Positions

Overview

  • The Banerjee laboratory is studying how hormones regulate metabolism, with a particular focus on glucose homeostasis. We use the pancreatic beta-cell as our model system. These amazing cells sense and integrate inputs from numerous hormones and metabolites to regulate secretion of hormones, including insulin, that in turn regulate metabolism in many tissues. Beta-cell failure to produce sufficient insulin underlies the development of diabetes mellitus.

    Our work has demonstrated a critical role for prolactin receptor (PRLR) and lactogen signaling in the beta-cell adaptations required to maintain euglycemia during pregnancy. Defective PRLR signaling in mice results in gestational diabetes mellitus (GDM). We are currently investigating targets of PRLR signaling responsible for maternal adaptation of beta-cells during pregnancy, and how these pathways may be deranged in GDM. Additionally, we are interested in molecular mechanisms underlying gestational beta-cell expansion and regression to pre-pregnancy levels following parturition. We are also exploring roles for PRLR regulation of maternal adaptation in other tissues during gestation.
  • Research Overview

  • pancreatic beta-cell biology
    prolactin receptor signaling
    gestational diabetes
    type 2 diabetes mellitus
    transcriptional regulation
  • Education And Training

  • Stanford Hospital & Clinics Medicine, Internship
  • Stanford Hospitals & Clinics Medicine, Residency
  • Stanford University, Internship 2006
  • Stanford University, Residency 2007
  • Stanford University, Postdoctoral Fellowship 2010
  • Full Name

  • Ronadip Banerjee