Science signaling podcast: 23 June 2015

Academic Article


  • This Podcast features an interview with David Sweatt and John Hablitz, senior authors of a Research Article that appears in the 23 June 2015 issue of Science Signaling, about the role of DNA methylation in synaptic plasticity. Making and recalling memories relies on synaptic plasticity, a collective term for changes in neuronal morphology or function that affect communication between neurons. Meadows et al. found that methylation of DNA was important for scaling of glutamatergic synapses, a type of synaptic plasticity, in cultured rat neurons. DNA methylation status controlled the expression of genes involved in glutamate signaling during multiplicative synaptic upscaling, a phenomenon in which receptor density increases simultaneously in each of a neuron's synapses. These findings illustrate that epigenetic mechanisms can coordinate cell?wide changes in synaptic function.
  • Authors

    Published In

  • Science Signaling  Journal
  • Digital Object Identifier (doi)

    Author List

  • Sweatt DJ; Hablitz JJ; Van Hook AM
  • Volume

  • 8
  • Issue

  • 382