Robin Lorenz M.D., Ph.D.

Robin Lorenz M.D., Ph.D.
Adjunct Professor

Overview

Robin Lorenz received her M.D., Ph.D. in Immunology from Washington University in St. Louis in 1990. She then completed her residency in Clinical Pathology at Barnes-Jewish Hospital, while also doing postdoctoral research in Gastrointestinal Biology at Washington University in St. Louis. Dr. Lorenz was hired at Washington University as an Assistant Professor of Pathology and Medicine in 1994. In addition, she served as the Medical Director of the Joint Clinical Immunology Laboratory for Barnes-Jewish and St. Louis Childrens Hospitals and as the Associate Director of the Laboratory Medicine Residency Training Program. Dr. Lorenz joined the UAB faculty in 2002 as an Associate Professor in the Department of Pathology. The National Institutes of Health, the Strategic Program for Asthma Research, and the Juvenile Diabetes Research Foundation have funded her laboratory research investigating the mucosal immune system. Dr. Lorenz is also Director of the UAB Medical Scientist Training Program and the Physician Scientist Development Office. She is married and has two children.

Selected Publications

Academic Article

Year	Title	Altmetric
2020	Erratum: The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids (Immunity (2017) 47(6) (1182–1196.e10), (S1074761317304892), (10.1016/j.immuni.2017.11.012)) 2020
2019	Optimization of Laboratory Ordering Practices for Complete Blood Count with Differential 2019
2019	Clinical factors and biomarkers predict outcome in patients with immune-mediated thrombotic thrombocytopenic purpura 2019
2018	Management of chronic myeloid leukemia in the setting of pregnancy: when is leukocytapheresis appropriate? A case report and review of the literature 2018
2018	The pathology workforce and clinical licensure: The role of the PhD clinical laboratorian in the United States 2018
2017	The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids 2017
2017	Impact of elective versus required medical school research experiences on career outcomes 2017
2016	Human neutrophil peptides and complement factor Bb in pathogenesis of acquired thrombotic thrombocytopenic purpura 2016
2016	High percentage of evanescent red cell antibodies in patients with sickle cell disease highlights need for a national antibody database 2016
2016	Anti–Blood Group Antibodies in Intravenous Immunoglobulin May Complicate Interpretation of Antibody Titers in ABO-Incompatible Transplantation 2016
2016	Hybrid inhibitor of peripheral cannabinoid-1 receptors and inducible nitric oxide synthase mitigates liver fibrosis. 2016
2016	Altered T-Cell Balance in Lymphoid Organs of a Mouse Model of Colorectal Cancer 2016
2016	Opportunity: Newly Created Physician-Scientist Research Pathway by the American Board of Pathology 2016
2015	Environmental-mediated intestinal homeostasis in neonatal mice 2015
2015	Rescuing the physician-scientist workforce: The time for action is now 2015
2015	Role of the gastrointestinal ecosystem in the development of type 1 diabetes 2015
2015	Response to Comment on Sofi et al. pH of drinking water influences the composition of gut microbiome and type 1 diabetes incidence. Diabetes 2014;63:632-644 2015
2015	Cross-fostering immediately after birth induces a permanent microbiota shift that is shaped by the nursing mother. 2015
2015	Insights into environmental factors impacting celiac disease microbiota modulation of disease pathogenesis 2015
2015	Pathogenesis of necrotizing enterocolitis: Modeling the innate immune response 2015
2014	Consumption of Acidic Water Alters the Gut Microbiome and Decreases the Risk of Diabetes in NOD Mice 2014
2013	Altered generation of induced regulatory T cells in the FVB.mdr1a ^-/- mouse model of colitis 2013
2013	Maintenance of host leukocytes in peripheral immune compartments following lethal irradiation and bone marrow reconstitution: Implications for graft versus host disease 2013
2013	Use of the cockroach antigen model of acute asthma to determine the ammunomodulatory role of early exposure to gastrointestinal infection 2013
2012	Murine P-glycoprotein deficiency alters intestinal injury repair and blunts lipopolysaccharide-induced radioprotection 2012
2012	Gut Microbiota and Obesity. 2012
2011	Critical role for P-glycoprotein expression in hematopoietic cells in the FVB.Mdr1a ^-/- model of colitis 2011
2011	Helicobacter felis-associated gastric disease in microbiota-restricted mice 2011
2010	Perspective: Residency 101 for Physician-Scientists 2010
2010	Role of postnatal acquisition of the intestinal microbiome in the early development of immune function 2010
2010	Toll-like receptor 4 is protective against neonatal murine ischemia-reperfusion intestinal injury 2010
2009	Postgraduate choices of graduates from medical scientist training programs, 2004-2008 2009
2009	Differential susceptibility of P-glycoprotein deficient mice to colitis induction by environmental insults 2009
2009	Gastric mucus alterations associated with murine Helicobacter infection 2009
2008	Celiac disease refractory to a gluten-free diet? Commentary 2008
2008	Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice 2008
2008	Helicobacter pylori Gastritis in Children Is Associated With a Regulatory T-Cell Response 2008
2008	Toll-like receptor 2 is protective of ischemia-reperfusion-mediated small-bowel injury in a murine model 2008
2007	Performance of the Sebia CAPILLARYS 2 for detection and immunotyping of serum monoclonal paraproteins 2007
2007	Two-hit rat model of short bowel syndrome and sepsis: independent of total parenteral nutrition, short bowel syndrome is proinflammatory and injurious to the liver 2007
2007	Expression of CXCL15 (lungkine) in murine gastrointestinal, urogenital and endocrine organs 2007
2006	Safety of celecoxib in patients with ulcerative colitis in remission: A randomized, placebo-controlled, pilot study 2006
2005	The Helicobacter felis model of adoptive transfer gastritis 2005
2005	Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota 2005
2005	Organizing a mucosal defense 2005
2005	Animal models of intestinal inflammation: Ineffective communication between coalition members 2005
2005	Increased prevalence of celiac disease and need for routine screening among patients with osteoporosis 2005
2005	Animal models of intestinal inflammation: ineffective communication between coalition members 2005
2005	Experimental models of inflammatory bowel disease reveal innate, adaptive, and regulatory mechanisms of host dialogue with the microbiota 2005
2004	New developments in experimental models of inflammatory bowel disease 2004
2004	Isolated lymphoid follicles can function as sites for induction of mucosal immune responses 2004
2004	New developments in experimental inflammatory bowel disease 2004
2004	TNFR1 mediates the radioprotective effects of lipopolysaccharide in the mouse intestine 2004
2004	TNFR1 mediates the radioprotective effects of lipopolysaccharide in the mouse intestine. 2004
2003	Isolated lymphoid follicle formation is inducible and dependent upon lymphotoxin-sufficient B lymphocytes, lymphotoxin β receptor, and TNF receptor I function 2003
2003	Toll-like receptor 4 on stromal and hematopoietic cells mediates innate resistance to uropathogenic Escherichia coli 2003
2003	CD14- and toll-like receptor-dependent activation of bladder epithelial cells by lipopolysaccharide and type 1 piliated Escherichia coli 2003
2002	Effect of trimethoprim-sulfamethoxazole on recurrent bacteriuria and bacterial persistence in mice infected with uropathogenic Escherichia coli 2002
2002	A gnotobiotic transgenic mouse model for studying interactions between small intestinal enterocytes and intraepithelial lymphocytes 2002
2002	Recent advances in the molecular basis of pathogen recognition and host responses in the urinary tract 2002
2002	Postgestational lymphotoxin/lymphotoxin β receptor interactions are essential for the presence of intestinal B lymphocytes 2002
2001	A role for IL-1α in inducing pathologic inflammation during bacterial infection 2001
2001	Development of intestinal intraepithelial lymphocytes, NK cells, and NK 1.1⁺ T cells in CD45-deficient mice 2001
2001	Spontaneous and continuous cyclooxygenase-2-dependent prostaglandin E2 production by stromal cells in the murine small intestine lamina propria: Directing the tone of the intestinal immune response 2001
2001	The gastrointestinal ecosystem: A precarious alliance among epithelium, immunity and microbiota 2001
2001	Bacterial invasion augments epithelial cytokine responses to Escherichia coli through a lipopolysaccharide-dependent mechanism 2001
2000	Altered enteroendocrine cell expression in T cell receptor alpha chain knock-out mice 2000
2000	Altered enteroendocrine cell expression in T cell receptor alpha chain knock-out mice. 2000
2000	The requirement for lymphotoxin and Peyer's patches in the development of intestinal lamina propria lymphocytes 2000
2000	Abnormal immune function in vivo in a murine model of lysosomal storage disease 2000
1999	Cellular immune responses are essential for the development of Helicobacter felis-associated gastric pathology 1999
1999	Cyclooxygenase-2-dependent arachidonic acid metabolites are essential modulators of the intestinal immune response to dietary antigen 1999
1999	Molecular basis for the enterocyte tropism exhibited by Salmonella typhimurium type 1 fimbriae 1999
1999	Helicobacter pylori attaches to NeuAcα2,3Galβ1,4 glycoconjugates produced in the stomach of transgenic mice lacking parietal cells 1999
1998	Epithelial attachment alters the outcome of Helicobacter pylori infection 1998
1997	Expression of thin aggregative fimbriae promotes interaction of Salmonella typhimurium SR-11 with mouse small intestinal epithelial 1997
1997	Enzyme-based antigen localization and quantitation in cell and tissue samples (Midwestern assay) 1997
1996	Autoimmune gastritis in a murume transgenic model 1996
1995	Moluccella laevis lectin, a marker for cellular differentiation programs in mouse gut epithelium 1995
1993	Use of transgenic mice to study regulation of gene expression in the parietal cell lineage of gastric units 1993
1991	Identification and characterization of a T cell-inducing epitope of bovine ribonuclease that can be restricted by multiple class II molecules 1991
1991	Problems with therapeutic monitoring of cyclosporine using silicone central venous line samples 1991
1990	Constitutive competition by self proteins for antigen presentation can be overcome by receptor-enhanced uptake 1990
1989	Binding of self-antigens to Ia molecules 1989
1989	Nonopiate active proenkephalin-derived peptides are secreted by T helper cells 1989
1989	Reconstruction of the immunogenic peptide RNase (43-56) by identification and transfer of the critical residues into an unrelated peptide backbone 1989
1989	Thymic cortical epithelial cells can present self-antigens in vivo 1989
1989	Thymic cortical epithelial cells lack full capacity for antigen presentation 1989
1988	T cell recognition of bovine ribonuclease. Self/non-self discrimination at the level of binding to the I-A(k) molecule 1988
1988	Direct evidence for functional self-protein/Ia-molecule complexes in vivo. 1988
1988	Methionine-enkephalin and thyrotropin-stimulating hormone are intimately related in the human anterior pituitary 1988
1988	Processing and Presentation of Self Proteins 1988
1986	Characterization of endorphins from the pituitary of the Spiny Dogfish Squalus acanthias 1986
1985	Effects of dehydration on pro-dynorphin derived peptides in the neuro-intermediate lobe of the rat pituitary 1985
1985	Co-Localization of substance P- and phenylethanolamine-N-methyltransferase-like immunoreactivity in neurons of ventrolateral medulla that project to the spinal cord: Potential role in control of vasomotor tone 1985
1983	Elucidation of the antigenic determinant in lipotropin for two monoclonal antibodies 1983
1983	Identification of gastrin releasing peptide-related substances in guinea pig and rat brain 1983
1982	Variants of alpha-melanocyte stimulating hormone in rat brain and pituitary: Evidence that acetylated α-MSH exists only in the intermediate lobe of pituitary 1982
1982	Hypothalamic catecholamine changes under acute stress occur independently of nicotinic stimulation 1982

Chapter

Year	Title	Altmetric
2017	Data interpretation in laboratory medicine. 489-510. 2017
2008	Microbial Sensing in the Intestine by Pattern Recognition Receptors. 33-43. 2008

Research Overview

Mucosal Immunology - The focus of research in our laboratory is the study of the cellular components of the mucosal immune system and their interactions with the gastrointestinal epithelium, the GI microbiome, and the systemic immune response.