Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival

Academic Article

Abstract

  • We describe a unique extracellular matrix (ECM) niche in the spleen, the marginal zone (MZ), characterized by the basement membrane glycoproteins, laminin α5 and agrin, that promotes formation of a specialized population of MZ B lymphocytes that respond rapidly to blood-borne antigens. Mice with reduced laminin α5 expression show reduced MZ B cells and increased numbers of newly formed (NF) transitional B cells that migrate from the bone marrow, without changes in other immune or stromal cell compartments. Transient integrin α6β1-mediated interaction of NF B cells with laminin α5 in the MZ supports the MZ B-cell population, their long-term survival, and antibody response. Data suggest that the unique 3D structure and biochemical composition of the ECM of lymphoid organs impacts on immune cell fate. © PNAS 2013.
  • Digital Object Identifier (doi)

    Author List

  • Song J; Lokmic Z; Lämmermann T; Rolf J; Wu C; Zhang X; Hallmann R; Hannocks MJ; Horn N; Ruegg MA
  • Volume

  • 110
  • Issue

  • 31