Molecular targeting of neural cancer stem cells: TTAGGG, you're it!

Academic Article

Abstract

  • Telomerase is an important mechanism by which cancers escape replicative senescence. In neural tumors, cancer stem cells express telomerase, suggesting that this may explain their preferential tumorigenesis. Oligonucleotide telomerase targeting selectively disrupts cancer stem cell growth through the induction of differentiation, adding to the armamentarium of anticancer stem cell therapies. ©2011 AACR.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Hjelmeland AB; Rich JN
  • Start Page

  • 3
  • End Page

  • 5
  • Volume

  • 17
  • Issue

  • 1