Positions

Overview

  • Dr. Cron began his research training at the NIH (as a HHMI scholar) and continued with a PhD in Immunology following my mentor, Dr. Jeff Bluestone, to the University of Chicago, where Dr. Cron characterized murine peripheral TCRgd T cell repertoire, phenotype, and effector function. He completed medical school at UCLA and did a Pediatrics residency at Stanford where he gained an interest in Rheumatology. This was followed by a fellowship at the University of Washington in Pediatric Rheumatology. Dr. Cron returned to the lab to study human CD4 T cell effector function regulated at the transcriptional level with Dr. David Lewis. Following Dr. Lewis to Stanford, Dr. Cron completed an HHMI post-doctoral fellowship exploring CD154 dysregulation in systemic lupus erythematosus, as well as HIV-1 transcriptional regulation by NFAT transcription factors. This was the basis for his own lab’s studies at the University of Pennsylvania. Dr. Cron was recruited to UAB in 2007 to begin a division of Pediatric Rheumatology. In general, my Dr. Cron's lab studies CD4 T cell transcription in primary human CD4 T cells. As such, the Cron lab has adapted or developed an array of useful methodologies/technologies for studying gene transcription (CD154, HIV-1, and others) in primary murine and human CD4 T cells. In addition, the Cron lab is exploring the role of the Treg transcription factor, FoxP3, for its ability to inhibit HIV-1 transcription, and for Tregs to inhibit HIV-1 expression in neighboring CD4 T cells and macrophages. In collaboration with the Kutsch lab, the Cron lab continues to explore transcriptional control of HIV-1 latency. Lastly, the Cron lab is studying the effect of macrophage activation syndrome (MAS) patient mutations for their ability to decrease perforin-mediated cytolytic activity in NK cells. Many MAS patients have single copy mutations in familial hemophagocytic lymphohistiocytosis genes, and these mutations function as partial dominant negative proteins to inhibit cytolysis. Dr. Cron is co-editor of the first textbook devoted to Cytokine Storm Syndrome, and Dr. Cron has been integral to research related to the COVID-19 pandemic.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2021 Discrete Choice Experiment on a Magnetic Resonance Imaging Scoring System for Temporomandibular Joints in Juvenile Idiopathic Arthritis..  Arthritis Care and Research.  2021
    2021 Effect of COVID-19 on anakinra-induced remission in homozygous STX11 hemophagocytosis lymphohistiocytosis 2021
    2020 Multidisciplinary Guidance Regarding the Use of Immunomodulatory Therapies for Acute Coronavirus Disease 2019 in Pediatric Patients..  Journal of the Pediatric Infectious Diseases Society.  9:716-737. 2020
    2020 Defining the scourge of COVID-19 hyperinflammatory syndrome.  Lancet Rheumatology.  2:e727-e729. 2020
    2020 Drs. cron and chatham reply.  Journal of Rheumatology.  47:1723. 2020
    2020 Highways to hell: Mechanism-based management of cytokine storm syndromes.  Journal of Allergy and Clinical Immunology.  146:949-959. 2020
    2020 The use of anakinra in the treatment of secondary hemophagocytic lymphohistiocytosis 2020
    2020 Drs. Cron and Chatham reply.  Journal of Rheumatology.  47:1590-1591. 2020
    2020 Intravenous anakinra for cytokine storm syndromes – Authors' reply.  Lancet Rheumatology.  2:e522-e523. 2020
    2020 One-two punch of cytokine storm syndrome.  Blood.  136:645-646. 2020
    2020 Coronavirus is the trigger, but the immune response is deadly.  Lancet Rheumatology.  2:e370-e371. 2020
    2020 On the Alert for Cytokine Storm: Immunopathology in COVID-19.  Arthritis and Rheumatology.  72:1059-1063. 2020
    2020 Silencing the cytokine storm: the use of intravenous anakinra in haemophagocytic lymphohistiocytosis or macrophage activation syndrome.  Lancet Rheumatology.  2:e358-e367. 2020
    2020 The Rheumatologist's Role in COVID-19.  Journal of Rheumatology.  47:639-642. 2020
    2020 The genetics of macrophage activation syndrome.  Genes and Immunity.  21:169-181. 2020
    2020 The Question of Whether to Remain on Therapy for Chronic Rheumatic Diseases in the Setting of the Covid-19 Pandemic.  Journal of Rheumatology.  2020
    2020 Alagille Syndrome and Chronic Arthritis: An International Case Series.  Journal of Pediatrics.  218:228-230.e1. 2020
    2020 Adolescent Sjogren's syndrome presenting as psychosis: A case series 2020
    2020 Benefit of Anakinra in Treating Pediatric Secondary Hemophagocytic Lymphohistiocytosis.  Arthritis and Rheumatology.  72:326-334. 2020
    2020 Macrophage Activation Syndrome and Secondary Hemophagocytic Lymphohistiocytosis in Childhood Inflammatory Disorders: Diagnosis and Management.  Pediatric Drugs.  22:29-44. 2020
    2020 Response to: Â &tild; Successful treatment of plasma exchange for refractory systemic juvenile idiopathic arthritis complicated with macrophage activation syndrome and severe lung disease' by Sato et al.  Annals of the Rheumatic Diseases.  2020
    2020 Severe neonatal coronavirus disease 2019 presenting as acute respiratory distress syndrome 2020
    2019 Characteristics of coexisting localized scleroderma and inflammatory arthritis..  European Journal of Rheumatology.  1-5. 2019
    2019 Pediatric macrophage activation syndrome, recognizing the tip of the Iceberg..  European Journal of Rheumatology.  1-8. 2019
    2019 Successful treatment of pediatric Tolosa-Hunt syndrome with adalimumab..  European Journal of Rheumatology.  1-3. 2019
    2019 Patterns of B Cell Repletion Following Rituximab Therapy in a Pediatric Rheumatology Cohort..  Acr Open Rheumatology.  1:527-532. 2019
    2019 Ferritin to Erythrocyte Sedimentation Rate Ratio: Simple Measure to Identify Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis..  Acr Open Rheumatology.  1:345-349. 2019
    2019 American College of Rheumatology Provisional Criteria for Clinically Relevant Improvement in Children and Adolescents With Childhood-Onset Systemic Lupus Erythematosus.  Arthritis Care and Research.  71:579-590. 2019
    2019 Serum S100A8/A9 and S100A12 Levels in Children With Polyarticular Forms of Juvenile Idiopathic Arthritis: Relationship to Maintenance of Clinically Inactive Disease During Anti–Tumor Necrosis Factor Therapy and Occurrence of Disease Flare After Discontinuation of Therapy.  Arthritis and Rheumatology.  71:451-459. 2019
    2019 Akkermansia muciniphila is permissive to arthritis in the K/BxN mouse model of arthritis.  Genes and Immunity.  20:158-166. 2019
    2019 Development and initial validation of the MS score for diagnosis of macrophage activation syndrome in systemic juvenile idiopathic arthritis.  Annals of the Rheumatic Diseases.  78:1357-1362. 2019
    2019 Emergent high fatality lung disease in systemic juvenile arthritis.  Annals of the Rheumatic Diseases.  78:1722-1731. 2019
    2019 Standardizing terminology and assessment for orofacial conditions in juvenile idiopathic arthritis: International, multidisciplinary consensus-based recommendations.  Journal of Rheumatology.  46:518-522. 2019
    2019 The immunology of macrophage activation syndrome.  Frontiers in Immunology.  10. 2019
    2018 Rituximab treatment for chronic steroid-dependent Henoch-Schonlein purpura: 8 cases and a review of the literature 2018
    2018 Risk factors for intraarticular heterotopic bone formation in the temporomandibular joint in Juvenile idiopathic arthritis.  Journal of Rheumatology.  45:1301-1307. 2018
    2018 Risk, Timing, and Predictors of Disease Flare After Discontinuation of Anti–Tumor Necrosis Factor Therapy in Children With Polyarticular Forms of Juvenile Idiopathic Arthritis With Clinically Inactive Disease.  Arthritis and Rheumatology.  70:1508-1518. 2018
    2018 Brief Report: Novel UNC13D Intronic Variant Disrupting an NF-κB Enhancer in a Patient With Recurrent Macrophage Activation Syndrome and Systemic Juvenile Idiopathic Arthritis.  Arthritis and Rheumatology.  70:963-970. 2018
    2018 Toward Establishing a Standardized Magnetic Resonance Imaging Scoring System for Temporomandibular Joints in Juvenile Idiopathic Arthritis.  Arthritis Care and Research.  70:758-767. 2018
    2018 Effectiveness and safety of tofacitinib in rheumatoid arthritis: A cohort study 2018
    2018 Pediatric rheumatology infusion center: Report on therapeutic protocols and infusions given over 4 Years with focus on adverse events over 1 Year 2018
    2018 Effect of Biologic Therapy on Clinical and Laboratory Features of Macrophage Activation Syndrome Associated With Systemic Juvenile Idiopathic Arthritis.  Arthritis Care and Research.  70:409-419. 2018
    2018 Regulatory CD4 T cells inhibit HIV-1 expression of other CD4 T cell subsets via interactions with cell surface regulatory proteins.  Virology.  516:21-29. 2018
    2018 Smoking is the most significant modifiable lung cancer risk factor in systemic lupus erythematosus.  Journal of Rheumatology.  45:393-396. 2018
    2018 Age and fecal microbial strain-specific differences in patients with spondyloarthritis 2018
    2018 Defining the normal appearance of the temporomandibular joints by magnetic resonance imaging with contrast: A comparative study of children with and without juvenile idiopathic arthritis 2018
    2018 Creating the Subspecialty Pediatrics Investigator Network.  Journal of Pediatrics.  192:3-4.e2. 2018
    2018 Temporomandibular joint arthritis in juvenile idiopathic arthritis, now what? 2018
    2017 Risk of tuberculosis among Alabama children and adolescents treated with tumor necrosis factor inhibitors: A retrospective study 2017
    2017 Isolated arthritis of the temporomandibular joint as the initial manifestation of juvenile idiopathic arthritis.  Journal of Rheumatology.  44:1632-1635. 2017
    2017 Development and Initial Validation of the Macrophage Activation Syndrome/Primary Hemophagocytic Lymphohistiocytosis Score, a Diagnostic Tool that Differentiates Primary Hemophagocytic Lymphohistiocytosis from Macrophage Activation Syndrome.  Journal of Pediatrics.  189:72-78.e3. 2017
    2017 Malignancy in pediatric-onset systemic lupus erythematosus.  Journal of Rheumatology.  44:1484-1486. 2017
    2017 Association of Anti–3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Autoantibodies With DRB1*07:01 and Severe Myositis in Juvenile Myositis Patients.  Arthritis Care and Research.  69:1088-1094. 2017
    2017 Weathering a macrophage storm.  Journal of Rheumatology.  44:970-972. 2017
    2017 A review on SLE and malignancy.  Best Practice and Research: Clinical Rheumatology.  31:373-396. 2017
    2017 CD4 regulatory T cells augment HIV-1 expression of polarized M1 and M2 monocyte derived macrophages.  Virology.  504:79-87. 2017
    2017 Clinical orofacial examination in juvenile idiopathic arthritis: International consensus-based recommendations for monitoring patients in clinical practice and research studies.  Journal of Rheumatology.  44:326-333. 2017
    2016 Fecal metabolomics in pediatric spondyloarthritis implicate decreased metabolic diversity and altered tryptophan metabolism as pathogenic factors.  Genes and Immunity.  17:400-405. 2016
    2016 The microbiota in pediatric rheumatic disease: Epiphenomenon or therapeutic target?.  Current Opinion in Rheumatology.  28:537-543. 2016
    2016 Ustekinumab as a Therapeutic Option for Children with Refractory Enthesitis-Related Arthritis 2016
    2016 Whole-exome sequencing reveals mutations in genes linked to hemophagocytic lymphohistiocytosis and macrophage activation syndrome in fatal cases of H1N1 influenza.  Journal of Infectious Diseases.  213:1180-1188. 2016
    2016 A heterozygous RAB27A mutation associated with delayed cytolytic granule polarization and hemophagocytic lymphohistiocytosis.  Journal of Immunology.  196:2492-2503. 2016
    2016 2016 Classification Criteria for Macrophage Activation Syndrome Complicating Systemic Juvenile Idiopathic Arthritis: A European League Against Rheumatism/American College of Rheumatology/Paediatric Rheumatology International Trials Organisation Collaborative Initiative.  Arthritis and Rheumatology.  68:566-576. 2016
    2016 2016 Classification criteria for macrophage activation syndrome complicating systemic juvenile idiopathic arthritis: A European league against Rheumatism/American college of Rheumatology/Paediatric rheumatology international trials organisation collaborative initiative.  Annals of the Rheumatic Diseases.  75:481-489. 2016
    2016 Association of Myositis Autoantibodies, Clinical Features, and Environmental Exposures at Illness Onset with Disease Course in Juvenile Myositis.  Arthritis and Rheumatology.  68:761-768. 2016
    2016 Interleukin-1 Receptor Blockade Is Associated with Reduced Mortality in Sepsis Patients with Features of Macrophage Activation Syndrome: Reanalysis of a Prior Phase III Trial∗.  Critical Care Medicine.  44:275-281. 2016
    2016 Development of spondyloarthropathy following episodes of macrophage activation syndrome in children with heterozygous mutations in haemophagocytic lymphohistiocytosis-associated genes.  Clinical and Experimental Rheumatology.  34:953. 2016
    2016 Expert consensus on dynamics of laboratory tests for diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis.  RMD Open.  2. 2016
    2015 Macrophage Activation Syndrome 2015
    2015 Clinical features and correct diagnosis of macrophage activation syndrome.  Expert Review of Clinical Immunology.  11:1043-1053. 2015
    2015 Dissecting the heterogeneity of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis.  Journal of Rheumatology.  42:994-1001. 2015
    2015 Does viral hemorrhagic fever represent reactive hemophagocytic syndrome?.  Journal of Rheumatology.  42:1078-1080. 2015
    2015 Kill or be killed.  Journal of Immunology.  194:5041-5043. 2015
    2015 Magnetic resonance imaging findings following intraarticular infliximab therapy for refractory temporomandibular joint arthritis among children with juvenile idiopathic arthritis.  Journal of Rheumatology.  42:2155-2159. 2015
    2015 Safety and efficacy of rituximab in childhood-onset systemic lupus erythematosus and other rheumatic diseases.  Journal of Rheumatology.  42:541-546. 2015
    2015 Systemic and intra-articular anti-inflammatory therapy of temporomandibular joint arthritis in children with juvenile idiopathic arthritis.  Seminars in Orthodontics.  21:125-133. 2015
    2015 Temporomandibular joint arthritis in juvenile idiopathic arthritis: The last frontier.  International Journal of Clinical Rheumatology.  10:273-285. 2015
    2015 What investigations are needed to optimally monitor for malignancies in SLE?.  Lupus.  24:781-787. 2015
    2014 Altered microbiota associated with abnormal humoral immune responses to commensal organisms in enthesitis-related arthritis 2014
    2014 Genetic Defects in Cytolysis in Macrophage Activation Syndrome.  Current Rheumatology Reports.  16. 2014
    2014 High dose anakinra for treatment of severe neonatal Kawasaki disease: A case report 2014
    2014 Treatment of juvenile idiopathic arthritis: A revolution in care 2014
    2014 Results of a multinational survey regarding the diagnosis and treatment of temporomandibular joint involvement in juvenile idiopathic arthritis 2014
    2014 Changes in body mass index in children with juvenile idiopathic arthritis treated with tumor necrosis factor inhibitors.  Journal of Rheumatology.  41:113-118. 2014
    2014 Clinical features, treatment, and outcome of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis: A multinational, multicenter study of 362 patients.  Arthritis and Rheumatology.  66:3160-3169. 2014
    2014 IL-15 prolongs CD154 expression on human CD4 T cells via STAT5 binding to the CD154 transcriptional promoter.  Genes and Immunity.  15:137-144. 2014
    2014 Imaging of the temporomandibular joint in juvenile idiopathic arthritis.  Arthritis Care and Research.  66:47-54. 2014
    2014 Kinase control of latent HIV-1 infection: PIM-1 kinase as a major contributor to HIV-1 reactivation.  Journal of Virology.  88:364-376. 2014
    2014 Performance of current guidelines for diagnosis of macrophage activation syndrome complicating systemic juvenile idiopathic arthritis.  Arthritis and Rheumatology.  66:2871-2880. 2014
    2014 Systemic lupus erythematosus and malignancies: A review article.  Rheumatic Disease Clinics of North America.  40:497-506. 2014
    2014 The impact of Nucleofection® on the activation state of primary human CD4 T cells.  Journal of Immunological Methods.  408:123-131. 2014
    2013 Cancer risk in childhood-onset systemic lupus 2013
    2013 Treatment of Juvenile Idiopathic Arthritis in the Biologic Age.  Rheumatic Disease Clinics of North America.  39:751-766. 2013
    2013 High doses of infliximab in the management of juvenile idiopathic arthritis.  Journal of Rheumatology.  40:1749-1755. 2013
    2013 MHCII is required for α-Synuclein-induced activation of microglia, CD4 T cell proliferation, and dopaminergic neurodegeneration 2013
    2013 Retinal vasculitis in two pediatric patients with systemic lupus erythematosus: A case report 2013
    2013 Condylar Degeneration and Diseases-Local and Systemic Etiologies.  Seminars in Orthodontics.  19:89-96. 2013
    2013 Higher-dose anakinra is effective in a case of medically refractory macrophage activation syndrome.  Journal of Rheumatology.  40:743-744. 2013
    2013 Anaphylaxis to etanercept in two children with juvenile idiopathic arthritis 2013
    2013 Safety and efficacy of intra-articular infliximab therapy for treatment-resistant temporomandibular joint arthritis in children: A retrospective study.  Rheumatology.  52:554-559. 2013
    2013 An AP-1 binding site in the enhancer/core element of the HIV-1 promoter controls the ability of HIV-1 to establish latent infection.  Journal of Virology.  87:2264-2277. 2013
    2012 Host factor transcriptional regulation contributes to preferential expression of HIV type 1 in IL-4-producing CD4 T cells.  Journal of Immunology.  189:2746-2757. 2012
    2012 Intensive care requirement, rather than degree of serum ferritin elevation, predicts mortality in macrophage activation syndrome.  Pediatric Critical Care Medicine.  13:616. 2012
    2012 Risk factors for temporomandibular joint arthritis in children with juvenile idiopathic arthritis.  Journal of Rheumatology.  39:1880-1887. 2012
    2012 Management of temporomandibular joint arthritis in adult rheumatology practices: a survey of adult rheumatologists 2012
    2012 Intra-articular corticosteroid injections to the temporomandibular joints are safe and appear to be effective therapy in children with juvenile idiopathic arthritis.  Journal of Oral and Maxillofacial Surgery.  70:1802-1807. 2012
    2012 Macrophage activation syndrome as part of systemic juvenile idiopathic arthritis: Diagnosis, genetics, pathophysiology and treatment.  Genes and Immunity.  13:289-298. 2012
    2012 NF-ATc1 levels are increased in murine and human lupus T cells: Comment on the article by kyttaris et al.  Arthritis and Rheumatism.  64:1294. 2012
    2011 Attainment of inactive disease status following initiation of TNF-α inhibitor therapy for juvenile idiopathic arthritis: Enthesitis-related arthritis predicts persistent active disease.  Journal of Rheumatology.  38:2675-2681. 2011
    2011 Temporomandibular joint arthritis in pediatric Sjögren disease and sarcoidosis.  Journal of Rheumatology.  38:2272-2273. 2011
    2011 Reply.  Arthritis Care and Research.  63:1355. 2011
    2011 High prevalence of myositis in a southeastern United States pediatric systemic lupus erythematosus cohort 2011
    2011 Brain cavernomas associated with en coup de sabre linear scleroderma: Two case reports 2011
    2011 1.5 Decades Later: Bearing fruits from the ACR/EULAR exchange Program 2011
    2011 An international consensus survey of diagnostic criteria for macrophage activation syndrome in systemic juvenile idiopathic arthritis.  Journal of Rheumatology.  38:764-768. 2011
    2011 Anakinra as first-line disease-modifying therapy in systemic juvenile idiopathic arthritis: Report of forty-six patients from an international multicenter series.  Arthritis and Rheumatism.  63:545-555. 2011
    2011 Corticosteroid-induced spinal epidural lipomatosis in the pediatric age group: Report of a new case and updated analysis of the literature 2011
    2011 Successful treatment of severe paediatric rheumatic disease-associated macrophage activation syndrome with interleukin-1 inhibition following conventional immunosuppressive therapy: Case series with 12 patients.  Rheumatology.  50:417-419. 2011
    2011 Successful treatment of pediatric IgG4 related systemic disease with mycophenolate mofetil: Case report and a review of the pediatric autoimmune pancreatitis literature 2011
    2011 2011 American College of Rheumatology recommendations for the treatment of juvenile idiopathic arthritis: initiation and safety monitoring of therapeutic agents for the treatment of arthritis and systemic features..  Arthritis Care and Research.  63:465-482. 2011
    2011 Combination therapy of abatacept and in children with refractory systemic juvenile idiopathic arthritis: A retrospective case series.  Journal of Rheumatology.  38:180-181. 2011
    2010 Guilt by association - what is the true risk of malignancy in children treated with etanercept for JIA? 2010
    2010 Prolonged expression of CD154 on CD4 T cells from pediatric lupus patients correlates with increased CD154 transcription, increased nuclear factor of activated T cell activity, and glomerulonephritis.  Arthritis and Rheumatism.  62:2499-2509. 2010
    2010 Effectiveness and toxicity of methotrexate in juvenile idiopathic arthritis: Comparison of 2 initial dosing regimens.  Journal of Rheumatology.  37:870-875. 2010
    2009 FOXP3 inhibits activation-induced NFAT2 expression in T cells thereby limiting effector cytokine expression.  Journal of Immunology.  183:907-915. 2009
    2009 Rituximab Therapy for Severe Refractory Chronic Henoch-Schönlein Purpura.  Journal of Pediatrics.  155:136-139. 2009
    2009 The temporomandibular joint in juvenile idiopathic arthritis: Frequently used and frequently arthritic 2009
    2009 Determinants of the Establishment of Human Immunodeficiency Virus Type 1 Latency.  Journal of Virology.  83:3078-3093. 2009
    2009 Rheumatology fellows' perception on training and careers in academia: The american college of rheumatology fellow research and academic training survey.  Arthritis Care and Research.  61:266-273. 2009
    2008 FOXP3 inhibits HIV-1 infection of CD4 T-cells via inhibition of LTR transcriptional activity.  Virology.  381:161-167. 2008
    2008 A T-cell-specific CD154 transcriptional enhancer located just upstream of the promoter.  Genes and Immunity.  9:640-649. 2008
    2008 High prevalence of temporomandibular joint arthritis at disease onset in children with juvenile idiopathic arthritis, as detected by magnetic resonance imaging but not by ultrasound.  Arthritis and Rheumatism.  58:1189-1196. 2008
    2008 Research priorities in pediatric rheumatology: The Childhood Arthritis and Rheumatology Research Alliance (CARRA) consensus 2008
    2008 Evaluation of the presentation of systemic onset juvenile rheumatoid arthritis: Data from the Pennsylvania Systemic Onset Juvenile Arthritis Registry (PASOJAR).  Journal of Rheumatology.  35:343-348. 2008
    2008 Neither cell-surface nor soluble CD154 levels are associated with coronary artery disease in systemic lupus erythematosus.  Journal of Rheumatology.  35:359-360. 2008
    2007 Pediatric rheumatology for the adult rheumatologist II: Uveitis in juvenile idiopathic arthritis 2007
    2007 Benefit of fluoroscopically guided intraarticular, long-acting corticosteroid injection for subtalar arthritis in juvenile idiopathic arthritis 2007
    2007 Occult macrophage activation syndrome in patients with systemic juvenile idiopathic arthritis.  Journal of Rheumatology.  34:1133-1138. 2007
    2007 Reactive arthritis of the temporomandibular joints and cervical spine in a child 2007
    2007 CT-guided percutaneous steroid injection for management of inflammatory arthropathy of the temporomandibular joint in children.  American Journal of Roentgenology.  188:182-186. 2007
    2007 Juvenile idiopathic arthritis classification criteria: Loopholes and diagnosis software [3].  Journal of Rheumatology.  34:234. 2007
    2006 Benefit of intraarticular corticosteroid injection under fluoroscopic guidance for subtalar arthritis in juvenile idiopathic arthritis.  Journal of Rheumatology.  33:2330-2336. 2006
    2006 Picture of the month: anaplastic large cell lymphoma with hemophagocytic lymphohistiocytosis..  JAMA Pediatrics.  160:1177-1179. 2006
    2006 Interleukin 1 receptor antagonist to treat cytophagic histiocytic panniculitis with secondary hemophagocytic lymphohistiocytosis.  Journal of Rheumatology.  33:2081-2084. 2006
    2006 Sjögren syndrome in a child: Favorable response of the arthritis to TNFα blockade.  Clinical Rheumatology.  25:746-748. 2006
    2006 Temporomandibular joint arthritis in juvenile idiopathic arthritis: The forgotten joint.  Current Opinion in Rheumatology.  18:490-495. 2006
    2006 Chronic arthritis without uveitis in velocardiofacial syndrome.  Journal of Pediatrics.  149:281. 2006
    2006 Homocysteine levels and disease duration independently correlate with coronary artery calcification in patients with systemic lupus erythematosus.  Arthritis and Rheumatism.  54:2220-2227. 2006
    2006 Effective gene suppression using small interfering RNA in hard-to-transfect human T cells.  Journal of Immunological Methods.  312:1-11. 2006
    2006 Septic abscess in a child with juvenile idiopathic arthritis receiving anti-tumor necrosis factor-α therapy [1].  Journal of Rheumatology.  33:825. 2006
    2006 Treatment of pediatric localized scleroderma with methotrexate.  Journal of Rheumatology.  33:609-614. 2006
    2006 The γc-cytokine regulated transcription factor, STAT5, increases HIV-1 production in primary CD4 T cells.  Virology.  344:283-291. 2006
    2006 Early growth response-1 is required for CD154 transcription.  Journal of Immunology.  176:811-818. 2006
    2006 NFAT transcription factors - New players in the pathogenesis of inflammatory arthropathies?.  Autoimmunity Reviews.  5:106-110. 2006
    2006 Picture of the month.  JAMA Pediatrics.  160:1177-1179. 2006
    2006 The spectrum of renal tubular acidosis in paediatric Sjögren syndrome.  Rheumatology.  45:85-91. 2006
    2005 Sweet syndrome as an initial presentation in a child with systemic lupus erythematosus [1].  Lupus.  14:974-975. 2005
    2005 Utility of corticosteroid injection for temporomandibular arthritis in children with juvenile idiopathic arthritis.  Arthritis and Rheumatism.  52:3563-3569. 2005
    2005 Editorial: A signal achievement in the treatment of arthritis.  Arthritis and Rheumatism.  52:2229-2232. 2005
    2005 Pediatric rheumatology for the adult rheumatologist I: Therapy and dosing for pediatric rheumatic disorders 2005
    2004 Reciprocal regulation of the nuclear factor of activated T cells and HIV-1.  Genes and Immunity.  5:158-167. 2004
    2004 Overexpression of octamer transcription factors 1 or 2 alone has no effect on HIV-1 transcription in primary human CD4 T cells.  Virology.  321:323-331. 2004
    2003 Decreased CD154 expression by neonatal CD4+ T cells is due to limitations in both proximal and distal events of T cells activation.  International Immunology.  15:1461-1472. 2003
    2003 Methotrexate used as a steroid-sparing agent in non-renal chronic Henoch-Schönlein purpura.  Clinical and Experimental Rheumatology.  21:767-769. 2003
    2003 Erratum: Delineation of a novel pathway that regulates CD154 (CD40 ligand) expression (Molecular and Cellular Biology (2003) 23:2 (510-525)).  Molecular and Cellular Biology.  23:6338. 2003
    2003 CD154 transcriptional regulation in primary human CD4 T cells.  Immunologic Research.  27:185-202. 2003
    2003 Delineation of a novel pathway that regulates CD154 (CD40 ligand) expression.  Molecular and Cellular Biology.  23:510-525. 2003
    2002 Current treatment for chronic arthritis in childhood.  Current Opinion in Pediatrics.  14:684-687. 2002
    2002 Regulation of the murine Nfatc1 gene by NFATc2.  Journal of Biological Chemistry.  277:10704-10711. 2002
    2002 HIV-1, NFAT, and cyclosporin: Immunosuppression for the immunosuppressed? 2002
    2002 A T cell-specific enhancer of the human CD40 ligand gene.  Journal of Biological Chemistry.  277:7386-7395. 2002
    2001 Octamer proteins inhibit IL-4 gene transcription in normal human CD4 T cells.  Genes and Immunity.  2:464-468. 2001
    2001 Treatment for JRA in the new millennium 2001
    2000 Nabumetone induced pseudoporphyria in childhood [3] (multiple letters).  Journal of Rheumatology.  27:1817-1818. 2000
    2000 Nabumetone induced pseudoporphyria in childhood..  Journal of Rheumatology.  27:1817-1818. 2000
    2000 NFAT1 enhances HIV-1 gene expression in primary human CD4 T cells.  Clinical Immunology.  94:179-191. 2000
    1999 Current treatment by United States and Canadian pediatric rheumatologists.  Journal of Rheumatology.  26:2036-2038. 1999
    1999 T cell priming enhances IL-4 gene expression by increasing nuclear factor of activated T cells.  Journal of Immunology.  162:860-870. 1999
    1998 Methotrexate-induced hypersensitivity pneumonitis in a child with juvenile rheumatoid arthritis.  Journal of Pediatrics.  132:901-902. 1998
    1997 Childhood sarcoidosis--does age of onset predict clinical manifestations?.  Journal of Rheumatology.  24:1654-1656. 1997
    1997 Consistent transient transfection of DNA into non-transformed human and murine T-lymphocytes.  Journal of Immunological Methods.  205:145-150. 1997
    1997 Reactive arthritis to Clostridium difficile in a child 1997
    1996 Picture of the month. Polyarteritis nodosa with angioedema..  JAMA Pediatrics.  150:875-876. 1996
    1996 Picture of the month.  JAMA Pediatrics.  150:875-876. 1996
    1996 Reiter syndrome initially misdiagnosed as Kawasaki disease.  Journal of Pediatrics.  128:366-369. 1996
    1995 The human gp39 promoter: Two distinct nuclear factors of activated T cell protein-binding elements contribute independently to transcriptional activation.  Journal of Biological Chemistry.  270:29624-29627. 1995
    1995 Index of suspicion. Case 2. Diagnosis: peritonsillitis..  Pediatrics in Review.  16:117-119. 1995
    1995 Necrobacillosis: An unusual cause of purulent otitis media and sepsis.  Pediatric Emergency Care.  11:379-380. 1995
    1995 Reiter's syndrome associated with cryptosporidial gastroenteritis.  Journal of Rheumatology.  22:1962-1963. 1995
    1994 Differential effects of T cell receptor ligation of TCRγδ thymocyte development in fetal thymic organ culture.  Thymus.  23:131-153. 1994
    1994 Scleredema Revisited: A Poststreptococcal Complication.  Clinical Pediatrics.  33:606-610. 1994
    1992 Peripheral T cell receptor γδ variable gene repertoire maps to the T cell receptor loci and is influenced by positive selection.  Journal of Immunology.  149:3200-3207. 1992
    1991 Ligand specificity and repertoire development of murine TCRγδ cells.  Current Topics in Microbiology and Immunology.  173:133-139. 1991
    1991 Repertoire Development and Ligand Specificity of Murine TCRγδ Cells.  Immunological Reviews.  120:5-33. 1991
    1990 Polymorphisms and diversity of T-cell receptor-γ proteins expressed in mouse spleen.  Immunogenetics.  31:220-228. 1990
    1990 Freshly isolated Thy-1+ dendritic epidermal cells express T cell receptor γδ-CD3.  Journal of Dermatological Science.  1:459-464. 1990
    1990 T cell receptor δ-gene expression and diversity in the mouse spleen.  Journal of Immunology.  145:1311-1317. 1990
    1989 A TCR gamma delta cell recognizing a novel TL-encoded gene product. 1989
    1989 Identification of distinct T cell receptor (TCR)-γδ heterodimers using an anti-TCR-γ variable region serum.  Journal of Immunology.  143:3769-3775. 1989
    1989 Phenotypic and functional analysis of murine CD3+, CD4-, CD8- TCR-γδ-expressing peripheral T cells.  Journal of Immunology.  142:3754-3762. 1989
    1989 Structure and specificity of a class II MHC alloreactive γδ T cell receptor heterodimer.  Science.  245:746-749. 1989
    1988 Systematic development of distinct T cell receptor-γδ T cell subsets during fetal ontogeny.  Journal of Immunology.  141:3753-3759. 1988
    1988 Structure and specificity of T cell receptor γ/δ on major histocompatibility complex antigen-specific CD3+, CD4−, CD8− T lymphocytes.  Journal of Experimental Medicine.  168:1899-1916. 1988
    1988 Peripheral murine CD3+, CD4-, CD8- T lymphocytes express novel T cell receptor gamma delta structures..  Journal of Immunology.  141:1074-1082. 1988
    1988 Peripheral murine CD3+, CD4-, CD8- T lymphocytes express novel T cell receptor γδ structures.  Journal of Immunology.  141:1074-1082. 1988
    1987 Major histocompatibility complex-linked specificity of γδ receptor-bearing T lymphocytes.  Nature.  330:262-264. 1987

    Chapter

    Year Title Altmetric
    2018 Macrophage activation syndrome.  151-182. 2018
    2018 Diskitis.  302-303. 2018
    2018 Sarcoidosis.  814-815. 2018
    2018 Spondyloarthropathy.  872-873. 2018
    2016 Macrophage activation syndrome.  275-292. 2016
    2014 Juvenile Idiopathic Arthritis.  1950-1963. 2014
    2013 Juvenile idiopathic arthritis.  637-647. 2013

    Research Overview

  • Functional Genetics of Macrophage Activation Syndrome
    Temporomandibular Joint Arthritis

    • Principal Investigator On

    Investigator On

  • Center for Clinical and Translational Science (3 Linked Awards UL1, KL2, TL1)  awarded by National Center for Advancing Translational Sciences/NIH/DHHS 2019 - 2024
  • A Randomized, Open Label, Multi-Center, Phase 3 Efficacy Study of Sub-Q Abatacept in Preventing Extension of Oligoarticular JIA (Limit-JIA)  awarded by Duke University 2020 - 2023
  • Private Grant  awarded by SWEDISH ORPHAN BIOVITRUM AB 2020 - 2021
  • Overcoming HIV-1 Transcriptional Latency in Unresponsive CD4 T Cells  awarded by National Institute of Allergy and Infectious Diseases/NIH/DHHS 2016 - 2021
  • DNA Sequencing for Newborn Nurseries in the South  awarded by HUDSONALPHA INSTITUTE FOR BIOTECHNOLOGY 2017 - 2021
  • Private Grant  awarded by SWEDISH ORPHAN BIOVITRUM AB 2016 - 2020
  • UAB Multidisciplinary Clinical Research Center (P60)  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2013 - 2019
  • UAB Multidisciplinary Clinical Research Center - Project 3  awarded by National Institute of Arthritis & Musculoskeletal & Skin Diseases/NIH/DHHS 2013 - 2019
  • Observational Study of Pediatric Rheumatic Diseases : The CARRA Registry  awarded by Duke University 2015 - 2018
  • Validation of the Class II MHC Transactivator (CIITA) in Models of PD  awarded by Fox (Michael J.) Foundation for Parkinson's Research 2014 - 2016
  • Childhood Arthritis and Rheumatology Research Alliance ("CARRA Registry")  awarded by Duke University 2012 - 2015
  • Childhood Arthritis and Research Alliance Network (CARRANet): Juvenile Dermatomyositis Consensus Treatment Plan  awarded by DUKE CLINICAL RESEARCH INSTITUTE 2013 - 2015
  • Private Grant  awarded by BRISTOL MYERS SQUIBB PHARMACEUTICAL COMPANY 2013 - 2015
  • Childhood Arthritis and Research Alliance Network (CARRANet): Juvenile Idiopathic Arthritis Consensus Treatment Plan  awarded by Duke University 2013 - 2014
  • Improved Understanding of the Biology and use of TNF Inhibition in Children with JIA  awarded by CHILDREN'S HOSPITAL MEDICAL CENTER (CINCINNATI) 2011 - 2013

    • Teaching Overview

  • Lecturer, Pathology 795, Rheumatology/CAMBAC Journal Club, 2008-present

    Case Presentation, University of Alabama at Birmingham School of Medicine, “Patient Centered Teaching”, Medicine/Rheumatology, Spring 2008, Fall 2009

    Lecturer, topic of “Pediatric Rheumatology”, University of Alabama at Birmingham School of Medicine 3rd year medical students required Pediatric clerkship, every 8 weeks, 2008-2010

    Lecturer, “Juvenile Idiopathic Arthritis”, UAB School of Medicine Musculoskeletal and Skin Module, September 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019

    Mentor, Integration of Basic Science and Clinical Medicine for 3rd year medical students, 2010-present

    Lecturer, “Transcription Factors in Autoimmunity and Autoimmune Diseases”, Advanced Course in Autoimmunity, Spring 2010


    Course Director, Pediatric Rheumatology Acting Internship for medical students, 2010-present


    Participating Faculty member, Pediatric Dentistry Physical Assessment I, Clinical Rotation, Fall 2010-present


    Evaluator, PROSCE (Pediatric Rheumatology Objective Structured Clinical Examination), Northwestern University, November 2011

    Lecturer, “Macrophage Activation Syndrome: A Killer Disease with a Killing Defect”, UAB HHMI Program course, “Modeling Human Diseases”, June 2014

    • Teaching Activities

  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2014) 2014
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2014) 2014
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2013) 2013
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2013) 2013
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2013) 2013
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2013) 2013
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2012) 2012
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2011) 2011
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2011) 2011
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2011) 2011
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2011) 2011
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2011) 2011
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2011) 2011
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2011) 2011
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2011) 2011
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2011) 2011
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Spring Term 2011) 2011
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2010) 2010
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2010) 2010
  • 52-525 - PEDIATRIC RHEUMATOLOGY (Fall Term 2010) 2010

    • Education And Training

  • Doctor of Medicine, University of California System : Los Angeles 1991
  • Doctor of Philosophy in Immunology, University of Chicago 1990
  • Lucille Salter Packard Childrens' Hospital, Internship 1992
  • Lucille Salter Packard Childrens' Hospital, Residency 1994
  • Howard Hughes Fellow, Postdoctoral Fellowship 1999
  • University of Washington Medical Center, Postdoctoral Fellowship 1997

    • Full Name

  • Randy Cron