• Dr. Qiang Ding is an Associate Professor of Medicine in the Division of Pulmonary, Allergy, and Critical Care Medicine. Dr. Ding received his PhD degree in molecular and cellular pathology at the University of Alabama at Birmingham. After completing his postdoctoral fellowship training in the UAB Department of Pathology, Dr. Ding joined the UAB Division of Pulmonary, Allergy, and Critical Care medicine at the rank of Assistant Professor. Dr. Ding is actively involved in education and service for the medical community. He holds a secondary appointment in the Department of Cell, Developmental, and Integrative Biology (CDIB), is a member of the Intellectual and Developmental Disabilities Research Center (IDDRC), and is a faculty member of the Graduate Biomedical Science PhD program at UAB.
  • Selected Publications

    Academic Article

    Year Title Altmetric
    2020 HOXA9, PCDH17, POU4F2, and ONECUT2 as a Urinary Biomarker Combination for the Detection of Bladder Cancer in Chinese Patients with Hematuria 2020
    2020 Enhanced O-linked Glcnacylation in Crohn's disease promotes intestinal inflammation 2020
    2020 First-time versus recurrent penoscrotal extramammary Paget's disease: Clinicopathological characteristics and risk factors in 164 Chinese male patients 2020
    2020 Methyltransferase like 3 promotes colorectal cancer proliferation by stabilizing CCNE1 mRNA in an m6A-dependent manner 2020
    2020 The Rare Variant rs35356162 in UHRF1BP1 Increases Bladder Cancer Risk in Han Chinese Population 2020
    2020 Neuronal Wiskott-Aldrich syndrome protein regulates Pseudomonas aeruginosa-induced lung vascular permeability through the modulation of actin cytoskeletal dynamics 2020
    2020 Targeting Src family kinase member Fyn by Saracatinib attenuated liver fibrosis in vitro and in vivo 2020
    2020 Erratum: The RNA binding protein RBMS3 inhibits the metastasis of breast cancer by regulating Twist1 expression (J Exp Clin Cancer Res (2019) 38 (105)DOI:10.1186/s13046-019-1111-5) 2020
    2020 The clinical characteristics of pneumonia patients coinfected with 2019 novel coronavirus and influenza virus in Wuhan, China 2020
    2019 Anticancer effect of icaritin on prostate cancer via regulating miR-381-3p and its target gene UBE2C 2019
    2019 Base pair editing in goat: nonsense codon introgression into FGF5 results in longer hair 2019
    2019 Increased flux through the mevalonate pathway mediates fibrotic repair without injury 2019
    2019 Phi-based risk calculators performed better in the prediction of prostate cancer in the Chinese population 2019
    2019 SWELL1 promotes cell growth and metastasis of hepatocellular carcinoma in vitro and in vivo 2019
    2019 4-Hydroxy estrogen metabolite, causing genomic instability by attenuating the function of spindle-assembly checkpoint, can serve as a biomarker for breast cancer 2019
    2019 CRISPR/Cas9-mediated MSTN gene editing induced mitochondrial alterations in C2C12 myoblast cells 2019
    2019 Hepatitis e virus assembly and release 2019
    2019 Differences across cyclophilin a orthologs contribute to the host range restriction of hepatitis c virus 2019
    2019 FABP5 regulates the proliferation of clear cell renal cell carcinoma cells via the PI3K/AKT signaling pathway 2019
    2019 Lymph node dissection could bring survival benefits to patients diagnosed with clinically node-negative upper urinary tract urothelial cancer: a population-based, propensity score-matched study 2019
    2019 The RNA binding protein RBMS3 inhibits the metastasis of breast cancer by regulating Twist1 expression 2019
    2019 Effects of diabetes mellitus and Metformin administration on prostate cancer detection at biopsy among Chinese men: a case-control study 2019
    2019 Effects of diabetes mellitus and metformin administration on prostate cancer detection at biopsy among Chinese men: A case-control study 2019
    2019 Exosomal micro RNAs derived from dermal papilla cells mediate hair follicle stem cell proliferation and differentiation 2019
    2019 Optimisation of the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9: Single-guide RNA (sgRNA) delivery system in a goat model 2019
    2019 Overexpression of steroid sulfotransferase genes is associated with worsened prognosis and with immune exclusion in clear cell-renal cell carcinoma 2019
    2019 Programmable base editing of the sheep genome revealed no genome-wide off-target mutations 2019
    2019 Rapamycin enhances the sensitivity of ER-positive breast cancer cells to tamoxifen by upregulating p73 expression 2019
    2019 TCDD-inducible poly-ADP-ribose polymerase (TIPARP), a novel therapeutic target of breast cancer 2019
    2018 Microwave ablation combined with doxorubicin enhances cell death via promoting reactive oxygen species generation in breast cancer cells 2018
    2018 Technical analysis of US imaging for precise microwave ablation for benign breast tumours 2018
    2018 Germline mutations in DNA repair genes are associated with bladder cancer risk and unfavourable prognosis 2018
    2018 NOS3 895G>T and CBR3 730G>A Are Associated with Recurrence Risk in Non-Muscle-Invasive Bladder Cancer with Intravesical Instillations of THP 2018
    2018 D Rhamnose β-hederin against human breast cancer by reducing tumor-derived exosomes 2018
    2018 Overexpression of low density lipoprotein receptor-related protein 1 (LRP1) is associated with worsened prognosis and decreased cancer immunity in clear-cell renal cell carcinoma 2018
    2018 Relationship between expression of RBM38 and distant metastasis and prognosis of breast cancer 2018
    2018 Review of grid dispatching considering thermal power and large-scale wind power integration 2018
    2018 Circulating microRNAs from the miR-106a–363 cluster on chromosome X as novel diagnostic biomarkers for breast cancer 2018
    2018 Correction to: Hepatitis C virus NS4B induces the degradation of TRIF to inhibit TLR3-mediated interferon signaling pathway (PLOS Pathogens, (2018), 14, 5, (e1007075), 10.1371/journal.ppat.1007075) 2018
    2018 A hederagenin saponin isolated from Clematis ganpiniana inducesapoptosis in breast cancer cells via the mitochondrial pathway 2018
    2018 D Rhamnose β-hederin inhibits migration and invasion of human breast cancer cell line MDA-MB-231 2018
    2018 EZH2 Expression is increased in BAP1-mutant renal clear cell carcinoma and is related to poor prognosis 2018
    2018 Generation of gene-edited sheep with a defined Booroola fecundity gene (FecB B ) mutation in bone morphogenetic protein receptor type 1B (BMPR1B) via clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) 9 2018
    2018 Pathologically examining a minimum of three lymph nodes could better determine node negativity in patients with non-metastatic chromophobe renal cell carcinoma 2018
    2017 Angiotensin-converting enzyme defines matrikine-regulated inflammation and fibrosis 2017
    2017 Variation of sentinel lymphatic channels (SLCs) and sentinel lymph nodes (SLNs) assessed by contrast-enhanced ultrasound (CEUS) in breast cancer patients 2017
    2017 Focal adhesion kinase signaling determines the fate of lung epithelial cells in response to TGF-β 2017
    2017 Predictive value of deregulated cryptochrome genes in human hepatocellular carcinoma 2017
    2017 Prognostic and clinicopathological significance of cyclin B expression in patients with breast cancer 2017
    2017 The role of c-Myc-RBM38 loop in the growth suppression in breast cancer 2017
    2017 Interaction between ezrin and cortactin in promoting epithelial to mesenchymal transition in breast cancer cells 2017
    2017 An Assessment of the Contrast Sensitivity in Patients with Ametropic and Anisometropic Amblyopia in Achieving the Corrected Visual Acuity of 1.0 2017
    2017 Tβ4-overexpression based on the piggyBac transposon system in cashmere goats alters hair fiber characteristics 2017
    2017 Insufficient microwave ablation-induced promotion of distant metastasis is suppressed by β-catenin pathway inhibition in breast cancer 2017
    2017 RNPC1 enhances progesterone receptor functions by regulating its mRNA stability in breast cancer 2017
    2016 CXCL9: evidence and contradictions for its role in tumor progression 2016
    2016 Breast cancer metastasis to the contralateral neck 22 years remote from initial diagnosis: A case report 2016
    2016 Great tumour burden in the axilla may influence lymphatic drainage in breast cancer patients 2016
    2016 A meta-analysis of clinical trials assessing the effect of radiofrequency ablation for breast cancer 2016
    2016 An alternatively spliced variant of CXCR3 mediates the metastasis of CD133+ liver cancer cells induced by CXCL9 2016
    2016 Ménétrier disease manifested by polyposis and involved in both the small bowel and entire colon A Case Report 2016
    2015 Baicalein inhibits progression of gallbladder cancer cells by downregulating ZFX 2015
    2015 Estrogen receptor (ER) was regulated by RNPC1 stabilizing mRNA in ER positive breast cancer 2015
    2015 Integrative genomic analyses of the RNA-binding protein, RNPC1, and its potential role in cancer prediction 2015
    2014 Effects of oxymatrine on the apoptosis and proliferation of gallbladder cancer cells 2014
    2014 Image and pathological changes after microwave ablation of breast cancer: a pilot study 2014
    2014 Baicalin induces apoptosis of gallbladder carcinoma cells in vitro via a mitochondrial-mediated pathway and suppresses tumor growth in vivo 2014
    2014 Clinical and prognostic significance of preoperative plasma hyperfibrinogenemia in gallbladder cancer patients following surgical resection: A retrospective and in vitro study 2014
    2014 RNA-binding protein RNPC1: Acting as a tumor suppressor in breast cancer 2014
    2014 Anti-tumor effect of 5-FU-PLLA-CNTs on human gastric carcinoma cell lines in vitro 2014
    2014 Evaluation of two inflammation-based prognostic scores in patients with resectable gallbladder carcinoma 2014
    2014 Reproductive factors and breast cancer risk among BRCA1 or BRCA2 mutation carriers: Results from ten studies 2014
    2014 Triptolide induces S phase arrest and apoptosis in gallbladder cancer cells 2014
    2014 Role of polymorphisms of the IGF2 and IGFBP3 genes and risk of gastric carcinoma in China 2014
    2014 Bufalin induces cell cycle arrest and apoptosis in gallbladder carcinoma cells 2014
    2014 CLIC1 overexpression is associated with poor prognosis in gallbladder cancer 2014
    2014 Downregulation of miR-106b induced breast cancer cell invasion and motility in association with overexpression of matrix metalloproteinase 2 2014
    2014 Lysophosphatidic acid accelerates lung fibrosis by inducing differentiation of mesenchymal stem cells into myofibroblasts 2014
    2014 The anticancer effect and mechanism of α-hederin on breast cancer cells 2014
    2014 The effect of CXCL9 on the invasion ability of hepatocellular carcinoma through up-regulation of PREX2 2014
    2014 Three-step method for systematic lymphadenectomy in gastric cancer surgery using the 'curettage and aspiration dissection technique' with Peng's multifunctional operative dissector 2014
    2014 Ursolic acid induces cell cycle arrest and apoptosis of gallbladder carcinoma cells 2014
    2013 [Change of coagulation in patients with gallbladder cancer and its clinical significance] 2013
    2013 The role of prophylactic transpapillary pancreatic stenting in distal pancreatectomy: A meta-analysis 2013
    2013 Regulation of cell proliferation and migration in gallbladder cancer by zinc finger X-chromosomal protein 2013
    2013 Long-term outcomes of breast cancer ablation 2013
    2013 Intraoperative Ultrasound Guidance Is Associated with Clear Lumpectomy Margins for Breast Cancer: A Systematic Review and Meta-Analysis 2013
    2013 The role of preoperative TACE on hepatocellular carcinoma located in caudate lobe 2013
    2013 Isolated complete caudate lobectomy for hepatic tumor of the anterior transhepatic approach: Surgical approaches and perioperative outcomes 2013
    2013 Surgical management of patients with bowel obstructions secondary to gastric cancer 2013
    2013 Downregulated expression of hepatoma-derived growth factor (HDGF) reduces gallbladder cancer cell proliferation and invasion 2013
    2013 FAK-related nonkinase is a multifunctional negative regulator of pulmonary fibrosis 2013
    2013 Duct-to-duct biliary reconstruction after radical resection of Bismuth IIIa hilar cholangiocarcinoma 2013
    2013 Combined Portal Vein Resection for Hilar Cholangiocarcinoma: A Meta-analysis of Comparative Studies 2013
    2013 Establishment of a stable urethral stricture model in New Zealand rabbits 2013
    2013 In vitro tumor cytotoxic activities of extracts from three Liriodendron plants 2013
    2013 Hypoxia-induced factor-1 alpha upregulates vascular endothelial growth factor C to promote lymphangiogenesis and angiogenesis in breast cancer patients 2013
    2012 A Novel Finding of Sentinel Lymphatic Channels in Early Stage Breast Cancer Patients: Which May Influence Detection Rate and False-Negative Rate of Sentinel Lymph Node Biopsy 2012
    2012 A novel mouse model of gastric cancer with human gastric microenvironment 2012
    2012 Urinary BLCA-4 level is useful to detect upper urinary tract urothelial cell carcinoma 2012
    2012 Response 2012
    2012 US-guided percutaneous microwave coagulation of small breast cancers: A clinical study 2012
    2012 Cancer/testis antigen SSX2 enhances invasiveness in MCF-7 cells by repressing ERá signaling 2012
    2012 Percutaneous microwave coagulation for eradication of VX2 tumors subcutaneously in rabbits 2012
    2012 The risk of amenorrhea is related to chemotherapy-induced leucopenia in breast cancer patients receiving epirubicin and taxane based chemotherapy 2012
    2012 Bone metastasis in a novel breast cancer mouse model containing human breast and human bone 2012
    2012 Bloody nipple discharge is a predictor of breast cancer risk: A meta-analysis 2012
    2012 Ethyl pyruvate administration suppresses growth and invasion of gallbladder cancer cells via downregulation of HMGB1-RAGE axis 2012
    2012 Postmenopausal hormone therapy is associated with in situ breast cancer risk 2012
    2011 Toremifene is an effective and safe alternative to tamoxifen in adjuvant endocrine therapy for breast cancer: Results of four randomized trials 2011
    2011 The influence of family history and histological stratification on breast cancer risk in women with benign breast disease: A meta-analysis 2011
    2010 Cytotoxic polyphenols against breast tumor cell in Smilax china L. 2010
    2010 A novel orthotopic and metastatic mouse model of breast cancer in human mammary microenvironment 2010
    2010 Concise regiospecific synthesis of 5-Chloropyrido[4,3-d]pyrimidin-4(3 H)-one 2010
    2010 Human tissue-specific microenvironment: An essential requirement for mouse models of breast cancer 2010
    2009 Cytotoxic and antibacterial triterpenoids derivatives from Clematis ganpiniana 2009
    2008 Focal adhesion kinase (FAK)-related non-kinase inhibits myofibroblast differentiation through differential MAPK activation in a FAK-dependent manner 2008
    2008 Rearrangement of N,N-di-tert-butoxycarbonylpyridin-4-amines and formation of polyfunctional pyridines 2008
    2004 Small Molecules that Induce Cardiomyogenesis in Embryonic Stem Cells 2004
    2002 A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells 2002
    2002 Resin-capture and release strategy toward combinatorial libraries of 2,6,9-substituted purines 2002
    2001 Expanding the diversity of purine libraries 2001
    1999 A multicentre clinical study on cefpiran in the treatment of urogenital tract infections 1999


    Year Title Altmetric
    2019 Mouse models for studying HCV vaccines and therapeutic antibodies.  481-503. 2019

    Research Overview

  • Dr. Ding's research focuses on cellular and extracellular environment interaction in various diseases and how such interaction affects the molecular mechanisms contributing to tissue injury and disregulated tissue repairing.

    Dr. Ding's laboratory is currently investigating the role of fibroblast migration and myofibroblast differentiation in the development of lung fibrosis, and the molecular mechanisms which contribute to fibroblast migration and myfibroblast differentiation.

    Focal adhesion kinase (FAK) plays an important role in regulation of fibroblast migration, differentiation, and proliferation. The Ding Lab has found that focal adhesion kinase (FAK) regulates cell proliferation through regulation of the expression of extracellular matrix proteins and Cyclin D1. The cytoplasmic protein FAK-related non-kinase (FRNK) acts to limit FAK-dependent cell migration and proliferation. Data from this laboratory indicates that FRNK acts to limit myofibroblast differentiation induced by transforming growth factor beta-1 (TGF-beta-1), a core signaling process in the development of lung fibrosis.

    The Ding Lab is also interested in exploring the expression of FRNK, its signaling pathways, and how that signaling regulates the pro-fibrotic phenotype and plasticity of the cell types involved. Recently, the lab investigated post-transcriptional regulation and its role in pathogenesis, along with examining the therapeutic potentials of small molecular inhibitors of involved signaling pathways in treating pulmonary fibrosis, cancer, and excessive tissue injury.
  • Education And Training

  • University of Alabama at Birmingham, Other
  • University of Alabama at Birmingham, Postdoctoral Research
  • Doctor of Philosophy in Pathology Residency Program, University of Alabama at Birmingham 1999
  • Bachelor's Level Degree in Biochemistry, Biophysics and Molecular Biology, Fudan University 1986
  • Full Name

  • Qiang Ding
  • Fax

  • 205-934-1721