Enzymes of the pentose phosphate pathway in glutathione-regulated membrane protection in β-thalassaemia

Academic Article

Abstract

  • The mass concentrations of whole blood reduced glutathione and catalytic activity concentrations of the enzymes, glucose-6-phosphate dehydrogenase (EC 1.1.1.49), glutathione reductase (EC 1.6.4.2) and glutathione peroxidase (EC 1.11.9) were analysed in 25 cases of homozygous β-thalassaemia, 20 cases of heterozygous β-thalassaemia and 10 controls. The results showed a significant elevation of reduced glutathione and enzymes of the pentose phosphate pathway in homozygous β-thalassaemia, indicating the existence of an enzyme-regulated glutathione turnover system in the overt state to combat the augmented red cell membrane damage due to autoxidant threat. However, in heterozygous β-thalassaemia, reduced glutathione was increased, but there was no similar elevation of enzymes except for glutathione peroxidase.
  • Author List

  • Ponnazhagan S; Sarkar R
  • Start Page

  • 481
  • End Page

  • 484
  • Volume

  • 30
  • Issue

  • 8