Doxacurium pharmacodynamics in children during volatile and opioid-based anaesthesia

Academic Article

Abstract

  • The interaction between doxacurium and halothane, isoflurane or alfentanil has not been studied in children. Using the cumulative dose-response technique and electromyography, we determined ED and ED of doxacurium during halothane (n = 9), isoflurane (n = 12) of alfentanil (n = 9) based anaesthesia in children aged 2-10 years. Both isoflurane and halothane potentiated the effects of doxacurium compared to alfentanil. The ED for doxacurium/halothane was 23.9 μg.kg compared to 32.7 μg.kg for doxacurium/alfentanil. The ED for doxacurium/isoflurane was 32.7 μg.kg compared to 48.2 μg.kg doxacurium/alfentanil (p <0.05). There were no significant time course differences between the groups. When equipotent doses of doxacurium were used to provide muscle relaxation the duration of the neuromuscular block was similar in children who received aflentanil, halothane or isoflurane supplementation of N O/O anaesthesia. 50 90 50 50 2 2 -1 -1 -1 -1
  • Published In

  • Anaesthesia  Journal
  • Digital Object Identifier (doi)

    Author List

  • Kern C; Tassonyi E; Rouge JC; Wilder-Smith OHG; Pittet JF
  • Start Page

  • 361
  • End Page

  • 364
  • Volume

  • 51
  • Issue

  • 4