The molecular basis of IL-10 function: From receptor structure to the onset of signaling



  • Assembly of the cell surface IL-10 receptor complex is the first step in initiating IL-10 signaling pathways that regulate intestinal inflammation, viral persistence and even tumor surveillance. The discovery of IL-10 homologs in the genomes of herpes viruses suggests IL-10 signaling pathways can be manipulated at the level of the receptor complex. This chapter will describe our current molecular understanding of IL-10 receptor assembly based on crystal structures and biochemical analyses of cellular and viral IL-10 receptor complexes. © 2014 Springer-Verlag Berlin Heidelberg.
  • Digital Object Identifier (doi)

    International Standard Book Number (isbn) 13

  • 9783662434918
  • Start Page

  • 191
  • End Page

  • 212
  • Volume

  • 380