Positions

Selected Publications

Chapter

Year Title Altmetric
2007 Nucleases in DNA repair, replication and recombination: Flap endonuclease-1 as a paradigm.  267-300. 2007

Research Overview

  • As an integral member of the Institute for Cancer Outcomes and Survivorship at UAB, my goal is to understand the molecular and epigenetic basis of adverse outcomes in childhood cancer survivors. Anthracycline-related cardiomyopathy and congestive heart failure is the leading cause of late morbidity in survivors of childhood cancers. There is a dose-dependent association between anthracycline exposure and cardiomyopathy risk, suggesting that genetic predisposition possibly modifies this association. I am following an integrative genomics approach to understand whether genetic and epigenetic predisposition can place childhood cancer survivors at an increased risk for developing treatment-related complications and therefore allow for targeted therapy, thus reducing morbidity in children with cancer.
  • Investigator On

  • COG PCR - Per Case Reimbursement NIH National Clinical Trials Network (NCTN) Grant (U10CA180886) Successor to NIH COG Chair Grant (U10CA098543)  awarded by CHILDREN'S HOSPITAL (PHILADELPHIA) 2019 - 2025
  • Mitigating Long-term Treatment-related Morbidity in Childhood Cancer Survivors  awarded by National Cancer Institute/NIH/DHHS 2018 - 2025
  • Per Case Reimbursement COG NCORP Research Base  awarded by CHILDREN'S HOSPITAL (PHILADELPHIA) 2019 - 2025
  • BMT Survivor Study-2 (BMTSS-2)  awarded by National Cancer Institute/NIH/DHHS 2019 - 2024
  • City of Hope Lymphoma SPORE  awarded by BECKMAN RESEARCH INSTITUTE (CITY OF HOPE) 2018 - 2023
  • St. Baldrick's Foundation Supplemental Reimbursement  awarded by CHILDREN'S HOSPITAL (PHILADELPHIA) 2018 - 2020
  • (PQB-1) Telomere Maintenance Defects and Thyroid Second Cancer in Childhood Cancer Survivors  awarded by Baylor College of Medicine 2015 - 2019
  • Per Case Reimbursement: COG NCORP Research Base  awarded by CHILDREN'S HOSPITAL (PHILADELPHIA) 2017 - 2019
  • COG PCR - Per Case Reimbursement NIH National Clinical Trials Network (NCTN) Grant (U10CA180886) Successor to NIH COG Chair Grant (U10CA098543)  awarded by CHILDREN'S HOSPITAL (PHILADELPHIA) 2018 - 2019
  • A Comprehensive Investigation of Outcome Disparities in Children, Adolescents and Young Adults with Cancer  awarded by KAUL PEDIATRIC RESEARCH INSTITUTE 2016 - 2018
  • Novel Methods to Detect Gene-Environment Interactions in Treatment-Related Brain Tumors Among Childhood Cancer Survivors  awarded by University of Wisconsin-Milwaukee 2015 - 2016
  • COG PCR - Per Case Reimbursement NIH National Clinical Trials Network (NCTN) Grant (U10CA180886) Successor to NIH COG Chair Grant (U10CA098543)  awarded by CHILDREN'S HOSPITAL (PHILADELPHIA) 2014 - 2015
  • Education And Training

  • Beckman Research Institute, City of Hope Molecular and Cellular Biology, Postdoctoral Research 2011
  • Beckman Research Institute, City of Hope Radiation Biology, Postdoctoral Research 2007
  • Doctor of Philosophy in Molecular Biology, 2001
  • Full Name

  • Purnima Singh
  • Fax

  • 205-638-2121