Transforming growth factor-beta in development and disease

Academic Article

Abstract

  • The transforming growth factor-beta (TGF-beta) superfamily consists of multifunctional peptides that control many aspects of cell growth and differentiation. Because of the multifunctional nature of the TGF-betas, an understanding of the mechanism of TGF-beta action should provide significant information regarding the pathogenesis of many diseases. This review will focus on the role and mechanisms of TGF-beta signaling in the mammary gland, skin, lung, and skeleton and will discuss how alterations in TGF-beta signaling may result in disease.
  • Published In

    Author List

  • Serra RA; McDonnell M; Bragg A
  • Start Page

  • 205
  • End Page

  • 218
  • Volume

  • 16
  • Issue

  • 4