Removal of Benzyl-Type Protecting Groups from Peptides by Catalytic Transfer Hydrogenation with Formic Acid

Academic Article

Abstract

  • Summary: Formic acid is shown to be a particularly effective hydrogen donor for the rapid removal of peptide benzyl and benzyloxycarbonyl protecting groups by catalytic transfer hydrogenation.Sir: Catalytic transfer hydrogenation has been shown to be a useful procedure for the removal of benzyl and benzyloxycarbonyl protecting groups in peptide synthesis.1-4 Good yields of deprotected products have been obtained under relatively mild conditionsusing both. © 1979, American Chemical Society. All rights reserved.
  • Published In

    Digital Object Identifier (doi)

    Start Page

  • 3442
  • End Page

  • 3444
  • Volume

  • 44
  • Issue

  • 19