Qin Wang

Qin Wang
Professor

Associate Scientist (C), Center for Biophysical Sciences and Engineering (CBSE) , School of Optometry 2008 -
Scientist (C), Comprehensive Neuroscience Center , General Clinical Research Center 2008 -
Scientist (C), Comprehensive Diabetes Center , School of Medicine 2011 -
Professor (P), Cell, Developmental and Integrative Biology (CDIB) , Academic Joint Departments 2012 -
Scientist (C), Alzheimer's Disease Center , Neurology 2016 -
Senior Scientist (C), Global Center for Craniofacial, Oral and Dental Disorders (GC-CODED) , School of Dentistry 2017 -
Professor (S), Neurobiology , Academic Joint Departments 2019 -

Overview

Dr. Qin Wang received her M.D. degree from Beijing Medical University, China. After traveling to the US, she obtained her Ph.D. degree in December 1999 from University of Iowa. She then did her postdoc work at Vanderbilt University, where she was appointed as a Research Assistant Professor two years later. In June 2005, Dr. Wang joined UAB as an Assistant Professor.

Selected Publications

Academic Article

Year	Title	Altmetric
2020	Author Correction: The in vivo specificity of synaptic Gβ and Gγ subunits to the α2a adrenergic receptor at CNS synapses (Scientific Reports, (2019), 9, 1, (1718), 10.1038/s41598-018-37222-1). Scientific Reports. 10. 2020
2020	CHD7 regulates cardiovascular development through ATP-dependent and -independent activities 2020
2020	Spinophilin-deficient mice are protected from diet-induced obesity and insulin resistance 2020
2020	β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade. Science Translational Medicine. 12. 2020
2019	The in vivo specificity of synaptic Gβ and Gγ subunits to the α2a adrenergic receptor at CNS synapses. Scientific Reports. 9. 2019
2019	Complex noradrenergic dysfunction in Alzheimer's disease: Low norepinephrine input is not always to blame. Brain Research. 1702:12-16. 2019
2017	Effective attenuation of adenosine a1r signaling by neurabin requires oligomerization of neurabin. Molecular Pharmacology. 92:630-639. 2017
2017	The amyloid precursor protein modulates α2A-adrenergic receptor endocytosis and signaling through disrupting arrestin 3 recruitment. The FASEB Journal. 31:4434-4446. 2017
2017	Strength of cholinergic tone dictates the polarity of dopamine D2 receptor modulation of striatal cholinergic interneuron excitability in DYT1 dystonia. Experimental Neurology. 295:162-175. 2017
2017	Age-dependent differential regulation of anxiety- and depression-related behaviors by neurabin and spinophilin. PLoS ONE. 12. 2017
2017	Cortical adrenoceptor expression, function and adaptation under conditions of cannabinoid receptor deletion. Experimental Neurology. 292:179-192. 2017
2017	Diverse arrestin-recruiting and endocytic profiles of tricyclic antipsychotics acting as direct α2A adrenergic receptor ligands. Neuropharmacology. 116:38-49. 2017
2016	Sema6D acts downstream of bone morphogenetic protein signalling to promote atrioventricular cushion development in mice. Cardiovascular Research. 112:532-542. 2016
2015	Spinophilin is indispensable for the α2B adrenergic receptor-elicited hypertensive response. PLoS ONE. 10. 2015
2015	Noradrenergic dysfunction in Alzheimer's disease. Frontiers in Neuroscience. 9. 2015
2015	Tau-dependent Kv4.2 depletion and dendritic hyperexcitability in a mouse model of Alzheimer’s disease 2015
2014	α(2A) adrenergic receptor promotes amyloidogenesis through disrupting APP-SorLA interaction 2014
2014	Cannabinoid modulation of alpha2 adrenergic receptor function in rodent medial prefrontal cortex. European Journal of Neuroscience. 40:3202-3214. 2014
2014	Tricyclic antidepressants exhibit variable pharmacological profiles at the α2A adrenergic receptor. Biochemical and Biophysical Research Communications. 451:461-466. 2014
2014	Critical roles of miRNA-mediated regulation of TGFβ signalling during mouse cardiogenesis. Cardiovascular Research. 103:258-267. 2014
2014	CHD7 interacts with BMP R-SMADs to epigenetically regulate cardiogenesis in mice. Human Molecular Genetics. 23:2145-2156. 2014
2014	The α2B-adrenergic receptor is mutant in cortical myoclonus and epilepsy. Annals of Neurology. 75:77-87. 2014
2014	α2A-adrenergic receptors filter parabrachial inputs to the bed nucleus of the stria terminalis 2014
2013	Cross-talk from β-adrenergic receptors modulates α2A -adrenergic receptor endocytosis in sympathetic neurons via protein kinase A and spinophilin. Journal of Biological Chemistry. 288:29193-29205. 2013
2012	α2 adrenergic receptor dysregulation in depressive disorders: implications for the neurobiology of depression and antidepressant therapy.. Neuroscience and Biobehavioral Reviews. 36:2214-2225. 2012
2012	Noradrenergic antidepressant responses to desipramine in vivo are reciprocally regulated by arrestin3 and spinophilin. Neuropharmacology. 62:2353-2361. 2012
2012	Desipramine selectively potentiates norepinephrine-elicited ERK1/2 activation through the α 2A adrenergic receptor. Biochemical and Biophysical Research Communications. 420:161-165. 2012
2012	Neurabin scaffolding of adenosine receptor and RGS4 regulates anti-seizure effect of endogenous adenosine 2012
2012	Noradrenergic antidepressant responses to desipramine in vivo are reciprocally regulated by arrestin3 and spinophilin. Neuropharmacology. 62:2354-2362. 2012
2012	α2 adrenergic receptor dysregulation in depressive disorders: Implications for the neurobiology of depression and antidepressant therapy. Neuroscience and Biobehavioral Reviews. 36:2214-2225. 2012
2011	Adrenergic receptors. Preface.. Current Topics in Membranes. 67. 2011
2011	The antidepressant desipramine is an arrestin-biased ligand at the α 2A-adrenergic receptor driving receptor down-regulation in vitro and in vivo. Journal of Biological Chemistry. 286:36063-36075. 2011
2011	Characterization of the novel interaction between muskelin and TBX20, a critical cardiogenic transcription factor. Biochemical and Biophysical Research Communications. 409:338-343. 2011
2011	Inactivation of Bmp4 from the Tbx1 expression domain causes abnormal pharyngeal arch artery and cardiac outflow tract remodeling 2011
2011	Dicer activity in neural crest cells is essential for craniofacial organogenesis and pharyngeal arch artery morphogenesis. Mechanisms of Development. 128:200-207. 2011
2011	Cell autonomous requirement of endocardial Smad4 during atrioventricular cushion development in mouse embryos. Developmental Dynamics. 240:211-220. 2011
2011	Study of GPCR-protein interactions using gel overlay assays and glutathione-S-transferase-fusion protein pull-downs. Methods in Molecular Biology. 746:347-355. 2011
2010	Enhanced hypotensive, bradycardic, and hypnotic responses to α2-adrenergic agonists in spinophilin-null mice are accompanied by increased G protein coupling to the α2A-adrenergic receptor. Molecular Pharmacology. 78:279-286. 2010
2009	α2A-adrenergic receptors heterosynaptically regulate glutamatergic transmission in the bed nucleus of the stria terminalis. Neuroscience. 163:339-351. 2009
2009	Epitope-tagged receptor knock-in mice reveal that differential desensitization of α2-adrenergic responses is because of ligand-selective internalization. Journal of Biological Chemistry. 284:13233-13243. 2009
2009	Knockout of spinophilin, an endogenous antagonist of arrestin-dependent α2-adrenoceptor functions, enhances receptor-mediated antinociception yet does not eliminate sex-related differences. Behavioural Brain Research. 197:457-461. 2009
2008	Protein kinase A phosphorylation of spinophilin modulates its interaction with the α2A-adrenergic receptor (AR) and alters temporal properties of α2AAR internalization. Journal of Biological Chemistry. 283:14516-14523. 2008
2008	Disruption of Smad4 in neural crest cells leads to mid-gestation death with pharyngeal arch, craniofacial and cardiac defects. Developmental Biology. 316:417-430. 2008
2007	Myocardial Smad4 is essential for cardiogenesis in mouse embryos. Circulation Research. 101:277-285. 2007
2007	Regulation of α2AR trafficking and signaling by interacting proteins. Biochemical Pharmacology. 73:1135-1145. 2007
2007	Characterization of cis-regulatory elements and transcription factor binding: gel mobility shift assay.. Methods in Molecular Biology. 366:183-201. 2007
2006	Arrestin serves as a molecular switch, linking endogenous α2-adrenergic receptor to SRC-dependent, but not SRC-independent, ERK activation. Journal of Biological Chemistry. 281:25948-25955. 2006
2005	α2-adrenergic agonist enrichment of spinophilin at the cell surface involves βγ subunits of Gi proteins and is preferentially induced by the α2A-subtype. Molecular Pharmacology. 67:1690-1696. 2005
2004	Spinophilin blocks arrestin actions in vitro and in vivo at G protein-coupled receptors. Science. 304:1940-1944. 2004
2004	Study of G-protein-coupled receptor-protein interactions using gel overlay assays and glutathione-S-transferase-fusion protein pull-downs.. Methods in Molecular Biology. 259:371-378. 2004
2003	Spinophilin stabilizes cell surface expression of α 2B-adrenergic receptors. Journal of Biological Chemistry. 278:32405-32412. 2003
2002	Regulated interactions of the α2A adrenergic receptor with spinophilin, 14-3-3ζ, and arrestin 3. Journal of Biological Chemistry. 277:50589-50596. 2002
2002	A novel TCTG(G/C) direct repeat and an A/T-rich HMG2-binding site control the expression of the rat cardiac troponin T gene.. Journal of Molecular and Cellular Cardiology. 34:1667-1679. 2002
2001	Agonist-regulated Interaction between α2-Adrenergic Receptors and Spinophilin. Journal of Biological Chemistry. 276:15003-15008. 2001
2001	Comparative studies on the expression patterns of three troponin T genes during mouse development.. Anatomical Record. 263:72-84. 2001
2000	Identification of cis elements in the cardiac troponin T gene conferring specific expression in cardiac muscle of transgenic mice.. Circulation Research. 86:478-484. 2000
1999	Requirement of a novel gene, Xin, in cardiac morphogenesis. 1999

Book

Year	Title	Altmetric
2011	Genetic Variations of α2-Adrenergic Receptors Illuminate the Diversity of Receptor Functions. Ed. 67. 2011
2009	An osteoblast-dependent mechanism contributes to the leptin regulation of insulin secretion. Ed. 1173. 2009
2004	Membrane Trafficking of G Protein-Coupled Receptors. Ed. 44. 2004

Chapter

Year	Title	Altmetric
2015	α2 adrenergic receptor trafficking as a therapeutic target in antidepressant drug action. 207-225. 2015
2012	α2-Adrenergic Receptors. 55-58. 2012
2007	Characterization of cis-Regulatory Elements and Transcription Factor Binding. 183-201. 2007
2000	Differentially expressed genes and cardiac morphogenesis. 2000

Research Overview

The lab has a general interest in neurosynaptic signaling in neurological and psychiatric disorders. Our goal is to translate our lab research to development of new therapeutic interventions for disease treatment. Current projects include: 1)Noradrenergic signaling in Alzheimer’s disease; 2)Protein trafficking in Alzheimer’s disease; 3)Synaptic signaling in social behavior and autism spectrum disorders; 4) Novel genetic risk factors for ADHD.
Keywords - synaptic receptors, signaling, protein trafficking, ligand regulation, neurodegeneration, neuroprotection, Alzheimer's disease, cognition, mood disorders