Deletion of C-reactive protein ameliorates experimental cerebral malaria?

Academic Article

Abstract

  • Background: C-reactive protein (CRP) level correlates with parasitemia and severity of malaria, but whether this reflects causality remains unknown. Methods: Using CRP-transgenic and CRP-deficient mice we compared the onset and severity of experimental cerebral malaria (ECM) induced by Plasmodium berghei ANKA (PbA). Results: CRP-deficient mice were most resistant to ECM. Conclusions: CRP might contribute to the development of cerebral malaria, rather than protect against it. © The Author 2014. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved.
  • Digital Object Identifier (doi)

    Author List

  • Szalai AJ; Barnum SR; Ramos TN
  • Start Page

  • 591
  • End Page

  • 593
  • Volume

  • 108
  • Issue

  • 9