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Ross Holmes
Professor
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rholmes@uab.edu
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Ross Holmes
Professor
Positions
Professor (P)
,
Urology
,
School of Medicine
2012 -
Senior Scientist (C)
,
Nephrology Research & Training Center
,
General Clinical Research Center
2014 -
Senior Scientist (C)
,
Nutrition Obesity Res Center (NORC)
,
Nutrition Sciences Research
2018 -
Publications
Research
Background
Contact
Publications
Selected Publications
Academic Article
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Year
Title
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2018
Hydroxyproline metabolism and oxalate synthesis in primary hyperoxaluria
.
Journal of the American Society of Nephrology
. 29:1615-1623.
2018
2018
Oxalate induces mitochondrial dysfunction and disrupts redox homeostasis in a human monocyte derived cell line
.
Redox Biology
. 15:207-215.
2018
2017
The L530R variation associated with recurrent kidney stones impairs the structure and function of TRPV5
.
Biochemical and Biophysical Research Communications
. 492:362-367.
2017
2017
Steatorrhea and Hyperoxaluria in Severely Obese Patients Before and After Roux-en-Y Gastric Bypass
.
Gastroenterology
. 152:1055-1067.e3.
2017
2017
An investigational RNAi therapeutic targeting glycolate oxidase reduces oxalate production in models of primary hyperoxaluria
.
Journal of the American Society of Nephrology
. 28:494-503.
2017
2016
RNA interference in the treatment of renal stone disease: Current status and future potentials
.
International Journal of Surgery
. 36:713-716.
2016
2016
Ascorbic acid intake and oxalate synthesis
.
Urolithiasis
. 44:289-297.
2016
2016
Monocyte Mitochondrial Function in Calcium Oxalate Stone Formers
.
Urology
. 93:224.e1-224.e6.
2016
2016
Effects of alanine: Glyoxylate aminotransferase variants and pyridoxine sensitivity on oxalate metabolism in a cell-based cytotoxicity assay
2016
2016
Oxalate Concentrations in Human Gastrointestinal Fluid
2016
2016
Molecular Modeling of the Structural and Dynamical Changes in Calcium Channel TRPV5 Induced by the African-Specific A563T Variation
.
Biochemistry
. 55:1254-1264.
2016
2016
Lowering urinary oxalate excretion to decrease calcium oxalate stone disease
.
Urolithiasis
. 44:27-32.
2016
2016
Metabolism of
13
C
5
-hydroxyproline in mouse models of Primary Hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenase
2016
2016
Oxalate formation from glyoxal in erythrocytes
.
Urology
. 88:226.e11-226.e15.
2016
2015
Hydroxyproline metabolism in a mouse model of Primary Hyperoxaluria Type 3
2015
2015
Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria
.
Biochemical Journal
. 466:273-281.
2015
2015
A mutation creating an out-of-frame alternative translation initiation site in the GRHPR 5′UTR causing primary hyperoxaluria type II
2015
2012
Hydroxyproline metabolism in mouse models of primary hyperoxaluria
2012
2012
Metabolism of [
13
C
5
]hydroxyproline in vitro and in vivo: Implications for primary hyperoxaluria
2012
2012
The association of cardiovascular disease and metabolic syndrome with nephrolithiasis
.
Current Opinion in Urology
. 22:154-159.
2012
2012
Multibacterial growth from a surgical renal stone culture: a case report and literature review.
.
Reviews in Urology
. 14:108-114.
2012
2011
Variability in urinary oxalate measurements between six international laboratories
.
Nephrology Dialysis Transplantation
. 26:3954-3959.
2011
2011
Difficulties with access in percutaneous renal surgery
2011
2011
Re: Oxalate and sucralose absorption in idiopathic calcium oxalate stone formers
2011
2011
Impact of dietary calcium and oxalate, and oxalobacter formigenes colonization on urinary oxalate excretion
2011
2011
Metabolism of primed, constant infusions of [1,2-
13
C
2
] glycine and [1-
13
C
1
] phenylalanine to urinary oxalate
2011
2011
Oxalate and sucralose absorption in idiopathic calcium oxalate stone formers
.
Urology
. 78:475.e9-475.e13.
2011
2006
Glyoxylate reductase activity in blood mononuclear cells and the diagnosis of primary hyperoxaluria type 2
.
Nephrology Dialysis Transplantation
. 21:2292-2295.
2006
2005
Genetic and dietary factors in urinary citrate excretion
2005
2005
Mitochondrial hydroxyproline metabolism: Implications for primary hyperoxaluria
.
American Journal of Nephrology
. 25:171-175.
2005
2005
Dietary oxalate loads and renal oxalate handling
2005
2004
Glycolate and glyoxylate metabolism in HepG2 cells
2004
2004
The impact of dietary oxalate on kidney stone formation
.
Urolithiasis
. 32:311-316.
2004
2001
(L)-2-oxothiazolidine-4-carboxylate in the treatment of primary hyperoxaluria type 1
.
BJU International
. 88:858-862.
2001
2001
Contribution of dietary oxalate to urinary oxalate excretion
.
Kidney International
. 59:270-276.
2001
2000
Identification of missense, nonsense, and deletion mutations in the GRHPR gene in patients with primary hyperoxaluria type II (PH2)
.
Human Genetics
. 107:176-185.
2000
2000
Role of diet in the therapy of urolithiasis
.
Urologic Clinics of North America
. 27:255-268.
2000
1997
Genes in idiopathic calcium oxalate stone disease
.
World Journal of Urology
. 15:186-194.
1997
1997
Pathways of hepatic oxalate synthesis and their regulation
.
American Journal of Physiology
. 272.
1997
1997
Pathways of hepatic oxalate synthesis and their regulation.
.
American Journal of Physiology
. 272:C289-C294.
1997
1997
The effects of (L)-2-oxothiazolidine-4-carboxylate on urinary oxalate excretion
1997
1996
Re: Family pattern of idiopathic hypercalciuria and its subtypes
1996
1995
Dietary oxalate and its intestinal absorption
.
Scanning microscopy
. 9:1109-1120.
1995
1995
Glucagon increases urinary oxalate excretion in the guinea pig.
.
American Journal of Physiology
. 269:E568-E574.
1995
1995
Genetic Factors in Calcium Oxalate Stone Disease
1995
1995
Glucagon increases urinary oxalate excretion in the guinea pig
1995
1995
Measurement of urinary oxalate and citrate by capillary electrophoresis and indirect ultraviolet absorbance
1995
1993
The absence of glyxylate cycle enzymes in rodent and embryonic chick liver
1993
1993
Relationship of protein intake to urinary oxalate and glycolate excretion
.
Kidney International
. 44:366-372.
1993
1992
Recent developments in assays for taurine, hypotaurine and some metabolic precursors
.
Advances in human genetics
. 315:423-428.
1992
1992
Tetrodotoxin protects against acute ischemic renal failure in the rat
1992
1989
Selective elevation of urinary enzyme levels after extracorporeal shock wave lithotripsy
1989
1987
Failure of leukotriene B
4
to translocate calcium across phosphatidylcholine membranes
.
Cell Calcium
. 8:449-454.
1987
Research
Principal Investigator On
Influence of Obesity on Oxalate Metabolism and Handling in Calcium Oxalate Stone Formers-Project-Core
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
2020 - 2022
4-Hydroxy-2-Oxoglutarate Metabolism in PH3
awarded by
Oxalosis and Hyperoxaluria Foundation
2020 - 2021
Influence of Obesity on Endogenous Oxalate Synthesis - Project
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
2018 - 2020
Mitochondrial Metabolism in Primary Hyperoxaluria
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
2014 - 2018
Glyoxal: A Novel Source of Endogenous Oxalate Synthesis and Its Clinical Contribution to Kidney Stones
awarded by
UROLOGY CARE FOUNDATION
2016 - 2018
Hydroxyproline Dehydrogenase as a Target for Lowering Urinary Oxalate Excretion
awarded by
WAKE FOREST UNIVERSITY
2015 - 2017
Metabolism Associated with Hyperoxaluria and Calcium Oxalate Stone Disease
awarded by
UROLOGY CARE FOUNDATION
2014 - 2016
Endogenous Oxalate Synthesis
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
2013 - 2016
Hereditary Causes of Nephrolithiasis and Kidney Failure
awarded by
MAYO CLINIC
2012 - 2014
Hydroxyproline Catabolism and Hyperoxaluria
awarded by
WAKE FOREST UNIVERSITY
2012 - 2014
Phenotypic Changes Associated with PH3
awarded by
WAKE FOREST UNIVERSITY
2012 - 2013
Investigator On
Interdisciplinary Training In Kidney-Related Research
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
2019 - 2024
Obesity and Endogenous Oxalate Synthesis
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
2018 - 2023
PRedoctoral Interdisciplinary Training in Renal Physiology and MEdIcIne (PRIME)
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
2018 - 2023
Private Grant
awarded by
CHINOOK THERAPEUTICS, INC
2019 - 2022
Glycolate Metabolism and Kidney Oxalate
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
2017 - 2022
The Influence of Obesity on Oxalate Metabolism and Handling in Calcium Oxalate Stone Formers
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
2020 - 2022
Hypercalciuria and TRPV6-Mediated Active Calcium Reabsorption in the Proximal Tubule
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
2017 - 2022
Oxalobacter Formigenes Colonization and Oxalate Excretion in Calcium Oxalate Kidney Stone Disease
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
2017 - 2022
Monocyte Mitochondrial Dysfunction and Kidney Stone Disease
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
2016 - 2021
Influence of Obesity on Endogenous Oxalate Synthesis
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
2018 - 2020
Influence of Obesity on Endogenous Oxalate Synthesis - Project
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
2018 - 2020
Private Grant
awarded by
ALNYLAM PHARMACEUTICALS, INC.
2018 - 2019
Hydroxyproline Dehydrogenase and Glycolate Oxidase as Targets for Lowering Urinary Oxalate Excretion
awarded by
WAKE FOREST BAPTIST HEALTH
2017 - 2018
Inhibition of Oxalate Synthesis by RNA Interference Rare Kidney Stone Consortium
awarded by
MAYO CLINIC
2017 - 2018
Oxalate Handling and Oxalobacter Formigenes Colonization in a Mouse Model
awarded by
National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS
2013 - 2017
Private Grant
awarded by
ALNYLAM PHARMACEUTICALS, INC.
2014 - 2015
Hereditary Causes of Nephrolitiasis and Kidney Failure
awarded by
MAYO CLINIC
2012 - 2014
Background
Education And Training
Doctor of Philosophy in Biochemistry,
The Australian National University
1978
Contact
Full Name
Ross
Holmes