Research.  318:1086-1093. 2012
2012 Dickkopf1: A tumor suppressor or metastasis promoter?International Journal of Cancer.  130:1477-1483. 2012
2012 Hedgehog signaling in tumor cells facilitates osteoblast-enhanced osteolytic metastasesPLoS ONE.  7. 2012
2012 Location, location, location: The BRMS1 protein and melanoma progressionBMC Medicine.  10. 2012
2012 Location, location, location: The BRMS1 protein and melanoma progressionBMC Medicine.  10. 2012
2012 The hedgehog pathway conditions the bone microenvironment for osteolytic metastasis of breast cancer.International Journal of Breast Cancer.  2012:298623. 2012
2012 The influence of the cancer microenvironment on the process of metastasis.International Journal of Breast Cancer.  2012:756257. 2012
2011 Loss of tumor suppressor merlin in advanced breast cancer is due to post-translational regulationJournal of Biological Chemistry.  286:40376-40385. 2011
2011 Hedgehog signaling: Networking to nurture a promalignant tumor microenvironmentCell Growth and Differentiation.  9:1165-1174. 2011
2011 Hedgehog signaling induced by breast cancer cells promotes osteoclastogenesis and osteolysisJournal of Biological Chemistry.  286:9612-9622. 2011
2011 Recent advances in anti-angiogenic therapy of cancerOncotarget.  2:122-134. 2011
2010 Rapid palliative radiotherapy: Comparing IG-IMRT with more conventional approachesJournal of Radiotherapy in Practice.  9:143-148. 2010
2010 DNAJB6 induces degradation of β-catenin and causes partial reversal of mesenchymal phenotypeJournal of Biological Chemistry.  285:24686-24694. 2010
2010 Functional characterization of the progestagen-associated endometrial protein gene in human melanomaJournal of Cellular and Molecular Medicine.  14:1432-1442. 2010
2010 Spheroid-forming subpopulation of breast cancer cells demonstrates vasculogenic mimicry via hsa-miR-299-5p regulated de novo expression of osteopontinJournal of Cellular and Molecular Medicine.  14:1693-1706. 2010
2010 Osteopontin: An effector and an effect of tumor metastasisCurrent Molecular Medicine.  10:71-81. 2010
2010 Comparison of Favorable Early-Stage Hodgkin's Lymphoma Treatments: A Single-Institution ReviewInternational Journal of Radiation Oncology - Biology - Physics.  76:1166-1170. 2010
2010 Elevated osteopontin levels in metastatic melanoma correlate with epigenetic silencing of breast cancer metastasis suppressor 1Oncology.  78:75-86. 2010
2009 Expression and functional analysis of the WAP four disulfide core domain 1 gene in human melanomaClinical and Experimental Metastasis.  26:739-749. 2009
2009 The hedgehog pathway transcription factor GLI1 promotes malignant behavior of cancer cells by up-regulating osteopontinJournal of Biological Chemistry.  284:22888-22897. 2009
2009 Multi-faceted role of HSP40 in cancerClinical and Experimental Metastasis.  26:559-567. 2009
2009 Nmi (N-Myc interactor) inhibits Wnt/β-catenin signaling and retards tumor growthInternational Journal of Cancer.  125:556-564. 2009
2009 Emerging role of nuclear protein 1 (NUPR1) in cancer biologyCancer and Metastasis Reviews.  28:225-232. 2009
2009 The emerging role of IG-IMRT for palliative radiotherapy: A single-institution experienceCurrent Oncology.  16:40-45. 2009
2008 Epigenetic silencing contributes to the loss of BRMS1 expression in breast cancerClinical and Experimental Metastasis.  25:753-763. 2008
2008 High-technology Palliative Radiotherapy using Image-guided Intensity-modulated RadiotherapyClinical Oncology.  20:718-720. 2008
2008 Decision making in oncology: A review of patient decision aids to support patient participationCA: A Cancer Journal for Clinicians.  58:293-304. 2008
2008 NUPR1 interacts with p53, transcriptionally regulates p21 and rescues breast epithelial cells from doxorubicin-induced genotoxic stressCurrent Cancer Drug Targets.  8:421-430. 2008
2008 The gene expression profiles of primary and metastatic melanoma yields a transition point of tumor progression and metastasis.BMC Medical Genomics.  1:13. 2008
2008 Elevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancerBBA - Molecular Basis of Disease.  1782:259-270. 2008
2008 Alterations of BRMS1-ARID4A interaction modify gene expression but still suppress metastasis in human breast cancer cellsJournal of Biological Chemistry.  283:7438-7444. 2008
2008 Large isoform of MRJ (DNAJB6) reduces malignant activity of breast cancerBreast Cancer Research.  10. 2008
2008 BRMS1Targeted Protein Database 1.  22093. 2008
2008 Global comparative gene expression analysis of melanoma patient samples, derived cell lines and corresponding tumor xenograftsCancer Genomics and Proteomics.  5:1-35. 2008
2007 Primary Vaginal Cancer Treated With Concurrent Chemoradiation Using Cis-PlatinumInternational Journal of Radiation Oncology - Biology - Physics.  69:746-750. 2007
2007 Rac1 activity regulates proliferation of aggressive metastatic melanomaExperimental Cell Research.  313:3832-3839. 2007
2007 Breast cancer metastasis suppressor 1 (BRMS1) inhibits osteopontin transcription by abrogating NF-κB activationMolecular Cancer.  6. 2007
2006 Awareness and use of the Rapid Palliative Radiotherapy Program by family physicians in Eastern Ontario: A surveyCurrent Oncology.  13. 2006
2006 Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperoneBiochemical and Biophysical Research Communications.  348:1429-1435. 2006
2006 Suppression of murine mammary carcinoma metastasis by the murine ortholog of breast cancer metastasis suppressor 1 (Brms1)Cancer Letters.  235:260-265. 2006
2006 Osteopontin knockdown suppresses tumorigenicity of human metastatic breast carcinoma, MDA-MB-435Clinical and Experimental Metastasis.  23:123-133. 2006
2005 Radiotherapy basics for family physicians. Potent tool for symptom reliefCanadian Family Physician.  51:1496-1501. 2005
2005 Radiotherapy for the treatment of primary vaginal cancerRadiotherapy and Oncology.  77:133-136. 2005
2005 Radical radiotherapy for cervix cancer: The effect of waiting time on outcomeInternational Journal of Radiation Oncology - Biology - Physics.  61:1071-1077. 2005
2005 Metastasis suppression by breast cancer metastasis suppressor 1 involves reduction of phosphoinositide signaling in MDA-MB-435 breast carcinoma cellsCancer Research.  65:713-717. 2005
2005 Evaluating changes in stage I seminoma management: a single institution review.Canadian Journal of Urology.  12:2738-2744. 2005
2004 Breast cancer metastatic potential: Correlation with increased heterotypic gap junctional intercellular communication between breast cancer cells and osteoblastic cellsInternational Journal of Cancer.  111:693-697. 2004
2004 A small molecule antagonist of the αυβ 3 integrin suppresses MDA-MB-435 skeletal metastasisClinical and Experimental Metastasis.  21:119-128. 2004
2004 Identification of metastasis-associated proteins through protein analysis of metastatic MDA-MB-435 and metastasis-suppressed BRMS1 transfected-MDA-MB-435 cellsClinical and Experimental Metastasis.  21:149-157. 2004
2004 Breast Cancer Metastasis Suppressor 1 (BRMS1) Forms Complexes with Retinoblastoma-binding Protein 1 (RBP1) and the mSin3 Histone Deacetylase Complex and Represses TranscriptionJournal of Biological Chemistry.  279:1562-1569. 2004
2004 Inhibition of prostate cancer metastatic colonization by ∼4.2 Mb of human chromosome 12International Journal of Cancer.  108:15-22. 2004
2002 Geographic delivery models for radiotherapy servicesAustralasian Radiology.  46:290-294. 2002
2002 Comparative sequence analysis in eight inbred strains of the metastasis modifier QTL candidate gene Brms1Mammalian Genome.  13:289-292. 2002
2002 Influence of polyamines on in vitro and in vivo features of aggressive and metastatic behavior by human breast cancer cellsClinical and Experimental Metastasis.  19:95-105. 2002
2002 Identification and characterization of the murine ortholog (brms1) of breast-cancer metastasis suppressor 1 (BRMS1).International Journal of Cancer.  97:15-20. 2002
2002 Suppression of human melanoma metastasis by the metastasis suppressor gene, BRMS1Experimental Cell Research.  273:229-239. 2002
2001 Analysis of mechanisms underlying BRMS1 suppression of metastasisClinical and Experimental Metastasis.  18:683-693. 2001
2001 Radiotherapy education among family physicians and residentsJournal of Cancer Education.  16:134-138. 2001
2001 Metastasis suppression in prostate cancerCancer and Metastasis Reviews.  20:279-286. 2001
2000 Functional evidence for a novel human breast carcinoma metastasis suppressor, BRMS1, encoded at chromosome 11q13Cancer Research.  60:2764-2769. 2000
1998 The development and production of radiotherapy patient education videos using computer-based digital imageryInternational Journal of Radiation Oncology - Biology - Physics.  41:485. 1998

Book

Year Title Altmetric
2017 Mechanisms and functions of spatial protein quality control.  Ed. 86.  2017

Education And Training

  • Doctor of Philosophy Level Degree in Molecular Biology, Indian Institute of Technology/Bombay 1998
  • Full Name

  • Rajeev Samant