© 2017 Taylor & Francis Group, LLC. Researchers have identified college student-athletes as a subgroup at risk for heavy drinking and associated consequences. Yet, few studies have examined multiple variables simultaneously to determine which stand out as most robust to explain drinking behavior among student-athletes. Student-athletes from 54 National Collegiate Athletic Association (NCAA) member institutions (N = 2,659) completed an online questionnaire as part of an online alcohol education program. Logistic regression analyses demonstrated a unique profile based on descriptive and injunctive norms and alcohol outcome expectancies among binge-drinking student-athletes compared to non-binge-drinking athletes. Gender differences also emerged within the sample. Implications for campus mental health, university, and athletic personnel are discussed.