Overweight adolescents with type 2 diabetes have significantly higher lipoprotein abnormalities than those with type 1 diabetes

Academic Article

Abstract

  • © 2016 Elsevier Ireland Ltd. Aim: Diabetes-associated glucoregulatory derangements may precipitate atherogenesis in childhood and CVD risk, particularly with obesity. We aimed to delineate lipoprotein profile differences between children with type 1 and 2 diabetes who are overweight/obese. Methods: Data were obtained from electronic medical records of patients ≥85th BMI percentile with type 1 (n = 159) and type 2 (n = 77) diabetes, ages 12-19 y. Group differences were evaluated by correlations and general linear modeling analysis, adjusting for BMI, HbA1c, and diabetes duration. Results: There were no group differences in TC, LDL, or non-HDL. Fewer subjects with type 1 diabetes had low HDL (17 vs. 30%; P < 0.05). While no difference in HbA1c level was observed between groups, HbA1c was positively correlated with TC (P ≤ 0.0001), LDL (P ≤ 0.0001), non-HDL (P ≤ 0.0001), ApoB100 (P ≤ 0.0001), and LDL pattern B (P ≤ 0.0001). In adjusted models, apoB100 (85.4 vs. 91.3 mg/dl; P < 0.05) and incidence of LDL pattern B (21 vs. 42%; P < 0.01) were lower in subjects with type 1 diabetes. BMI was inversely correlated with HDL, HDL-2 and HDL-3 (all P ≤ 0.0001). The correlation of BMI with HDL-2 and HDL-3 were attenuated when evaluating subjects by diabetes type. Conclusions: Despite having no difference in absolute LDL levels, children with type 2 diabetes were more likely to have small, dense LDL particle pattern, higher apo B100 and lower total HDL, HDL-2, and HDL-3 fractions. Furthermore, poor glycemic control was associated with abnormal lipoprotein profiles in patients with both type 1 and 2 diabetes.
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    Author List

  • Hanks LJ; Pelham JH; Vaid S; Casazza K; Ashraf AP
  • Start Page

  • 83
  • End Page

  • 89
  • Volume

  • 115