Positions

Overview

  • My research training began at the NIH (as a HHMI scholar) and continued with a PhD in Immunology following my mentor, Dr. Jeff Bluestone, to the University of Chicago, where I characterized murine peripheral TCR T cell repertoire, phenotype, and effector function. I completed medical school at UCLA and did a Pediatrics residency at Stanford where I gained an interest in Rheumatology. This was followed by a fellowship at the University of Washington in Pediatric Rheumatology. I returned to the lab to study human CD4 T cell effector function regulated at the transcriptional level with Dr. David Lewis. Following Dr. Lewis to Stanford, I completed an HHMI post-doctoral fellowship exploring CD154 dysregulation in systemic lupus erythematosus, as well as HIV-1 transcriptional regulation by NFAT transcription factors. This was the basis for my own lab’s studies at the University of Pennsylvania. I was recruited to UAB in 2007 to begin a division of Pediatric Rheumatology. In general, my lab studies CD4 T cell transcription in primary human CD4 T cells. As such, we have adapted or developed an array of useful methodologies/technologies for studying gene transcription (CD154, HIV-1, and others) in primary murine and human CD4 T cells. In addition, we are exploring the role of the Treg transcription factor, FoxP3, for its ability to inhibit HIV-1 transcription, and for Tregs to inhibit HIV-1 expression in neighboring CD4 T cells and macrophages. In collaboration with the Kutsch lab, we continue to explore transcriptional control of HIV-1 latency. Lastly, we are studying the effect of macrophage activation syndrome (MAS) patient mutations for their ability to decrease perforin-mediated cytolytic activity in NK cells. Many MAS patients have single copy mutations in familial hemophagocytic lymphohistiocytosis genes, and these mutations function as partial dominant negative proteins to inhibit cytolysis.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 American College of Rheumatology Provisional Criteria for Clinically Relevant Improvement in Children and Adolescents With Childhood-Onset Systemic Lupus ErythematosusArthritis Care and Research.  71:579-590. 2019
    2019 Serum S100A8/A9 and S100A12 Levels in Children With Polyarticular Forms of Juvenile Idiopathic Arthritis: Relationship to Maintenance of Clinically Inactive Disease During Anti–Tumor Necrosis Factor Therapy and Occurrence of Disease Flare After Discontinuation of TherapyArthritis and Rheumatology.  71:451-459. 2019
    2019 Akkermansia muciniphila is permissive to arthritis in the K/BxN mouse model of arthritisGenes and Immunity.  20:158-166. 2019
    2019 Development and initial validation of the MS score for diagnosis of macrophage activation syndrome in systemic juvenile idiopathic arthritisAnnals of the Rheumatic Diseases.  78:1357-1362. 2019
    2019 Emergent high fatality lung disease in systemic juvenile arthritisAnnals of the Rheumatic Diseases.  78:1722-1731. 2019
    2019 Macrophage Activation Syndrome and Secondary Hemophagocytic Lymphohistiocytosis in Childhood Inflammatory Disorders: Diagnosis and ManagementPediatric Drugs2019
    2019 Standardizing terminology and assessment for orofacial conditions in juvenile idiopathic arthritis: International, multidisciplinary consensus-based recommendationsJournal of Rheumatology.  46:518-522. 2019
    2019 The immunology of macrophage activation syndromeFrontiers in Immunology.  10. 2019
    2018 Rituximab treatment for chronic steroid-dependent Henoch-Schonlein purpura: 8 cases and a review of the literaturePediatric Rheumatology.  16. 2018
    2018 Risk factors for intraarticular heterotopic bone formation in the temporomandibular joint in Juvenile idiopathic arthritisJournal of Rheumatology.  45:1301-1307. 2018
    2018 Risk, Timing, and Predictors of Disease Flare After Discontinuation of Anti–Tumor Necrosis Factor Therapy in Children With Polyarticular Forms of Juvenile Idiopathic Arthritis With Clinically Inactive DiseaseArthritis and Rheumatology.  70:1508-1518. 2018
    2018 Brief Report: Novel UNC13D Intronic Variant Disrupting an NF-κB Enhancer in a Patient With Recurrent Macrophage Activation Syndrome and Systemic Juvenile Idiopathic ArthritisArthritis and Rheumatology.  70:963-970. 2018
    2018 Toward Establishing a Standardized Magnetic Resonance Imaging Scoring System for Temporomandibular Joints in Juvenile Idiopathic ArthritisArthritis Care and Research.  70:758-767. 2018
    2018 Effectiveness and safety of tofacitinib in rheumatoid arthritis: A cohort studyArthritis Research.  20. 2018
    2018 Pediatric rheumatology infusion center: Report on therapeutic protocols and infusions given over 4 Years with focus on adverse events over 1 YearPediatric Rheumatology.  16. 2018
    2018 Effect of Biologic Therapy on Clinical and Laboratory Features of Macrophage Activation Syndrome Associated With Systemic Juvenile Idiopathic ArthritisArthritis Care and Research.  70:409-419. 2018
    2018 Regulatory CD4 T cells inhibit HIV-1 expression of other CD4 T cell subsets via interactions with cell surface regulatory proteinsVirology.  516:21-29. 2018
    2018 Smoking is the most significant modifiable lung cancer risk factor in systemic lupus erythematosusJournal of Rheumatology.  45:393-396. 2018
    2018 Age and fecal microbial strain-specific differences in patients with spondyloarthritisArthritis Research.  20. 2018
    2018 Defining the normal appearance of the temporomandibular joints by magnetic resonance imaging with contrast: A comparative study of children with and without juvenile idiopathic arthritisPediatric Rheumatology.  16. 2018
    2018 Creating the Subspecialty Pediatrics Investigator NetworkJournal of Pediatrics.  192:3-4.e2. 2018
    2018 Temporomandibular joint arthritis in juvenile idiopathic arthritis, now what?Pediatric Rheumatology.  16. 2018
    2017 Risk of tuberculosis among Alabama children and adolescents treated with tumor necrosis factor inhibitors: A retrospective studyPediatric Rheumatology.  15. 2017
    2017 Isolated arthritis of the temporomandibular joint as the initial manifestation of juvenile idiopathic arthritisJournal of Rheumatology.  44:1632-1635. 2017
    2017 Development and Initial Validation of the Macrophage Activation Syndrome/Primary Hemophagocytic Lymphohistiocytosis Score, a Diagnostic Tool that Differentiates Primary Hemophagocytic Lymphohistiocytosis from Macrophage Activation SyndromeJournal of Pediatrics.  189:72-78.e3. 2017
    2017 Malignancy in pediatric-onset systemic lupus erythematosusJournal of Rheumatology.  44:1484-1486. 2017
    2017 Association of Anti–3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Autoantibodies With DRB1*07:01 and Severe Myositis in Juvenile Myositis PatientsArthritis Care and Research.  69:1088-1094. 2017
    2017 Weathering a macrophage stormJournal of Rheumatology.  44:970-972. 2017
    2017 A review on SLE and malignancyBest Practice and Research: Clinical Rheumatology.  31:373-396. 2017
    2017 CD4 regulatory T cells augment HIV-1 expression of polarized M1 and M2 monocyte derived macrophagesVirology.  504:79-87. 2017
    2017 Clinical orofacial examination in juvenile idiopathic arthritis: International consensus-based recommendations for monitoring patients in clinical practice and research studiesJournal of Rheumatology.  44:326-333. 2017
    2016 Fecal metabolomics in pediatric spondyloarthritis implicate decreased metabolic diversity and altered tryptophan metabolism as pathogenic factorsGenes and Immunity.  17:400-405. 2016
    2016 The microbiota in pediatric rheumatic disease: Epiphenomenon or therapeutic target?Current Opinion in Rheumatology.  28:537-543. 2016
    2016 Ustekinumab as a Therapeutic Option for Children with Refractory Enthesitis-Related ArthritisJCR: Journal of Clinical Rheumatology.  22:282-284. 2016
    2016 A heterozygous RAB27A mutation associated with delayed cytolytic granule polarization and hemophagocytic lymphohistiocytosisJournal of Immunology.  196:2492-2503. 2016
    2016 2016 Classification Criteria for Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: A European League Against Rheumatism/American College of Rheumatology/Paediatric Rheumatology International Trials Organisation Collaborative InitiativeArthritis and Rheumatology.  68:566-576. 2016
    2016 2016 Classification criteria for macrophage activation syndrome complicating systemic juvenile idiopathic arthritis: A European league against Rheumatism/American college of Rheumatology/Paediatric rheumatology international trials organisation collaborative initiativeAnnals of the Rheumatic Diseases.  75:481-489. 2016
    2016 Association of Myositis Autoantibodies, Clinical Features, and Environmental Exposures at Illness Onset with Disease Course in Juvenile MyositisArthritis and Rheumatology.  68:761-768. 2016
    2016 Interleukin-1 Receptor Blockade Is Associated with Reduced Mortality in Sepsis Patients with Features of Macrophage Activation Syndrome: Reanalysis of a Prior Phase III Trial∗Critical Care Medicine.  44:275-281. 2016
    2016 Development of spondyloarthropathy following episodes of macrophage activation syndrome in children with heterozygous mutations in haemophagocytic lymphohistiocytosis-associated genesClinical and Experimental Rheumatology.  34:953. 2016
    2016 Expert consensus on dynamics of laboratory tests for diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritisRMD Open.  2. 2016
    2016 Whole-exome sequencing reveals mutations in genes linked to hemophagocytic lymphohistiocytosis and macrophage activation syndrome in fatal cases of H1N1 influenzaJournal of Infectious Diseases.  213:1180-1188. 2016
    2015 Macrophage Activation SyndromeHematology/Oncology Clinics of North America.  29:927-941. 2015
    2015 Clinical features and correct diagnosis of macrophage activation syndromeExpert Review of Clinical Immunology.  11:1043-1053. 2015
    2015 Dissecting the heterogeneity of macrophage activation syndrome complicating systemic juvenile idiopathic arthritisJournal of Rheumatology.  42:994-1001. 2015
    2015 Does viral hemorrhagic fever represent reactive hemophagocytic syndrome?Journal of Rheumatology.  42:1078-1080. 2015
    2015 Kill or be killedJournal of Immunology.  194:5041-5043. 2015
    2015 Magnetic resonance imaging findings following intraarticular infliximab therapy for refractory temporomandibular joint arthritis among children with juvenile idiopathic arthritisJournal of Rheumatology.  42:2155-2159. 2015
    2015 Safety and efficacy of rituximab in childhood-onset systemic lupus erythematosus and other rheumatic diseasesJournal of Rheumatology.  42:541-546. 2015
    2015 Systemic and intra-articular anti-inflammatory therapy of temporomandibular joint arthritis in children with juvenile idiopathic arthritisSeminars in Orthodontics.  21:125-133. 2015
    2015 Temporomandibular joint arthritis in juvenile idiopathic arthritis: The last frontierInternational Journal of Clinical Rheumatology.  10:273-285. 2015
    2015 What investigations are needed to optimally monitor for malignancies in SLE?Lupus.  24:781-787. 2015
    2014 High dose anakinra for treatment of severe neonatal Kawasaki disease: A case reportPediatric Rheumatology.  12. 2014
    2014 Treatment of juvenile idiopathic arthritis: A revolution in carePediatric Rheumatology.  12. 2014
    2014 Results of a multinational survey regarding the diagnosis and treatment of temporomandibular joint involvement in juvenile idiopathic arthritisPediatric Rheumatology.  12. 2014
    2014 Altered microbiota associated with abnormal humoral immune responses to commensal organisms in enthesitis-related arthritisArthritis Research.  16:486. 2014
    2014 Changes in body mass index in children with juvenile idiopathic arthritis treated with tumor necrosis factor inhibitorsJournal of Rheumatology.  41:113-118. 2014
    2014 Clinical features, treatment, and outcome of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis: A multinational, multicenter study of 362 patientsArthritis and Rheumatology.  66:3160-3169. 2014
    2014 Genetic Defects in Cytolysis in Macrophage Activation SyndromeCurrent Rheumatology Reports.  16. 2014
    2014 IL-15 prolongs CD154 expression on human CD4 T cells via STAT5 binding to the CD154 transcriptional promoterGenes and Immunity.  15:137-144. 2014
    2014 Imaging of the temporomandibular joint in juvenile idiopathic arthritisArthritis Care and Research.  66:47-54. 2014
    2014 Kinase control of latent HIV-1 infection: PIM-1 kinase as a major contributor to HIV-1 reactivationJournal of Virology.  88:364-376. 2014
    2014 Performance of current guidelines for diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritisArthritis and Rheumatology.  66:2871-2880. 2014
    2014 Systemic lupus erythematosus and malignancies: A review articleRheumatic Disease Clinics of North America.  40:497-506. 2014
    2014 The impact of Nucleofection® on the activation state of primary human CD4 T cellsJournal of Immunological Methods.  408:123-131. 2014
    2013 Cancer risk in childhood-onset systemic lupusArthritis Research.  15. 2013
    2013 Treatment of Juvenile Idiopathic Arthritis in the Biologic AgeRheumatic Disease Clinics of North America.  39:751-766. 2013
    2013 High doses of infliximab in the management of juvenile idiopathic arthritisJournal of Rheumatology.  40:1749-1755. 2013
    2013 MHCII is required for α-Synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegenerationJournal of Neuroscience.  33:9592-9600. 2013
    2013 Retinal vasculitis in two pediatric patients with systemic lupus erythematosus: A case reportPediatric Rheumatology.  11. 2013
    2013 Condylar Degeneration and Diseases-Local and Systemic EtiologiesSeminars in Orthodontics.  19:89-96. 2013
    2013 Higher-dose anakinra is effective in a case of medically refractory macrophage activation syndromeJournal of Rheumatology.  40:743-744. 2013
    2013 Anaphylaxis to etanercept in two children with juvenile idiopathic arthritisJCR: Journal of Clinical Rheumatology.  19:129-131. 2013
    2013 Safety and efficacy of intra-articular infliximab therapy for treatment-resistant temporomandibular joint arthritis in children: A retrospective studyRheumatology.  52:554-559. 2013
    2013 An AP-1 binding site in the enhancer/core element of the HIV-1 promoter controls the ability of HIV-1 to establish latent infectionJournal of Virology.  87:2264-2277. 2013
    2012 Host factor transcriptional regulation contributes to preferential expression of HIV type 1 in IL-4-producing CD4 T cellsJournal of Immunology.  189:2746-2757. 2012
    2012 Intensive care requirement, rather than degree of serum ferritin elevation, predicts mortality in macrophage activation syndromePediatric Critical Care Medicine.  13:616. 2012
    2012 Risk factors for temporomandibular joint arthritis in children with juvenile idiopathic arthritisJournal of Rheumatology.  39:1880-1887. 2012
    2012 Management of temporomandibular joint arthritis in adult rheumatology practices: a survey of adult rheumatologistsPediatric Rheumatology.  10. 2012
    2012 Intra-articular corticosteroid injections to the temporomandibular joints are safe and appear to be effective therapy in children with juvenile idiopathic arthritisJournal of Oral and Maxillofacial Surgery.  70:1802-1807. 2012
    2012 Macrophage activation syndrome as part of systemic juvenile idiopathic arthritis: Diagnosis, genetics, pathophysiology and treatmentGenes and Immunity.  13:289-298. 2012
    2012 NF-ATc1 levels are increased in murine and human lupus T cells: Comment on the article by kyttaris et alArthritis and Rheumatism.  64:1294. 2012
    2011 Attainment of inactive disease status following initiation of TNF-α inhibitor therapy for juvenile idiopathic arthritis: Enthesitis-related arthritis predicts persistent active diseaseJournal of Rheumatology.  38:2675-2681. 2011
    2011 Temporomandibular joint arthritis in pediatric Sjögren disease and sarcoidosisJournal of Rheumatology.  38:2272-2273. 2011
    2011 ReplyArthritis Care and Research.  63:1355. 2011
    2011 High prevalence of myositis in a southeastern United States pediatric systemic lupus erythematosus cohortPediatric Rheumatology.  9. 2011
    2011 Brain cavernomas associated with en coup de sabre linear scleroderma: Two case reportsPediatric Rheumatology.  9. 2011
    2011 1.5 Decades Later: Bearing fruits from the ACR/EULAR exchange ProgramPediatric Rheumatology.  9. 2011
    2011 2011 American College of Rheumatology recommendations for the treatment of juvenile idiopathic arthritis: initiation and safety monitoring of therapeutic agents for the treatment of arthritis and systemic features.Arthritis Care and Research.  63:465-482. 2011
    2011 An international consensus survey of diagnostic criteria for macrophage activation syndrome in systemic juvenile idiopathic arthritisJournal of Rheumatology.  38:764-768. 2011
    2011 Anakinra as first-line disease-modifying therapy in systemic juvenile idiopathic arthritis: Report of forty-six patients from an international multicenter seriesArthritis and Rheumatism.  63:545-555. 2011
    2011 Corticosteroid-induced spinal epidural lipomatosis in the pediatric age group: Report of a new case and updated analysis of the literaturePediatric Rheumatology.  9. 2011
    2011 Successful treatment of severe paediatric rheumatic disease-associated macrophage activation syndrome with interleukin-1 inhibition following conventional immunosuppressive therapy: Case series with 12 patientsRheumatology.  50:417-419. 2011
    2011 Successful treatment of pediatric IgG4 related systemic disease with mycophenolate mofetil: Case report and a review of the pediatric autoimmune pancreatitis literaturePediatric Rheumatology.  9. 2011
    2011 Combination therapy of abatacept and in children with refractory systemic juvenile idiopathic arthritis: A retrospective case seriesJournal of Rheumatology.  38:180-181. 2011
    2010 Guilt by association - what is the true risk of malignancy in children treated with etanercept for JIA?Pediatric Rheumatology.  8. 2010
    2010 Prolonged expression of CD154 on CD4 T cells from pediatric lupus patients correlates with increased CD154 transcription, increased nuclear factor of activated T cell activity, and glomerulonephritisArthritis and Rheumatism.  62:2499-2509. 2010
    2010 Effectiveness and toxicity of methotrexate in juvenile idiopathic arthritis: Comparison of 2 initial dosing regimensJournal of Rheumatology.  37:870-875. 2010
    2009 FOXP3 inhibits activation-induced NFAT2 expression in T cells thereby limiting effector cytokine expressionJournal of Immunology.  183:907-915. 2009
    2009 Rituximab Therapy for Severe Refractory Chronic Henoch-Schönlein PurpuraJournal of Pediatrics.  155:136-139. 2009
    2009 The temporomandibular joint in juvenile idiopathic arthritis: Frequently used and frequently arthriticPediatric Rheumatology.  7. 2009
    2009 Determinants of the Establishment of Human Immunodeficiency Virus Type 1 LatencyJournal of Virology.  83:3078-3093. 2009
    2009 Rheumatology fellows' perception on training and careers in academia: The american college of rheumatology fellow research and academic training surveyArthritis Care and Research.  61:266-273. 2009
    2008 FOXP3 inhibits HIV-1 infection of CD4 T-cells via inhibition of LTR transcriptional activityVirology.  381:161-167. 2008
    2008 A T-cell-specific CD154 transcriptional enhancer located just upstream of the promoterGenes and Immunity.  9:640-649. 2008
    2008 High prevalence of temporomandibular joint arthritis at disease onset in children with juvenile idiopathic arthritis, as detected by magnetic resonance imaging but not by ultrasoundArthritis and Rheumatism.  58:1189-1196. 2008
    2008 Research priorities in pediatric rheumatology: The Childhood Arthritis and Rheumatology Research Alliance (CARRA) consensusPediatric Rheumatology.  6. 2008
    2008 Evaluation of the presentation of systemic onset juvenile rheumatoid arthritis: Data from the Pennsylvania Systemic Onset Juvenile Arthritis Registry (PASOJAR)Journal of Rheumatology.  35:343-348. 2008
    2008 Neither cell-surface nor soluble CD154 levels are associated with coronary artery disease in systemic lupus erythematosusJournal of Rheumatology.  35:359-360. 2008
    2007 Pediatric rheumatology for the adult rheumatologist II: Uveitis in juvenile idiopathic arthritisJCR: Journal of Clinical Rheumatology.  13:205-210. 2007
    2007 Benefit of fluoroscopically guided intraarticular, long-acting corticosteroid injection for subtalar arthritis in juvenile idiopathic arthritisPediatric Radiology.  37:544-548. 2007
    2007 Occult macrophage activation syndrome in patients with systemic juvenile idiopathic arthritisJournal of Rheumatology.  34:1133-1138. 2007
    2007 Reactive arthritis of the temporomandibular joints and cervical spine in a childPediatric Rheumatology.  5. 2007
    2007 CT-guided percutaneous steroid injection for management of inflammatory arthropathy of the temporomandibular joint in childrenAmerican Journal of Roentgenology.  188:182-186. 2007
    2007 Juvenile idiopathic arthritis classification criteria: Loopholes and diagnosis software [3]Journal of Rheumatology.  34:234. 2007
    2006 Benefit of intraarticular corticosteroid injection under fluoroscopic guidance for subtalar arthritis in juvenile idiopathic arthritisJournal of Rheumatology.  33:2330-2336. 2006
    2006 Picture of the month: anaplastic large cell lymphoma with hemophagocytic lymphohistiocytosis.Archives of Pediatrics and Adolescent Medicine.  160:1177-1179. 2006
    2006 Interleukin 1 receptor antagonist to treat cytophagic histiocytic panniculitis with secondary hemophagocytic lymphohistiocytosisJournal of Rheumatology.  33:2081-2084. 2006
    2006 Sjögren syndrome in a child: Favorable response of the arthritis to TNFα blockadeClinical Rheumatology.  25:746-748. 2006
    2006 Temporomandibular joint arthritis in juvenile idiopathic arthritis: The forgotten jointCurrent Opinion in Rheumatology.  18:490-495. 2006
    2006 Chronic arthritis without uveitis in velocardiofacial syndromeJournal of Pediatrics.  149:281. 2006
    2006 Homocysteine levels and disease duration independently correlate with coronary artery calcification in patients with systemic lupus erythematosusArthritis and Rheumatism.  54:2220-2227. 2006
    2006 Effective gene suppression using small interfering RNA in hard-to-transfect human T cellsJournal of Immunological Methods.  312:1-11. 2006
    2006 Septic abscess in a child with juvenile idiopathic arthritis receiving anti-tumor necrosis factor-α therapy [1]Journal of Rheumatology.  33:825. 2006
    2006 Treatment of pediatric localized scleroderma with methotrexateJournal of Rheumatology.  33:609-614. 2006
    2006 The γc-cytokine regulated transcription factor, STAT5, increases HIV-1 production in primary CD4 T cellsVirology.  344:283-291. 2006
    2006 Early growth response-1 is required for CD154 transcriptionJournal of Immunology.  176:811-818. 2006
    2006 NFAT transcription factors - New players in the pathogenesis of inflammatory arthropathies?Autoimmunity Reviews.  5:106-110. 2006
    2006 Picture of the monthArchives of Pediatrics and Adolescent Medicine.  160:1177-1179. 2006
    2006 The spectrum of renal tubular acidosis in paediatric Sjögren syndromeRheumatology.  45:85-91. 2006
    2005 Sweet syndrome as an initial presentation in a child with systemic lupus erythematosus [1]Lupus.  14:974-975. 2005
    2005 Utility of corticosteroid injection for temporomandibular arthritis in children with juvenile idiopathic arthritisArthritis and Rheumatism.  52:3563-3569. 2005
    2005 Editorial: A signal achievement in the treatment of arthritisArthritis and Rheumatism.  52:2229-2232. 2005
    2005 Pediatric rheumatology for the adult rheumatologist I: Therapy and dosing for pediatric rheumatic disordersJCR: Journal of Clinical Rheumatology.  11:21-33. 2005
    2004 Reciprocal regulation of the nuclear factor of activated T cells and HIV-1Genes and Immunity.  5:158-167. 2004
    2004 Overexpression of octamer transcription factors 1 or 2 alone has no effect on HIV-1 transcription in primary human CD4 T cellsVirology.  321:323-331. 2004
    2003 Decreased CD154 expression by neonatal CD4+ T cells is due to limitations in both proximal and distal events of T cells activationInternational Immunology.  15:1461-1472. 2003
    2003 Methotrexate used as a steroid-sparing agent in non-renal chronic Henoch-Schönlein purpuraClinical and Experimental Rheumatology.  21:767-769. 2003
    2003 Erratum: Delineation of a novel pathway that regulates CD154 (CD40 ligand) expression (Molecular and Cellular Biology (2003) 23:2 (510-525))Molecular and Cellular Biology.  23:6338. 2003
    2003 CD154 transcriptional regulation in primary human CD4 T cellsImmunologic Research.  27:185-202. 2003
    2003 Delineation of a novel pathway that regulates CD154 (CD40 ligand) expressionMolecular and Cellular Biology.  23:510-525. 2003
    2002 Current treatment for chronic arthritis in childhoodCurrent Opinion in Pediatrics.  14:684-687. 2002
    2002 Regulation of the murine Nfatc1 gene by NFATc2Journal of Biological Chemistry.  277:10704-10711. 2002
    2002 HIV-1, NFAT, and cyclosporin: Immunosuppression for the immunosuppressed?DNA (Mary Ann Liebert, Inc.).  20:761-767. 2002
    2002 A T cell-specific enhancer of the human CD40 ligand geneJournal of Biological Chemistry.  277:7386-7395. 2002
    2001 Octamer proteins inhibit IL-4 gene transcription in normal human CD4 T cellsGenes and Immunity.  2:464-468. 2001
    2001 Treatment for JRA in the new millenniumJCR: Journal of Clinical Rheumatology.  7:283-285. 2001
    2000 Nabumetone induced pseudoporphyria in childhood [3] (multiple letters)Journal of Rheumatology.  27:1817-1818. 2000
    2000 Nabumetone induced pseudoporphyria in childhood.Journal of Rheumatology.  27:1817-1818. 2000
    2000 NFAT1 enhances HIV-1 gene expression in primary human CD4 T cellsClinical Immunology.  94:179-191. 2000
    1999 Current treatment by United States and Canadian pediatric rheumatologistsJournal of Rheumatology.  26:2036-2038. 1999
    1999 T cell priming enhances IL-4 gene expression by increasing nuclear factor of activated T cellsJournal of Immunology.  162:860-870. 1999
    1998 Methotrexate-induced hypersensitivity pneumonitis in a child with juvenile rheumatoid arthritisJournal of Pediatrics.  132:901-902. 1998
    1997 Childhood sarcoidosis--does age of onset predict clinical manifestations?Journal of Rheumatology.  24:1654-1656. 1997
    1997 Consistent transient transfection of DNA into non-transformed human and murine T-lymphocytesJournal of Immunological Methods.  205:145-150. 1997
    1997 Reactive arthritis to Clostridium difficile in a childWestern Journal of Medicine.  166:419-421. 1997
    1996 Picture of the month. Polyarteritis nodosa with angioedema.Archives of Pediatrics and Adolescent Medicine.  150:875-876. 1996
    1996 Picture of the monthArchives of Pediatrics and Adolescent Medicine.  150:875-876. 1996
    1996 Reiter syndrome initially misdiagnosed as Kawasaki diseaseJournal of Pediatrics.  128:366-369. 1996
    1995 The human gp39 promoter: Two distinct nuclear factors of activated T cell protein-binding elements contribute independently to transcriptional activationJournal of Biological Chemistry.  270:29624-29627. 1995
    1995 Index of suspicion. Case 2. Diagnosis: peritonsillitis.Pediatrics in Review.  16:117-119. 1995
    1995 Necrobacillosis: An unusual cause of purulent otitis media and sepsisPediatric Emergency Care.  11:379-380. 1995
    1995 Reiter's syndrome associated with cryptosporidial gastroenteritisJournal of Rheumatology.  22:1962-1963. 1995
    1994 Differential effects of T cell receptor ligation of TCRγδ thymocyte development in fetal thymic organ cultureThymus.  23:131-153. 1994
    1994 Scleredema Revisited: A Poststreptococcal ComplicationClinical Pediatrics.  33:606-610. 1994
    1992 Peripheral T cell receptor γδ variable gene repertoire maps to the T cell receptor loci and is influenced by positive selectionJournal of Immunology.  149:3200-3207. 1992
    1991 Ligand specificity and repertoire development of murine TCRγδ cellsCurrent Topics in Microbiology and Immunology.  173:133-139. 1991
    1991 Repertoire Development and Ligand Specificity of Murine TCRγδ CellsImmunological Reviews.  120:5-33. 1991
    1990 Polymorphisms and diversity of T-cell receptor-γ proteins expressed in mouse spleenImmunogenetics.  31:220-228. 1990
    1990 Freshly isolated Thy-1+ dendritic epidermal cells express T cell receptor γδ-CD3Journal of Dermatological Science.  1:459-464. 1990
    1990 T cell receptor δ-gene expression and diversity in the mouse spleenJournal of Immunology.  145:1311-1317. 1990
    1989 A TCR gamma delta cell recognizing a novel TL-encoded gene product.Cold Spring Harbor Symposia on Quantitative Biology.  54 Pt 1:45-55. 1989
    1989 Identification of distinct T cell receptor (TCR)-γδ heterodimers using an anti-TCR-γ variable region serumJournal of Immunology.  143:3769-3775. 1989
    1989 Phenotypic and functional analysis of murine CD3+, CD4-, CD8- TCR-γδ-expressing peripheral T cellsJournal of Immunology.  142:3754-3762. 1989
    1989 Structure and specificity of a class II MHC alloreactive γδ T cell receptor heterodimerScience.  245:746-749. 1989
    1988 Systematic development of distinct T cell receptor-γδ T cell subsets during fetal ontogenyJournal of Immunology.  141:3753-3759. 1988
    1988 Structure and specificity of T cell receptor γ/δ on major histocompatibility complex antigen-specific CD3+, CD4, CD8 T lymphocytesJournal of Experimental Medicine.  168:1899-1916. 1988
    1988 Peripheral murine CD3+, CD4-, CD8- T lymphocytes express novel T cell receptor gamma delta structures.Journal of Immunology.  141:1074-1082. 1988
    1988 Peripheral murine CD3+, CD4-, CD8- T lymphocytes express novel T cell receptor γδ structuresJournal of Immunology.  141:1074-1082. 1988
    1987 Major histocompatibility complex-linked specificity of γδ receptor-bearing T lymphocytesNature.  330:262-264. 1987

    Chapter

    Year Title Altmetric
    2018 Macrophage activation syndrome.  151-182. 2018
    2018 Diskitis.  302-303. 2018
    2018 Sarcoidosis.  814-815. 2018
    2018 Spondyloarthropathy.  872-873. 2018
    2016 Macrophage activation syndrome.  275-292. 2016
    2014 Juvenile Idiopathic Arthritis.  1950-1963. 2014
    2013 Juvenile idiopathic arthritis.  637-647. 2013

    Research Overview

  • Functional Genetics of Macrophage Activation Syndrome
    Temporomandibular Joint Arthritis
  • Investigator On

  • Overcoming HIV-1 Transcriptional Latency in Unresponsive CD4 T Cells  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2016 - 2021
  • UAB Multidisciplinary Clinical Research Center (P60)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2013 - 2019
  • UAB Multidisciplinary Clinical Research Center - Project 3  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2013 - 2019
  • Observational Study of Pediatric Rheumatic Diseases : The CARRA Registry  awarded by Duke University 2015 - 2018
  • Private Grant  awarded by SWEDISH ORPHAN BIOVITRUM AB 2016 - 2017
  • Validation of the Class II MHC Transactivator (CIITA) in Models of PD  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2014 - 2016
  • Childhood Arthritis and Rheumatology Research Alliance ("CARRA Registry")  awarded by Duke University 2012 - 2015
  • Childhood Arthritis and Research Alliance Network (CARRANet): Juvenile Dermatomyositis Consensus Treatment Plan  awarded by DUKE CLINICAL RESEARCH INSTITUTE 2013 - 2015
  • Private Grant  awarded by BRISTOL MYERS SQUIBB PHARMACEUTICAL COMPANY 2013 - 2015
  • Childhood Arthritis and Research Alliance Network (CARRANet): Juvenile Idiopathic Arthritis Consensus Treatment Plan  awarded by Duke University 2013 - 2014
  • Improved Understanding of the Biology and use of TNF Inhibition in Children with JIA  awarded by CHILDREN'S HOSPITAL MEDICAL CENTER (CINCINNATI) 2011 - 2013
  • Teaching Activities

  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2014) 2014
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2014) 2014
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2013) 2013
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2013) 2013
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2013) 2013
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2013) 2013
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2011) 2011
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2011) 2011
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2011) 2011
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2011) 2011
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2011) 2011
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2011) 2011
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2011) 2011
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2011) 2011
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2011) 2011
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2011) 2011
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2010) 2010
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2010) 2010
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2010) 2010
  • Education And Training

  • Doctor of Medicine, University of California System : Los Angeles 1991
  • Doctor of Philosophy in Immunology, University of Chicago 1990
  • Lucille Salter Packard Childrens' Hospital, Internship 1992
  • Lucille Salter Packard Childrens' Hospital, Residency 1994
  • Howard Hughes Fellow, Postdoctoral Fellowship 1999
  • University of Washington Medical Center, Postdoctoral Fellowship 1997
  • Full Name

  • Randy Cron