Acetylcholine receptors in the retinas of the α7 nicotinic acetylcholine receptor knockout mouse

Academic Article

Abstract

  • Purpose: The α7 nicotinic acetylcholine receptor (nAChR) is widely expressed in the nervous system, including in the inner retinal neurons in all species studied to date. Although reductions in the expression of α7 nAChRs are thought to contribute to the memory and visual defcits reported in Alzheimer’s disease (AD) and schizophrenia, the α7 nAChR knockout (KO) mouse is viable and has only slight visual dysfunction. The absence of a major phenotypic abnormality may be attributable to developmental mechanisms that serve to compensate for α7 nAChR loss. We hypothesized that the upregulation of genes encoding other nAChR subunits or muscarinic acetylcholine receptor (mAChR) subtypes during development partially accounts for the absence of major deficiencies in the α7 nAChR KO mouse. The purpose of this study was to determine whether the deletion of the α7 nAChR subunit in a mouse model resulted in changes in the regulation of other cholinergic receptors or other ion channels in an α7 nAChR KO mouse when compared to a wild-type (WT) mouse.
  • Published In

  • Molecular Vision  Journal
  • Author List

  • Smith ML; Oliveira Souza FG; Bruce KS; Strang CE; Morley BJ; Keyser KT
  • Start Page

  • 1328
  • End Page

  • 1356
  • Volume

  • 20