Studies of generation of B cell diversity in mouse, man, and chicken Origins of Lymphocyte Diversity

Academic Article

Abstract

  • The authors have compared the development of B cells in chickens, mice, and humans, attempting whenever possible to use the differences among them to experimental advantage. Because expression of immunoglobulins at the cell surface occurs earlier in the life history of B cells in chickens, the authors used them to study generation of diversity of antigen-binding cells (ABC). Studies in mammals have focused on the parallel problem of expression of different immunoglobulin classes. The authors' studies suggest that: clonal diversity is generated sequentially in a programmed manner and first among B cells that express only IgM; and that Ig class heterogeneity is developed secondarily by an antigen-independent switch in expression of heavy-chain genes by members of each B-cell clone.
  • Author List

  • Cooper MD; Kearney JF; Lydyard PM; Grossi CE; Lawton AR
  • Start Page

  • 139
  • End Page

  • 146
  • Volume

  • 41
  • Issue

  • 1