GABAergic signalling to adult-generated neurons

Academic Article

Abstract

  • New neurons are continuously generated in discrete regions of the adult brain. In the hippocampus, newly generated cells undergo a step-wise progression of maturation that is regulated at multiple stages by a variety of physiological and pathological stimuli. Neural progenitors and newborn neurons initially receive exclusively GABAergic synaptic input, and accumulating evidence suggests that depolarizing actions of GABA contribute to activity-dependent regulation. Here we provide a brief overview of GABAergic signalling to newborn neurons in the hippocampus and describe how it regulates adult neurogenesis. © 2008 The Authors. Journal compilation © 2008 The Physiological Society.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Markwardt S; Overstreet-Wadiche L
  • Start Page

  • 3745
  • End Page

  • 3749
  • Volume

  • 586
  • Issue

  • 16