Overexpression of the Oncogenic Kinase Pim-1 Leads to Genomic Instability

Academic Article

Abstract

  • Aneuploidy and chromosomal aberrations are hallmarks of most human epithelial malignancies. Here we show that overexpression of the oncogenic kinase Pim-1 in human prostate epithelial cells induces genomic instability by subverting the mitotic spindle checkpoint. Cells overexpressing Pim-1 have a defect in the mitotic spindle checkpoint, abnormal mitotic spindles, centrosome amplification, and chromosome missegregation. Polyploidy and aneuploidy ensue due to a delay in completing cytokinesis. These results define a novel role for elevated Pim-1 expression in promoting genomic instability in human prostate tumors.
  • Published In

    Author List

  • Roh M; Gary B; Song C; Said-Al-Naief N; Tousson A; Kraft A; Eltoum IE; Abdulkadir SA
  • Start Page

  • 8079
  • End Page

  • 8084
  • Volume

  • 63
  • Issue

  • 23