• The Banerjee laboratory is studying how hormones regulate metabolism, with a particular focus on glucose homeostasis. We use the pancreatic beta-cell as our model system. These amazing cells sense and integrate inputs from numerous hormones and metabolites to regulate secretion of hormones, including insulin, that in turn regulate metabolism in many tissues. Beta-cell failure to produce sufficient insulin underlies the development of diabetes mellitus.

    Our work has demonstrated a critical role for prolactin receptor (PRLR) and lactogen signaling in the beta-cell adaptations required to maintain euglycemia during pregnancy. Defective PRLR signaling in mice results in gestational diabetes mellitus (GDM). We are currently investigating targets of PRLR signaling responsible for maternal adaptation of beta-cells during pregnancy, and how these pathways may be deranged in GDM. Additionally, we are interested in molecular mechanisms underlying gestational beta-cell expansion and regression to pre-pregnancy levels following parturition. We are also exploring roles for PRLR regulation of maternal adaptation in other tissues during gestation.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 Lactation improves pancreatic β cell mass and function through serotonin productionScience Translational Medicine.  12. 2020
    2020 Serotonin regulates adult β-cell mass by stimulating perinatal β-cell proliferationDiabetes.  69:205-214. 2020
    2019 Prolactin receptor signaling regulates a pregnancy-specific transcriptional program in mouse isletsEndocrinology.  160:1150-1163. 2019
    2018 Differential tissue response to growth hormone in miceFEBS Open Bio.  8:1146-1154. 2018
    2018 Piecing together the puzzle of pancreatic islet adaptation in pregnancyAnnals of the New York Academy of Sciences.  1411:120-139. 2018
    2017 ASF1B chaperones histone 3.3 to the β-cell cycle danceCell Cycle.  16:161-162. 2017
    2016 Gestational diabetes mellitus from inactivation of prolactin receptor and MafB in islet β-cellsDiabetes.  65:2331-2341. 2016
    2015 Mifepristone treatment of cushing's syndrome in a pediatric patientPediatrics.  136:e1377-e1381. 2015
    2005 Mouse and human resistins impair glucose transport in primary mouse cardiomyocytes, and oligomerization is required for this biological actionJournal of Biological Chemistry.  280:31679-31685. 2005
    2004 Regulation of resistin expression and circulating levels in obesity, diabetes, and fastingDiabetes.  53:1671-1679. 2004
    2004 Regulation of Fasted Blood Glucose by ResistinScience.  303:1195-1198. 2004
    2003 Resistin: Molecular history and prognosis 2003
    2001 Resistin: A newly discovered hormone from adipose tissue accounts for insulin resistance and metabolic disorders in obesityDiabetes und Stoffwechsel.  10:87-89. 2001
    2001 Dimerization of Resistin and Resistin-like Molecules is Determined by a Single CysteineJournal of Biological Chemistry.  276:25970-25973. 2001
    2001 The hormone resistin links obesity to diabetesNature.  409:307-312. 2001
    2001 A family of tissue-specific resistin-like molecules 2001
    1998 Studies of the interaction between Rad52 protein and the yeast single-stranded DNA binding protein RPA.Molecular and Cellular Biology.  18:4400-4406. 1998
    Prolactin Receptor Signaling Regulates a Pregnancy-Specific Transcriptional Program in Mouse Islets

    Research Overview

  • pancreatic beta-cell biology
    prolactin receptor signaling
    gestational diabetes
    type 2 diabetes mellitus
    transcriptional regulation
  • Education And Training

  • Stanford Hospital & Clinics Medicine, Internship
  • Stanford Hospitals & Clinics Medicine, Residency
  • Doctor of Medicine, University of Pennsylvania 2005
  • Doctor of Philosophy in Molecular Biology, University of Pennsylvania 2003
  • Stanford University, Internship 2006
  • Stanford University, Residency 2007
  • Stanford University, Postdoctoral Fellowship 2010
  • Full Name

  • Ronadip Banerjee