Rui-Ming Liu M.D., Ph.D.

Rui-Ming Liu M.D., Ph.D.
Professor of Medicine

Senior Scientist (C), O'Neal Comprehensive Cancer Center , School of Medicine
Senior Scientist (C), Integrative Center for Aging Research , School of Medicine
Scientist (C), Cystic Fibrosis Research Center , School of Medicine
Senior Scientist, Cancer Control and Population Sciences , O'Neal Comprehensive Cancer Center
Senior Scientist (C), Comprehensive Neuroscience Center , General Clinical Research Center
Professor (P), Medicine - Pulmonary, Allergy, & Critical Care Medicine , Department of Medicine
Associate Professor (S), Medicine - Pulmonary, Allergy, & Critical Care Medicine , Department of Medicine
Professor (S), Environmental Health Sciences , School of Public Health
Assistant Professor (S), Pharmacology and Toxicology , Academic Joint Departments
Associate Professor (S), Mechanical Engineering , School of Engineering

Overview

Dr. Rui-Ming Liu received her M.D. and PhD (in Toxicology) degrees from Tongji Medical University, Wuhan, China. She is an American Board of Toxicology certified Toxicologist. Dr. Liu joined the UAB School of Public Health in 1999 as an Assistant Professor and was promoted to Associate Professor in 2005. In 2014, Dr. Liu was promoted to Professor with tenure and moved from School of Public Health to School of Medicine, Pulmonary, Allergy, and Critical Care Division.

Selected Publications

Academic Article

Year	Title	Altmetric
2021	Divergent Regulation of Alveolar Type 2 Cell and Fibroblast Apoptosis by Plasminogen Activator Inhibitor 1 in Lung Fibrosis. American Journal of Pathology. 191:1227-1239. 2021
2020	Cell senescence and fibrotic lung diseases. Experimental Gerontology. 132. 2020
2020	Monocyte-derived alveolar macrophage apolipoprotein E participates in pulmonary fibrosis resolution. JCI insight. 5. 2020
2020	PAI-1 regulation of TGF-β1-induced alveolar Type II cell senescence, SASP secretion, and SASP-mediated activation of alveolar macrophages. American Journal of Respiratory Cell and Molecular Biology. 62:319-330. 2020
2019	Cyclic O3 exposure synergizes with aging leading to memory impairment in male APOE ε3, but not APOE ε4, targeted replacement mice. Neurobiology of Aging. 81:9-21. 2019
2018	A Small Molecule Inhibitor of Plasminogen Activator Inhibitor-1 Reduces Brain Amyloid-β Load and Improves Memory in an Animal Model of Alzheimer's Disease. Journal of Alzheimer's Disease. 64:447-457. 2018
2017	NADPH oxidase 4 modulates hepatic responses to lipopolysaccharide mediated by Toll-like receptor-4. Scientific Reports. 7. 2017
2017	A Human Long Non-Coding RNA ALT1 Controls the Cell Cycle of Vascular Endothelial Cells Via ACE2 and Cyclin D1 Pathway. Cellular Physiology and Biochemistry. 43:1152-1167. 2017
2017	Metabolic characterization and RNA profiling reveal glycolytic dependence of profibrotic phenotype of alveolar macrophages in lung fibrosis 2017
2017	Serpine 1 induces alveolar type II cell senescence through activating p53-p21-Rb pathway in fibrotic lung disease. Aging Cell. 16:1114-1124. 2017
2017	3D pulmospheres serve as a personalized and predictive multicellular model for assessment of antifibrotic drugs. JCI insight. 2. 2017
2017	miR-34a promotes fibrosis in aged lungs by inducing alveolarepithelial dysfunctions 2017
2017	IP-10/CXCR3 Axis Promotes the Proliferation of Vascular Smooth Muscle Cells through ERK1/2/CREB Signaling Pathway. Cell Biochemistry and Biophysics. 75:139-147. 2017
2017	3D pulmospheres serve as a personalized and predictive multicellular model for assessment of antifibrotic drugs.. JCI insight. 2:e91377. 2017
2017	Exacerbation of diabetic cardiac hypertrophy in OVE26 mice by angiotensin II is associated with JNK/c-Jun/miR-221-mediated autophagy inhibition. Oncotarget. 8:106661-106671. 2017
2017	Low-dose cadmium exposure induces peribronchiolar fibrosis through site-specific phosphorylation of vimentin 2017
2016	Chronic hypoxia increases intracellular Ca(2+) concentration and augments proliferation by enhancing store-operated Ca(2+) entry in pulmonary arterial smooth muscle cells 2016
2016	MicroRNA-27a-3p is a negative regulator of lung fibrosis by targeting myofibroblast differentiation. American Journal of Respiratory Cell and Molecular Biology. 54:843-852. 2016
2016	The matricellular protein CCN1 enhances TGF-β1/SMAD3-dependent profibrotic signaling in fibroblasts and contributes to fibrogenic responses to lung injury. The FASEB Journal. 30:2135-2150. 2016
2016	Role of further-neighbor interactions in modulating the critical behavior of the Ising model with frustration. Physical Review E. 93. 2016
2016	Integrative topological analysis of mass spectrometry data reveals molecular features with clinical relevance in esophageal squamous cell carcinoma. Scientific Reports. 6. 2016
2016	Therapeutic potential of an orally effective small molecule inhibitor of plasminogen activator inhibitor for asthma 2016
2015	Glycolytic reprogramming in myofibroblast differentiation and lung fibrosis. American Journal of Respiratory and Critical Care Medicine. 192:1462-1474. 2015
2015	Reciprocal regulation of TGF-β and reactive oxygen species: A perverse cycle for fibrosis. Redox Biology. 6:565-577. 2015
2015	Cyclic ozone exposure induces gender-dependent neuropathology and memory decline in an animal model of Alzheimer's disease. Toxicological Sciences. 147:222-234. 2015
2015	Influence of O2/Ar on structure and optical properties of ZnO: Mg thin films deposited by RF magnetron sputtering. Guangdianzi Jiguang ==. 26:883-888. 2015
2015	Evidence-based clinical guidelines on medication therapy for juvenile idiopathic arthritis: A systematic review. Zhongguo Xunzheng Yixue Zazhi. 15:152-158. 2015
2015	Evidence-based guidelines on medication therapy for children with rheumatic fever: A systematic review. Zhongguo Xunzheng Yixue Zazhi. 15:23-27. 2015
2015	Experimental investigations of springing and slamming responses of a ultra-VLCC 2015
2015	Investigating the Role of the Post-transcriptional Gene Regulator MIR-24-3p in the Proliferation, Migration and Apoptosis of Human Arterial Smooth Muscle Cells in Arteriosclerosis Obliterans. Cellular Physiology and Biochemistry. 36:1359-1370. 2015
2015	Plasminogen activator inhibitor 1, fibroblast apoptosis resistance, and aging-related susceptibility to lung fibrosis. Experimental Gerontology. 61:62-75. 2015
2014	Therapeutic targeting of Src kinase in myofibroblast differentiation and pulmonary fibrosis. Journal of Pharmacology and Experimental Therapeutics. 351:87-95. 2014
2013	Pleural mesothelial cell differentiation and invasion in fibrogenic lung injury. American Journal of Pathology. 182:1239-1247. 2013
2013	The progress and development trend of the geoscience information technology viewed from the abstracts submitted to the 34th IGC held in Brisbane, Australia. Geological Bulletin of China. 32:685-692. 2013
2013	A new ganoderic acid from Ganoderma lucidum mycelia and its stability. Fitoterapia. 84:115-122. 2013
2013	[The mechanism of inhibition of the increase in intracellular calcium concentration by the islet amyloid polypeptide in high glucose-stimulated INS-1 cells]. 2013
2012	Transforming growth factor β suppresses glutamate-cysteine ligase gene expression and induces oxidative stress in a lung fibrosis model. Free Radical Biology and Medicine. 53:554-563. 2012
2012	Anti-proliferation and induced mitochondria-mediated apoptosis of ganoderic acid Mk from Ganoderma lucidum mycelia in cervical cancer hela cells 2012
2012	Corrigendum to "Ozone exposure is a risk factor for Alzheimer's disease" [Free Radical Biology and Medicine (2011) 51 (S68)). Free Radical Biology and Medicine. 52:1334. 2012
2012	Cytotoxic and pro-apoptotic effects of novel ganoderic acid derivatives on human cervical cancer cells in vitro 2012
2012	Erratum: Ganoderic acid Mf and S induce mitochondria mediated apoptosis in human cervical carcinoma HeLa cells (Phytomedicine (2011) 18 (349-355)). Phytomedicine. 19:569. 2012
2012	Therapeutic value of small molecule inhibitor to plasminogen activator inhibitor-1 for lung fibrosis. American Journal of Respiratory Cell and Molecular Biology. 46:87-95. 2012
2011	Increased transforming growth factor beta 1 expression mediates ozone-induced airway fibrosis in mice. Inhalation Toxicology. 23:486-494. 2011
2011	Knockout of plasminogen activator inhibitor 1 gene reduces amyloid beta peptide burden in a mouse model of Alzheimer's disease. Neurobiology of Aging. 32:1079-1089. 2011
2011	Efficacy and safety of mesalazine versus sulfasalazine for ulcerative colitis: A systematic review. Zhongguo Xunzheng Yixue Zazhi. 11:181-186. 2011
2011	Telbivudine in the treatment of chronic hepatitis B: A systematic review. Zhongguo Xunzheng Yixue Zazhi. 11:101-105. 2011
2011	Pyrolysis and gasification characteristics of coals in different depositional environment. Huaxue Gongcheng/Chemical Engineering. 39:94-97. 2011
2011	Ganoderic acid Mf and S induce mitochondria mediated apoptosis in human cervical carcinoma HeLa cells. Phytomedicine. 18:349-355. 2011
2011	Nonlinear superposition formula for SUSY SG/MKdV equations revisited 2011
2011	Therapeutic potential and anti-amyloidosis mechanisms of tert-butylhydroquinone for Alzheimer's disease. Journal of Alzheimer's Disease. 26:767-778. 2011
2010	Hydro-liquefaction behavior of Shengli brown coal in CO/H2O and H2 /THN systems 2010
2010	Low-dose and standard-dose cyclosporine immunosuppressive therapy in kidney transplant recipients: A meta-analysis of effectiveness and safety. Zhongguo Xunzheng Yixue Zazhi. 10:683-687. 2010
2010	A new ganoderic acid from Ganoderma lucidum mycelia. Journal of Asian Natural Products Research. 12:727-730. 2010
2010	Oxidative modification of nuclear mitogen-activated protein kinase phosphatase 1 is involved in transforming growth factor β1-induced expression of plasminogen activator inhibitor 1 in fibroblasts. Journal of Biological Chemistry. 285:16239-16247. 2010
2010	Oxidative stress and glutathione in TGF-β-mediated fibrogenesis. Free Radical Biology and Medicine. 48:1-15. 2010
2009	Glimepiride therapy for type 2 diabetes mellitus: A systematic review. Zhongguo Xunzheng Yixue Zazhi. 9:1094-1098. 2009
2009	Tacrolimus versus cyclosporine A for simultaneous pancreas-kidney transplant recipients: A meta-analysis. Zhongguo Xunzheng Yixue Zazhi. 9:1214-1219. 2009
2009	On the design of codebook for space division multiple access system. Shanghai Jiao Tong Da Xue Xue Bao ==. 43:385-388. 2009
2008	Oxidative stress, plasminogen activator inhibitor 1, and lung fibrosis. Antioxidants and Redox Signaling. 10:303-319. 2008
2008	Methodology research of high-speed counter-current chromatography in separation of natural products. Chinese Journal of Natural Medicines. 6:13-19. 2008
2007	Glutathione suppresses TGF-β-induced PAI-1 expression by inhibiting p38 and JNK MAPK and the binding of AP-1, SP-1, and Smad to the PAI-1 promoter 2007
2006	γ-Glutamyl transpeptidase is induced by 4-hydroxynonenal via EpRE/Nrf2 signaling in rat epithelial type II cells. Free Radical Biology and Medicine. 40:1281-1292. 2006
2005	Glutathione restores collagen degradation in TGF-β-treated fibroblasts by blocking plasminogen activator inhibitor-1 expression and activating plasminogen 2005
2004	Glutathione regulates transforming growth factor-β-stimulated collagen production in fibroblasts 2004
2003	Decreased Synthetic Capacity Underlies the Age-Associated Decline in Glutathione Content in Fisher 344 Rats. Antioxidants and Redox Signaling. 5:529-536. 2003
2002	Down-regulation of γ-glutamylcysteine synthetase regulatory subunit gene expression in rat brain tissue during aging. Journal of Neuroscience Research. 68:344-351. 2002
2001	4-Hydroxy-2-nonenal increases γ-glutamylcysteine synthetase gene expression in alveolar epithelial cells. American Journal of Respiratory Cell and Molecular Biology. 24:499-505. 2001
2001	Oxidant-induced regulation of glutathione synthesis. 2001
1999	Depletion of glutathione by buthionine sulfoximine is cytotoxic for human neuroblastoma cell lines via apoptosis. Experimental Cell Research. 246:183-192. 1999
1998	Quinones increase γ-glutamyl transpeptidase expression by multiple mechanisms in rat lung epithelial cells 1998
1997	Adaptation to oxidative stress: Quinone-mediated protection of signaling in rat lung epithelial L2 cells. Biochemical Pharmacology. 53:987-993. 1997
1996	Differential Enhancement of γ-Glutamyl Transpeptidase and γ-Glutamylcysteine Synthetase by Tert-butylhydroquinone in Rat Lung Epithelial L2 Cells. American Journal of Respiratory Cell and Molecular Biology. 14:186-191. 1996
1996	Increased γ-Glutamylcysteine Synthetase and γ-Glutamyl Transpeptidase Activities Enhance Resistance of Rat Lung Epithelial L2 Cells to Quinone Toxicity. American Journal of Respiratory Cell and Molecular Biology. 14:192-197. 1996
1994	gamma-Glutamyl transpeptidase is increased by oxidative stress in rat alveolar L2 epithelial cells.. American Journal of Respiratory Cell and Molecular Biology. 11:586-592. 1994

Research Overview

Dr. Liu’s laboratory research focuses on oxidative stress, aging, and aging-related diseases, mainly Idiopathic Pulmonary Fibrosis (IPF). Her lab is interested in the etiologies and pathogeneses as well as the development of therapeutics for the treatment of these diseases. Specifically, the lab is interested in the mechanism and biological significance of depletion of glutathione (GSH), the most abundant intracellular free thiol and an important antioxidant, during aging and in IPF; the mechanisms whereby plasminogen activator inhibitor 1 (PAI-1), a physiological inhibitor of urokinase type and tissue type plasminogen activators, promotes cell senescence, aging, and fibrosis as well as the therapeutic potential of small molecule of PAI-1 inhibitors for the treatment of lung fibrotic diseases; and Interaction between genetic and environmental factors as well as aging in the onset of Alzheimer’s disease.