• Richard Myers, Ph.D., received his B.S. in biochemistry from the University of Alabama in 1977, his Ph.D. in biochemistry from the University of California at Berkeley and performed post-doctoral work at Harvard University. He began his first faculty position at the University of California at San Francisco in 1986 and moved his laboratory to Stanford University’s Department of Genetics in 1993. At Stanford, he was chair of the Department of Genetics and director of the Stanford Human Genome Center, which contributed more than 10 percent of the data in the public Human Genome Project’s efforts to sequence the human genome. Dr. Myers moved to HudsonAlpha in July 2008.

    Myers’s research program is focused on human genetics and genomics. Work in his laboratory has led to the identification of genes involved in several inherited diseases, and his genome center contributed more than 10 percent of the data in the public Human Genome Project’s efforts to sequence the human genome. His lab continues to use genomics tools and genetics to understand how genes interacting with the environment contribute to human diseases and other traits.

    Myers has won several awards, including the Pritzker Award and an honorary doctorate of human letters from the University of Alabama. He is an editor of Genome Research and reviews manuscripts for a variety of other journals.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Electrophysiological evaluation of extracellular spermine and alkaline pH on synaptic human GABAA receptors 2019
    2019 Determining the Origins of Human Immunodeficiency Virus Type 1 Drug-resistant Minority Variants in People Who Are Recently Infected Using Phylogenetic Reconstruction 2019
    2019 CRISPR/Cas9-targeted removal of unwanted sequences from small-RNA sequencing libraries 2019
    2019 Transmembrane Protein Aptamer Induces Cooperative Signaling by the EPO Receptor and the Cytokine Receptor β-Common Subunit 2019
    2019 Splice-Break: exploiting an RNA-seq splice junction algorithm to discover mitochondrial DNA deletion breakpoints and analyses of psychiatric disorders 2019
    2019 Tumour-specific amplitude-modulated radiofrequency electromagnetic fields induce differentiation of hepatocellular carcinoma via targeting Cav3.2 T-type voltage-gated calcium channels and Ca2+ influx 2019
    2019 A new approach for rare variation collapsing on functional protein domains implicates specific genic regions in ALS 2019
    2019 Genetic origin of a large family with a novel PSEN1 mutation (Ile416Thr) 2019
    2019 Genome-wide association study identifies 30 loci associated with bipolar disorder 2019
    2019 HDAC2 Regulates Site-Specific Acetylation of MDM2 and Its Ubiquitination Signaling in Tumor Suppression 2019
    2019 Genetic variation at the glycosaminoglycan metabolism pathway contributes to the risk of psoriatic arthritis but not psoriasis 2019
    2019 Genetic variation at the glycosaminoglycan metabolism pathway contributes to the risk of psoriatic arthritis but not psoriasis 2019
    2019 Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia 2019
    2018 Aberrant Inclusion of a Poison Exon Causes Dravet Syndrome and Related SCN1A-Associated Genetic Epilepsies 2018
    2018 Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder 2018
    2018 Extremely rare variants reveal patterns of germline mutation rate heterogeneity in humans 2018
    2018 Genomic sequencing identifies secondary findings in a cohort of parent study participants 2018
    2018 Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function 2018
    2018 Stage-specific epigenetic regulation of CD4 expression by coordinated enhancer elements during T cell development 2018
    2018 De novo mutations in the GTP/GDP-binding region of RALA, a RAS-like small GTPase, cause intellectual disability and developmental delay 2018
    2018 powerTCR: A model-based approach to comparative analysis of the clone size distribution of the T cell receptor repertoire 2018
    2018 Connective Tissue Growth Factor Is a Novel Prodepressant 2018
    2018 Erratum to: DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions (Nature, (2015), 528, 7583, (517-522), 10.1038/nature16193) 2018
    2018 SnapperDB: a database solution for routine sequencing analysis of bacterial isolates 2018
    2018 Control of artifactual variation in reported intersample relatedness during clinical use of a mycobacterium tuberculosis sequencing pipeline 2018
    2018 Inference of cell type content from human brain transcriptomic datasets illuminates the effects of age, manner of death, dissection, and psychiatric diagnosis 2018
    2018 Systematic reanalysis of genomic data improves quality of variant interpretation 2018
    2018 A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed framework 2018
    2018 Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes 2018
    2018 Discovery and validation of circulating biomarkers of colorectal adenoma by high-depth small RNA sequencing 2018
    2018 Sustained transmission of high-level azithromycin-resistant Neisseria gonorrhoeae in England: an observational study 2018
    2018 A toolbox of immunoprecipitation-grade monoclonal antibodies to human transcription factors 2018
    2018 Genome-wide Analyses Identify KIF5A as a Novel ALS Gene 2018
    2018 Quantitative validation of immunofluorescence and lectin staining using reduced CLARITY acrylamide formulations 2018
    2018 Evidence for a pan-neurodegenerative disease response in Huntington’s and Parkinson’s disease expression profiles 2018
    2018 Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease 2018
    2018 MicroRNAs in CSF as prodromal biomarkers for Huntington disease in the PREDICT-HD study 2018
    2017 The pathogenic exon 1 HTT protein is produced by incomplete splicing in Huntington's disease patients 2017
    2017 Stress amplifies sex differences in primate prefrontal profiles of gene expression 2017
    2017 A genome-wide interactome of DNA-associated proteins in the human liver 2017
    2017 Genetic Overlap Between Attention-Deficit/Hyperactivity Disorder and Bipolar Disorder: Evidence From Genome-wide Association Study Meta-analysis 2017
    2017 Haplotype-based stratification of Huntington's disease 2017
    2017 A modifier of Huntington's disease onset at the MLH1 locus 2017
    2017 CCCTC-Binding Factor Translates Interleukin 2- and α-Ketoglutarate-Sensitive Metabolic Changes in T Cells into Context-Dependent Gene Programs 2017
    2017 Molecular surveillance of measles and rubella in the WHO European Region: new challenges in the elimination phase 2017
    2017 Post-mortem molecular profiling of three psychiatric disorders 2017
    2017 Epigenome-wide association study of rheumatoid arthritis identifies differentially methylated loci in B cells 2017
    2017 Genome-wide association study of borderline personality disorder reveals genetic overlap with bipolar disorder, major depression and schizophrenia 2017
    2017 Genome-wide pathway analysis identifies VEGF pathway association with oral ulceration in systemic lupus erythematosus 2017
    2017 ARNApipe: A balanced, efficient and distributed pipeline for processing RNA-seq data in high-performance computing environments 2017
    2017 Genomic diagnosis for children with intellectual disability and/or developmental delay 2017
    2017 Genome-wide DNA methylation measurements in prostate tissues uncovers novel prostate cancer diagnostic biomarkers and transcription factor binding patterns 2017
    2017 Eliciting preferences on secondary findings: The Preferences Instrument for Genomic Secondary Results 2017
    2017 Evaluation of logistic regression models and effect of covariates for case-control study in RNA-Seq analysis 2017
    2017 Mutations in EBF3 Disturb Transcriptional Profiles and Cause Intellectual Disability, Ataxia, and Facial Dysmorphism 2017
    2017 Enhanced surveillance of HIV-1 drug resistance in recently infected MSM in the UK 2017
    2017 Genomic regulation of invasion by STAT3 in triple negative breast cancer 2017
    2017 RNA sequencing-based cell proliferation analysis across 19 cancers identifies a subset of proliferation-informative cancers with a common survival signature 2017
    2016 Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SLC1A3 and EPHB2 2016
    2016 DNM3 and genetic modifiers of age of onset in LRRK2 Gly2019Ser parkinsonism: a genome-wide linkage and association study 2016
    2016 The microRNA network is altered in anterior cingulate cortex of patients with unipolar and bipolar depression 2016
    2016 Novel microRNA discovery using small RNA sequencing in post-mortem human brain 2016
    2016 A reference panel of 64,976 haplotypes for genotype imputation 2016
    2016 Comparison of next-generation sequencing technologies for comprehensive assessment of full-length hepatitis C viral genomes 2016
    2016 RNA sequencing of pancreatic adenocarcinoma tumors yields novel expression patterns associated with long-term survival and reveals a role for ANGPTL4 2016
    2016 De Novo Mutations in SON Disrupt RNA Splicing of Genes Essential for Brain Development and Metabolism, Causing an Intellectual-Disability Syndrome 2016
    2016 Decoding transcriptional enhancers: Evolving from annotation to functional interpretation 2016
    2016 Kinase gene expression profiling of metastatic clear cell renal cell carcinoma tissue identifies potential new therapeutic targets 2016
    2016 The 4p16.3 Parkinson disease risk locus is associated with GAK expression and genes involved with the synaptic vesicle membrane 2016
    2016 Distinct gene regulatory programs define the inhibitory effects of liver X receptors and PPARG on cancer cell proliferation 2016
    2016 Erratum: Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine (American Journal of Human Genetics (2016) 98(6) (1067–1076) (S0002929716301069) (10.1016/j.ajhg.2016.04.011)) 2016
    2016 Correction: RNA sequence analysis of human huntington disease brain reveals an extensive increase in inflammatory and developmental gene expression 2016
    2016 Clinical Sequencing Exploratory Research Consortium: Accelerating Evidence-Based Practice of Genomic Medicine 2016
    2016 A genome-wide association study identifies SLC8A3 as a susceptibility locus for ACPA-positive rheumatoid arthritis 2016
    2016 Identification of IRX1 as a Risk Locus for Rheumatoid Factor Positivity in Rheumatoid Arthritis in a Genome-Wide Association Study 2016
    2016 Corrigendum: DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions 2016
    2016 Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression 2016
    2016 SON and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated Genes 2016
    2016 microRNA profiles in Parkinson's disease prefrontal cortex 2016
    2016 Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels 2016
    2016 Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function 2016
    2016 Integrative analyses of proteomics and RNA transcriptomics implicate mitochondrial processes, protein folding pathways and GWAS loci in Parkinson disease 2016
    2016 Evolving New Skeletal Traits by cis-Regulatory Changes in Bone Morphogenetic Proteins 2016
    2016 Clinical-genetic associations in the Prospective Huntington at Risk Observational Study (PHAROS) implications for clinical trials 2016
    2016 Evidence for alterations of the glial syncytial function in major depressive disorder 2016
    2016 Genome-Wide Pathway Analysis Identifies Genetic Pathways Associated with Psoriasis 2016
    2016 Whole-exome sequencing in familial Parkinson disease 2016
    2015 DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions 2015
    2015 Promoter-distal RNA polymerase II binding discriminates active from inactive CCAAT/ enhancer-binding protein beta binding sites 2015
    2015 RNA sequence analysis of human huntington disease brain reveals an extensive increase in inflammatory and developmental gene expression 2015
    2015 Study of plasma-derived miRNAs mimic differences in Huntington's disease brain 2015
    2015 The role of H3K4me3 in transcriptional regulation is altered in Huntington's disease 2015
    2015 Assessment of the utility of whole genome sequencing of measles virus in the characterisation of outbreaks 2015
    2015 Evidence of extensive alternative splicing in post mortem human brain HTT transcription by mRNA sequencing 2015
    2015 A deletion at adamts9-magi1 locus is associated with psoriatic arthritis risk 2015
    2015 CETCh-seq: CRISPR epitope tagging ChIP-seq of DNA-binding proteins 2015
    2015 The Genetic Modifiers of Motor OnsetAge (GeM MOA) Website: Genome-wide Association Analysis for Genetic Modifiers of Huntington's Disease 2015
    2015 Variable telomere length across post-mortem human brain regions and specific reduction in the hippocampus of major depressive disorder 2015
    2015 Fibroblast growth factor 9 is a novel modulator of negative affect 2015
    2015 Sequence-Level Analysis of the Major European Huntington Disease Haplotype 2015
    2015 Identification of Genetic Factors that Modify Clinical Onset of Huntington's Disease 2015
    2015 Directional dominance on stature and cognition in diverse human populations 2015
    2015 TBCRC 019: A phase II trial of nanoparticle albumin-bound paclitaxel with or without the anti-death receptor 5 monoclonal antibody tigatuzumab in patients with triple-negative breast cancer 2015
    2015 NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells 2015
    2015 Genome sequence analysis of Ebola virus in clinical samples from three British healthcare workers, august 2014 to march 2015 2015
    2015 Mitochondrial Mutations in Subjects with Psychiatric Disorders 2015
    2015 Identification of risk loci for crohn's disease phenotypes using a genome-wide association study 2015
    2015 Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways 2015
    2015 MiR-10b-5p expression in Huntington's disease brain relates to age of onset and the extent of striatal involvement 2015
    2015 Psychiatric genome-wide association study analyses implicate neuronal, immune and histone pathways 2015
    2015 Joint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder 2015
    2015 Blocking of targeted microRNAs from next-generation sequencing libraries 2015
    2015 Circadian dysregulation of clock genes: Clues to rapid treatments in major depressive disorder 2015
    2015 Epigenetic dysregulation of hairy and enhancer of split 4 (HES4) is associated with striatal degeneration in postmortem Huntington brains 2015
    2015 Genomic diversity of mumps virus and global distribution of the 12 genotypes 2015
    2015 Long-term transmission of measles virus in Central and continental Western Europe 2015
    2015 Systems Genomics Identifies a Key Role for Hypocretin/Orexin Receptor-2 in Human Heart Failure 2015
    2014 A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis 2014
    2014 DNA methylation profiling reveals novel diagnostic biomarkers in renal cell carcinoma 2014
    2014 In search of rare variants: Preliminary results from whole genome sequencing of 1,325 individuals with psychophysiological endophenotypes 2014
    2014 Reply to Brunet and Doolittle: Both selected effect and causal role elements can influence human biology and disease 2014
    2014 Fully automated high-throughput chromatin immunoprecipitation for ChIP-seq: Identifying ChIP-quality p300 monoclonal antibodies 2014
    2014 Identification of pathways for bipolar disorder: A meta-analysis 2014
    2014 Defining functional DNA elements in the human genome 2014
    2014 Altered choroid plexus gene expression in major depressive disorder 2014
    2014 Feasibility of Huntington disease trials in the disease prodrome 2014
    2014 Correction for multiple testing in a gene region 2014
    2014 Regionally selective atrophy of subcortical structures in prodromal HD as revealed by statistical shape analysis 2014
    2014 Cross-neutralizing antibodies elicited by the Cervarix ® human papillomavirus vaccine display a range of Alpha-9 inter-type specificities 2014
    2014 MicroRNAs Located in the Hox Gene Clusters Are Implicated in Huntington's Disease Pathogenesis 2014
    2014 Middle East respiratory syndrome coronavirus in dromedary camels: An outbreak investigation 2014
    2014 Conserved higher-order chromatin regulates NMDA receptor gene expression and cognition 2014
    2014 Evidence of allelic imbalance in the schizophrenia susceptibility gene ZNF804A in human dorsolateral prefrontal cortex 2014
    2014 From single-cell to cell-pool transcriptomes: Stochasticity in gene expression and RNA splicing 2014
    2014 Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease 2014
    2014 Recurrent read-through fusion transcripts in breast cancer 2014
    2013 G protein-linked signaling pathways in bipolar and major depressive disorders 2013
    2013 Integrating and mining the chromatin landscape of cell-type specificity using self-organizing maps 2013
    2013 Distinct properties of cell-type-specific and shared transcription factor binding sites 2013
    2013 Mapping genome-wide transcription factor binding sites in frozen tissues 2013
    2013 Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape 2013
    2013 Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs 2013
    2013 A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model 2013
    2013 The 'Red Queen' dilemma - Running to stay in the same place: Reflections on the evolutionary vector of HBV in humans 2013
    2013 Circadian patterns of gene expression in the human brain and disruption in major depressive disorder 2013
    2013 Serum Iron Levels and the Risk of Parkinson Disease: A Mendelian Randomization Study 2013
    2013 Candidate glutamatergic and dopaminergic pathway gene variants do not influence Huntington's disease motor onset 2013
    2013 Dynamic DNA methylation across diverse human cell lines and tissues 2013
    2013 Intricate interplay between astrocytes and motor neurons in ALS 2013
    2013 Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts 2013
    2013 Analysis of miR-137 expression and rs1625579 in dorsolateral prefrontal cortex 2013
    2013 David R. Cox 1946-2013. 2013
    2013 Early de novo DNA methylation and prolonged demethylation in the muscle lineage 2013
    2013 Glucocorticoid and mineralocorticoid receptor expression in the human hippocampus in major depressive disorder 2013
    2013 Glutamate transporters: A key piece in the glutamate puzzle of major depressive disorder 2013
    2012 CTCF/cohesin-mediated DNA looping is required for protocadherin α promoter choice 2012
    2012 Evidence for transcriptional factor dysregulation in the dorsal raphe nucleus of patients with major depressive disorder 2012
    2012 Population stratiWcation may bias analysis of PGC-1α as a modiWer of age at Huntington disease motor onset 2012
    2012 Theria-Specific Homeodomain and cis-Regulatory Element Evolution of the Dlx3-4 Bigene Cluster in 12 Different Mammalian Species 2012
    2012 Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner 2012
    2012 Human-Specific Histone Methylation Signatures at Transcription Start Sites in Prefrontal Neurons 2012
    2012 Genome-Wide Association Studies of Quantitatively Measured Skin, Hair, and Eye Pigmentation in Four European Populations 2012
    2012 Assessment of cortical and striatal involvement in 523 Huntington disease brains 2012
    2012 A validated regulatory network for Th17 cell specification 2012
    2012 Evaluation of Parkinson Disease Risk Variants as Expression-QTLs 2012
    2012 Severe respiratory illness caused by a novel coronavirus, in a patient transferred to the United Kingdom from the Middle East, September 2012 2012
    2012 Development of the Huntington disease work function scale 2012
    2012 Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction 2012
    2012 An integrated encyclopedia of DNA elements in the human genome 2012
    2012 Architecture of the human regulatory network derived from ENCODE data 2012
    2012 Functional analysis of transcription factor binding sites in human promoters 2012
    2012 ChIP-seq guidelines and practices of the ENCODE and modENCODE consortia 2012
    2012 Genetic architecture of variation in the lateral line sensory system of threespine sticklebacks 2012
    2012 Phylodynamic and phylogeographic patterns of the HIV type 1 subtype F1 parenteral epidemic in Romania 2012
    2012 Sequence features and chromatin structure around the genomic regions bound by 119 human transcription factors 2012
    2012 The hypersensitive glucocorticoid response specifically regulates period 1 and expression of circadian genes 2012
    2012 Widespread plasticity in CTCF occupancy linked to DNA methylation 2012
    2012 Genomic patterns of homozygosity in worldwide human populations 2012
    2012 TAA repeat variation in the GRIK2 gene does not influence age at onset in Huntington's disease 2012
    2012 Role of CCCTC binding factor (CTCF) and cohesin in the generation of single-cell diversity of Protocadherin-α gene expression 2012
    2012 8OHdG as a marker for Huntington disease progression 2012
    2012 Cognitive domains that predict time to diagnosis in prodromal Huntington disease 2012
    2012 Gene expression profiles in Parkinson disease prefrontal cortex implicate FOXO1 and genes under its transcriptional regulation 2012
    2012 Systematic evaluation of factors influencing ChIP-seq fidelity 2012
    2012 Effects of sequence variation on differential allelic transcription factor occupancy and gene expression 2012
    2012 Molecular epidemiology of human rhinovirus infections in Kilifi, coastal Kenya 2012
    2012 Gene expression changes in the prefrontal cortex, anterior cingulate cortex and nucleus accumbens of mood disorders subjects that committed suicide 2012
    2012 Postmortem interval influences α-synuclein expression in Parkinson disease brain 2012
    2012 The genomic basis of adaptive evolution in threespine sticklebacks 2012
    2012 Dynamic microRNA gene transcription and processing during T cell development 2012
    2012 Common SNP-based haplotype analysis of the 4p16.3 Huntington disease gene region 2012
    2012 CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion 2012
    2012 Fatal cases of influenza A(H3N2) in children: Insights from whole genome sequence analysis 2012
    2012 Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDgene database 2012
    2012 Meta-analysis of Parkinson's Disease: Identification of a novel locus, RIT2 2012
    2012 Transposase mediated construction of RNA-seq libraries (Genome Research (2012) 22, (134-141)) 2012
    2012 Identification of a Functional In Vivo p53 Response Element in the Coding Sequence of the Xeroderma Pigmentosum Group C Gene 2012
    2012 Molecular epidemiology of a large community-based outbreak of hepatitis B in Bristol, UK 2012
    2012 Genetic signatures of exceptional longevity in humans 2012
    2012 Cancer cell proliferation is inhibited by specific modulation frequencies 2012
    2012 A genome-wide SNP genotyping array reveals patterns of global and repeated species-pair divergence in sticklebacks 2012
    2012 Evolutionary dynamics of local pandemic H1N1/2009 influenza virus lineages revealed by whole-genome analysis 2012
    2012 Research resource: Enhanced genome-wide occupancy of estrogen receptor α by the cochaperone p23 in breast cancer cells 2012
    2012 Transposase mediated construction of RNA-seq libraries 2012
    2011 IκB kinase ε (IKKε) regulates the balance between type I and type II interferon responses 2011
    2011 RANTES/CCL5 and risk for coronary events: Results from the MONICA/KORA Augsburg case-cohort, Athero-express and CARDIoGRAM studies 2011
    2011 Allele-specific distribution of RNA polymerase II On female X chromosomes 2011
    2011 Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes 2011
    2011 Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure 2011
    2011 Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 2011
    2011 Genomewide linkage study of modifiers of LRRK2-related Parkinson's disease 2011
    2011 Lack of association to a NRG1 missense polymorphism in schizophrenia or bipolar disorder in a Costa Rican population 2011
    2011 Evolutionary pathways of the pandemic influenza a (H1N1) 2009 in the UK 2011
    2011 Erratum: Generation of isogenic pluripotent stem cells differing exclusively at two early onset parkinson point mutations (Cell (2011) 146 (318-331)) 2011
    2011 Association of DRD2 and DRD3 polymorphisms with Parkinson's disease in a multiethnic consortium 2011
    2011 Copy number variation in familial parkinson disease 2011
    2011 Analysis of dna methylation in a three-generation family reveals widespread genetic influence on epigenetic regulation 2011
    2011 The genetic basis of divergent pigment patterns in juvenile threespine sticklebacks 2011
    2011 Generation of isogenic pluripotent stem cells differing exclusively at two early onset parkinson point mutations 2011
    2011 Retraction (Science) 2011
    2011 DNA methylation profiling reveals novel biomarkers and important roles for DNA methyltransferases in prostate cancer 2011
    2011 Integrated genomic analyses of ovarian carcinoma 2011
    2011 Altered expression of glutamate signaling, growth factor, and glia genes in the locus coeruleus of patients with major depression 2011
    2011 Erratum: Mitochondrial involvement in psychiatric disorders (Annals of Medicine (2008) 40 (281-295)) 2011
    2011 Coffee, ADORA2A, and CYP1A2: The caffeine connection in Parkinson's disease 2011
    2011 Investigating transmission of Mycobacterium bovis in the United Kingdom in 2005 to 2008 2011
    2011 A user's guide to the Encyclopedia of DNA elements (ENCODE) 2011
    2011 Appearance of a novel measles G3 strain in multiple European countries within a two month period, 2010 2011
    2011 Cyclin-G-associated kinase modifies α-synuclein expression levels and toxicity in Parkinson's disease: Results from the GenePD Study 2011
    2011 Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits 2011
    2011 Three residues in HIV-1 matrix contribute to protease inhibitor susceptibility and replication capacity 2011
    2010 Lack of Association between the Trp719Arg Polymorphism in Kinesin-Like Protein-6 and Coronary Artery Disease in 19 Case-Control Studies 2010
    2010 Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index 2010
    2010 Decreased glutamic acid decarboxylase mRNA expression in prefrontal cortex in Parkinson's disease 2010
    2010 Expression patterns of corticotropin-releasing factor, arginine vasopressin, histidine decarboxylase, melanin-concentrating hormone, and orexin genes in the human hypothalamus 2010
    2010 Pandemic (H1N1) 2009 influenza in the UK: Clinical and epidemiological findings from the first few hundred (FF100) cases 2010
    2010 Early changes in the hypothalamic region in prodromal Huntington disease revealed by MRI analysis 2010
    2010 Estrogen-related and other disease diagnoses preceding Parkinson's disease 2010
    2010 Sequence features that drive human promoter function and tissue specificity 2010
    2010 Risk of Parkinson's disease after tamoxifen treatment 2010
    2010 Evolutionary constraint facilitates interpretation of genetic variation in resequenced human genomes 2010
    2010 Neonatal maternal deprivation response and developmental changes in gene expression revealed by hypothalamic gene expression profiling in mice 2010
    2010 Complete HOX cluster characterization of the coelacanth provides further evidence for slow evolution of its genome 2010
    2010 Characterization of X-Linked SNP genotypic variation in globally-distributed human populations 2010
    2010 High throughput sequencing reveals a complex pattern of dynamic interrelationships among human T cell subsets 2010
    2010 Adaptive evolution of pelvic reduction in sticklebacks by recurrent deletion of a pitxl enhancer 2010
    2009 Education and personalized genomics: Deciphering the public's genetic health report 2009
    2009 Characterizing the admixed African ancestry of African Americans 2009
    2009 Evidence for three novel QTLs for adiposity on chromosome 2 with epistatic interactions: The NHLBI family heart study 2009
    2009 Genomic determination of the glucocorticoid response reveals unexpected mechanisms of gene regulation 2009
    2009 Multiple genes influence bmi on chromosome 7q31-34: The NHLBI family heart study 2009
    2009 The completion of the Mammalian Gene Collection 2009
    2009 A role for a neo-sex chromosome in stickleback speciation 2009
    2009 Exon expression in lymphoblastoid cell lines from subjects with schizophrenia before and after glucose deprivation 2009
    2009 Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging 2009
    2009 Genomewide association study for onset age in Parkinson disease 2009
    2009 Genetic variation in the proximal promoter of ABC and SLC superfamilies: Liver and kidney specific expression and promoter activity predict variation 2009
    2009 Somatic expansion of the Huntington's disease CAG repeat in the brain is associated with an earlier age of disease onset 2009
    2009 One step forward toward identification of the genetic signature of glioblastomas 2009
    2009 Estimating the probability of de novo HD cases from transmissions of expanded penetrant CAG alleles in the Huntington disease gene from male carriers of high normal alleles (27-35 CAG) 2009
    2009 Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver 2009
    2009 The role of geography in human adaptation 2009
    2009 Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry 2009
    2009 LIPC variants in the promoter and intron 1 modify HDL-C levels in a sex-specific fashion 2009
    2009 Signals of recent positive selection in a worldwide sample of human populations 2009
    2009 The association of cell cycle checkpoint 2 variants and kidney function: Findings of the family blood pressure program and the atherosclerosis risk in communities study 2009
    2009 Mitochondrial variants in schizophrenia, bipolar disorder, and major depressive disorder 2009
    2009 A QTL on 12q Influencing an inflammation marker and obesity in white women: The NHLBI family heart study 2009
    2009 A genome-wide association study of pulmonary function measures in the framingham heart study 2009
    2009 Leptin is associated with blood pressure and hypertension in women from the National Heart, Lung, and Blood Institute family heart study 2009
    2009 Genomewide association study for susceptibility genes contributing to familial Parkinson disease 2009
    2009 Analysis of the genetic variability of the mumps SH gene in viruses circulating in the UK between 1996 and 2005 2009
    2009 Genetic effect on blood pressure is modulated by age the hypertension genetic epidemiology network study 2009
    2008 Development and optimization of an internally controlled dried blood spot assay for surveillance of human immunodeficiency virus type-1 drug resistance 2008
    2008 The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: The GenePD study 2008
    2008 An integrated software system for analyzing ChIP-chip and ChIP-seq data 2008
    2008 Comprehensive genomic characterization defines human glioblastoma genes and core pathways 2008
    2008 Model-based analysis of ChIP-Seq (MACS) 2008
    2008 Analysis of natural sequence variation and covariation in human immunodeficiency virus type 1 integrase 2008
    2008 Genome-wide analysis of transcription factor binding sites based on ChIP-Seq data 2008
    2008 Huntington CAG repeat size does not modify onset age in familial Parkinson's disease: The GenePD study 2008
    2008 Population analysis of large copy number variants and hotspots of human genetic disease 2008
    2008 Replication of association between ELAVL4 and Parkinson disease: The Gene PD study 2008
    2008 Ribosomal mutations cause p53-mediated dark skin and pleiotropic effects 2008
    2008 Susceptibility locus for clinical and subclinical coronary artery disease at chromosome 9p21 in the multi-ethnic ADVANCE study 2008
    2008 Circulating soluble ICAM-1 levels shows linkage to ICAM gene cluster region on chromosome 19: The NHLBI Family Heart Study follow-up examination 2008
    2008 Haplotypes and gene expression implicate the MAPT region for Parkinson disease: The GenePD Study 2008
    2008 NYD-SP18 is associated with obesity in the NHLBI Family Heart Study 2008
    2008 Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; The NHLBI Family Heart Study 2008
    2008 A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease 2008
    2008 Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease 2008
    2008 Multiple transcription start sites for FOXP2 with varying cellular specificities 2008
    2008 Mitochondrial involvement in psychiatric disorders 2008
    2008 Failure to replicate an association of SNPs in the oxidized LDL receptor gene (OLR1) with CAD 2008
    2008 Coding SNPs included in exon arrays for the study of psychiatric disorders 2008
    2008 Genome-wide admixture mapping for coronary artery calcification in African Americans: The NHLBI family heart study 2008
    2008 Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets 2008
    2008 Worldwide human relationships inferred from genome-wide patterns of variation 2008
    2008 Recombination and population mosaic of a multifunctional viral gene, adeno-associated virus cap 2008
    2008 Polymorphisms within the C-Reactive Protein (CRP) Promoter Region Are Associated with Plasma CRP Levels (PII:S0002-9297(07)60902-1) 2008
    2008 HepSEQ--an integrated hepatitis B epidemiology and sequence analysis platform. 2008
    2008 Sequence census methods for functional genomics 2008
    2007 Association of polymorphisms in platelet and hemostasis system genes with acute myocardial infarction 2007
    2007 Circulating MCP-1 levels shows linkage to chemokine receptor gene cluster on chromosome 3: The NHLBI Family Heart Study follow-up examination 2007
    2007 Matrix metalloproteinase circulating levels, genetic polymorphisms, and susceptibility to acute myocardial infarction among patients with coronary artery disease 2007
    2007 Polymorphisms in hypoxia inducible factor 1 and the initial clinical presentation of coronary disease 2007
    2007 Stress-induced changes in primate prefrontal profiles of gene expression 2007
    2007 Factors associated with HD CAG repeat instability in Huntington disease 2007
    2007 The ets-related transcription factor GABP directs bidirectional transcription 2007
    2007 Sample matching by inferred agonal stress in gene expression analyses of the brain 2007
    2007 HaploBuild: An algorithm to construct non-contiguous associated haplotypes in family based genetic studies 2007
    2007 Methodological considerations for gene expression profiling of human brain 2007
    2007 Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project 2007
    2007 Genome-wide mapping of in vivo protein-DNA interactions 2007
    2007 Integrated analysis of experimental data sets reveals many novel promoters in 1% of the human genome 2007
    2007 Prominent use of distal 5′ transcription start sites and discovery of a large number of additional exons in ENCODE regions 2007
    2007 Transcription factor binding and modified histones in human bidirectional promoters 2007
    2007 The etiopathogenesis of Parkinson disease and suggestions for future research. Part II 2007
    2007 The relationship between CAG repeat length and age of onset differs for Huntington's disease patients with juvenile onset or adult onset 2007
    2007 Comprehensive linkage and linkage heterogeneity analysis of 4344 sibling pairs affected with hypertension from the Family Blood Pressure Program 2007
    2007 The etiopathogenesis of Parkinson disease and suggestions for future research. Part I 2007
    2007 Sepiapterin reductase expression is increased in Parkinson's disease brain tissue 2007
    2007 Wild-type huntingtin participates in protein trafficking between the Golgi and the extracellular space 2007
    2007 Serum response factor binding sites differ in three human cell types 2007
    2007 Evidence of QTL on 15q21 for high-density lipoprotein cholesterol: The National Heart, Lung, and Blood Institute Family Heart Study (NHLBI FHS) 2007
    2007 Genotype-by-sex interaction on fasting insulin concentration: The HyperGEN study 2007
    2007 LRRK2 is not a significant cause of Parkinson's disease in French-Canadians 2007
    2006 Longitudinal and age trends of metabolic syndrome and its risk factors: The Family Heart Study 2006
    2006 Herbicide exposure modifies GSTP1 haplotype association to Parkinson onset age: The GenePD study 2006
    2006 Brain-derived neurotrophic factor does not influence age at neurologic onset of Huntington's disease 2006
    2006 tRNAs promote nuclear import of HIV-1 intracellular reverse transcription complexes 2006
    2006 Comparative genomics modeling of the NRSF/REST repressor network: From single conserved sites to genome-wide repertoire 2006
    2006 Genotype-by-sex interaction in the aetiology of type 2 diabetes mellitus: Support for sex-specific quantitative trait loci in Hypertension Genetic Epidemiology Network participants 2006
    2006 Genetic analysis of the GRIK2 modifier effect in Huntington's disease 2006
    2006 Adrenergic receptor polymorphisms associated with resting heart rate: The HyperGEN study 2006
    2006 Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: The HD MAPS study 2006
    2006 Mitochondrial related gene expression changes are sensitive to agonal-pH state 2006
    2006 Mitochondrial-related gene expression changes are sensitive to agonal-pH state: Implications for brain disorders 2006
    2006 Erratum: Sequencing and analysis of 10,967 full-length cDNA clones from Xenopus laevis and Xenopus tropicalis reveals post-tetraploidization transcriptome remodeling (Genome Research (2006) 16, (796-803)) 2006
    2006 Assessment of automated genotyping protocols as tools for surveillance of HIV-1 genetic diversity 2006
    2006 Influence of heterozygosity for Parkin mutation on onset age in familial parkinson disease: The genePD study 2006
    2006 Genetic background modifies nuclear mutant huntingtin accumulation and HD CAG repeat instability in Huntington's disease knock-in mice 2006
    2006 Genotyping hepatitis B virus from whole- and sub-genomic fragments using position-specific scoring matrices in HBV STAR 2006
    2006 Sequencing and analysis of 10,967 full-length cDNA clones from Xenopus laevis and Xenopus tropicalis reveals post-tetraploidization transcriptome remodeling 2006
    2006 Application of microarray technology in primate behavioral neuroscience research 2006
    2006 Evidence for a gene influencing heart rate on chromosome 5p13-14 in a meta-analysis of genome-wide scans from the NHLBI Family Blood Pressure Program 2006
    2006 Quantitative trait loci on chromosome 8q24 for pancreatic β-cell function and 7q11 for insulin sensitivity in obese nondiabetic white and black families: Evidence from genome-wide linkage scans in the NHLBI Hypertension Genetic Epidemiology Network (HyperGEN) study 2006
    2006 Comprehensive analysis of transcriptional promoter structure and function in 1% of the human genome 2006
    2006 Considerations for genomewide association studies in Parkinson disease [1] 2006
    2006 Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study 2006
    2005 Evolving gene/transcript definitions significantly alter the interpretation of GeneChip data 2005
    2005 BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD Study 2005
    2005 Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression 2005
    2005 HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism 2005
    2005 A statistical model for HIV-1 sequence classification using the subtype analyser (STAR) 2005
    2005 Absence of previously reported variants in the SCNA (G88C and G209A), NR4A2 (T291D and T245G) and the DJ-1 (T497C) genes in familial Parkinson's disease from the GenePD study 2005
    2005 A haplotype similarity based transmission/disequilibrium test under founder heterogeneity 2005
    2005 Direct isolation and identification of promoters in the human genome 2005
    2005 Monozygotic twins discordant for Huntington disease after 7 years 2005
    2005 Variability and conservation in hepatitis B virus core protein 2005
    2005 Sensitization of stefin B-deficient thymocytes towards staurosporin-induced apoptosis is independent of cysteine cathepsins 2005
    2005 Generation and annotation of the DNA sequences of human chromosomes 2 and 4 2005
    2005 Widespread parallel evolution in sticklebacks by repeated fixation of ectodysplasin alleles 2005
    2005 Linkage of the cholesterol 7α-hydroxylase gene and low-density lipoprotein cholesterol conditional on apolipoprotein E association: The National Heart, Lung, and Blood Institute Family Heart Study 2005
    2005 An evaluation of the metabolic syndrome in the HyperGEN study 2005
    2005 Polymorphisms within the C-reactive protein (CRP) promoter region are associated with plasma CRP levels 2005
    2005 Quantitative trait loci for metabolic syndrome in the hypertension genetic epidemiology network study 2005
    2004 The sequence and analysis of duplication-rich human chromosome 16 2004
    2004 Apolipoprotein E polymorphism modifies the alcohol-HDL association observed in the National Heart, Lung, and Blood Institute Family Heart Study 2004
    2004 Coelacanth genome sequence reveals the evolutionary history of vertebrate genes 2004
    2004 Evidence and consequence of porcine endogenous retrovirus recombination 2004
    2004 Linkage analysis of diabetes status among hypertensive families: The hypertension genetc epidemiology network study 2004
    2004 Dysregulation of the fibroblast growth factor system in major depression 2004
    2004 The ENCODE (ENCyclopedia of DNA Elements) Project 2004
    2004 The DNA sequence and comparative analysis of human chromosome 5 2004
    2004 Genome-wide linkage analyses for age at diagnosis of hypertension and early-onset hypertension in the HyperGEN study 2004
    2004 The master sex-determination locus in threespine sticklebacks is on a nascent Y chromosome 2004
    2004 Evidence for a modifier of onset age in Huntington disease linked to the HD gene in 4p16 2004
    2004 Quality assessment of the human genome sequence 2004
    2004 Diverse and Specific Gene Expression Responses to Stresses in Cultured Human Cells 2004
    2004 Huntington's Disease Genetics 2004
    2004 Lack of Evidence for An Association between WNT2 and RELN Polymorphisms and Auitism 2004
    2004 The DNA sequence and biology of human chromosome 19 2004
    2004 Systematic changes in gene expression in postmortem human brains associated with tissue pH and terminal medical conditions 2004
    2004 Genome-Wide Scan Identifies Novel QTLs for Cholesterol and LDL Levels in F2[Dahl RxS] Intercross Rats 2004
    2004 Gene conversion and the evolution of protocadherin gene cluster diversity 2004
    2004 The Role of Heat Shock Transcription Factor 1 in the Genome-wide Regulation of the Mammalian Heat Shock Response 2004
    2004 Transcriptional regulation and binding of heat shock factor 1 and heat shock factor 2 to 32 human heat shock genes during thermal stress and differentiation 2004
    2004 Effect of agonal and postmortem factors on gene expression profile: Quality control in microarray analyses of postmortem human brain 2004
    2004 Gender-Specific Gene Expression in Post-Mortem Human Brain: Localization to Sex Chromosomes 2004
    2004 Selective Disruption of Lysosomes in HeLa Cells Triggers Apoptosis Mediated by Cleavage of Bid by Multiple Papain-like Lysosomal Cathepsins 2004
    2004 An abundance of bidirectional promoters in the human genome 2004
    2004 Assembly of DNA sequencing data. 2004
    2004 Common variants in the 5′ region of the leptin gene are associated with body mass index in men from the National Heart, Lung, and Blood Institute Family Heart Study 2004
    2004 Development of a novel human immunodeficiency virus type 1 subtyping tool, subtype analyzer (STAR): Analysis of subtype distribution in London 2004
    2004 Quality assessment of finished BAC sequences. 2004
    2004 Sequence finishing. 2004
    2004 The status, quality, and expansion of the NIH full-length cDNA project: The Mammalian Gene Collection (MGC) 2004
    2003 A haplotype at the PARK3 locus influences onset age for Parkinson's disease: The GenePD study 2003
    2003 Coding potential of laboratory and clinical strains of human cytomegalovirus 2003
    2003 Apoptosis caused by cathepsins does not require Bid signaling in an in vivo model of progressive myoclonus epilepsy (EPM1) 2003
    2003 A genome-wide scan for loci affecting normal adult height in the Framingham Heart Study 2003
    2003 Linkage Analysis of a Composite Factor for the Multiple Metabolic Syndrome: The National Heart, Lung, and Blood Institute Family Heart Study 2003
    2003 Linkage and association with pulmonary function measures on chromosome 6q27 in the Framingham Heart Study 2003
    2003 The analysis of survival data with a non-susceptible fraction and dual censoring mechanisms 2003
    2003 A genome scan for modifiers of age at onset in Huntington disease: The HD MAPS study 2003
    2003 Cathepsin B but not cathepsins L or S contributes to the pathogenesis of Unverricht-Lundborg progressive myoclonus epilepsy (EPM1) 2003
    2003 Identification of promoter regions in the human genome by using a retroviral plasmid library-based functional reporter gene assay 2003
    2003 Interaction of normal and expanded CAG repeat sizes influences age at onset of Huntington disease 2003
    2003 A Genome-Wide Scan of Pulmonary Function Measures in the National Heart, Lung, and Blood Institute Family Heart Study 2003
    2003 A note of caution on correlation between sibling pairs [6] (multiple letters) 2003
    2003 A genome scan for loci linked to quantitative insulin traits in persons without diabetes: The Framingham Offspring Study 2003
    2003 Microarray technology: A review of new strategies to discover candidate vulnerability genes in psychiatric disorders 2003
    2003 Predictors of nursing home placement in Huntington disease 2003
    2003 Combined analysis of genomewide scans for adult height: Results from the NHLBI family blood pressure program 2003
    2003 Extensive linkage disequilibrium, a common 16.7-kilobase deletion, and evidence of balancing selection in the human protocadherin α cluster 2003
    2003 Genomewide linkage analysis to presbycusis in the Framingham Heart Study 2003
    2003 Identification and functional analysis of human transcriptional promoters 2003
    2003 DNA microarray analysis of functionally discrete human brain regions reveals divergent transcriptional profiles 2003
    2003 Molecular diagnosis of unherited movement disorders. Movement disorders society task force on molecular diagnosis 2003
    2003 Rabbit endogenous retrovirus-H encodes a functional protease 2003
    2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences 2002
    2002 Is DFNA5 a susceptibility gene for age-related hearing impairment? 2002
    2002 Neuropathological changes in a mouse model of progressive myoclonus epilepsy: Cystatin B deficiency and Unverricht-Lundborg disease 2002
    2002 Rapid development of nucleic acid diagnostics 2002
    2002 Rapid mapping of zebrafish mutations with SNPs and oligonucleotide microarrays 2002
    2002 Weight loss in early stage of Huntington's disease 2002
    2002 Mapping of quantitative ultrasound of the calcaneus bone to chromosome 1 by genome-wide linkage analysis 2002
    2002 A genome-wide screen reveals evidence for a locus on chromosome 11 influencing variation in LDL cholesterol in the NHLBI Family Heart Study 2002
    2002 Evidence for a gene influencing heart rate on chromosome 4 among hypertensives 2002
    2002 Influence of apolipoprotein E, smoking, and alcohol intake on carotid atherosclerosis: National Heart, Lung, and Blood institute Family Heart Study 2002
    2002 Segregation analysis of Parkinson disease revealing evidence for a major causative gene 2002
    2002 Genome scan for quantity of hand osteoarthritis: The Framingham Study 2002
    2002 Genetic loci influencing lung function: A genomewide scan in the Framingham Study 2002
    2002 Behavioral phenotypic variation in autism multiplex families: Evidence for a continuous severity gradient 2002
    2002 Absence of linkage or association for osteoarthritis with the vitamin D receptor/type II collagen locus: The Framingham Osteoarthritis Study 2002
    2002 Epidemiologic study of 203 sibling pairs with Parkinson's disease: The GenePD study 2002
    2002 Lack of association between HoxA1 and HoxB1 gene variants and autism in 110 multiplex families 2002
    2002 A genome-wide scan for loci linked to plasma levels of glucose and HbA1c in a community-based sample of Caucasian pedigrees: The Framingham Offspring Study 2002
    2002 Candidate-gene approaches for studying complex genetic traits: Practical considerations 2002
    2002 Genetic variability of adult body mass index: A longitudinal assessment in Framingham families 2002
    2002 Genome screen for quantitative trait loci contributing to normal variation in bone mineral density: The Framingham study 2002
    2002 PARK3 influences age at onset in Parkinson disease: A genome scan in the GenePD study 2002
    2002 Quantitative-trait loci influencing body-mass index reside on chromosomes 7 and 13: The National Heart, Lung, and Blood Institute Family Heart Study 2002
    2001 Heritability of longitudinal change in lung function: The Framingham study 2001
    2001 Birth Order Effects on Nonverbal IQ Scores in Autism Multiplex Families 2001
    2001 Juvenile onset Huntington's disease - Clinical and research perspectives 2001
    2001 Genome-wide scan for Parkinson's disease: The GenePD study 2001
    2001 Cystatin B-deficient mice have increased expression of apoptosis and glial activation genes 2001
    2001 Erratum: Initial sequencing and analysis of the human genome: International Human Genome Sequencing Consortium (Nature (2001) 409 (860-921)) 2001
    2001 A dose-ranging study to evaluate the antiretroviral activity and safety of amprenavir alone and in combination with abacavir in HIV-infected adults with limited antiretroviral experience 2001
    2001 Genetic and environmental contributions to platelet aggregation: The Framingham Heart Study 2001
    2001 Comparative DNA sequence analysis of mouse and human protocadherin gene clusters [3] 2001
    2001 A high-resolution radiation hybrid map of the human genome draft sequence 2001
    2001 A physical map of the human genome 2001
    2001 Association of plasma bilirubin with coronary heart disease and segregation of bilirubin as a major gene trait: The NHLBI family heart study 2001
    2001 Initial sequencing and analysis of the human genome 2001
    2001 Genome scan for quantitative trait loci linked to high-density lipoprotein cholesterol: The NHLBI Family Heart Study 2001
    2001 Genome-wide linkage analysis of lipids in the hypertension genetic epidemiology network (HyperGEN) blood pressure study 2001
    2001 Interaction of α1-Na,K-ATPase and Na,K,2Cl-cotransporter genes in human essential hypertension 2001
    2001 Quantitative neuropathological changes in presymptomatic Huntington's disease 2001
    2001 The effect of isolated soy protein on plasma biomarkers in elderly men with elevated serum prostate specific antigen 2001
    2000 Absence of linkage for bone mineral density to chromosome 12q12-14 in the region of the vitamin D receptor gene 2000
    2000 HIV type 1 protease cleavage site mutations and viral fitness: Implications for drug susceptibility phenotyping assays 2000
    2000 Genetic background of Lewis negative blood group phenotype and its association with atherosclerotic disease in the NHLBI Family Heart Study 2000
    2000 Evidence for major genes influencing pulmonary function in the NHLBI Family Heart Study 2000
    2000 Evidence for a gene influencing the TG/HDL-C ratio on chromosome 7q32.3-qter: A genome-wide scan in the Framingham Study 2000
    2000 Segregation analysis of serum uric acid in the NHLBI Family Heart Study 2000
    2000 Insulin and hypertension in the NHLBI family heart study 2000
    2000 Rate of functional decline in Huntington's disease 2000
    2000 Evidence for a gene influencing blood pressure on chromosome 17: Genome scan linkage results for longitudinal blood pressure phenotypes in subjects from the Framingham Heart Study 2000
    2000 No evidence of linkage between the very-low-density lipoprotein receptor gene and fasting serum insulin or homeostasis model assessment insulin resistance index: The National Heart, Lung, and Blood Institute Family Heart Study 2000
    2000 Replication of linkage of familial combined hyperlipidemia to chromosome 1q with additional heterogeneous effect of apolipoprotein A-I/C-III/A-IV locus: The NHLBI family heart study 2000
    2000 Resistance to the HIV protease inhibitor amprenavir in vitro and in clinical studies: A review 2000
    2000 Smoking influences the association between apolipoprotein E and lipids: The National Heart, Lung, and Blood Institute Family Heart Study 2000
    1999 Environmental, medical, and family history risk factors for Parkinson's disease: A new England-based case control study 1999
    1999 Absence of effect of seven functional mutations in the CYP2D6 gene in Parkinson's disease 1999
    1999 Parental age at child's birth and son's risk of prostate cancer. The Framingham Study 1999
    1999 Effects of similarities in lifestyle habits on familial aggregation of high density lipoprotein and low density lipoprotein cholesterol: The NHLBI Family Heart Study 1999
    1999 Absence of linkage and linkage disequilibrium to chromosome 15q11-q13 markers in 139 multiplex families with autism 1999
    1999 Evidence for the GluR6 gene associated with younger onset age of Huntington's disease 1999
    1999 A putative Drosophila homolog of the Huntington's disease gene 1999
    1999 Evidence for a major gene accounting for mild elevation in LDL cholesterol: The NHLBI Family Heart Study 1999
    1999 Evaluation of biomarker modulation by fenretinide in prostate cancer patients 1999
    1999 Lewis blood group phenotype as an independent risk factor for coronary heart disease (the NHLBI Family Heart Study) 1999
    1999 A Huntington's disease CAG expansion at the murine Hdh locus is unstable and associated with behavioural abnormalities in mice 1999
    1999 A genomic screen of autism: Evidence for a multilocus etiology 1999
    1999 Exclusion of linkage to the HLA region in ninety multiplex sibships with autism 1999
    1999 Impaired synaptic plasticity in mice carrying the Huntington's disease mutation 1999
    1999 Increased platelet aggregability associated with platelet GPIIIa Pl(A2) polymorphism: The Framingham offspring study 1999
    1999 The molecular genetic bases of the progressive myoclonus epilepsies. 1999
    1998 Segregation analysis of pulmonary function among families in the framingham study 1998
    1998 Progressive ataxia, myoclonic epilepsy and cerebellar apoptosis in cystatin B-deficient mice 1998
    1998 A physical map of 30,000 human genes 1998
    1998 Characterization of the Huntington's disease (HD) gene homolog in the zebrafish Danio rerio 1998
    1998 On the pathological progression of Huntington's disease [1] (multiple letters) 1998
    1998 β-glucocerebrosidase gene locus as a link for Gaucher's disease and familial hypo-α-lipoproteinaemia 1998
    1998 Evidence for a Mendelian gene in a segregation analysis of generalized radiographic osteoarthritis: The Framingham Study 1998
    1998 Evidence for association and genetic linkage of the angiotensin- converting enzyme locus with hypertension and blood pressure in men but not women in the Framingham Heart Study 1998
    1998 Effects of age and ethnicity on the link between apoe ε4 and Alzheimer disease [2] (multiple letters) 1998
    1998 1H NMR spectroscopy studies of Huntington's disease. Correlations with CAG repeat numbers 1998
    1998 Angiotensinogen and angiotensin converting enzyme genotypes and carotid atherosclerosis: The atherosclerosis risk in communities and the NHLBI family heart studies 1998
    1997 Gastrogenomic delights: A movable feast 1997
    1997 Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: A meta-analysis 1997
    1997 Identification and characterization of the human homologue of SH3BP2, an SH3 binding domain protein within a common region of deletion at 4p16.3 Involved in bladder cancer 1997
    1997 The BsmI vitamin D receptor restriction fragment length polymorphism (bb) influences the effect of calcium intake on bone mineral density 1997
    1997 Long-term impact of Huntington disease linkage testing 1997
    1997 CAG repeat number governs the development rate of pathology in huntington's disease 1997
    1997 Unstable minisatellite expansion causing recessively inherited myoclonus epilepsy, EPM1 1997
    1997 An STS-based radiation hybrid map of the human genome 1997
    1997 Familial history of stroke and stroke risk: The Family Heart Study 1997
    1997 Heritability of left ventricular mass: The Framingham Heart Study 1997
    1997 High-resolution physical and transcriptional mapping of the autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy locus on chromosome 21q22.3 by FISH 1997
    1997 Reduced penetrance of the Huntington's disease mutation 1997
    1996 Isolation and characterization of the mouse cystatin B gene 1996
    1996 Human immunodeficiency virus: Mutations in the viral protease that confer resistance to saquinavir increase the dissociation rate constant of the protease-saquinavir complex 1996
    1996 Evidence of cortical metabolic dysfunction in early Huntington's disease by single -photon-emission computed tomography 1996
    1996 Fluorescence in situ hybridization deletion mapping at 4p16.3 in bladder cancer cell lines refines the localisation of the critical interval to 30 kb 1996
    1996 Human homolog of patched, a candidate gene for the basal cell nevus syndrome 1996
    1996 Progressive myoclonus epilepsy EPM1 locus maps to a 175-kb interval in distal 21q 1996
    1996 Construction of a 750-kb bacterial clone contig and restriction map in the region of human chromosome 21 containing the progressive myoclonus epilepsy gene 1996
    1996 Incomplete dominance of type III hyperlipoproteinemia is associated with the rare apolipoprotein E2 (Arg136 → Ser) variant in multigenerational pedigree studies 1996
    1996 Absence of association or genetic linkage between the angiotensin-converting-enzyme gene and left ventricular mass 1996
    1996 Mutations in the gene encoding cystatin B in progressive myoclonus epilepsy (EPM1) 1996
    1996 Associations of types of lens opacities between and within eyes of individuals: An application of second-order generalized estimating equations 1996
    1996 A gene map of the human genome 1996
    1996 A map to the future 1996
    1996 Apolipoprotein E ∈4 association with dementia in a population-based study: The Framingham Study 1996
    1996 Genomes and evolution 1996
    1996 Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH 1996
    1996 Mutation of the prion protein gene at codon 208 in familial Creutzfeldt- Jakob disease 1996
    1996 The end of the beginning: the race to begin human genome sequencing. 1996
    1995 In vitro selection and characterization of human immunodeficiency virus type 1 (HIV-1) isolates with reduced sensitivity to hydroxyethylamino sulfonamide inhibitors of HIV-1 aspartyl protease 1995
    1995 Evidence from antibody studies that the CAG repeat in the huntington disease gene is expressed in the protein 1995
    1995 A potassium channel mutation in weaver mice implicates membrane excitability in granule cell differentiation 1995
    1995 Cross-resistance analysis of human immunodeficiency virus type 1 variants individually selected for resistance to five different protease inhibitors 1995
    1995 Statement on use of apolipoprotein E testing for Alzheimer disease 1995
    1994 Localization of the α2-Macroglobulin Receptor-Associated Protein 1 Gene (LRPAP1) and Other Gene Fragments to Human Chromosome 4p16.3 by Direct cDNA Selection 1994
    1994 A high resolution physical map of 2.5 Mbp of the down syndrome region on chromosome 21 1994
    1994 A transcript map of the down syndrome critical region on chromosome 21 1994
    1994 Assessing mapping progress in the human genome project 1994
    1994 Identification of genes within CpG-enriched DNA from human chromosome 4p16.3 1994
    1994 Isolation of yeast artificial chromosome clones from 54 polymorphic loci mapped with high odds on human chromosome 4 1994
    1994 A clinical genetic study of parkinson’s disease: Evidence for dominant transmission 1994
    1994 Apolipoprotein E Alleles, Dyslipidemia, and Coronary Heart Disease: The Framingham Offspring Study 1994
    1994 Huntington’s disease cag trinucleotide repeats in pathologically confirmed post-mortem brains 1994
    1994 Neocortical Dendritic Pathology in Human Partial Epilepsy: A Quantitative Golgi Study 1994
    1994 Pituitary cell line GH3 expresses two somatostatin receptor subtypes that inhibit adenylyl cyclase: Functional expression of rat somatostatin receptor subtypes 1 and 2 in human embryonic kidney 293 cells 1994
    1994 Report of the third international workshop on human chromosome 4 mapping 1993 1994
    1993 The development of sequence-tagged sites for human chromosome 4 1993
    1993 Construction of cosmid contigs and high-resolution restriction mapping of the huntington disease region of human chromosome 4 1993
    1993 Sensitivity of HincW to CpG methylation 1993
    1993 A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes 1993
    1993 A radiation hybrid map of the distal short arm of human chromosome 11, containing the Beckwith-Weidemann and associated embryonal tumor disease loci 1993
    1993 De novo expansion of a (CAG)n repeat in sporadic Huntington's disease 1993
    1993 Discrepancy resolved 1993
    1993 Discrimination among potential activators of the β-globin CACCC element by correlation of binding and transcriptional properties 1993
    1993 Evidence for neuronal degeneration and dendritic plasticity in cortical pyramidal neurons of huntington's disease: A quantitative golgi study 1993
    1993 Familial aggregation of stroke the framingham study 1993
    1993 Gametic but not somatic instability of CAG repeat length in Huntington's disease 1993
    1993 Identification and characterization of a β-globin promoter-binding factor from murine erythroleukemia cells 1993
    1993 International Commission for Protection against Environmental Mutagens and Carcinogens. Report of a workshop on the application of molecular genetics to the study of mutation in the children of atomic bomb survivors. 1993
    1993 Report of a workshop on the application of molecular genetics to the study of mutation in the children of atomic bomb survivors 1993
    1993 Segregation analysis for high density lipoprotein in the berkeley data 1993
    1993 The normal Huntington disease (HD) allele, or a closely linked gene, influences age at onset of HD 1993
    1993 The pluses of subtraction 1993
    1993 Trinucleotide repeat length instability and age of onset in Huntington's disease 1993
    1992 Improved sequencing of cosmids using new primers and linearized DNA 1992
    1992 Cloning of the huntington disease region in yeast artificial chromosomes 1992
    1992 Genetic linkage analysis of bipolar affective disorder in an Old Order Amish pedigree 1992
    1992 A radiation hybrid map of the region on human chromosome 22 containing the neurofibromatosis type 2 locus 1992
    1992 A simple and efficient method for attachment of a 40-base pair, GC-rich sequence to PCR-amplified DNA 1992
    1992 Bridging the gaps 1992
    1992 Does the omission of missing information bias the estimates of age-at- onset distributions? [5] 1992
    1992 Evidence of presymptomatic cognitive decline in Huntington's disease 1992
    1992 Familial lipoprotein disorders in patients with premature coronary artery disease 1992
    1992 Family patterns of coronary heart disease mortality: The Framingham Longevity Study 1992
    1992 Huntington's disease: Seven cases with relatively preserved neostriatal islets 1992
    1992 Identification and molecular cloning of a neuropeptide y homolog that produces prolonged inhibition in aplysia neurons 1992
    1992 Inverse relationship between age at onset of Huntington disease and paternal age suggests involvement of genetic imprinting 1992
    1992 Kynurenine pathway abnormalities in Parkinson's disease 1992
    1992 Recombination of 4p16 DNA markers in an unusual family with Huntington disease 1992
    1992 Segregation analysis in Alzheimer disease: No evidence for a major gene [2] 1992
    1992 The Huntington's disease candidate region exhibits many different haplotypes 1992
    1991 A radiation hybrid map of the proximal long arm of human chromosome 11 containing the multiple endocrine neoplasia type 1 (MEN-1) and bcl-1 disease loci 1991
    1991 Dinucleotide repeat polymorphism located at D4S169 1991
    1991 Taql RFLP at D21S137 1991
    1991 Segregation analysis reveals evidence of a major gene for Alzheimer disease 1991
    1991 Identification of polymorphisms by genomic denaturing gradient gel electrophoresis: Application to the proximal region of human chromosome 21 1991
    1991 A map of the distal region of the long arm of human chromosome 21 constructed by radiation hybrid mapping and pulsed-field gel electrophoresis 1991
    1991 Cerebral amyloid angiopathy without and with cerebral hemorrhages: A comparative histological study 1991
    1991 Decreased neuronal and increased oligodendroglial densities in huntington’s disease caudate nucleus 1991
    1991 Estimation of morbid risk and age at onset with missing information 1991
    1991 Factors Associated With Slow Progression in Huntington's Disease 1991
    1991 Invited editorial: The end in sight for Huntington disease? 1991
    1991 Morphometric analysis of the prefrontal cortex in huntington’s disease 1991
    1991 Physical mapping of yeast artificial chromosomes containing sequences from the human β-globin gene region 1991
    1991 Primary structure and functional expression of the 5HT3receptor, a serotonin-gated ion channel 1991
    1991 Understanding the decision to take the predictive test for Huntington disease 1991
    1990 Exon trapping: A genetic screen to identify candidate transcribed sequences in cloned mammalian genomic DNA 1990
    1990 Dinucleotide repeat polymorphism located at D21S120 1990
    1990 A directly repeated sequence in the β-globin promoter regulates transcription in murine erythroleukemia cells 1990
    1990 A cloned DNA segment from the telomeric region of human chromosome 4p is not detectably rearranged in Huntington disease patients 1990
    1990 Analysis of the site in CD4 that binds to the HIV envelope glycoprotein 1990
    1990 Estimation of familial risk in Alzheimer's disease 1990
    1990 Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder 1990
    1990 Multiple sclerosis sibling pairs: Clustered onset and familial predisposition 1990
    1990 Non-hydrophobic extracytoplasmic determinant of stop transfer in the prion protein 1990
    1990 Parental history is an independent risk factor for coronary artery disease: The Framingham Study 1990
    1990 Radiation hybrid mapping: A somatic cell genetic method for constructing high-resolution maps of mammalian chromosomes 1990
    1990 Reply 1990
    1990 Structure and variability of human chromosome ends 1990
    1990 Transmission and age-at-onset patterns in familial alzheimer’s disease: Evidence for heterogeneity 1990
    1990 Unusual topogenic sequence directs prion protein biogenesis 1990
    1989 Genetic and biochemical analysis of the mouse beta-major globin promoter. 1989
    1989 Linkage map of anonymous loci near the CF gene. 1989
    1989 Coronary risk associated with age and sex of parental heart disease in the Framingham Study 1989
    1989 Methylation at the Huntington disease-linked D4S95 locus. 1989
    1989 Assessment of genetic risk for alzheimer's disease among first‐degree relatives 1989
    1989 Attachment of a 40-base-pair G + C-rich sequence (GC-clamp) to genomic DNA fragments by the polymerase chain reaction results in improved detection of single-base changes 1989
    1989 Authors' response to commentaries 1989
    1989 Clustering of multiallele DNA markers near the Huntington's disease gene 1989
    1989 Estimation of fertility and fitness in Huntington disease in New England 1989
    1989 Familial Alzheimer's disease: Progress and problems 1989
    1989 Homozygote for Huntington disease 1989
    1989 Huntington disease: No evidence for locus heterogeneity 1989
    1989 Isolation and field-inversion gel electrophoresis analysis of DNA markers located close to the Huntington disease gene 1989
    1989 Molecular Genetics of Familial Alzheimer's Disease 1989
    1989 Molecular genetics of familial alzheimer’s disease 1989
    1989 Phenotypic variation in 2 huntington’s disease families with linkage to chromosome 4 1989
    1989 Segregation of the Huntington disease region of human chromosome 4 in a somatic cell hybrid 1989
    1989 Using survival methods to estimate age‐at‐onset distributions for genetic diseases with an application to Huntington disease 1989
    1988 Predictive Testing for Huntington's Disease Using Linked DNA Markers 1988
    1988 Predictive Testing for Huntingtons Disease with Use of a Linked DNA Marker 1988
    1988 Clinical and neuropathologic assessment of severity in huntington’s disease 1988
    1988 Considerations in using linkage analysis as a presymptomatic test for Huntington's disease 1988
    1988 DNA sequences involved in transcriptional regulation of the mouse β-globin promoter in murine erythroleukemia cells 1988
    1987 Alterations in DNA helix stability due to base modifications can be evaluated using denaturing gradient gel electrophoresis 1987
    1987 Absence of duplication of chromosome 21 genes in familial and sporadic alzheimer's disease 1987
    1987 Detection and Localization of Single Base Changes by Denaturing Gradient Gel Electrophoresis 1987
    1987 Search for the familial Alzheimer's disease gene. 1987
    1987 The genetic defect causing familial Alzheimer's disease maps on chromosome 21 1987
    1986 Attitudes toward presymptomatic testing in Huntington disease 1986
    1986 Recent advances in the development of methods for detecting single-base substitutions associated with human genetic diseases 1986
    1986 Change in attitudes toward presymptomatic testing in Huntington disease 1986
    1986 Fine structure genetic analysis of a β-globin promoter 1986
    1985 Detection of single base substitutions in total genomic DNA 1985
    1985 Huntington's disease: genetics, chemical pathology, and management. 1985
    1985 Maternal factors in onset of Huntington disease 1985
    1985 Modification of the melting properties of duplex DNA by attachment of a GC-rich DNA sequence as determined by denaturing gradient gel electrophoresis 1985
    1985 Nearly all single base substitutions in DNA fragments joined to a GC-clamp can be detected by denaturing gradient gel electrophoresis 1985
    1985 A general method for saturation mutagenesis of cloned DNA fragments 1985
    1985 Detection of single base substitutions by ribonuclease cleavage at mismatches in RNA:DNA duplexes 1985
    1985 Late onset of Huntington's disease 1985
    1985 Neuropathological classification of huntington’s disease 1985
    1984 Mutational analysis of simian virus 40 large T antigen DNA binding sites. 1984
    1984 Attitudes toward marriage and childbearing of individuals at risk for huntington’s disease 1984
    1984 Increased rate of suicide among patients with Huntington's disease 1984
    1984 Noninvasive cardiology tools and endpoints in genetic epidemiology: the Framingham Study. 1984
    1984 Potential impact of a predictive test on the gene frequency of Huntington disease 1984
    1983 Huntington's disease in monozygotic twins reared apart 1983
    1982 False-Negative Results with Levodopa for Early Detection of Huntington's Disease 1982
    1982 Alzheimer's Disease, Down's Syndrome, and Aging: The Genetic Approach 1982
    1982 Factors related to onset age of Huntington disease 1982
    1981 Does simian virus 40 T antigen unwind DNA? 1981
    1981 Oligomeric structure of a simian virus 40 T antigen in free form and bound to DNA 1981
    1981 SV40 gene expression is modulated by the cooperative binding of T antigen to DNA 1981
    1980 Regulation of simian virus 40 early transcription in vitro by a purified tumor antigen 1980
    1980 Characteristics of a Gibbon-Siamang hybrid ape 1980
    1980 Construction and analysis of simian virus 40 origins defective in tumor antigen binding and DNA replication 1980
    1979 Quantification of muscle tremor of Huntington's disease patients and their offspring in an early detection study 1979
    1979 Hybrid ape offspring of a mating of gibbon and siamang 1979
    1977 Learned aversions to intracerebral carbachol 1977


    Year Title Altmetric
    2016 Advancements in Next-Generation Sequencing.  Ed. 17.  2016


    Year Title Altmetric
    2016 Huntington’s disease.  503-516. 2016
    2015 Mutation detection by PCR, GC-ciamps, and denaturing gradient gel electrophoresis.  71-88. 2015
    2008 The fibroblast growth factor family and mood disorders. 2008

    Full Name

  • Richard Myers