Like niacin deficient rats, CD38-/- mice show improved performance in the water maze

Academic Article

Abstract

  • CD38 is a type II glycoprotein that catalyzes the formation of the intracellular calcium signalling molecule cyclic ADP-ribose (cADPR) from nicotinamide adenine dinucleotide (NAD ), which is derived from dietary niacin. We recently demonstrated that in niacin deficient rats, brain cADPR is decreased and performance in the Morris Water Maze (MWM) is improved. Since brain cADPR is simuarly decreased in Cd3 mice, we used the MWM to determine whether water maze performance is also improved in CD38 knockouts. In the hidden platform water maze task, Cd38 mice showed a reduction in latencies and proximity averages, and a tendency towards greater spatial accuracy in a probe trial, which suggests an improvement in spatial learning ability. However, the effect was less significant than that seen with niacin deficiency. The magnitude of cADPR change was greater in the niacin deficiency models than in Cd3 mice (25-35% vs. 16%), so when considered relative to this, these results suggest that although CD38 forms only a portion of brain cADPR, its removal impacts on brain function by a similar mechanism as that of niacin deficiency. Copyright © 2007 by New Century Health Publishers, LLC. All rights of reproduction in any form reserved. + -/- -/- -/-
  • Author List

  • Young GS; Choleris E; Lund FE; Kirkland JB
  • Start Page

  • 111
  • End Page

  • 119
  • Volume

  • 5
  • Issue

  • 2-3