A unique DR-related B cell differentiation antigen

Academic Article


  • The Ia or class II molecules in both mouse and man are the basis for the genetic control of the immune response. In addition to DR, other class II antigens have been described in man. We describe a new human Ia antigen K19, recognized by three monoclonal antibodies (HK-9, HK-19, and HK-20). This antigen has the general biochemical characteristics of an Ia antigen but is different from a DR antigen. Further, this antigen is found only on mature B lymphocytes and not on monocytes and activated T cells. Thus, this antigen may represent a new Ia-like molecule that is preferentially expressed on mature B cells.
  • Authors

    Published In

    Author List

  • Shipp MA; Schwartz BD; Kannapell CC; Griffith RC; Scott MG; Ahmed P; Davie JM; Nahm MH
  • Start Page

  • 2458
  • End Page

  • 2467
  • Volume

  • 131
  • Issue

  • 5