Cancer stem cells and their interaction with the tumor microenvironment in neuroblastoma

Academic Article

Abstract

  • © 2015 by the authors; licensee MDPI, Basel, Switzerland. Neuroblastoma, a solid tumor arising from neural crest cells, accounts for over 15% of all pediatric cancer deaths. The interaction of neuroblastoma cancer-initiating cells with their microenvironment likely plays an integral role in the maintenance of resistant disease and tumor relapse. In this review, we discuss the interaction between neuroblastoma cancer-initiating cells and the elements of the tumor microenvironment and how these interactions may provide novel therapeutic targets for this difficult to treat disease.
  • Published In

  • Cancers  Journal
  • Digital Object Identifier (doi)

    Author List

  • Garner EF; Beierle EA
  • Start Page

  • 1
  • End Page

  • 13
  • Volume

  • 8
  • Issue

  • 1