PI3 Kinase Signals BCR-Dependent Mature B Cell Survival

Academic Article


  • Previous work has shown that mature B cells depend upon survival signals delivered to the cells by their antigen receptor (BCR). To identify the molecular nature of this survival signal, we have developed a genetic approach in which ablation of the BCR is combined with the activation of specific, BCR dependent signaling cascades in mature B cells in vivo. Using this system, we provide evidence that the survival of BCR deficient mature B cells can be rescued by a single signaling pathway downstream of the BCR, namely PI3K signaling, with the FOXO1 transcription factor playing a central role. © 2009 Elsevier Inc. All rights reserved.
  • Published In

  • Cell  Journal
  • Digital Object Identifier (doi)

    Author List

  • Srinivasan L; Sasaki Y; Calado DP; Zhang B; Paik JH; DePinho RA; Kutok JL; Kearney JF; Otipoby KL; Rajewsky K
  • Start Page

  • 573
  • End Page

  • 586
  • Volume

  • 139
  • Issue

  • 3