Selected Publications

Academic Article

Year Title Altmetric
2021 Quantitative assessment of successive carbohydrate additions to the clustered O-glycosylation sites of IgA1 by glycosyltransferasesGlycobiology.  31:540-556. 2021
2021 Stability of the Retinoid X Receptor-α Homodimer in the Presence and Absence of Rexinoid and Coactivator PeptideBiochemistry.  60:1165-1177. 2021
2020 Analysis of O-glycoforms of the IgA1 hinge region by sequential deglycosylationScientific Reports.  10. 2020
2020 Glycan Positioning Impacts HIV-1 Env Glycan-Shield Density, Function, and Recognition by AntibodiesiScience.  23. 2020
2020 Longitudinal Changes in Health-Related Quality of Life in Primary Glomerular Disease: Results From the CureGN StudyKidney International Reports.  5:1679-1689. 2020
2020 Persistent Disease Activity in Patients With Long-Standing Glomerular DiseaseKidney International Reports.  5:860-871. 2020
2020 Mass spectrometry for the identification and analysis of highly complex glycosylation of therapeutic or pathogenic proteinsExpert Review of Proteomics.  17:275-296. 2020
2019 IgA1 hinge-region clustered glycan fidelity is established early during semi-ordered glycosylation by GalNAc-T2Glycobiology.  29:543-556. 2019
2019 Glycosylation in health and diseaseNature Reviews Nephrology.  15:346-366. 2019
2019 Glycosylation of viral surface proteins probed by mass spectrometryCurrent Opinion in Virology.  36:56-66. 2019
2019 Health-related quality of life in glomerular diseaseKidney International.  95:1209-1224. 2019
2019 Human neutrophil peptide-1 inhibits thrombus formation under arterial flow via its terminal free cysteine thiolsJournal of Thrombosis and Haemostasis.  17:596-606. 2019
2019 Pyrazolopyrimidinones, a novel class of copper-dependent bactericidal antibiotics against multi-drug resistant: S. aureus 2019
2019 CureGN Study Rationale, Design, and Methods: Establishing a Large Prospective Observational Study of Glomerular DiseaseAmerican Journal of Kidney Diseases.  73:218-229. 2019
2019 Defining HIV-1 envelope N-glycan microdomains through site-specific heterogeneity profilesJournal of Virology.  93. 2019
2018 Clinical Characteristics and Treatment Patterns of Children and Adults With IgA Nephropathy or IgA Vasculitis: Findings From the CureGN StudyKidney International Reports.  3:1373-1384. 2018
2018 Aberrant Glycosylation of the IgA1 Molecule in IgA NephropathySeminars in Nephrology.  38:461-476. 2018
2018 Phosphorylation of Pnut in the early stages of Drosophila embryo development affects association of the septin complex with the membrane and is important for viability 2018
2018 Serum galactose-deficient-IgA1 and IgG autoantibodies correlate in patients with IgA nephropathyPLoS ONE.  13. 2018
2017 Role of remodeling and spacing factor 1 in histone H2A ubiquitination-mediated gene silencing 2017
2017 What insights can proteomics give us into IgA nephropathy (Berger’s disease)?Expert Review of Proteomics.  14:645-647. 2017
2017 Efficient, ultra-high-Affinity chromatography in a one-step purification of complex proteins 2017
2016 Training in metabolomics research. II. Processing and statistical analysis of metabolomics data, metabolite identification, pathway analysis, applications of metabolomics and its futureJournal of Mass Spectrometry.  51:535-548. 2016
2016 Training in metabolomics research. II. Processing and statistical analysis of metabolomics data, metabolite identification, pathway analysis, applications of metabolomics and its futureJournal of Mass Spectrometry.  51:535-548. 2016
2016 Training in metabolomics research. I. Designing the experiment, collecting and extracting samples and generating metabolomics dataJournal of Mass Spectrometry.  461-475. 2016
2016 Training in metabolomics research. I. Designing the experiment, collecting and extracting samples and generating metabolomics dataJournal of Mass Spectrometry.  51:ii-iii. 2016
2016 The origin and activities of IgA1-containing immune complexes in IGA nephropathyFrontiers in Immunology.  7. 2016
2016 Somatic mutations modulate autoantibodies against galactose-deficient IgA1 in IgA nephropathyJournal of the American Society of Nephrology.  27:3278-3284. 2016
2015 General N- and O-linked glycosylation of lipoproteins in mycoplasmas and role of exogenous oligosaccharidePLoS ONE.  10. 2015
2015 New Insights into the Pathogenesis of IgA Nephropathy.Kidney Diseases.  1:8-18. 2015
2015 Rac1 modification by an electrophilic 15-deoxy δ12,14-prostaglandin J2 analogRedox Biology.  4:346-354. 2015
2015 N-Acetylgalactosaminide α2,6-sialyltransferase II is a candidate enzyme for sialylation of galactose-deficient IgA1, the key autoantigen in IgA nephropathyNephrology Dialysis Transplantation.  30:234-238. 2015
2015 The serum very-low-density lipoprotein serves as a restriction factor against hepatitis C virus infectionJournal of Virology.  89:6782-6791. 2015
2014 Enzymatic sialylation of IgA1 O-glycans: Implications for studies of IgA nephropathyPLoS ONE.  9. 2014
2014 Self-poisoning of Mycobacterium tuberculosis by interrupting siderophore recycling 2014
2014 Defining the communication between agonist and coactivator binding in the retinoid x receptor α ligand binding domainJournal of Biological Chemistry.  289:814-826. 2014
2013 O-linked protein glycosylation in mycoplasma 2013
2013 Biomarkers in IgA nephropathy: Relationship to pathogenetic hitsExpert Opinion on Medical Diagnostics.  7:615-627. 2013
2013 Elucidating heterogeneity of IgA1 hinge-region O-glycosylation by use of MALDI-TOF/TOF mass spectrometry: Role of cysteine alkylation during sample processing 2013
2013 USP49 deubiquitinates histone H2B and regulates cotranscriptional pre-mRNA splicingGenes and Development.  27:1581-1595. 2013
2013 Pathogenesis of immunoglobulin A nephropathyCurrent Opinion in Nephrology and Hypertension.  22:287-294. 2013
2013 IgA nephropathy: Molecular mechanisms of the diseaseAnnual Review of Pathology: Mechanisms of Disease.  8:217-240. 2013
2013 Ubp-M serine 552 phosphorylation by cyclin-dependent kinase 1 regulates cell cycle progressionCell Cycle.  12:3408-3416. 2013
2012 Glycosylation of IgA1 and pathogenesis of IgA nephropathySpringer Seminars in Immunopathology.  34:365-382. 2012
2012 SRY (sex determining region Y)-box2 (Sox2)/poly ADP-ribose polymerase 1 (Parp1) complexes regulate pluripotency 2012
2012 Naturally occurring structural isomers in serum IgA1 O -glycosylationJournal of Proteome Research.  11:692-702. 2012
2012 Production of N-acetylgalactosaminyl-transferase 2 (GalNAc-T2) fused with secretory signal Igκ in insect cellsProtein Expression and Purification.  81:175-180. 2012
2011 The pathophysiology of IgA nephropathyJournal of the American Society of Nephrology.  22:1795-1803. 2011
2011 Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activitiesJournal of Molecular Biology.  412:94-110. 2011
2011 Regulation of histone H2A and H2B deubiquitination and xenopus development by USP12 and USP46Journal of Biological Chemistry.  286:7190-7201. 2011
2011 Structure, energetics, and dynamics of binding coactivator peptide to the human retinoid X receptor α ligand binding domain complex with 9- cis -retinoic acidBiochemistry.  50:93-105. 2011
2010 Clustered O-glycans of IgA1: Defining macro- and microheterogeneity by use of electron capture/transfer dissociationMolecular and Cellular Proteomics.  9:2545-2557. 2010
2010 Tissue localization and solubilities of αA-crystallin and its numerous C-terminal truncation products in pre- and postcataractous ICR/F Rat lensesInvestigative Ophthalmology and Visual Science.  51:5153-5161. 2010
2010 Glycosylation patterns of HIV-1 gp120 depend on the type of expressing cells and affect antibody recognitionJournal of Biological Chemistry.  285:20860-20869. 2010
2010 The RNA polymerase-associated factor 1 complex (Paf1C) directly increases the elongation rate of RNA polymerase I and is required for efficient regulation of rRNA synthesisJournal of Biological Chemistry.  285:14152-14159. 2010
2010 Comparison of methods for profiling O-glycosylation: Human proteome organisation human disease glycomics/proteome initiative multi-institutional study of IgA1Molecular and Cellular Proteomics.  9:719-727. 2010
2009 Mycobacterium tuberculosis WhiB3 Maintains redox homeostasis by regulating virulence lipid anabolism to modulate macrophage responsePLoS Pathogens.  5. 2009
2009 Drosophila Orc6 facilitates GTPase activity and filament formation of the septin complex 2009
2008 Analysis of IgA1 N-glycosylation and its contribution to FcαRI bindingBiochemistry.  47:11285-11299. 2008
2008 High-resolution mass spectrometry analysis of protein oxidations and resultant loss of functionBiochemical Society Transactions.  36:1037-1044. 2008
2008 Probing Conserved Helical Modules of Portal Complexes by Mass Spectrometry-based Hydrogen/Deuterium ExchangeJournal of Molecular Biology.  381:772-784. 2008
2008 SNO-hemoglobin is not essential for red blood cell-dependent hypoxic vasodilationNature Medicine.  14:773-777. 2008
2008 Atrial natriuretic peptide inhibits transforming growth factor β-induced Smad signaling and myofibroblast transformation in mouse cardiac fibroblastsCirculation Research.  102:185-192. 2008
2008 Inactivation of human liver bile acid CoA:amino acid N-acyltransferase by the electrophilic lipid, 4-hydroxynonenalJournal of Lipid Research.  49:282-294. 2008
2008 Role of aberrant glycosylation of IgA1 molecules in the pathogenesis of iga nephropathyKidney and Blood Pressure Research.  31:29-37. 2008
2007 Analysis of O-glycan heterogeneity in IgA1 myeloma proteins by Fourier transform ion cyclotron resonance mass spectrometry: Implications for IgA nephropathy 2007
2007 Active site modifications of the brain isoform of creatine kinase by 4-hydroxy-2-nonenal correlate with reduced enzyme activity: Mapping of modified sites by fourier transform-ion cyclotron resonance mass spectrometryChemical Research in Toxicology.  20:1260-1268. 2007
2007 IgA nephropathy and henoch-schoenlein purpura nephritis: Aberrant glycosylation of IgA1, formation of IgA1-containing immune complexes, and activation of mesangial cellsContributions to Nephrology.  157:134-138. 2007
2006 Biomarker discovery by CE-MS enables sequence analysis via MS/MS with platform-independent separationELECTROPHORESIS.  27:2111-2125. 2006
2005 Determination of aberrant O-glycosylation in the IgA1 hinge region by electron capture dissociation Fourier transform-ion cyclotron resonance mass spectrometryJournal of Biological Chemistry.  280:19136-19145. 2005
2005 Enhanced binding of RNAP II CTD phosphatase FCP1 to RAP74 following CK2 phosphorylationBiochemistry.  44:2732-2745. 2005
2004 Transcription Factor B Contacts Promoter DNA Near the Transcription Start Site of the Archaeal Transcription Initiation ComplexJournal of Biological Chemistry.  279:2825-2831. 2004
1997 Inductively coupled plasma-atomic emission spectrometric analysis of aqueous slurries of solidsMicrochemical Journal.  56:30-39. 1997
Impact of Glycan Positioning on HIV-1 Env Glycan Shield Density, Function, and Antibody Recognition


Year Title Altmetric
2016 Heterogeneity of aberrant O-glycosylation of IgA1 in IgA nephropathy.  53-68. 2016

Research Overview

  • My research involves the analysis of proteins that are glycosylated in the context of human diseases. This includes O-glycosylation of the immunoglobulin IgA1 involved in the pathogenesis of a kidney disease called IgA nephropathy and the multiple N-glycans of the HIV Env glycoprotein which is a target for HIV vaccine design. My lab makes use of high resolution mass spectrometry to gain a better understanding of the range of glycans present on proteins. We then put that knowledge of the characterized glycans into the context of how the various proteins function. Additionally, we make use of a variety of MS based techniques to characterize protein structure and protein complexes.
  • Investigator On

  • Mechanism of Tgfbr2 in Chondroprotection  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2020 - 2025
  • Hepatic Retinoid Metabolism and Signaling in Starvation and Diabetes  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2021 - 2024
  • Molecular Basis of Pathogenicity of IgA1-Containing Immune Complexes  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2019 - 2024
  • PRedoctoral Interdisciplinary Training in Renal Physiology and MEdIcIne (PRIME)  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2018 - 2023
  • RXR Rexinoids for Cancer Chemoprevention  awarded by National Cancer Institute/NIH/DHHS 2017 - 2022
  • RXR Rexinoids for Cancer Chemoprevention - Project 2: Design and Development of Third Generation RXR Rexinoids as Potential Chemoprevention Agents  awarded by National Cancer Institute/NIH/DHHS 2017 - 2022
  • Amino Acids Incorporated at CFTR Nonsense Mutations During Readthrough  awarded by Cystic Fibrosis Foundation ^ 2019 - 2022
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2022
  • Integrating Novel Mechanisms Controlling Sodium Excretion and Blood Pressure - Project 3 = HDAC-Mediated Regulation of Endothelin and Nitric Oxide  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2017 - 2022
  • Elucidating IgA Nephropathy Through Genetic Studies of IgA1 Glycosylation  awarded by Columbia University 2014 - 2020
  • GDCN Clinical Center - Advancing Clinical Research in Primary Glomerular Diseases  awarded by University of North Carolina at Chapel Hill 2014 - 2019
  • UAB Center for AIDS Research  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2014 - 2019
  • Molecular Basis of Pathogenicity of IgA1-containing Immune Complexes  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2012 - 2019
  • UAB Metabolomics Workshop: From Design to Decision  awarded by National Institute of General Medical Sciences/NIH/DHHS 2012 - 2019
  • Aptamers-Based Arrays for Detection of Pathogenic IgA 1 O-Glycoforms in IgA Nephropathy  awarded by Columbia University 2016 - 2018
  • Novel Therapeutics of Acquired Thrombotic Thrombocytopenic Purpura  awarded by National Heart, Lung, and Blood Institute/NIH/DHHS 2015 - 2018
  • IgA Nephropathy and the Role of Clustered Glycosylation Initiation by GaINAc-Transferases  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2016 - 2018
  • Active - Proteomics - Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Comprehensive Cancer Center Core Support Grant  awarded by National Cancer Institute/NIH/DHHS 2011 - 2016
  • Private Grant  awarded by ANTHERA PHARMACEUTICALS, INC 2015 - 2016
  • Private Grant  awarded by Pfizer Pharmaceuticals 2013 - 2015
  • Biological Chemistry of Reactive Nitrogen Species Signaling in Cancer Etiology  awarded by National Cancer Institute/NIH/DHHS 2009 - 2014
  • Education And Training

  • Doctor of Philosophy in Biochemistry, University of Georgia 2002
  • Full Name

  • Matthew Renfrow