Positions

Overview

  • Robert P. Kimberly, MD, a native of New Haven, Conn., received his Doctor of Medicine degree from Harvard Medical School after receiving a baccalaureate degree magna cum laude from Princeton University and a baccalaureate / master's degree from the University of Oxford, Oxford, England. Dr. Kimberly's achievements and honors include election to Phi Beta Kappa from Princeton University, a Rhodes Scholarship at Oxford University, a "First" class degree from Oxford, and election to both the American Society for Clinical Investigation and the Association of American Physicians.

    Dr. Kimberly proceeded to do his internship and residency in Medicine at the Hospital of the University of Pennsylvania. His professional training and experience has included appointments as Clinical Associate at the Arthritis and Rheumatism Branch of the National Institute of Arthritis, Metabolism, and Digestive Diseases; Fellow, Assistant, Associate, and Professor of Medicine at Cornell University Medical Center; Director of the Multipurpose Arthritis and Musculoskeletal Diseases Center at Cornell; and Program Director of the NIAMS Research Training Program in Arthritis and Rheumatic Diseases at Cornell.

    Dr. Kimberly joined the UAB faculty in 1996 as Professor of Medicine and the Howard L. Holley Research Chair of Rheumatology. He began his career at UAB as the Director of the Division of Clinical Immunology and Rheumatology (1996-2007). Presently, Dr. Kimberly is the Director of the Center for Clinical and Translational Science (2012 – present), the Senior Associate Dean for Clinical and Translational Research (2006-present) in the UAB School of Medicine and the Associate Vice President for Medicine and Biomedical Research (2012 – present).

    Dr. Kimberly served on and has chaired the Association of American Medical Colleges (AAMC) Group of Research Advancement and Development (GRAND) Steering Committee, served as president for the Association for Clinical and Translational Science (ACTS) in addition to being director of the UAB FOCIS Center of Excellence in Clinical Immunology.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2018 Genome-wide association studies suggest that APOL1-environment interactions more likely trigger kidney disease in African Americans with nondiabetic nephropathy than strong APOL1–second gene interactions 2018
    2017 Transancestral mapping and genetic load in systemic lupus erythematosus 2017
    2015 Blocking of targeted microRNAs from next-generation sequencing libraries 2015
    2013 Allelic-dependent expression of an activating Fc receptor on B cells enhances humoral immune responses 2013
    2013 Preferential Binding to Elk-1 by SLE-Associated IL10 Risk Allele Upregulates IL10 Expression 2013
    2013 PTPN22 Association in Systemic Lupus Erythematosus (SLE) with Respect to Individual Ancestry and Clinical Sub-Phenotypes 2013
    2013 Genome-Wide DNA Methylation Analysis of Systemic Lupus Erythematosus Reveals Persistent Hypomethylation of Interferon Genes and Compositional Changes to CD4+ T-cell Populations 2013
    2013 Trans-Ancestral Studies Fine Map the SLE-Susceptibility Locus TNFSF4 2013
    2013 Genomic Copy Number Variants: Evidence for Association with Antibody Response to Anthrax Vaccine Adsorbed 2013
    2013 Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis 2013
    2013 Admixture Mapping in Lupus Identifies Multiple Functional Variants within IFIH1 Associated with Apoptosis, Inflammation, and Autoantibody Production 2013
    2013 MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus Erythematosus 2013
    2012 CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation 2012
    2012 Genome-wide association study of African and European Americans implicates multiple shared and ethnic specific loci in sarcoidosis susceptibility 2012
    2012 A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed 2012
    2012 Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase 2012
    2011 IgA and IgG antineutrophil cytoplasmic antibody engagement of Fc receptor genetic variants influences granulomatosis with polyangiitis 2011
    2011 A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap 2011
    2011 Human FasL gene is a target of β-catenin/T-cell factor pathway and complex FasL haplotypes alter promoter functions 2011
    2011 Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility. 2011
    2011 Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus 2011
    2011 Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. 2011
    2010 Genetic factors predisposing to systemic lupus erythematosus and lupus nephritis 2010
    2009 A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus 2009
    2009 Factors associated with arterial vascular events in PROFILE: A multiethnic lupus cohort 2009
    2009 An african ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in african americans 2009
    2009 Retraction: an African ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in African Americans. 2009
    2008 Time to seizure occurrence and damage in PROFILE, a multi-ethnic systemic lupus erythematosus cohort 2008
    2008 Common variants within MECP2 confer risk of systemic lupus erythematosus 2008
    2008 A nonsynonymous functional variant in integrin-α M (encoded by ITGAM) is associated with systemic lupus erythematosus 2008
    2008 Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci 2008
    2007 Biologic therapies in rheumatology: Lessons learned, future directions 2007
    2006 Time to renal disease and end-stage renal disease in PROFILE: A multiethnic lupus cohort 2006
    2006 Regional admixture mapping and structured association testing: Conceptual unification and an extensible general linear model 2006
    2006 Regional admixture mapping and structured association testing: conceptual unification and an extensible general linear model. 2006
    2005 Systemic lupus erythematosus in a multiethnic US Cohort (LUMINA). XXX: Association between C-reactive protein (CRP) gene polymorphisms and vascular events 2005
    2005 Single-nucleotide polymorphisms in the C-reactive protein (CRP) gene promoter that affect transcription factor binding, alter transcriptional activity, and associate with differences in baseline serum CRP level 2005
    2004 An exposed domain in the severe acute respiratory syndrome coronavirus spike protein induces neutralizing antibodies 2004
    2003 Can the weighted criteria improve our ability to capture a larger number of lupus patients into observational and interventional studies? A comparison with the American College of Rheumatology Criteria 2003
    2003 Synergistic induction of tumor cell apoptosis by death receptor antibody and chemotherapy agent through JNK/p38 and mitochondrial death pathway 2003
    2003 The FcγRIIIA-F158 allele is a risk factor for the development of lupus nephritis: A meta-analysis 2003
    2002 Baseline characteristics of a multiethnic lupus cohort: PROFILE 2002
    2002 Conservation of FcεRI gamma chain coding region in normals and in SLE patients 2002
    2002 Erratum: Baseline characteristics of a multiethnic lupus cohort: PROFILE (Lupus (2002) 11 (95)) 2002
    2001 Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity 2001
    2001 The Influence of Genetic Variation in Fcγ RIIIb (NA1/NA2) on Neutrophil Specific Granule Release 2001
    2001 Treatment of lupus with corticosteroids 2001
    1997 Antibodies to C1q in systemic lupus erythematosus: Characteristics and relation to FcγRIIA alleles 1997
    1991 Regulation of phagocytosis and [Ca2+]i flux by distinct regions of an Fc receptor 1991
    1988 Treatment. Corticosteroids and anti-inflammatory drugs 1988
    1987 Immune complexes in the rheumatic diseases. 1987
    1986 Treatment of Refractory Immune Thrombocytopenic Purpura with an Anti-Fcγ-Receptor Antibody 1986
    1986 Methyldopa and Reticuloendothelial Function 1986
    1985 Elevation of platelet associated antibody levels in patients with chronic idiopathic thrombocytopenic purpura expressing the B8 and/or DR3 allotypes 1985
    1983 End-Stage Renal Disease in Systemic Lupus Erythematosus 1983
    1982 Acute pancreatitis in systemic lupus erythematosus: Report of twenty cases and a review of the literature 1982
    1981 End-stage lupus nephritis: Clinical course to and outcome on dialysis: Experience with 39 patients 1981
    1979 Fc-receptor dysfunction in lupus. 1979
    1979 Defective Reticuloendothelial System Fc-Receptor Function in Systemic Lupus Erythematosus 1979
    1979 Treatment of Lupus Nephritis with Combined Therapy 1979
    1979 Stable model immune complexes produced by bivalent affinity labeling haptens: In-vivo survival 1979
    1978 RENAL PROSTAGLANDINS IN SYSTEMIC LUPUS ERYTHEMATOSUS 1978
    1977 Aspirin and Renal Function 1977
    1977 Aspirin-Induced Depression of Renal Function 1977
    1971 Response characteristics of pigeon forebrain cells to visual stimulation 1971
    1970 Rhythmic patterns in human interaction 1970

    Book

    Year Title Altmetric
    2014 Human FcR polymorphism and disease.  Ed. 382.  2014

    Chapter

    Year Title Altmetric
    2012 Abnormalities in Immune Complex Clearance and Fcγ Receptor Function.  127-140. 2012
    2008 Genetics and disease.  108-113. 2008
    2004 Corticosteroid use in systemic lupus erythematosus.  1241-1272. 2004

    Research Overview

  • Dr. Kimberly is a clinical rheumatologist, immunologist and human geneticist; therefore, his research expertise involves the use of molecular immunology and immunogenetics to identify susceptibility and severity factors for human autoimmune disease and to identify new targets for therapeutic approaches. He is currently applying these strategies in several key clinical areas, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and the systemic vasculitides.

    Dr. Kimberly is experienced in establishing collaborative research groups in clinical and translational research. Having been Principal Investigator of the NIH-funded Multidisciplinary Clinical Research Center (MCRC) and Rheumatic Diseases Core Center (RDCC), he was also the Principal Investigator of the NIH-funded, UAB Program Project in the Genetics of Systemic Lupus Erythematosus (SLE), a unique consortium of seven academic centers that seeks to elucidate the underlying genetic basis of SLE with the intent of enhanced understanding of disease pathophysiology, improved patient care, informed drug design, and ultimately, disease prevention. He also created the Lupus End-Stage Renal Disease consortium (ESRD) to define the genetic underpinnings of one of the most important and expensive outcomes in lupus.
  • Principal Investigator On

  • Center for Clinical and Translational Science (3 Linked Awards UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2019 - 2024
  • Private Grant  awarded by REGENERON GENETICS CENTER 2017 - 2020
  • UAB Center for Clinical and Translational Science (CCTS) (3 Linked Awards UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2015 - 2019
  • Institute for Clinical and Translational Science  awarded by University of California, Irvine 2018 - 2019
  • Tufts Clinical and Translational Research Institute  awarded by TUFTS UNIVERSITY - NEW 2016 - 2017
  • Innovation and Economic Development in Clinical and Translational Science  awarded by ALABAMA DEPARTMENT OF COMMERCE 2012 - 2015
  • UAB Center for Clinical and Translational Science (CCTS) (3 linked awards: UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2014 - 2015
  • Private Grant  awarded by ALEXION PHARMACEUTICALS, INC. 2013 - 2014
  • Genomics of Lupus  awarded by Oklahoma Medical Research Foundation (OMRF) 2009 - 2014
  • NIAMS Multidiscipllinary Clinical Research Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2014
  • NIAMS Multidiscipllinary Clinical Research Center - Administrative Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2014
  • UAB Center for Clinical and Translational Science (CCTS) KL2 Component  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2011 - 2014
  • UAB Center for Clinical and Translational Science (CCTS) T32 (TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2011 - 2014
  • UAB Center for Clinical and Translational Science (CCTS) UL1  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2011 - 2014
  • Program Project in the Genetics of SLE  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2014
  • Program Project in the Genetics of SLE - Administrative Unit ( Administrative Core & Specimen Repository)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2014
  • Program Project in the Genetics of SLE - Project 1 (Copy Number Variation in Genetic Susceptibility and Severity of SLE)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2014
  • SLEGEN ImmunoChip Proposal  awarded by LUPUS RESEARCH ALLIANCE 2011 - 2013
  • Program Project in the Genetics of SLE - Project 2 (Genomics of Lupus Associations in the Hispanic 12q24 Linkage)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2013
  • Program Project in the Genetics of SLE - Project 3 (Genetic Susceptibilty to SLE in African Americans Using Admixture)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2013
  • Genes and Phenotypes (GAP) Studies of Immunologic and Inflammatory Pathways  awarded by FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH 2010 - 2012
  • A National Consortium to Explore the Genotypic Basis for ESRD in Lupus  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2009 - 2012
  • Mononuclear Phagocyte Function in Immunologic Diseases  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2006 - 2012
  • Private Grant  awarded by PIKAMAB, INC. 2011 - 2012
  • Private Grant  awarded by PIKAMAB, INC. 2011 - 2012
  • Private Grant  awarded by DAIICHI SANKYO COMPANY LTD 2006 - 2011
  • Private Grant  awarded by DAIICHI SANKYO COMPANY LTD 2006 - 2011
  • Private Grant  awarded by PGXHEALTH 2010 - 2011
  • Training Program in Rheumatic Diseases Research  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2007 - 2011
  • Investigator On

  • INvestigations In Gout, Hyperuricemia, and ComorbidiTies (INSIGHT) Center of Research Translation (CORT)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2017 - 2022
  • INvestigations In Gout, Hyperuricemia, and ComorbidiTies (INSIGHT) Center of Research Translation (CORT) - Administrative Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2017 - 2022
  • Private Grant  awarded by MALLINCKRODT, INC. 2018 - 2021
  • Private Grant  awarded by TEARSOLUTIONS, INC. 2018 - 2020
  • Association of Genetic and Autoantibody Signatures with SLE Clinical Course  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2014 - 2019
  • Southern All of Us Network  awarded by NIH - OFFICE OF THE DIRECTOR 2017 - 2018
  • Individualized Patient Decision Making for Treatment Choices Among Minorities with Lupus  awarded by PATIENT CENTERED OUTCOMES RESEARCH INSTITUTE 2013 - 2018
  • Centers of Research Translation (CoRT)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2017
  • Centers of Research Translation (CoRT) - Administrative Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2017
  • Population Genetics Analysis Program: Immunity to Vaccines/Infections II  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2012 - 2015
  • Biological Mechanisms of ITGAM Variants for Genetic Risk in SLE  awarded by LUPUS RESEARCH ALLIANCE 2009 - 2013
  • Dental Academic Research Training - DART  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2007 - 2012
  • Education And Training

  • Doctor of Medicine, Harvard University 1973
  • Full Name

  • Robert Kimberly