Positions

Selected Publications

Academic Article

Year Title Altmetric
2018 Hydroxyproline metabolism and oxalate synthesis in primary hyperoxaluriaJournal of the American Society of Nephrology.  29:1615-1623. 2018
2018 Oxalate induces mitochondrial dysfunction and disrupts redox homeostasis in a human monocyte derived cell lineRedox Biology.  15:207-215. 2018
2017 The L530R variation associated with recurrent kidney stones impairs the structure and function of TRPV5Biochemical and Biophysical Research Communications.  492:362-367. 2017
2017 Steatorrhea and Hyperoxaluria in Severely Obese Patients Before and After Roux-en-Y Gastric BypassGastroenterology.  152:1055-1067.e3. 2017
2017 An investigational RNAi therapeutic targeting glycolate oxidase reduces oxalate production in models of primary hyperoxaluriaJournal of the American Society of Nephrology.  28:494-503. 2017
2016 RNA interference in the treatment of renal stone disease: Current status and future potentialsInternational Journal of Surgery.  36:713-716. 2016
2016 Ascorbic acid intake and oxalate synthesisUrolithiasis.  44:289-297. 2016
2016 Monocyte Mitochondrial Function in Calcium Oxalate Stone FormersUrology.  93:224.e1-224.e6. 2016
2016 Effects of alanine: Glyoxylate aminotransferase variants and pyridoxine sensitivity on oxalate metabolism in a cell-based cytotoxicity assayBBA - Molecular Basis of Disease.  1862:1055-1062. 2016
2016 Oxalate Concentrations in Human Gastrointestinal FluidJournal of Endourology and Part B, Videourology.  30:S8-S11. 2016
2016 Molecular Modeling of the Structural and Dynamical Changes in Calcium Channel TRPV5 Induced by the African-Specific A563T VariationBiochemistry.  55:1254-1264. 2016
2016 Lowering urinary oxalate excretion to decrease calcium oxalate stone diseaseUrolithiasis.  44:27-32. 2016
2016 Metabolism of 13C5-hydroxyproline in mouse models of Primary Hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenaseBBA - Molecular Basis of Disease.  1862:233-239. 2016
2016 Oxalate formation from glyoxal in erythrocytesUrology.  88:226.e11-226.e15. 2016
2015 Hydroxyproline metabolism in a mouse model of Primary Hyperoxaluria Type 3BBA - Molecular Basis of Disease.  1852:2700-2705. 2015
2015 Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluriaBiochemical Journal.  466:273-281. 2015
2015 A mutation creating an out-of-frame alternative translation initiation site in the GRHPR 5′UTR causing primary hyperoxaluria type IIClinical Genetics.  88:494-498. 2015
2012 Hydroxyproline metabolism in mouse models of primary hyperoxaluriaAJP - Renal Physiology.  302. 2012
2012 Metabolism of [ 13C 5]hydroxyproline in vitro and in vivo: Implications for primary hyperoxaluriaAJP - Gastrointestinal and Liver Physiology.  302. 2012
2012 The association of cardiovascular disease and metabolic syndrome with nephrolithiasisCurrent Opinion in Urology.  22:154-159. 2012
2012 Multibacterial growth from a surgical renal stone culture: a case report and literature review.Reviews in Urology.  14:108-114. 2012
2011 Variability in urinary oxalate measurements between six international laboratoriesNephrology Dialysis Transplantation.  26:3954-3959. 2011
2011 Difficulties with access in percutaneous renal surgeryJournal of Endourology and Part B, Videourology.  25:1689-1690. 2011
2011 Re: Oxalate and sucralose absorption in idiopathic calcium oxalate stone formersJournal of Urology, The.  186:1916-1917. 2011
2011 Impact of dietary calcium and oxalate, and oxalobacter formigenes colonization on urinary oxalate excretionJournal of Urology, The.  186:135-139. 2011
2011 Metabolism of primed, constant infusions of [1,2-13C 2] glycine and [1-13C1] phenylalanine to urinary oxalateMetabolism.  60:950-956. 2011
2011 Oxalate and sucralose absorption in idiopathic calcium oxalate stone formersUrology.  78:475.e9-475.e13. 2011
2006 Glyoxylate reductase activity in blood mononuclear cells and the diagnosis of primary hyperoxaluria type 2Nephrology Dialysis Transplantation.  21:2292-2295. 2006
2005 Genetic and dietary factors in urinary citrate excretionJournal of Endourology and Part B, Videourology.  19:177-182. 2005
2005 Mitochondrial hydroxyproline metabolism: Implications for primary hyperoxaluriaAmerican Journal of Nephrology.  25:171-175. 2005
2005 Dietary oxalate loads and renal oxalate handlingJournal of Urology, The.  174:943-947. 2005
2004 Glycolate and glyoxylate metabolism in HepG2 cellsAmerican Journal of Physiology - Cell Physiology.  287. 2004
2004 The impact of dietary oxalate on kidney stone formationUrological Research.  32:311-316. 2004
2001 (L)-2-oxothiazolidine-4-carboxylate in the treatment of primary hyperoxaluria type 1BJU International.  88:858-862. 2001
2001 Contribution of dietary oxalate to urinary oxalate excretionKidney International.  59:270-276. 2001
2000 Identification of missense, nonsense, and deletion mutations in the GRHPR gene in patients with primary hyperoxaluria type II (PH2)Human Genetics.  107:176-185. 2000
2000 Role of diet in the therapy of urolithiasisUrologic Clinics of North America.  27:255-268. 2000
1997 Pathways of hepatic oxalate synthesis and their regulationAmerican Journal of Physiology.  272. 1997
1997 Genes in idiopathic calcium oxalate stone diseaseWorld Journal of Urology.  15:186-194. 1997
1997 Pathways of hepatic oxalate synthesis and their regulation.American Journal of Physiology.  272:C289-C294. 1997
1997 The effects of (L)-2-oxothiazolidine-4-carboxylate on urinary oxalate excretionJournal of Urology, The.  158:34-37. 1997
1996 Re: Family pattern of idiopathic hypercalciuria and its subtypesJournal of Urology, The.  156:2012. 1996
1995 Dietary oxalate and its intestinal absorptionScanning microscopy.  9:1109-1120. 1995
1995 Glucagon increases urinary oxalate excretion in the guinea pig.American Journal of Physiology.  269:E568-E574. 1995
1995 Genetic Factors in Calcium Oxalate Stone DiseaseJournal of Urology, The.  153:301-307. 1995
1995 Glucagon increases urinary oxalate excretion in the guinea pigAJP - Endocrinology and Metabolism.  269. 1995
1995 Measurement of urinary oxalate and citrate by capillary electrophoresis and indirect ultraviolet absorbanceClinical Chemistry.  41:1297-1301. 1995
1993 The absence of glyxylate cycle enzymes in rodent and embryonic chick liverBBA - General Subjects.  1158:47-51. 1993
1993 Relationship of protein intake to urinary oxalate and glycolate excretionKidney International.  44:366-372. 1993
1992 Recent developments in assays for taurine, hypotaurine and some metabolic precursorsAdvances in human genetics.  315:423-428. 1992
1992 Tetrodotoxin protects against acute ischemic renal failure in the ratJournal of Urology, The.  147:519-522. 1992
1989 Selective elevation of urinary enzyme levels after extracorporeal shock wave lithotripsyJournal of Urology, The.  142:687-690. 1989
1987 Failure of leukotriene B 4 to translocate calcium across phosphatidylcholine membranesCell Calcium.  8:449-454. 1987

Investigator On

  • Obesity and Endogenous Oxalate Synthesis  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • Glycolate Metabolism and Kidney Oxalate  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017 - 2022
  • Hypercalciuria and TRPV6-Mediated Active Calcium Reabsorption in the Proximal Tubule  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017 - 2022
  • Monocyte Mitochondrial Dysfunction and Kidney Stone Disease  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2016 - 2021
  • Oxalobacter Formigenes Colonization and Oxalate Excretion in Calcium Oxalate Kidney Stone Disease  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017 - 2021
  • Influence of Obesity on Endogenous Oxalate Synthesis  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2020
  • Influence of Obesity on Endogenous Oxalate Synthesis - Project  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2020
  • Private Grant  awarded by ALNYLAM PHARMACEUTICALS, INC. 2018 - 2019
  • Hydroxyproline Dehydrogenase and Glycolate Oxidase as Targets for Lowering Urinary Oxalate Excretion  awarded by WAKE FOREST BAPTIST HEALTH 2017 - 2018
  • Inhibition of Oxalate Synthesis by RNA Interference Rare Kidney Stone Consortium  awarded by MAYO CLINIC 2017 - 2018
  • Oxalate Handling and Oxalobacter Formigenes Colonization in a Mouse Model  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2013 - 2017
  • Private Grant  awarded by ALNYLAM PHARMACEUTICALS, INC. 2014 - 2015
  • Hereditary Causes of Nephrolitiasis and Kidney Failure  awarded by MAYO CLINIC 2012 - 2014
  • Education And Training

  • Doctor of Philosophy in Biochemistry, The Australian National University 1978
  • Full Name

  • Ross Holmes