Adult-onset Alexander disease with progressive ataxia and palatal tremor

Academic Article

Abstract

  • A novel glial fibrillary acidic protein (GFAP) mutation, Y257C, is reported in a patient with adult-onset Alexander disease. This is the oldest reported case with confirmation of a GFAP mutation. Onset was late in the sixth decade. Genetic analysis of the GFAP gene is recommended in cases of progressive ataxia and palatal tremor. © 2007 Movement Disorder Society.
  • Authors

    Published In

  • Movement Disorders  Journal
  • Digital Object Identifier (doi)

    Author List

  • Howard KL; Hall DA; Moon M; Agarwal P; Newman E; Brenner M
  • Start Page

  • 118
  • End Page

  • 122
  • Volume

  • 23
  • Issue

  • 1