T-bet employs diverse regulatory mechanisms to repress transcription

Academic Article


  • Lineage-defining transcription factors are responsible for activating the signature genes required for a given cell fate. They are also needed to repress the genetic programs associated with alternative lineage decisions. The T-box transcription factor T-bet is required for CD4 + T helper 1 (Th1) cell differentiation. Numerous studies have explored the mechanisms by which T-bet activates the Th1 gene profile, but until recently not much was known about the mechanisms that T-bet utilizes to negatively regulate alternative T helper cell differentiation pathways such as the Th2 and Th17 fates. Here, we discuss new advances in the field that highlight the diverse mechanisms that T-bet employs to antagonize the gene programs for alternative T helper cell fates. © 2011 Elsevier Ltd.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Oestreich KJ; Weinmann AS
  • Start Page

  • 78
  • End Page

  • 83
  • Volume

  • 33
  • Issue

  • 2