tdic(9;12): A nonrandom chromosome abnormality in childhood B-cell precursor acute lymphoblastic leukemia: A pediatric oncology group study

Academic Article


  • In a review of 432 children with newly diagnosed acute lymphoblastic leukemia (ALL), we identified a new nonrandom translocation, tdic(9;12)(p1?1;p1?2), in the leukemic marrow cells of eight patients. Seven had hypodiploid karyotypes that lacked chromosomes 9 and 12 and contained a der(12), tdic(9;12); the eighth had a pseudodiploid karyotype with two normal 9 chromosomes, one normal 12 and the der(12), tdic(9;12). Abnormalities involving chromosomes other than 9 and 12 were noted in four of the eight patients. All cells with the tdic(9;12) expressed both the common ALL antigen and HLA-DR. Cytoplasmic immunoglobulin, a marker of pre-B ALL, was detected in one case with the tdic(9;12) but was absent in the other seven. Our results suggest that the tdic(9;12)(p1?1;p1?2) rearrangement is specifically associated with leukemic B cell precursors.
  • Published In

  • Blood  Journal
  • Digital Object Identifier (doi)

    Author List

  • Carroll AJ; Raimondi SC; Williams DL; Behm FG; Borowitz M; Castleberry RP; Harris MB; Patterson RB; Pullen DJ; Crist WM
  • Start Page

  • 1962
  • End Page

  • 1965
  • Volume

  • 70
  • Issue

  • 6