Positions

Selected Publications

Academic Article

Year Title Altmetric
2022 MicroRNA-181c-5p modulates phagocytosis efficiency in bone marrow-derived macrophagesInflammation Research.  71:321-330. 2022
2021 Fabrication and characterization of a thick, viable bi-layered stem cell-derived surrogate for future myocardial tissue regenerationBiomedical Materials.  16. 2021
2021 Engineered Aging Cardiac Tissue Chip Model for Studying Cardiovascular Disease 2021
2021 Role of exosomal microRNA signatures: An emerging factor in preeclampsia-mediated cardiovascular diseasePlacenta.  103:226-231. 2021
2020 DNA damage-free iPS cells exhibit potential to yield competent cardiomyocytes 2020
2019 Cardiac tissue chips (ctcs) for modeling cardiovascular diseaseIEEE Transactions on Biomedical Engineering.  66:3436-3443. 2019
2019 Correction: Maturation of three-dimensional, hiPSC-derived cardiomyocyte spheroids utilizing cyclic, uniaxial stretch and electrical stimulation (PLoS ONE (2019) 14: 7 (e0219442) DOI: 10.1371/journal.pone.0219442)PLoS ONE.  14. 2019
2019 Scaffold-free bioprinter utilizing layer-by-layer printing of cellular spheroidsMicromachines.  10. 2019
2019 Functionally Competent DNA Damage-Free Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Myocardial RepairCirculation.  140:520-522. 2019
2019 Maturation of three-dimensional, hiPSC-derived cardiomyocyte spheroids utilizing cyclic, uniaxial stretch and electrical stimulationPLoS ONE.  14. 2019
2019 Hemodynamic Stimulation Using the Biomimetic Cardiac Tissue Model (BCTM) Enhances Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes 2019
2019 Expression of Concern: Growth properties of cardiac stem cells are a novel biomarker of patients' outcome after coronary bypass surgery (Circulation Research (2014) 129 (157-172) DOI: 10.1161/CIRCULATIONAHA.113.006591)Circulation Research.  124:e4-e5. 2019
2019 Assessing stem cell DNA integrity for cardiac cell therapyJournal of Visualized Experiments.  2019. 2019
2019 Corrigendum: Transactivation domain of p53 regulates DNA repair and integrity in human iPS cells (Am J Physiol Heart Circ Physiol, (2018) 315, (H512-H521), 10.1152/ajpheart.00160.2018) 2019
2018 Erratum: Spheroids of cardiomyocytes derived from human-induced pluripotent stem cells improve recovery from myocardial injury in mice (American Journal of Physiology - Heart and Circulatory Physiology (2018) 315 (H327-H339) DOI: 10.1152/ajpheart.00688.2017) 2018
2018 Retraction: γ-tocotrienol promotes trail-induced apoptosis through reactive oxygen species/extracellular signal-regulated kinase/P53–mediated upregulation of death receptors (Molecular Cancer Therapeutics (2010) 9 (2196–207) DOI: 10.1158/1535-7163.MCT-10-0277)Molecular Cancer Therapeutics.  17:2072. 2018
2018 Transactivation domain of p53 regulates DNA repair and integrity in human ips cells 2018
2018 Spheroids of cardiomyocytes derived from human-induced pluripotent stem cells improve recovery from myocardial injury in mice 2018
2018 VEGF nanoparticles repair the heart after myocardial infarction 2018
2018 Large cardiac muscle patches engineered from human induced-pluripotent stem cell-derived cardiac cells improve recovery from myocardial infarction in swineCirculation.  137:1712-1730. 2018
2018 Oxytocin alters cell fate selection of rat neural progenitor cells in vitroPLoS ONE.  13. 2018
2017 Single-cell analysis of the fate of c-kit-positive bone marrow cells 2017
2017 p53 Modulates the Fate of Cardiac Progenitor Cells Ex Vivo and in the Diabetic Heart In VivoEBioMedicine.  16:224-237. 2017
2016 Meeting Report for NIH 2016 Progenitor Cell Biology Consortium Cardiovascular Tissue Engineering 2016Circulation Research.  119:981-983. 2016
2016 Correction: Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors. Evidence for the Role of Reactive Oxygen Species and JNK (Journal of Biological Chemistry (2011) 286 (5546-5557))Journal of Biological Chemistry.  291:16924. 2016
2016 Correction: γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP-1 and sensitizes tumor cells to chemotherapeutic agents (Journal of Biological Chemistry (2010) 285 (33520-33528))Journal of Biological Chemistry.  291:16922. 2016
2016 Myocyte repolarization modulates myocardial function in aging dogs 2016
2016 Retraction notice to "cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptake" (Biochem. Pharmacol. (2010) 80 (1021-1032) DOI:10.1016/j.bcp.2010.06.022)Biochemical Pharmacology.  102:142. 2016
2016 Reduction in kv current enhances the temporal dispersion of theaction potential in diabetic myocytes: Insights from a novelrepolarization algorithm 2016
2015 Late Na + current and protracted electrical recovery are critical determinants of the aging myopathyNature Communications.  6. 2015
2014 Inositol 1,4,5-trisphosphate receptors and human left ventricular myocytesCirculation.  129. 2014
2014 Growth properties of cardiac stem cells are a novel biomarker of patients' outcome after coronary bypass surgeryCirculation.  129:157-172. 2014
2014 Response to letter regarding article, "growth properties of cardiac stem cells are a novel biomarker of patients' outcome after coronary bypass surgeryCirculation.  130:e118-e119. 2014
2013 Age-Associated defects in epha2 signaling impair the migration of human cardiac progenitor cellsCirculation.  128:2211-2223. 2013
2013 Inositol 1, 4, 5-trisphosphate receptors and human left ventricular myocytesCirculation.  128:1286-1297. 2013
2013 Erratum: Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor (Journal of Molecular Medicine (2010) 88: 12 (1243-1253) DOI: 10.1007/s00109-010-0669-3) 2013
2012 Ursolic acid inhibits growth and metastasis of human, colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: Chemosensitization with capecitabineClinical Cancer Research.  18:4942-4953. 2012
2012 Modification of cysteine 179 of IκBα kinase by nimbolide leads to down-regulation of NF-κB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents (Journal of Biological Chemistry (2010) 285, (35406-35417))Journal of Biological Chemistry.  287:12152. 2012
2012 Zyflamend sensitizes tumor cells to TRAIL-induced apoptosis through up-regulation of death receptors and down-regulation of survival proteins: Role of ROS-dependent CCAAT/enhancer-binding protein-homologous protein pathwayAntioxidants and Redox Signaling.  16:413-427. 2012
2012 Tocotrienols fight cancer by targeting multiple cell signaling pathwaysGenes and Nutrition.  7:43-52. 2012
2011 Bharangin, a diterpenoid quinonemethide, abolishes constitutive and inducible nuclear factor-κB (NF-κB) activation by modifying p65 on cysteine 38 residue and reducing inhibitor of nuclear factor-κB α kinase activation, leading to suppression of NF-κB-regulated gene expression and sensitization of tumor cells to chemotherapeutic agentsMolecular Pharmacology.  80:769-781. 2011
2011 Dihydroxypentamethoxyflavone down-regulates constitutive and inducible signal transducers and activators of transcription-3 through the induction of tyrosine phosphatase SHP-1Molecular Pharmacology.  80:889-899. 2011
2011 Identification of novel anti-inflammatory agents from ayurvedic medicine for prevention of chronic diseases: "Reverse pharmacology" and "Bedside to bench" approachCurrent Drug Targets.  12:1595-1653. 2011
2011 Role of nuclear factor-kB-mediated inflammatory pathways in cancer-related symptoms and their regulation by nutritional agents 2011
2011 NF-κB addiction and its role in cancer: One size does not fit allOncogene.  30:1615-1630. 2011
2011 Ursolic acid, a pentacyclin triterpene, potentiates trail-induced apoptosis through p53-independent up-regulation of death receptors: Evidence for the role of reactive oxygen species and JNKJournal of Biological Chemistry.  286:5546-5557. 2011
2011 A novel pentamethoxyflavone down-regulates tumor cell survival and proliferative and angiogenic gene products through inhibition of IκB kinase activation and sensitizes tumor cells to apoptosis by cytokines and chemotherapeutic agentsMolecular Pharmacology.  79:279-289. 2011
2011 Chemosensitization of tumors by resveratrolAnnals of the New York Academy of Sciences.  1215:150-160. 2011
2011 Neuroprotection by spice-derived nutraceuticals: You are what you eat!Molecular Neurobiology.  44:142-159. 2011
2010 Delivery of antiinflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancerBiochemical Pharmacology.  80:1833-1843. 2010
2010 Tocotrienols, the vitamin E of the 21st century: Its potential against cancer and other chronic diseasesBiochemical Pharmacology.  80:1613-1631. 2010
2010 Modification of cysteine 179 of IκBα kinase by nimbolide leads to down-regulation of NF-κB-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agentsJournal of Biological Chemistry.  285:35406-35417. 2010
2010 Thiocolchicoside exhibits anticancer effects through downregulation of NF-κB pathway and its regulated gene products linked to inflammation and cancerCancer Prevention Research.  3:1462-1472. 2010
2010 γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP-1 and sensitizes tumor cells to chemotherapeutic agentsJournal of Biological Chemistry.  285:33520-33528. 2010
2010 Targeting inflammatory pathways by triterpenoids for prevention and treatment of cancerToxins.  2:2428-2466. 2010
2010 Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor 2010
2010 Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptakeBiochemical Pharmacology.  80:1021-1032. 2010
2010 Embelin suppresses osteoclastogenesis induced by receptor activator of NF-κB ligand and tumor cells in vitro through inhibition of the NF-κB cell signaling pathway 2010
2010 γ-Tocotrienol promotes TRAIL-induced apoptosis through reactive oxygen species/extracellular signal-regulated kinase/p53-mediated upregulation of death receptorsMolecular Cancer Therapeutics.  9:2196-2207. 2010
2008 Photoaffinity labeling of sialidase with a biotin-conjugated phenylaminodiazirine derivative of 2,3-didehydro-2-deoxy-N-acetylneuraminic acidBiological and Pharmaceutical Bulletin.  31:352-356. 2008
2008 Identification and characterization of cathepsin D in a highly purified sialidase from starfish A. pectiniferaJournal of Biochemistry.  143:117-122. 2008

Chapter

Year Title Altmetric
2016 Chronic diseases caused by chronic inflammation require chronic treatment: The anti-inflammatory lifestyle.  373-446. 2016

Education And Training

  • Doctor of Science in Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences 2008
  • Full Name

  • Ramaswamy Kannappan