1. 1. Cell-free homogenates of male and female pyloric caeca, body wall, testis and ovary were incubated with radiolabeled 3H-androstenedione. 2. 2. Pyloric caeca had highest rates of androstenedione conversion. The predoimannt metabolites in the pyloric caeca were testosterone, 5α-andostane-3β,17β-diol and 5β-andostane-3β,17β-diol. 3. 3. In body wall, testicular and ovarian homogenates, androstenedione was converted primarily to testosterone and also to 5α-andostanedione and epiandrosterone. 4. 4. Qualitative and quantitative differences in androgen metabolism in somatic and germinal tissuesmay be related to tissue-specific regulation of cellular metabolism. © 1992.
