Positions

Selected Publications

Academic Article

Year Title Altmetric
2019 Batf Pioneers the Reorganization of Chromatin in Developing Effector T Cells via Ets1-Dependent Recruitment of CtcfCell Reports.  29:1203-1220.e7. 2019
2018 Differential IL-2 expression defines developmental fates of follicular versus nonfollicular helper T cellsScience.  361. 2018
2018 IL-1R signaling promotes STAT3 and NF-B factor recruitment to distal cis-regulatory elements that regulate Il17a/f transcriptionJournal of Biological Chemistry.  293:15790-15800. 2018
2015 IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iT reg cell balanceNature Immunology.  16:286-295. 2015
2014 Deletion of a Conserved cis-Element in the Ifng Locus Highlights the Role of Acute Histone Acetylation in Modulating Inducible Gene TranscriptionPLoS Genetics.  10. 2014
2013 Notch Simultaneously Orchestrates Multiple Helper T Cell Programs Independently of Cytokine SignalsImmunity.  39:148-159. 2013
2013 The Th17 family: Flexibility follows functionImmunological Reviews.  252:89-103. 2013
2012 Th22 Cells Are an Important Source of IL-22 for Host Protection against Enteropathogenic BacteriaImmunity.  37:1061-1075. 2012
2012 Reciprocal interactions of the intestinal microbiota and immune systemNature.  489:231-241. 2012
2011 TGF-β in Th17 cell development: The truth is out thereImmunity.  34:288-290. 2011
2010 Regulation of the Ifng locus in the context of T-lineage specification and plasticityImmunological Reviews.  238:216-232. 2010
2010 Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuliImmunity.  33:35-47. 2010
2010 Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineageImmunity.  32:616-627. 2010
2009 Interplay between the TH 17 and TReg cell lineages: A (co-)evolutionary perspectiveNature Reviews Immunology.  9:883-889. 2009
2009 The AP-1 transcription factor Batf controls T H 17 differentiationNature.  460:405-409. 2009
2009 Developmental plasticity of Th17 and Treg cellsCurrent Opinion in Immunology.  21:274-280. 2009
2009 Contrasting roles for all-trans retinoic acid in TGF-β-mediated induction of Foxp3 and Il10 genes in developing regulatory T cellsJournal of Experimental Medicine.  206:343-357. 2009
2009 Duality in the Th17-Treg developmental decision.F1000 biology reports.  1:5. 2009
2007 IL-17 family cytokines and the expanding diversity of effector T cell lineagesAnnual Review of Immunology.  25:821-852. 2007
2006 A Distal Conserved Sequence Element Controls Ifng Gene Expression by T Cells and NK CellsImmunity.  25:717-729. 2006
2006 Transforming growth factor-β induces development of the T H17 lineageNature.  441:231-234. 2006
2005 Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineagesNature Immunology.  6:1123-1132. 2005
2005 Generation of antigen-specific, Foxp3-expressing CD4+ regulatory T cells by inhibition of APC proteosome functionJournal of Immunology.  174:2787-2795. 2005
2004 Regulatory T cell suppression and anergy are differentially regulated by proinflammatory cytokines produced by TLR-activated dendritic cellsJournal of Immunology.  173:7249-7258. 2004
2003 T-bet or Not T-betScience.  302:993-994. 2003
2002 Gene delivery into primary T cells: Overview and characterization of a transgenic model for efficient adenoviral transductionImmunologic Research.  26:131-141. 2002
2002 Efficient adenovirus-mediated gene transfer into primary T cells and thymocytes in a new coxsackie/adenovirus receptor transgenic modelBMC Immunology.  3. 2002
2002 Efficient adenovirus-mediated gene transfer into primary T cells and thymocytes in a new coxsackie/adenovirus receptor transgenic model.BMC Immunology.  3:4. 2002
2001 Differential expression of Fas ligand in Th1 and Th2 cells is regulated by early growth response gene and NF-AT family membersJournal of Immunology.  166:4534-4542. 2001

Investigator On

  • Specialization of Innate and Adaptive Immune Cells in Intestinal Barrier Function  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017 - 2022
  • Mechanisms Controlling Regulatory T Cell Effector Function in IBD  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2017 - 2021
  • Private Grant  awarded by JT PHARMA INC. 2017 - 2020
  • Th17 Pathway Plasticity in the Pathogenesis of Inflammatory Bowel Disease  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2019
  • Molecular Regulation of MS Susceptibility Genes  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2013 - 2018
  • Factors Controlling Effector T Cell Maintenance in the Pathogenesis of Colitis  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2011 - 2017
  • Gene Regulatory Networks Controlling Effector and Regulatory T Cell Balance in IBD  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2015 - 2016
  • Innate and Adaptive Immunity in IBD  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2010 - 2016
  • Innate and Adaptive Immunity in IBD - Project 3  awarded by National Institute of Diabetes and Digestive and Kidney Diseases/NIH/DHHS 2010 - 2016
  • Control of Chromatin Landscapes in Effector T Cell Lineage Specifications  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2009 - 2014
  • Education And Training

  • Doctor of Philosophy in Microbiological Sciences and Immunology, University of Alabama at Birmingham 1996
  • Bachelor of Science or Mathematics in Biotechnology, Worcester Polytechnic Institute 1987
  • Full Name

  • Robin Hatton