An Altered 11-Kilobase Transcript in Leukemic Cell Lines with the t(4;11)(q21;q23) chromosome translocation

Academic Article

Abstract

  • The 11q23 chromosome band is frequently associated with chromosomal aberrations in human leukemias. We have previously cloned a DNA fragment derived from chromosome 11 which could be used as a probe to detect rearrangements in DNAs from the leukemic cells of patients with the t(4;11), t(9;11), and t(11;19) translocations In this study we now show that the same probe detects DNA rearrangements in malignant cells from patients with the t(1;11), t(6;11), t(10;11), and del (11q23) chromosomal abnormalities. A second probe obtained from a region located centrometric to the breakpoint cluster detects major and minor transcripts of 12.5 and 11.5 kilobases, respectively, in all cell lines examined. The same probe identifies an altered 11-kilobase RNA in all three independent cell lines with the t(4;11)(q21;q23) chromosome translocation. © 1992, American Association for Cancer Research. All rights reserved.
  • Published In

  • Cancer Research  Journal
  • Author List

  • Cimino G; Nakamura T; Gu Y; Canaani O; Prasad R; Crist WM; Carroll AJ; Baer M; Bloomfield CD; Nowell PC
  • Start Page

  • 3811
  • End Page

  • 3813
  • Volume

  • 52
  • Issue

  • 13