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Rajasekaran Namakkal Soorappan
Associate Professor
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E-mail
rajnsr@uabmc.edu
rajnsr@uab.edu
Phone
205-996-9839
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Rajasekaran Namakkal Soorappan
Associate Professor
Positions
Associate Scientist (C)
,
Comprehensive Cardiovascular Center
,
School of Medicine
Associate Scientist (C)
,
Comprehensive Diabetes Center
,
School of Medicine
Assistant Professor (S)
,
Dept of Biomedical Engineering
,
Academic Joint Departments
Associate Professor (P)
,
Molecular & Cellular Pathology
,
Joint Pathology
Associate Scientist (C)
,
Center for Exercise Medicine
,
Cell, Developmental and Integrative Biology (CDIB)
Publications
Research
Teaching
Background
Contact
Publications
Selected Publications
Academic Article
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Year
Title
Altmetric
2022
Transgenic Expression of Nrf2 Induces a Pro-Reductive Stress and Adaptive Cardiac Remodeling in the Mouse
.
Genes
. 13.
2022
2022
Tandem Mass Tagging Based Identification of Proteome Signatures for Reductive Stress Cardiomyopathy
.
Frontiers in Cardiovascular Medicine
. 9.
2022
2022
Editorial: Metabolic and Redox Regulation at the Center of Aging.
.
Frontiers in Aging
. 3:858295.
2022
2021
Identification of Nrf2-responsive microRNA networks as putative mediators of myocardial reductive stress
.
Scientific Reports
. 11.
2021
2021
Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathy
.
Free Radical Biology and Medicine
. 169:317-342.
2021
2021
Attenuation of protein glycation by functional polyphenolics of dragon fruit (Hylocereus polyrhizus); an in vitro and in silico evaluation
.
Food Research International
. 140.
2021
2021
Activation of EP4 receptor limits transition of acute to chronic heart failure in lipoxygenase deficient mice.
.
Theranostics
. 11:2742-2754.
2021
2021
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
1
.
Autophagy
. 17:1-382.
2021
2021
Role of exosomal microRNA signatures: An emerging factor in preeclampsia-mediated cardiovascular disease
.
Placenta
. 103:226-231.
2021
2021
Transcriptional Regulation of Structural and Functional Adaptations in a Developing Adulthood Myocardium.
2021
2021
microRNA-377 Signaling Modulates Anticancer Drug-Induced Cardiotoxicity in Mice.
.
Frontiers in Cardiovascular Medicine
. 8:737826.
2021
2020
Reductive stress promotes protein aggregation and impairs neurogenesis
.
Redox Biology
. 37.
2020
2020
Reductive stress impairs myogenic differentiation
.
Redox Biology
. 34.
2020
2020
Reductive Stress: Neglected Science.
.
Antioxidants and Redox Signaling
.
2020
2020
Reductive Stress Causes Pathological Cardiac Remodeling and Diastolic Dysfunction
.
Antioxidants and Redox Signaling
. 32:1293-1312.
2020
2020
Role of Free Radical Formation in Murine Cytomegalovirus–Induced Hearing Loss
2020
2020
DNA damage-free iPS cells exhibit potential to yield competent cardiomyocytes
2020
2020
MitoQ regulates redox-related noncoding RNAs to preserve mitochondrial network integrity in pressure-overload heart failure
2020
2019
Altered C10 domain in cardiac myosin binding protein-C results in hypertrophic cardiomyopathy.
.
Cardioscience
. 115:1986-1997.
2019
2019
Enhanced Keap1-Nrf2 signaling protects the myocardium from isoproterenol-induced pathological remodeling in mice
.
Redox Biology
. 27.
2019
2019
Functionally Competent DNA Damage-Free Induced Pluripotent Stem Cell-Derived Cardiomyocytes for Myocardial Repair
.
Circulation
. 140:520-522.
2019
2019
OBG-like ATPase 1 inhibition attenuates angiotensin II-induced hypertrophic response in human ventricular myocytes via GSK-3beta/beta-catenin signalling
.
Clinical and Experimental Pharmacology and Physiology
. 46:743-751.
2019
2019
Exercise Mediated Nrf2 Signaling Protects the Myocardium From Isoproterenol-Induced Pathological Remodeling
.
Frontiers in Cardiovascular Medicine
. 6.
2019
2019
Evaluation of flow-modulation approaches in ventricular assist devices using an in-vitro endothelial cell culture model
.
Journal of Heart and Lung Transplantation
. 38:456-465.
2019
2019
Mitoquinone ameliorates pressure overload-induced cardiac fibrosis and left ventricular dysfunction in mice
.
Redox Biology
. 21.
2019
2019
Convergences of Life Sciences and Engineering in Understanding and Treating Heart Failure
.
Circulation Research
. 124:161-169.
2019
2019
Maternal perinatal calorie restriction temporally regulates the hepatic autophagy and redox status in male rat
.
Free Radical Biology and Medicine
. 130:592-600.
2019
2019
Morinda citrifolia and Its Active Principle Scopoletin Mitigate Protein Aggregation and Neuronal Apoptosis through Augmenting the DJ-1/Nrf2/ARE Signaling Pathway.
.
Oxidative Medicine and Cellular Longevity
. 2019:2761041.
2019
2018
Evidence for a hyper-reductive redox in a sub-set of heart failure patients
.
Journal of Translational Medicine
. 16.
2018
2018
Recurrent heat shock impairs the proliferation and differentiation of C2C12 myoblasts
.
Cell Stress and Chaperones
. 23:399-410.
2018
2018
Temporal partitioning of adaptive responses of the murine heart to fasting
.
Life Sciences
. 197:30-39.
2018
2018
Excess ω-6 fatty acids influx in aging drives metabolic dysregulation, electrocardiographic alterations, and low-grade chronic inflammation
2018
2018
Blueberry Metabolites Attenuate Lipotoxicity-Induced Endothelial Dysfunction
.
Molecular Nutrition and Food Research
. 62.
2018
2017
Identification of transcriptome signature for myocardial reductive stress
.
Redox Biology
. 13:568-580.
2017
2017
Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heart
.
Journal of Molecular and Cellular Cardiology
. 110:80-95.
2017
2017
TNF-alpha Is not a Miscreant: A Hero for Basal Nrf2-Antioxidant Signaling.
2017
2017
Constitutive activation of Nrf2 induces a stable reductive state in the mouse myocardium
.
Redox Biology
. 12:937-945.
2017
2017
Differential regulation of miRNA and mRNA expression in the myocardium of Nrf2 knockout mice
.
BMC Genomics
. 18.
2017
2017
Chronic endurance exercise impairs cardiac structure and function in middle-aged mice with impaired Nrf2 signaling
.
Frontiers in Physiology
. 8.
2017
2017
Cardiac aging – benefits of exercise, Nrf2 activation and antioxidant signaling
.
Advances in Experimental Medicine and Biology
. 999:231-255.
2017
2016
Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism
.
Free Radical Biology and Medicine
. 100:94-107.
2016
2016
A biphasic effect of TNF-α in regulation of the Keap1/Nrf2 pathway in cardiomyocytes
.
Redox Biology
. 9:77-89.
2016
2016
Disruption of desmin-mitochondrial architecture in patients with regurgitant mitral valves and preserved ventricular function
.
Journal of Thoracic and Cardiovascular Surgery
. 152:1059-1070.e2.
2016
2016
Evaluation of the effect of diminished pulsatility as seen in continuous flow ventricular assist devices on arterial endothelial cell phenotype and function
.
Journal of Heart and Lung Transplantation
. 35:930-932.
2016
2016
Nuclear Factor–Erythroid-2–Related Factor 2 in Aging and Lung Fibrosis
.
American Journal of Pathology
. 186:1712-1723.
2016
2016
Exercise, Nrf2 and antioxidant signaling in cardiac aging
.
Frontiers in Physiology
. 7.
2016
2016
Disruption of nuclear factor (erythroid-derived-2)-like 2 antioxidant signaling: A mechanism for impaired activation of stem cells and delayed regeneration of skeletal muscle
2016
2016
Abrogation of Nrf2 impairs antioxidant signaling and promotes atrial hypertrophy in response to high-intensity exercise stress
.
Journal of Translational Medicine
. 14.
2016
2015
Erratum: KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity (Biochemical Journal (2015) 469 (347-355))
.
Biochemical Journal
. 471:431.
2015
2015
KEAP1-NRF2 signalling and autophagy in protection against oxidative and reductive proteotoxicity
.
Biochemical Journal
. 469:347-355.
2015
2015
Nickel elution properties of contemporary interatrial shunt closure devices
2015
2015
Redox Signaling and the Cardiovascular and Skeletal Muscle System
.
Oxidative Medicine and Cellular Longevity
. 2015.
2015
2015
Reductive potential - A savior turns stressor in protein aggregation cardiomyopathy
2015
2014
Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages
.
Cell
. 156:1223-1234.
2014
2014
Nrf2 deficiency promotes apoptosis and impairs PAX7/MyoD expression in aging skeletal muscle cells
.
Free Radical Biology and Medicine
. 71:402-414.
2014
2013
Nrf2 deficiency prevents reductive stress-induced hypertrophic cardiomyopathy.
.
Cardioscience
. 100:63-73.
2013
2013
The NADPH metabolic network regulates human αB-crystallin cardiomyopathy and reductive stress in Drosophila melanogaster.
.
PLoS Genetics
. 9:e1003544.
2013
2012
Disruption of Nrf2/ARE signaling impairs antioxidant mechanisms and promotes cell degradation pathways in aged skeletal muscle.
2012
2012
Acute exercise stress activates Nrf2/ARE signaling and promotes antioxidant mechanisms in the myocardium.
.
Free Radical Biology and Medicine
. 52:366-376.
2012
2012
Impaired transcriptional activity of Nrf2 in age-related myocardial oxidative stress is reversible by moderate exercise training.
.
PLoS One
. 7:e45697.
2012
2011
Sustained activation of nuclear erythroid 2-related factor 2/antioxidant response element signaling promotes reductive stress in the human mutant protein aggregation cardiomyopathy in mice.
.
Antioxidants and Redox Signaling
. 14:957-971.
2011
2010
Selective degradation of aggregate-prone CryAB mutants by HSPB1 is mediated by ubiquitin-proteasome pathways.
.
Journal of Molecular and Cellular Cardiology
. 49:918-930.
2010
2008
Global expression profiling identifies a novel biosignature for protein aggregation R120GCryAB cardiomyopathy in mice.
.
Physiological Genomics
. 35:165-172.
2008
2008
Autophagy is an adaptive response in desmin-related cardiomyopathy.
2008
2008
Unmasking different mechanical and energetic roles for the small heat shock proteins CryAB and HSPB2 using genetically modified mouse hearts.
2008
2007
CRYAB and HSPB2 deficiency alters cardiac metabolism and paradoxically confers protection against myocardial ischemia in aging mice.
2007
2007
TNF-alpha-induced mitochondrial oxidative stress and cardiac dysfunction: restoration by superoxide dismutase mimetic Tempol.
2007
2007
Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice.
.
Cell
. 130:427-439.
2007
2005
Effects of the antioxidant properties of millet species on oxidative stress and glycemic status in alloxan-induced rats
.
Progress in food & nutrition science
. 25:1109-1120.
2005
2005
Chronic depletion of glutathione (GSH) and minimal modification of LDL in vivo: its prevention by glutathione mono ester (GME) therapy.
2005
2005
Mouse HSF1 disruption perturbs redox state and increases mitochondrial oxidative stress in kidney.
.
Antioxidants and Redox Signaling
. 7:465-471.
2005
2004
The effect of finger millet feeding on the early responses during the process of wound healing in diabetic rats.
2004
2004
Modulation of rat erythrocyte antioxidant defense system by buthionine sulfoximine and its reversal by glutathione monoester therapy.
2004
2004
Vitamin E prevents buthionine sulfoximine-induced biochemical disorders in the rat.
.
Journal of Pharmacy and Pharmacology
. 56:91-99.
2004
2002
The effect of glutathione monoester (GME) on glutathione (GSH) depleted rat liver.
.
Journal of Nutritional Biochemistry
. 13:302-306.
2002
Research
Principal Investigator On
Defining the Role of miR-671 in Cardiomyocyte Redox State and Pathology
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
Reductive Stress Induces Proteotoxic Cardiac Disease
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
Reductive Stress Induces Proteotoxic Cardiac Disease
awarded by
National Heart, Lung, and Blood Institute/NIH/DHHS
Role of Nrf2 Signaling in Myocardial Defense on Aging
awarded by
American Heart Association
Screening for Nrf2 mutations and circulatory redox state in heart failure patients.
awarded by
SRI RAMACHANDRA INSTITUTE OF HIGHER EDUCATION AND LEARNING
Targeting Oxidative Stress to Prevent Vascular and Skeletal Muscle Dysfunction during Disuse
awarded by
University of Utah
The Human G31R Mutation in Nrf2 (Nrf2G31R) Induces Reductive Stress Cardiomyopathy
awarded by
American Heart Association
Teaching
Teaching Activities
BME798 - Non-Dissertation Research (Fall Term 2018)
GBSC700 - Journal Clubs (Fall Term 2016)
GBSC700 - Journal Clubs (Fall Term 2017)
GBSC700 - Journal Clubs (Spring Term 2017)
GBSC700 - Journal Clubs (Spring Term 2018)
GBSC700 - Journal Clubs (Spring Term 2022)
Background
Education And Training
Doctor of Philosophy in Biochemistry,
University of Madras
2001
Contact
Full Name
Rajasekaran
Namakkal Soorappan