Positions

Overview

  • Robert P. Kimberly, MD, a native of New Haven, Conn., received his Doctor of Medicine degree from Harvard Medical School after receiving a baccalaureate degree magna cum laude from Princeton University and a baccalaureate / master's degree from the University of Oxford, Oxford, England. Dr. Kimberly's achievements and honors include election to Phi Beta Kappa from Princeton University, a Rhodes Scholarship at Oxford University, a "First" class degree from Oxford, and election to both the American Society for Clinical Investigation and the Association of American Physicians.

    Dr. Kimberly proceeded to do his internship and residency in Medicine at the Hospital of the University of Pennsylvania. His professional training and experience has included appointments as Clinical Associate at the Arthritis and Rheumatism Branch of the National Institute of Arthritis, Metabolism, and Digestive Diseases; Fellow, Assistant, Associate, and Professor of Medicine at Cornell University Medical Center; Director of the Multipurpose Arthritis and Musculoskeletal Diseases Center at Cornell; and Program Director of the NIAMS Research Training Program in Arthritis and Rheumatic Diseases at Cornell.

    Dr. Kimberly joined the UAB faculty in 1996 as Professor of Medicine and the Howard L. Holley Research Chair of Rheumatology. He began his career at UAB as the Director of the Division of Clinical Immunology and Rheumatology (1996-2007). Presently, Dr. Kimberly is the Director of the Center for Clinical and Translational Science (2012 – present), the Senior Associate Dean for Clinical and Translational Research (2006-present) in the UAB School of Medicine and the Associate Vice President for Medicine and Biomedical Research (2012 – present).

    Dr. Kimberly served on and has chaired the Association of American Medical Colleges (AAMC) Group of Research Advancement and Development (GRAND) Steering Committee, served as president for the Association for Clinical and Translational Science (ACTS) in addition to being director of the UAB FOCIS Center of Excellence in Clinical Immunology.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Epigenetic Defects in the B cell lineage of Systemic Lupus Erythematosus Patients Display Population-Specific Patterns. 2019
    2019 Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for CD40 and CD39 2019
    2019 Ifnγ induces epigenetic programming of human t-bethi b cells and promotes tlr7/8 and il-21 induced differentiation 2019
    2019 Individualized decision aid for diverse women with lupus nephritis (IDEA-WON): A randomized controlled trial 2019
    2019 Genetic variants at the 16p13 locus confer risk for eosinophilic esophagitis 2019
    2019 Type 1 diabetes risk in African-ancestry participants and utility of an ancestry-specific genetic risk score 2019
    2019 Genetic influences on susceptibility to rheumatoid arthritis in African-Americans 2019
    2018 Genome-wide association studies suggest that APOL1-environment interactions more likely trigger kidney disease in African Americans with nondiabetic nephropathy than strong APOL1–second gene interactions 2018
    2018 Trans-ethnic mapping of BANK1 identifies two independent SLE-Risk linkage groups enriched for co-transcriptional splicing marks 2018
    2018 A plausibly causal functional lupus-associated risk variant in the STAT1-STAT4 locus 2018
    2018 Discovery and validation of circulating biomarkers of colorectal adenoma by high-depth small RNA sequencing 2018
    2018 Genetic fine mapping of systemic lupus erythematosus MHC associations in Europeans and African Americans 2018
    2017 Transancestral mapping and genetic load in systemic lupus erythematosus 2017
    2017 Regulation of FcRγ function by site-specific serine phosphorylation 2017
    2016 Decreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody production 2016
    2016 Prospecting for precision: Promises for personalized medicine 2016
    2016 Identification of a Systemic Lupus Erythematosus Risk Locus Spanning ATG16L2, FCHSD2, and P2RY2 in Koreans 2016
    2016 X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome 2016
    2016 Genome-Wide Association Study in an Amerindian Ancestry Population Reveals Novel Systemic Lupus Erythematosus Risk Loci and the Role of European Admixture 2016
    2016 Estimation of cell-type composition including T and B cell subtypes for whole blood methylation microarray data 2016
    2016 Preferential association of a functional variant in complement receptor 2 with antibodies to double-stranded DNA 2016
    2015 Genetic associations of leptin-related polymorphisms with systemic lupus erythematosus 2015
    2015 Characterization of Genetic Loci That Affect Susceptibility to Inflammatory Bowel Diseases in African Americans 2015
    2015 Clinical associations of anti-Smith antibodies in PROFILE: a multi-ethnic lupus cohort 2015
    2015 Genetic analysis of the pathogenic molecular sub-phenotype interferon-alpha identifies multiple novel loci involved in systemic lupus erythematosus 2015
    2015 Blocking of targeted microRNAs from next-generation sequencing libraries 2015
    2015 Editorial: The road traveled: Genomics and biomarkers in antineutrophil cytoplasmic antibody-associated vasculitis 2015
    2015 Genetic association of CD247 (CD3ζ) with SLE in a large-scale multiethnic study 2015
    2015 Lack of association of the APOL1 G3 haplotype in African Americans with ESRD 2015
    2015 Lupus risk variant increases pSTAT1 binding and decreases ETS1 expression 2015
    2015 The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share 2015
    2014 GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region 2014
    2014 Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription 2014
    2014 MHC associations with clinical and autoantibody manifestations in European SLE. 2014
    2014 Targeting the Fc receptor in autoimmune disease 2014
    2014 Brief report: A polymorphism in TLR2 is associated with arterial thrombosis in a multiethnic population of patients with systemic lupus erythematosus 2014
    2014 End-stage renal disease in African Americans with lupus nephritis is associated with APOL1 2014
    2014 Fcγ receptor IIIa single-nucleotide polymorphisms and haplotypes affect human IgG binding and are associated with lupus nephritis in African Americans 2014
    2014 Human FcR polymorphism and disease 2014
    2014 Lupus nephritis susceptibility loci in women with systemic lupus erythematosus 2014
    2014 Lupus risk variants in the PXK locus alter B-cell receptor internalization 2014
    2013 FcγRIIIa SNPs and haplotypes affect human IgG binding and association with lupus nephritis in African Americans. 2013
    2013 Allelic-dependent expression of an activating Fc receptor on B cells enhances humoral immune responses 2013
    2013 ABIN1 dysfunction as a genetic basis for lupus nephritis 2013
    2013 A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. 2013
    2013 Preferential Binding to Elk-1 by SLE-Associated IL10 Risk Allele Upregulates IL10 Expression 2013
    2013 PTPN22 Association in Systemic Lupus Erythematosus (SLE) with Respect to Individual Ancestry and Clinical Sub-Phenotypes 2013
    2013 Genome-Wide DNA Methylation Analysis of Systemic Lupus Erythematosus Reveals Persistent Hypomethylation of Interferon Genes and Compositional Changes to CD4+ T-cell Populations 2013
    2013 Trans-Ancestral Studies Fine Map the SLE-Susceptibility Locus TNFSF4 2013
    2013 Variable association of reactive intermediate genes with systemic lupus erythematosus in populations with different African ancestry 2013
    2013 Genomic Copy Number Variants: Evidence for Association with Antibody Response to Anthrax Vaccine Adsorbed 2013
    2013 Genome-Wide Association Study and Gene Expression Analysis Identifies CD84 as a Predictor of Response to Etanercept Therapy in Rheumatoid Arthritis 2013
    2013 Fine mapping of Xq28: Both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups 2013
    2013 Admixture Mapping in Lupus Identifies Multiple Functional Variants within IFIH1 Associated with Apoptosis, Inflammation, and Autoantibody Production 2013
    2013 MicroRNA-3148 Modulates Allelic Expression of Toll-Like Receptor 7 Variant Associated with Systemic Lupus Erythematosus 2013
    2013 Single-nucleotide polymorphisms in VKORC1 are risk factors for systemic lupus erythematosus in Asians 2013
    2012 Unraveling multiple MHC gene associations with systemic lupus erythematosus: model choice indicates a role for HLA alleles and non-HLA genes in Europeans. 2012
    2012 Association of two independent functional risk haplotypes in TNIP1 with systemic lupus erythematosus 2012
    2012 CSK regulatory polymorphism is associated with systemic lupus erythematosus and influences B-cell signaling and activation 2012
    2012 Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populations 2012
    2012 The unique cytoplasmic domain of human FcγRIIIA regulates receptor-mediated function 2012
    2012 Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries 2012
    2012 Genome-wide association study of African and European Americans implicates multiple shared and ethnic specific loci in sarcoidosis susceptibility 2012
    2012 Genetic risk factors for thrombosis in systemic lupus erythematosus 2012
    2012 A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed 2012
    2012 A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus 2012
    2012 Evaluation of TRAF6 in a large multiancestral lupus cohort 2012
    2012 Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus 2012
    2012 Association of discoid lupus erythematosus with clinical manifestations and damage accrual in a multiethnic lupus cohort. 2012
    2012 Association of single-nucleotide polymorphisms in CCR6, TAGAP, and TNFAIP3 with rheumatoid arthritis in African Americans 2012
    2012 Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study 2012
    2012 Role of MYH9 and APOL1 in African and non-African populations with lupus nephritis 2012
    2012 IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus 2012
    2012 Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus 2012
    2012 Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase 2012
    2012 Gene-gene interaction of BLK, TNFSF4, TRAF1, TNFAIP3, and REL in systemic lupus erythematosus. 2012
    2012 Serine phosphorylation of FcγRI cytoplasmic domain directs lipid raft localization and interaction with protein 4.1G 2012
    2012 Treatment of arthritis by macrophage depletion and immunomodulation: testing an apoptosis-mediated therapy in a humanized death receptor mouse model. 2012
    2011 IgA and IgG antineutrophil cytoplasmic antibody engagement of Fc receptor genetic variants influences granulomatosis with polyangiitis 2011
    2011 A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap 2011
    2011 FAS mRNA editing in human systemic lupus erythematosus 2011
    2011 Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study 2011
    2011 Human FasL gene is a target of β-catenin/T-cell factor pathway and complex FasL haplotypes alter promoter functions 2011
    2011 Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus 2011
    2011 Association of PPP2CA polymorphisms with systemic lupus erythematosus susceptibility in multiple ethnic groups 2011
    2011 The role of HLA-DR-DQ haplotypes in variable antibody responses to Anthrax Vaccine Adsorbed 2011
    2011 Genetic analyses of interferon pathway-related genes reveal multiple new loci associated with systemic lupus erythematosus 2011
    2011 Evaluation of the TREX1 gene in a large multi-ancestral lupus cohort 2011
    2011 Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21 2011
    2011 Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility. 2011
    2011 Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus 2011
    2011 Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. 2011
    2011 The functional polymorphism 844 A>G in Fc αRI (CD89) does not contribute to systemic sclerosis or rheumatoid arthritis susceptibility 2011
    2011 Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study 2011
    2010 Most common single-nucleotide polymorphisms associated with rheumatoid arthritis in persons of European ancestry confer risk of rheumatoid arthritis in African Americans 2010
    2010 The role of genetic variation near interferon-kappa in systemic lupus erythematosus 2010
    2010 ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash and immunological manifestations in patients with systemic lupus erythematosus with European ancestry 2010
    2010 The non-muscle myosin heavy chain 9 gene (MYH9) is not associated with lupus nephritis in African Americans 2010
    2010 Pathways: Strategies for susceptibility genes in SLE 2010
    2010 Genetic variants of STAT4 associated with rheumatoid arthritis in persons of Asian and European ancestry do not replicate in African Americans 2010
    2010 The TRAF1-C5 region on chromosome 9q33 is associated with multiple autoimmune diseases 2010
    2010 Genetic factors predisposing to systemic lupus erythematosus and lupus nephritis 2010
    2010 Wegener's granulomatosis: A model of auto-antibodies in mucosal autoimmunity 2010
    2010 Erratum: Genetic associations of LYN with systemic lupus erythematosus (Genes and Immunity (2009) 10 (397-403) DOI: 10.1038/gene.2009.19) 2010
    2009 A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus 2009
    2009 The FCRL3 -169CT promoter single-nucleotide polymorphism, which is associated with systemic lupus erythematosus in a Japanese population, predicts expression of receptor protein on CD19+ B cells 2009
    2009 Factors associated with arterial vascular events in PROFILE: A multiethnic lupus cohort 2009
    2009 Erratum: Complement receptor 2 polymorphisms associated with systemic lupus erythematosus modulate alternative splicing (Genes and Immunity (2009) vol. 10 (457-469) 10.1038/gene.2009.27) 2009
    2009 A polymorphism within IL21R confers risk for systemic lupus erythematosus 2009
    2009 Replication of the BANK1 genetic association with systemic lupus erythematosus in a European-derived population 2009
    2009 Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans 2009
    2009 Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus 2009
    2009 Evaluation of imputation-based association in and around the integrin-α-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE) 2009
    2009 An african ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in african americans 2009
    2009 Complement receptor 2 polymorphisms associated with systemic lupus erythematosus modulate alternative splicing 2009
    2009 Genetic associations of LYN with systemic lupus erythematosus 2009
    2009 Retraction: an African ancestry-specific allele of CTLA4 confers protection against rheumatoid arthritis in African Americans. 2009
    2008 Functional expression of IgA receptor FcαRI on human platelets 2008
    2008 Variability in the biological response to anti-CD20 B cell depletion in systemic lupus erythaematosus 2008
    2008 Features associated with, and the impact of, hemolytic anemia in patients with systemic lupus erythematosus: LX, results from a multiethnic cohort 2008
    2008 Klinefelter's syndrome (47,XXY) in male systemic lupus erythematosus patients: Support for the notion of a gene-dose effect from the X chromosome 2008
    2008 Immune opsonins modulate BLyS/BAFF release in a receptor-specific fashion 2008
    2008 Time to seizure occurrence and damage in PROFILE, a multi-ethnic systemic lupus erythematosus cohort 2008
    2008 Genetic variation in the CRP promoter: Association with systemic lupus erythematosus 2008
    2008 Interferon regulatory factor-5 is genetically associated with systemic lupus erythematosus in African Americans 2008
    2008 Common variants within MECP2 confer risk of systemic lupus erythematosus 2008
    2008 A nonsynonymous functional variant in integrin-αM (encoded by ITGAM) is associated with systemic lupus erythematosus 2008
    2008 Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci 2008
    2008 IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1 2008
    2007 Fc receptor genes and the systemic lupus erythematosus diathesis 2007
    2007 Variation in the relative copy number of the TLR7 gene in patients with systemic lupus erythematosus and healthy control subjects 2007
    2007 Curcumin reverses breast tumor exosomes mediated immune suppression of NK cell tumor cytotoxicity 2007
    2007 Tumor exosomes inhibit differentiation of bone marrow dendritic cells 2007
    2007 FcalphaRI (CD89) alleles determine the proinflammatory potential of serum IgA. 2007
    2007 FcαRI (CD89) alleles determine the proinflammatory potential of serum IgA 2007
    2007 Expression profile of FcγRIIb on leukocytes and its dysregulation in systemic lupus erythematosus 2007
    2007 Biologic therapies in rheumatology: Lessons learned, future directions 2007
    2006 Dectin-2 is a pattern recognition receptor for fungi that couples with the Fc receptor γ chain to induce innate immune responses 2006
    2006 Association of a transmembrane polymorphism of Fcγ receptor IIb (FCGR2B) with systemic lupus erythematosus in Taiwanese patients 2006
    2006 Time to renal disease and end-stage renal disease in PROFILE: A multiethnic lupus cohort 2006
    2006 Regional admixture mapping and structured association testing: Conceptual unification and an extensible general linear model 2006
    2006 Inducible resistance of tumor cells to tumor necrosis factor-related apoptosis-inducing ligand receptor 2-mediated apoptosis by generation of a blockade at the death domain function 2006
    2006 Regional admixture mapping and structured association testing: conceptual unification and an extensible general linear model. 2006
    2006 Erratum: A membrane form of TNF-α presented by exosomes delays T cell activation-induced cell death (Journal of Immunology (2006) 176 (7385-7393)) 2006
    2006 A membrane form of TNF-α presented by exosomes delays T cell activation-induced cell death 2006
    2006 Murine mammary carcinoma exosomes promote tumor growth by suppression of NK cell function 2006
    2006 No evidence for an association between the -871 T/C promoter polymorphism in the B-cell-activating factor gene and primary Sjögren's syndrome 2006
    2006 JAB1 determines the response of rheumatoid arthritis synovial fibroblasts to tumor necrosis factor-α 2006
    2005 Expression and occupancy of BAFF-R on B cells in systemic lupus erythematosus 2005
    2005 SLE: Challenges and candidates in human disease 2005
    2005 Genetics of susceptibility and severity in systemic lupus erythematosus 2005
    2005 Correlation of serum B lymphocyte stimulator and β2 microglobulin with autoantibody secretion and systemic involvement in primary Sjögren's syndrome 2005
    2005 Systemic lupus erythematosus in a multiethnic US Cohort (LUMINA). XXX: Association between C-reactive protein (CRP) gene polymorphisms and vascular events 2005
    2005 Single-nucleotide polymorphisms in the C-reactive protein (CRP) gene promoter that affect transcription factor binding, alter transcriptional activity, and associate with differences in baseline serum CRP level 2005
    2005 Cleavage of p53-vimentin complex enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of rheumatoid arthritis synovial fibroblasts 2005
    2004 Genetic risk factors for infection in patients with early rheumatoid arthritis 2004
    2004 Differential gene expression modulated by the cytoplasmic domain of FcγRIa (CD64) α-chain 2004
    2004 The influence of genetic variation in the HLA-DRB1 and LTA-TNF regions on the response to treatment of early rheumatoid arthritis with methotrexate or etanercept 2004
    2004 An exposed domain in the severe acute respiratory syndrome coronavirus spike protein induces neutralizing antibodies 2004
    2004 Associations, populations, and the truth: Recommendations for genetic association studies in Arthritis & Rheumatism 2004
    2004 A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcγRIIb alters receptor expression and associates with autoimmunity. I. Regulatory FCGR2B polymorphisms and their association with systemic lupus erythematosus 2004
    2004 A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcγRIIb alters receptor expression and associates with autoimmunity. II. Differential binding of GATA4 and Yin-Yang1 transcription factors and correlated receptor expression and function 2004
    2004 Control of spontaneous B lymphocyte autoimmunity with adenovirus-encoded soluble TACI 2004
    2003 Fc gamma RIIIb allele-sensitive release of alpha-defensins: anti-neutrophil cytoplasmic antibody-induced release of chemotaxins. 2003
    2003 FcγRIIIb Allele-Sensitive Release of α-Defensins: Anti-Neutrophil Cytoplasmic Antibody-Induced Release of Chemotaxins 2003
    2003 Study of host and virological factors of patients with chronic HCV infection and associated laboratory or clinical autoimmune manifestations 2003
    2003 A Novel Polymorphism in the Fcγ Receptor IIB (CD32B) Transmembrane Region Alters Receptor Signaling 2003
    2003 Study of host and virological factors of patients with chronic HCV infection and associated laboratory or clinical autoimmune manifestations. 2003
    2003 Can the weighted criteria improve our ability to capture a larger number of lupus patients into observational and interventional studies? A comparison with the American College of Rheumatology Criteria 2003
    2003 FcγRs modulate cytotoxicity of anti-Fas antibodies: Implications for agonistic antibody-based therapeutics 2003
    2003 TRAIL-R2 (DR5) mediates apoptosis of synovial fibroblasts in rheumatoid arthritis 2003
    2003 Synergistic induction of tumor cell apoptosis by death receptor antibody and chemotherapy agent through JNK/p38 and mitochondrial death pathway 2003
    2003 The FcγRIIIA-F158 allele is a risk factor for the development of lupus nephritis: A meta-analysis 2003
    2003 The level of BLyS (BAFF) correlates with the titre of autoantibodies in human Sjögren's syndrome 2003
    2003 A novel polymorphic CAAT/enhancer-binding protein β element in the FasL gene promoter alters Fas ligand expression: A candidate background gene in African American systemic lupus erythematosus patients 2003
    2003 BLyS and B cell autoimmunity. 2003
    2002 Fc receptor homologs: Newest members of a remarkably diverse Fc receptor gene family 2002
    2002 Diversity and duplicity: Human Fcγ receptors in host defense and autoimmunity 2002
    2002 Immunobiology of tumor necrosis factor receptor superfamily 2002
    2002 The CY domain of the FcγRIa α-chain (CD64) alters γ-chain tyrosine-based signaling and phagocytosis 2002
    2002 Cytokine gene polymorphism in human disease: On-line databases, supplement 2 2002
    2002 Genetic linkage and association of Fcγ receptor IIIA (CD16A) on chromosome 1q23 with human systemic lupus erythematosus 2002
    2002 Association between baseline levels of C-reactive protein (CRP) and a dinucleotide repeat polymorphism in the intron of the CRP gene 2002
    2002 Baseline characteristics of a multiethnic lupus cohort: PROFILE 2002
    2002 Conservation of FcεRI gamma chain coding region in normals and in SLE patients 2002
    2002 Erratum: Baseline characteristics of a multiethnic lupus cohort: PROFILE (Lupus (2002) 11 (95)) 2002
    2002 Genomic organization of classical human low-affinity Fcγ receptor genes 2002
    2001 Tumoricidal activity of a novel anti-human DR5 monoclonal antibody without hepatocyte cytotoxicity 2001
    2001 The Influence of Genetic Variation in Fcγ RIIIb (NA1/NA2) on Neutrophil Specific Granule Release 2001
    2001 Novel single nucleotide polymorphisms in the distal IL-10 promoter affect IL-10 production and enhance the risk of systemic lupus erythematosus 2001
    2001 Prospects for autoimmune disease: Research advances in systemic lupus erythematosus. 2001
    2001 Research advances in systemic lupus erythematosus 2001
    2001 Cutting edge: A role for B lymphocyte stimulator in systemic lupus erythematosus 2001
    2001 Cytokine gene polymorphism in human disease: On-line databases, Supplement 1 2001
    2001 Interleukin 10 polymorphisms as predictors of sustained response in antiviral therapy for chronic hepatitis C infection 2001
    2001 Treatment of lupus with corticosteroids 2001
    2000 C-reactive protein binding to FcγRIIa on human monocytes and neutrophils is allele-specific 2000
    2000 Genome scan of human systemic lupus erythematosus by regression modeling: Evidence of linkage and epistasis at 4p16-15.2 2000
    1999 Transcriptional regulation of Fas gene expression by GA-binding protein and AP-1 in T cell antigen receptor · CD3 complex-stimulated T cells 1999
    1999 Single-nucleotide polymorphisms of T cell receptor zeta chain in patients with systemic lupus erythematosus. 1999
    1999 Single-nucleotide polymorphisms of T cell receptor ζ chain in patients with systemic lupus erythematosus 1999
    1999 The cytoplasmic domain of human FcγRIa alters the functional properties of the FcγRI·γ-chain receptor complex 1999
    1999 Cytokine gene polymorphism in human disease: On-line databases 1999
    1999 Genetics of human lupus. 1999
    1998 Antineutrophil cytoplasmic antibodies preferentially engage FcγrIIIb on human neutrophils 1998
    1998 Cutting edge: Differential CD5-dependent regulation of CD5-associated CK2 activity in mature and immature T cells: Implication on TCR/CD3-mediated activation 1998
    1998 Differential CD5-dependent regulation of CD5-associated CK2 activity in mature and immature T cells: implication on TCR/CD3-mediated activation. 1998
    1998 Localization of FCGR1 encoding Fcγ receptor class I in primates: Molecular evidence for two pericentric inversions during the evolution of human chromosome 1 1998
    1998 Regulation of casein kinase 2 by direct interaction with cell surface receptor CD5 1998
    1998 Differential regulation of human neutrophil FcγRIIa (CD32) and FcγRIIIb (CD16)-induced Ca2+ transients 1998
    1998 CD5 regulates Casein Kinase 2 (CK2) by direct interaction with the holoenzyme 1998
    1998 Analysis of FcγRII gene polymorphisms in Wegener's granulomatosis 1998
    1997 Cell Type-Specific Glycoforms of FcγRIIIa (CD16): Differential Ligand Binding 1997
    1997 Cross-Linking of Fcγ Receptor IIa and Fcγ Receptor IIIb Induces Different Proadhesive Phenotypes on Human Neutrophils 1997
    1997 A novel polymorphism of FcγRIIIa (CD16) alters receptor function and predisposes to autoimmune disease 1997
    1997 Antibodies to C1q in systemic lupus erythematosus: Characteristics and relation to FcγRIIA alleles 1997
    1996 Fc gamma RIIA alleles are heritable risk factors for lupus nephritis in African Americans. 1996
    1996 FcγRIIA alleles are heritable risk factors for lupus nephritis in African Americans 1996
    1995 Differential Regulation of Fcgamma Receptor Isoforms: Implications for Therapeutic Intervention. 1995
    1995 Fc gamma receptor IIIb enhances Fc gamma receptor IIa function in an oxidant-dependent and allele-sensitive manner. 1995
    1995 B cell differentiation factor-induced human B cell maturation: Stimulation of intracellular calcium release 1995
    1995 Fcγ receptor IIIb enhances Fcγ receptor IIa function in an oxidant-dependent and allele-sensitive manner 1995
    1995 Receptors for immunoglobulin g molecular diversity and implications for disease 1995
    1995 The Ca 2+ dependence of human Fcγ receptor-initiated phagocytosis 1995
    1994 Anti-neutrophil cytoplasmic antibodies engage and activate human neutrophils via FcγRIIa 1994
    1994 Ciprofloxacin reactions mimicking lupus flares 1994
    1994 Glucocorticoids 1994
    1994 Modulation of Fcγ and complement receptor function by the glycosyl- phosphatidylinositol-anchored form of FcγRIII 1994
    1994 The high affinity Fcγ receptor [CD64) induces phagocytosis in the absence of its cytoplasmic domain: The γ subunit of FcγRIIIA imparts phagocytic function to FcγRI 1994
    1993 Human mononuclear phagocytes express adenosine A1 receptors: A novel mechanism for differential regulation of Fcγ receptor function 1993
    1992 Functional capacity of Fcγ receptor III (CD16) on human neutrophils 1992
    1992 Allelic polymorphisms of human Fcγ receptor IIA and Fcγ receptor IIIB: Independent mechanisms for differences in human phagocyte function 1992
    1992 Functional characterization of non‐human primate erythrocyte immune adherence receptors: implications for the uptake of immune complexes by the cells of the mononuclear phagocytic system 1992
    1992 Glucocorticoid therapy for rheumatic diseases 1992
    1992 Novel Fcγ receptor I family gene products in human mononuclear cells 1992
    1992 Patients with systemic lupus erythematosus at risk for Pneumocystis carinii pneumonia 1992
    1992 Receptor specific probes for the study of Fcγ receptor specific function 1992
    1991 Fc gamma receptor III induces actin polymerization in human neutrophils and primes phagocytosis mediated by Fc gamma receptor II. 1991
    1991 A single amino acid distinguishes the high‐responder from the low‐responder form of Fc receptor II on human monocytes 1991
    1991 Fcγ receptor III induces actin polymerization in human neutrophils and primes phagocytosis mediated by Fcγ receptor II 1991
    1991 Intravenous Anti-D treatment of immune thrombocytopenic purpura: Analysis of efficacy, toxicity, and mechanism of effect 1991
    1991 Mechanisms of action, dosage schedules, and side effects of steroid therapy 1991
    1991 Of mice and men: Insights into the complexity of mononuclear phagocyte system blockade provided by autoimmune mouse strains 1991
    1991 Of mice and men: Insights into the complexity of mononuclear phagocyte system blockade provided by autoimmune mouse strains 1991
    1991 Preferential expression of human FcγRIII(PMN) (CD16) in paroxysmal nocturnal hemoglobinuria. Discordant expression of glycosyl phosphatidylinositol-linked proteins 1991
    1991 Regulation of phagocytosis and [Ca2+]i flux by distinct regions of an Fc receptor 1991
    1990 Fc gamma RIII expressed on cultured monocytes is a N-glycosylated transmembrane protein distinct from Fc gamma RIII expressed on natural killer cells. 1990
    1990 Fc gamma receptor III on human neutrophils. Allelic variants have functionally distinct capacities. 1990
    1990 The glycosyl phosphatidylinositol-linked fcγRIIIPMN mediates transmembrane signaling events distinct from FCγRII 1990
    1990 Fcγ receptor III on human neutrophils: Allelic variants have functionally distinct capacities 1990
    1990 FcγRIII expressed on cultured monocytes is an N-glycosylated transmembrane protein distinct from FcγRIII expressed on natural killer cells 1990
    1990 Steroids 1990
    1989 The role of Fcγ receptors in mononuclear phagocyte system function 1989
    1989 Carbohydrates on human Fcγ receptors. Interdependence of the classical IgG and nonclassical lectin-binding sites on human FcγRIII expressed on neutrophils 1989
    1989 Glucocorticoids 1989
    1989 High‐Dose, pulse intravenous methylprednisolone enhances fcγ receptor–mediated mononuclear phagocyte function in systemic lupus erythematosus 1989
    1989 Human FcγRIII (CD16). Isoforms with distinct allelic expression, extracellular domains, and membrane linkages on polymorphonuclear and natural killer cells 1989
    1989 In vivo handling of soluble complement fixing Ab/dsDNA immune complexes in chimpanzees 1989
    1988 Treatment. Corticosteroids and anti-inflammatory drugs 1988
    1987 Immune complexes in the rheumatic diseases. 1987
    1987 Differences among immune complexes: Association of Clq in SLE immune complexes with renal disease 1987
    1987 Gammaglobulin for intravenous use induces an Fc γ receptor-specific decrement in phagocytosis by blood monocytes 1987
    1987 Mononuclear phagocyte system complement receptor dysfunction in rheumatoid arthritis 1987
    1986 Blockade of clearance of immune complexes by an anti-fcγ receptor monoclonal antibody 1986
    1986 Treatment of Refractory Immune Thrombocytopenic Purpura with an Anti-Fcγ-Receptor Antibody 1986
    1986 Methyldopa and Reticuloendothelial Function 1986
    1986 Altered phagocytosis by monocytes from HLA-DR2 and DR3-positive healthy adults is Fc γ receptor specific 1986
    1986 Mononuclear phagocyte function in SLE. I. Bipartite Fc- and complement-dependent dysfunction 1986
    1986 Mononuclear phagocyte system in SLE. II. A kinetic model of immune complex handling in systemic lupus erythematosus 1986
    1986 Phagocytosis of concanavalin A-treated erythrocytes is mediated by the FCγ receptor 1986
    1985 Elevation of platelet associated antibody levels in patients with chronic idiopathic thrombocytopenic purpura expressing the B8 and/or DR3 allotypes 1985
    1984 Defective mononuclear phagocyte function in systemic lupus erythematosus: Dissociation of Fc receptor-ligand binding and internalization 1984
    1984 Modulation of mononuclear phagocyte function by intravenous γ-globulin 1984
    1984 Hemophilia, antineoplastic factor, and immune complexes 1984
    1984 Modulation of mononuclear phagocyte system function and circulating immune complexes by lyophilized concentrates in patients with classic hemophilia 1984
    1983 Intravenous gammaglobulin treatment of chronic idiopathic thrombocytopenic purpura 1983
    1983 End-Stage Renal Disease in Systemic Lupus Erythematosus 1983
    1983 Impaired Fc-mediated mononuclear phagocyte system clearance in HLA-DR2 and MT1-positive healthy young adults 1983
    1983 Dynamics of mononuclear phagocyte system Fc receptor function in systemic lupus erythematosus. Relation to disease activity and circulating immune complexes 1983
    1983 Endocytosis by the mononuclear phagocyte system and autoimmune disease 1983
    1983 Reversible "end-stage" lupus nephritis. Analysis of patients able to discontinue dialysis 1983
    1983 Reversible 'end-stage' lupus nephritis. Analysis of patients able to discontinue dialysis 1983
    1983 Serial circulating immune complexes and mononuclear phagocyte system function in infective endocarditis 1983
    1982 Pulse methylprednisolone in SLE. 1982
    1982 A serial study of splenic reticuloendothelial system fc receptor functional activity in systemic lupus erythematosus 1982
    1982 Acute pancreatitis in systemic lupus erythematosus: Report of twenty cases and a review of the literature 1982
    1982 Comparative effects of aspirin and ibuprofen in the management of systemic Lupus erythematosus 1982
    1982 Defective Fc receptor-mediated function of the mononuclear phagocyte system in lupus nephritis 1982
    1981 Acute Effects of Aspirin and Acetaminophen on Renal Function 1981
    1981 Acute effects of aspirin and acetaminophen on renal function. 1981
    1981 Acute corticosteroid-induced depression of renal function in systemic lupus erythematosus (SLE): Association with decreased renal prostaglandin synthesis 1981
    1981 End-stage lupus nephritis: Clinical course to and outcome on dialysis: Experience with 39 patients 1981
    1981 High-dose intravenous methylprednisolone pulse therapy in systemic lupus erythematosus 1981
    1980 Comparative effects of aspirin and ibuprofen in the management of systemic lupus erythematosus 1980
    1980 Dynamics of renal function in lupus nephritis: predictive value and implications of drug-induced transient changes 1980
    1980 Great reduction in renal function associated with cimetidine 1980
    1979 Renal changes in systemic lupus erythematosus. 1979
    1979 Fc-receptor dysfunction in lupus. 1979
    1979 Defective Reticuloendothelial System Fc-Receptor Function in Systemic Lupus Erythematosus 1979
    1979 Treatment of Lupus Nephritis with Combined Therapy 1979
    1979 Acute corticosteroid-induced depression of renal function in systemic lupus erythematosus 1979
    1979 Apparent acute renal failure associated with therapeutic aspirin and ibuprofen administration 1979
    1979 Clinical efficacy of high dose intravenous methylprednisolone pulse therapy in systemic lupus erythematosus 1979
    1979 Presumptive autonephrectomy in scleroderma 1979
    1979 Renal Changes in Systemic Lupus Erythematosus 1979
    1979 Stable model immune complexes produced by bivalent affinity labeling haptens: In-vivo survival 1979
    1978 RENAL PROSTAGLANDINS IN SYSTEMIC LUPUS ERYTHEMATOSUS 1978
    1978 Elevated urinary prostaglandins and the effect of aspirin on renal function in lupus erythematosus 1978
    1978 Exacerbation of Phenylbutazone-Related Renal Failure by Indomethacin 1978
    1978 Increased risk of lymphoma in sicca syndrome 1978
    1978 Reduction of renal function by newer nonsteroidal anti-inflammatory drugs 1978
    1977 Aspirin and Renal Function 1977
    1977 Aspirin-Induced Depression of Renal Function 1977
    1976 Effect of salicylates on creatinine clearance 1976
    1971 Response characteristics of pigeon forebrain cells to visual stimulation 1971
    1970 Rhythmic patterns in human interaction 1970

    Book

    Year Title Altmetric
    2014 Human FcR polymorphism and disease.  Ed. 382.  2014

    Chapter

    Year Title Altmetric
    2012 Abnormalities in Immune Complex Clearance and Fcγ Receptor Function.  127-140. 2012
    2008 Genetics and disease.  108-113. 2008
    2004 Corticosteroid use in systemic lupus erythematosus.  1241-1272. 2004

    Research Overview

  • Dr. Kimberly is a clinical rheumatologist, immunologist and human geneticist; therefore, his research expertise involves the use of molecular immunology and immunogenetics to identify susceptibility and severity factors for human autoimmune disease and to identify new targets for therapeutic approaches. He is currently applying these strategies in several key clinical areas, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and the systemic vasculitides.

    Dr. Kimberly is experienced in establishing collaborative research groups in clinical and translational research. Having been Principal Investigator of the NIH-funded Multidisciplinary Clinical Research Center (MCRC) and Rheumatic Diseases Core Center (RDCC), he was also the Principal Investigator of the NIH-funded, UAB Program Project in the Genetics of Systemic Lupus Erythematosus (SLE), a unique consortium of seven academic centers that seeks to elucidate the underlying genetic basis of SLE with the intent of enhanced understanding of disease pathophysiology, improved patient care, informed drug design, and ultimately, disease prevention. He also created the Lupus End-Stage Renal Disease consortium (ESRD) to define the genetic underpinnings of one of the most important and expensive outcomes in lupus.
  • Principal Investigator On

  • Center for Clinical and Translational Science (3 Linked Awards UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2019 - 2024
  • Private Grant  awarded by REGENERON GENETICS CENTER 2017 - 2020
  • UAB Center for Clinical and Translational Science (CCTS) (3 Linked Awards UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2015 - 2019
  • Institute for Clinical and Translational Science  awarded by University of California, Irvine 2018 - 2019
  • Tufts Clinical and Translational Research Institute  awarded by TUFTS UNIVERSITY - NEW 2016 - 2017
  • Innovation and Economic Development in Clinical and Translational Science  awarded by ALABAMA DEPARTMENT OF COMMERCE 2012 - 2015
  • UAB Center for Clinical and Translational Science (CCTS) (3 linked awards: UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2014 - 2015
  • Private Grant  awarded by ALEXION PHARMACEUTICALS, INC. 2013 - 2014
  • Genomics of Lupus  awarded by Oklahoma Medical Research Foundation (OMRF) 2009 - 2014
  • NIAMS Multidiscipllinary Clinical Research Center  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2014
  • NIAMS Multidiscipllinary Clinical Research Center - Administrative Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2014
  • UAB Center for Clinical and Translational Science (CCTS) KL2 Component  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2011 - 2014
  • UAB Center for Clinical and Translational Science (CCTS) T32 (TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2011 - 2014
  • UAB Center for Clinical and Translational Science (CCTS) UL1  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2011 - 2014
  • Program Project in the Genetics of SLE  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2014
  • Program Project in the Genetics of SLE - Administrative Unit ( Administrative Core & Specimen Repository)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2014
  • Program Project in the Genetics of SLE - Project 1 (Copy Number Variation in Genetic Susceptibility and Severity of SLE)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2014
  • SLEGEN ImmunoChip Proposal  awarded by LUPUS RESEARCH ALLIANCE 2011 - 2013
  • Program Project in the Genetics of SLE - Project 2 (Genomics of Lupus Associations in the Hispanic 12q24 Linkage)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2013
  • Program Project in the Genetics of SLE - Project 3 (Genetic Susceptibilty to SLE in African Americans Using Admixture)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2008 - 2013
  • Genes and Phenotypes (GAP) Studies of Immunologic and Inflammatory Pathways  awarded by FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH 2010 - 2012
  • A National Consortium to Explore the Genotypic Basis for ESRD in Lupus  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2009 - 2012
  • Mononuclear Phagocyte Function in Immunologic Diseases  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2006 - 2012
  • Private Grant  awarded by PIKAMAB, INC. 2011 - 2012
  • Private Grant  awarded by PIKAMAB, INC. 2011 - 2012
  • Private Grant  awarded by DAIICHI SANKYO COMPANY LTD 2006 - 2011
  • Private Grant  awarded by DAIICHI SANKYO COMPANY LTD 2006 - 2011
  • Private Grant  awarded by PGXHEALTH 2010 - 2011
  • Training Program in Rheumatic Diseases Research  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2007 - 2011
  • Investigator On

  • INvestigations In Gout, Hyperuricemia, and ComorbidiTies (INSIGHT) Center of Research Translation (CORT)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2017 - 2022
  • INvestigations In Gout, Hyperuricemia, and ComorbidiTies (INSIGHT) Center of Research Translation (CORT) - Administrative Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2017 - 2022
  • Private Grant  awarded by MALLINCKRODT, INC. 2018 - 2021
  • Private Grant  awarded by TEARSOLUTIONS, INC. 2018 - 2020
  • Association of Genetic and Autoantibody Signatures with SLE Clinical Course  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2014 - 2019
  • Southern All of Us Network  awarded by NIH - OFFICE OF THE DIRECTOR 2017 - 2018
  • Individualized Patient Decision Making for Treatment Choices Among Minorities with Lupus  awarded by PATIENT CENTERED OUTCOMES RESEARCH INSTITUTE 2013 - 2018
  • Centers of Research Translation (CoRT)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2017
  • Centers of Research Translation (CoRT) - Administrative Core  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2012 - 2017
  • Population Genetics Analysis Program: Immunity to Vaccines/Infections II  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2012 - 2015
  • Biological Mechanisms of ITGAM Variants for Genetic Risk in SLE  awarded by LUPUS RESEARCH ALLIANCE 2009 - 2013
  • Dental Academic Research Training - DART  awarded by National Institute of Dental and Craniofacial Research/NIH/DHHS 2007 - 2012
  • Education And Training

  • University of Pennsylvania Hospital, Internship 1974
  • University of Pennsylvania Hospital, Residency 1975
  • Cornell University Medical Center, Postdoctoral Fellowship 1979
  • Warren G. Magnuson Clinical Center, Postdoctoral Fellowship 1977
  • Full Name

  • Robert Kimberly