Paradoxical organ-specific adaptations to streptozotocin diabetes mellitus in adult rats

Academic Article


  • Adult male Fisher rats injected with streptozotocin (Stz) to produce diabetes mellitus demonstrated a significant loss of total body weight associated with adipose and muscle tissue wasting. Paradoxically, intestinal mass and length were increased in Stz-treated rats despite catabolism of other tissues. Concomitant with increased intestinal mass, food and water intake increased significantly in Stz-diabetic animals. Renal weight was not reduced despite the fall in total body weight. It is proposed that the adult Stz-diabetic rat responds to a loss of available insulin by polyphagia, polydipsia, and catabolism of adipose and muscle tissue and that a large percentage of available synthetic fuel is devoted to the production of additional intestinal tissue.
  • Published In

    Author List

  • Pillion DJ; Jenkins RL; Atchison JA; Stockard CR; Clements RS; Grizzle WE
  • Volume

  • 254
  • Issue

  • 6