Positions

Overview

  • Dr. Qiang Ding is an Associate Professor of Medicine in the Division of Pulmonary, Allergy, and Critical Care Medicine. Dr. Ding received his PhD degree in molecular and cellular pathology at the University of Alabama at Birmingham. After completing his postdoctoral fellowship training in the UAB Department of Pathology, Dr. Ding joined the UAB Division of Pulmonary, Allergy, and Critical Care medicine at the rank of Assistant Professor. Dr. Ding is actively involved in education and service for the medical community. He holds a secondary appointment in the Department of Cell, Developmental, and Integrative Biology (CDIB), is a member of the Intellectual and Developmental Disabilities Research Center (IDDRC), and is a faculty member of the Graduate Biomedical Science PhD program at UAB.

    • Selected Publications

    Academic Article

    Year Title Altmetric
    2019 Phi-based risk calculators performed better in the prediction of prostate cancer in the Chinese population.  Asian Journal of Andrology.  21:592-597. 2019
    2019 CRISPR/Cas9-mediated MSTN gene editing induced mitochondrial alterations in C2C12 myoblast cells.  Electronic Journal of Biotechnology.  40:30-39. 2019
    2019 Hepatitis e virus assembly and release.  Viruses.  11. 2019
    2019 Differences across cyclophilin a orthologs contribute to the host range restriction of hepatitis c virus.  eLife.  8. 2019
    2019 FABP5 regulates the proliferation of clear cell renal cell carcinoma cells via the PI3K/AKT signaling pathway.  International Journal of Oncology.  54:1221-1232. 2019
    2019 Lymph node dissection could bring survival benefits to patients diagnosed with clinically node-negative upper urinary tract urothelial cancer: a population-based, propensity score-matched study.  International Journal of Clinical Oncology.  24:296-305. 2019
    2019 Anticancer effect of icaritin on prostate cancer via regulating miR-381-3p and its target gene UBE2C.  Cancer Medicine.  2019
    2019 Base pair editing in goat: nonsense codon introgression into FGF5 results in longer hair.  European Journal of Biochemistry.  2019
    2019 Effects of diabetes mellitus and Metformin administration on prostate cancer detection at biopsy among Chinese men: a case-control study.  Journal of Balkan Union of Oncology.  24:227-232. 2019
    2019 Effects of diabetes mellitus and metformin administration on prostate cancer detection at biopsy among Chinese men: A case-control study.  Journal of Balkan Union of Oncology.  24:214-219. 2019
    2019 Exosomal micro RNAs derived from dermal papilla cells mediate hair follicle stem cell proliferation and differentiation.  International Journal of Biological Sciences.  15:1368-1382. 2019
    2019 Optimisation of the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9: Single-guide RNA (sgRNA) delivery system in a goat model.  Reproduction, Fertility and Development.  31:1533-1537. 2019
    2019 Overexpression of steroid sulfotransferase genes is associated with worsened prognosis and with immune exclusion in clear cell-renal cell carcinoma.  Aging.  11:9209-9219. 2019
    2019 Programmable base editing of the sheep genome revealed no genome-wide off-target mutations.  Frontiers in Genetics.  10. 2019
    2018 Germline mutations in DNA repair genes are associated with bladder cancer risk and unfavourable prognosis.  BJU International.  122:808-813. 2018
    2018 NOS3 895G>T and CBR3 730G>A Are Associated with Recurrence Risk in Non-Muscle-Invasive Bladder Cancer with Intravesical Instillations of THP.  Chemotherapy.  63:191-197. 2018
    2018 Overexpression of low density lipoprotein receptor-related protein 1 (LRP1) is associated with worsened prognosis and decreased cancer immunity in clear-cell renal cell carcinoma.  Biochemical and Biophysical Research Communications.  503:1537-1543. 2018
    2018 Review of grid dispatching considering thermal power and large-scale wind power integration.  Dianli Xitong Baohu Yu Kongzhi.  46:162-170. 2018
    2018 Correction to: Hepatitis C virus NS4B induces the degradation of TRIF to inhibit TLR3-mediated interferon signaling pathway (PLOS Pathogens, (2018), 14, 5, (e1007075), 10.1371/journal.ppat.1007075).  PLoS Pathogens.  14. 2018
    2018 EZH2 Expression is increased in BAP1-mutant renal clear cell carcinoma and is related to poor prognosis.  Journal of Cancer.  9:3787-3796. 2018
    2018 Generation of gene-edited sheep with a defined Booroola fecundity gene (FecB B ) mutation in bone morphogenetic protein receptor type 1B (BMPR1B) via clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) 9.  Reproduction, Fertility and Development.  30:1616-1621. 2018
    2018 HOXA9, PCDH17, POU4F2, and ONECUT2 as a Urinary Biomarker Combination for the Detection of Bladder Cancer in Chinese Patients with Hematuria.  European urology focus.  2018
    2018 Pathologically examining a minimum of three lymph nodes could better determine node negativity in patients with non-metastatic chromophobe renal cell carcinoma.  Japanese Journal of Clinical Oncology.  48:942-949. 2018
    2017 Angiotensin-converting enzyme defines matrikine-regulated inflammation and fibrosis.  JCI insight.  2. 2017
    2017 Focal adhesion kinase signaling determines the fate of lung epithelial cells in response to TGF-β.  AJP - Lung Cellular and Molecular Physiology.  312:L926-L935. 2017
    2017 Predictive value of deregulated cryptochrome genes in human hepatocellular carcinoma.  Bulletin- John Rylands University Library of Manchester.  39:127-133. 2017
    2017 Tβ4-overexpression based on the piggyBac transposon system in cashmere goats alters hair fiber characteristics.  Transgenic Research.  26:77-85. 2017
    2016 CXCL9: evidence and contradictions for its role in tumor progression.  Cancer Medicine.  5:3246-3259. 2016
    2016 An alternatively spliced variant of CXCR3 mediates the metastasis of CD133+ liver cancer cells induced by CXCL9.  Oncotarget.  7:14405-14414. 2016
    2016 Ménétrier disease manifested by polyposis and involved in both the small bowel and entire colon A Case Report.  Medicine.  95. 2016
    2014 Lysophosphatidic acid accelerates lung fibrosis by inducing differentiation of mesenchymal stem cells into myofibroblasts.  Journal of Cellular and Molecular Medicine.  18:156-169. 2014
    2014 The effect of CXCL9 on the invasion ability of hepatocellular carcinoma through up-regulation of PREX2.  Histochemical Journal.  45:689-696. 2014
    2013 FAK-related nonkinase is a multifunctional negative regulator of pulmonary fibrosis.  American Journal of Pathology.  182:1572-1584. 2013
    2013 Establishment of a stable urethral stricture model in New Zealand rabbits.  Actas Urológicas Españolas.  37:162-166. 2013
    2012 Urinary BLCA-4 level is useful to detect upper urinary tract urothelial cell carcinoma.  Actas Urológicas Españolas.  36:597-602. 2012
    2008 Focal adhesion kinase (FAK)-related non-kinase inhibits myofibroblast differentiation through differential MAPK activation in a FAK-dependent manner.  Journal of Biological Chemistry.  283:26839-26849. 2008
    1999 A multicentre clinical study on cefpiran in the treatment of urogenital tract infections.  Zhongguo Kang Sheng Su Za Zhi ==.  24. 1999

    Chapter

    Year Title Altmetric
    2019 Mouse models for studying HCV vaccines and therapeutic antibodies.  481-503. 2019

    Research Overview

  • Dr. Ding's research focuses on cellular and extracellular environment interaction in various diseases and how such interaction affects the molecular mechanisms contributing to tissue injury and disregulated tissue repairing.

    Dr. Ding's laboratory is currently investigating the role of fibroblast migration and myofibroblast differentiation in the development of lung fibrosis, and the molecular mechanisms which contribute to fibroblast migration and myfibroblast differentiation.

    Focal adhesion kinase (FAK) plays an important role in regulation of fibroblast migration, differentiation, and proliferation. The Ding Lab has found that focal adhesion kinase (FAK) regulates cell proliferation through regulation of the expression of extracellular matrix proteins and Cyclin D1. The cytoplasmic protein FAK-related non-kinase (FRNK) acts to limit FAK-dependent cell migration and proliferation. Data from this laboratory indicates that FRNK acts to limit myofibroblast differentiation induced by transforming growth factor beta-1 (TGF-beta-1), a core signaling process in the development of lung fibrosis.

    The Ding Lab is also interested in exploring the expression of FRNK, its signaling pathways, and how that signaling regulates the pro-fibrotic phenotype and plasticity of the cell types involved. Recently, the lab investigated post-transcriptional regulation and its role in pathogenesis, along with examining the therapeutic potentials of small molecular inhibitors of involved signaling pathways in treating pulmonary fibrosis, cancer, and excessive tissue injury.

    • Principal Investigator On

    Investigator On

    Education And Training

  • University of Alabama at Birmingham, Other
  • University of Alabama at Birmingham, Postdoctoral Research
  • Doctor of Philosophy in Pathology Residency Program, University of Alabama at Birmingham 1999
  • Bachelor's Level Degree in Biochemistry, Biophysics and Molecular Biology, Fudan University 1986

    • Full Name

  • Qiang Ding

    • Fax

  • 205-934-1721