© 2016 Taylor & Francis Group, LLC. Objective: To review a case of quintuplets with all babies developing necrotizing enterocolitis. Methods: A retrospective study of preterm quintuplets all developing necrotizing enterocolitis. Clinical outcomes were reviewed. Results: Quintuplets were born at 24 weeks gestation. Each baby developed NEC and was treated. One baby died. Currently the remaining 4 infants are on full enteral nutrition. Conclusion: Further studies are needed to better understand this emerging population of multiple birth pregnancy and the frequency of NEC development.