Tissue distribution of IgA receptor-bearing cells in mouse and guinea pig with special reference to the lymphoid population of the gastrointestinal tract

Academic Article

Abstract

  • The presence and relative number of cells bearing IgA and IgG receptors in various mouse and guinea pig lymphoid tissues was determined using rosetting techniques. Both types of cells were found to be widely distributed, with cells binding IgG (range 10 to 45%) being more common than cells binding IgA (range 2 to 6%) in all tissues examined. In the mouse, cells bearing IgA receptors were not more prevalent in the intestinal lymphoid organs, Peyer's patches and mesenteric lymph nodes, as compared to the systemic lymphoid organs, spleen and peripheral lymph nodes, although PP contained the highest percentage. In addition, the percentage of cells with IgA or IgG receptors in a given murine tissue did not directly correlate with the capacity of lymphocytes from that tissue to synthesize immunoglobulin of the same isotype upon LPS stimulation. In the guinea pig, cells with IgA receptors were found in both lamina propria and intraepithelial lymphocyte populations isolated from small intestinal mucosa. However, their number there was only marginally higher than that found in other guinea pig tissues, such as spleen. Thus, cells bearing IgA receptors are not preferentially localized in tissues which are active in the secretory (IgA) immune system. © 1980, All rights reserved.
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    Digital Object Identifier (doi)

    Author List

  • Arnaud-Battandier F; Hague NE; Lum LG; Elson CO; Strober W
  • Start Page

  • 106
  • End Page

  • 113
  • Volume

  • 55
  • Issue

  • 1