Enhanced hippocampal neurodegeneration after traumatic or kainate excitotoxicity in GFAP-null mice

Academic Article

Abstract

  • Astrocytes perform a variety of functions in the adult central nervous system. Recent evidence suggests that the upregulation of glial fibrillary acidic protein (GFAP), an astrocyte-specific intermediate filament component, is a biological marker of neurotoxicity after cerebral injury. We herein compared the response to traumatic brain injury or kainic acid (KA)-induced neurotoxicity in GFAP knockout (GFAP-KO) and wild-type (WT) mice. Seventy-two hours after injury, all GFAP-KO mice showed hippocampal CA3 neurodegeneration, whereas WT mice did not show neurodegeneration. Seventy-two hours after KA administration, GFAP-KO mice were more susceptible to KA-induced seizures and had an increased number of pyknotic damaged CA3 neurons than did WT mice. These results indicate that GFAP plays a crucial role in pyramidal neuronal survival after injury or KA-induced neurotoxicity. © 2006 Elsevier Ltd. All rights reserved.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Otani N; Nawashiro H; Fukui S; Ooigawa H; Ohsumi A; Toyooka T; Shima K; Gomi H; Brenner M
  • Start Page

  • 934
  • End Page

  • 938
  • Volume

  • 13
  • Issue

  • 9